期刊
FRONTIERS IN PEDIATRICS
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fped.2022.934505
关键词
small for gestational age; lipids; cholesterol; triglycerides; pregnancy; systematic review
类别
资金
- Science and Technology Program of Nantong City
- [MS12020036]
- [MS12021040]
This study included 8 studies (14,213 pregnancies) and found that decreased levels of TC, TG, and LDL-C during pregnancy were risk factors for the delivery of SGA infants. No significant association was observed between HDL-C levels and SGA delivery.
Background: Studies investigating the relationship between gestational dyslipidemia and small for gestational age (SGA) have reported differing results. This review was performed to determine whether maternal lipid levels during pregnancy were associated with SGA. Methods: Literature searches for relevant studies were conducted systematically from establishment until February 2022 with PubMed, Embase, Cochrane Library and Web of Science. Risk of bias was assessed with the Newcastle-Ottawa Scale and 11-item checklist. According to the classification of GHD parameters, meta-analyses reporting cases regarding total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C) and high-density lipoprotein-cholesterol (HDL-C) were performed respectively. If I-2 >= 50%, considered to demonstrate substantial heterogeneity, the random effect model was employed. Otherwise, a fixed effect model was employed. Results: Eight studies (14,213 pregnancies) were included. Decreased levels of TC (MD -0.13; 95% CI -0.24 to -0.02), TG (MD -0.09; 95% CI -0.14 to -0.03) and LDL-C (MD -0.12; 95% CI -0.23 to -0.00) were risk factors for SGA infant birth. No evident association was observed between HDL-C and delivery of SGA (MD -0.08; 95% CI -0.19 to 0.02). Conclusion: Gestations complicated with dyslipidemia, especially lower concentrations of TC, TG and LDL-C, were at significantly higher risk of delivery of SGA.
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