Porous Oxide-Functionalized Seaweed Fabric as a Flexible Breath Sensor for Noninvasive Nephropathy Diagnosis

Ever-increasing quality of life demands low-power and reliable gas-sensing technology for point-of-care monitoring of human health by relevant breath biomarkers. However, precise identification is rather challenging due to the relatively small concentration and an abundance of interferents. Herein, a breath sensor that can detect ppb-level ammonia is constructed based on a soft-hard interface design of biocompatible seaweed fabric and nanosheet-assembled bismuth oxide architectures after undergoing heat treatment. Benefiting from abundant defective sites and surface chemical state changes, the flexible sensor can work at room temperature and exhibits superior characteristics for ammonia detection, including ultrahigh response (1296), short response/recovery time (12/6 s), small detection limit (117 ppb), and remarkable anti-interference, even after repetitive mechanical bending and long-term fatigue. Furthermore, the flexible sensor demonstrates a noticeable response to the exhaled breath of a patient with Helicobacter pylori infection. After connecting the sensor with a green-light-emitting diode (LED) in the circuit, an alarm system successfully warns about ammonia levels based on the brightness of the LED. This work provides a potential strategy for wide-range ammonia detection and opens new applications in predictive and personalized healthcare platforms for noninvasive medical diagnosis.

Automated summary

This study presents a breath sensor that can detect ppb-level ammonia at room temperature. The sensor is constructed based on a soft-hard interface design of biocompatible seaweed fabric and nanosheet-assembled bismuth oxide architectures. It exhibits superior characteristics for ammonia detection, including ultrahigh response, short response/recovery time, small detection limit, and remarkable anti-interference. Furthermore, the sensor shows a noticeable response to the exhaled breath of a patient with Helicobacter pylori infection and can be connected to an alarm system for warning about ammonia levels.