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Article
Pediatrics
Dilek Yilmaz Ciftdogan et al.
Summary: This study retrospectively analyzed the clinical and laboratory features of MIS-C patients with or without overlap with Kawasaki disease (KD). The findings showed that almost half of the MIS-C patients had clinical features that overlapped with KD, especially incomplete KD. Patients with overlap with KD had lower lymphocyte and platelet counts, and higher levels of ferritin and procalcitonin.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Immunology
Eric J. Chow et al.
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA
(2022)
Article
Immunology
Shana Godfred-Cato et al.
Summary: This study compares the clinical characteristics and laboratory data of patients with MIS-C, COVID-19, KD, and TSS, and finds that patients with MIS-C have significantly higher prevalence of cardiac complications, elevated markers of inflammation and cardiac damage, thrombocytopenia, and lymphopenia compared with patients with the other conditions. Diagnostic scores utilizing clinical findings effectively distinguish MIS-C from COVID-19, KD, and TSS.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Review
Pediatrics
Debjyoti Dhar et al.
Summary: This study systematically reviewed and analyzed the demographic profile, clinical characteristics, management strategies, prognosis, and pathophysiology of Multisystem Inflammatory Syndrome in Children associated with COVID-19. It found a male predilection, gastrointestinal and cardiac symptoms being prominent, and emphasized the importance of early diagnosis and treatment for a favorable outcome.
PEDIATRIC RESEARCH
(2022)
Review
Allergy
Julisa M. Patel
Summary: This review provides an overview of the presenting features, proposed pathogenesis, suggested therapies, and outcomes of MIS-C. Patients with MIS-C present with a wide range of clinical features, with main characteristics including fever, gastrointestinal symptoms, and cardiac complications. Younger children may present with Kawasaki-like features, while older children often experience cardiogenic shock. Current treatment guidelines recommend IVIG and glucocorticoids, with biologics used in refractory cases. Most patients recover and mortality from MIS-C is rare. Prompt diagnosis and treatment are important for the best possible outcome.
CURRENT ALLERGY AND ASTHMA REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Ozren Polasek et al.
Summary: This study used the CHNRI method to identify research priorities related to COVID-19, highlighting the importance of vaccination and healthcare delivery in low- and middle-income countries. The research emphasizes the urgent need for health policy and systems research in these countries.
JOURNAL OF GLOBAL HEALTH
(2022)
Review
Rheumatology
Roberta Caorsi et al.
Summary: This article provides an update on the main pediatric disorders associated with SARS-CoV-2 infection, with a focus on multisystem inflammatory syndrome in children (MIS-C) and other complications such as thrombotic events, neurologic manifestations, and chilblain-like lesions. MIS-C is a novel postinfectious manifestation similar to Kawasaki disease, requiring intensive care therapy. Appropriate treatment with immunomodulatory therapies leads to favorable outcomes in most patients.
CURRENT OPINION IN RHEUMATOLOGY
(2022)
Correction
Multidisciplinary Sciences
Pradipta Ghosh et al.
NATURE COMMUNICATIONS
(2022)
Review
Pediatrics
Arianna Dondi et al.
Summary: COVID-19 can present with various skin manifestations in children, and mucocutaneous manifestations may be early signs that physicians should be familiar with.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Review
Health Care Sciences & Services
Sigamani Panneer et al.
Summary: The COVID-19 pandemic has presented global challenges in global health cooperation, crisis management, funding coordination, and access to prevention, treatment, and control measures. Non-pharmaceutical measures have had long-term impacts on the economy, highlighting health inequalities and healthcare access issues. More empirical research and transdisciplinary approaches are needed to develop effective strategies for combating the pandemic and its aftermath.
Article
Rheumatology
Fatih Haslak et al.
Summary: MIS-C is a rare complication of COVID-19 in children. A study on 76 MIS-C patients found that 35.5% were admitted to PICU, with cardiac and gastrointestinal involvement being most common. Patients with older age and lower initial serum albumin levels had a higher risk for PICU admission.
CLINICAL RHEUMATOLOGY
(2021)
Review
Pediatrics
Fatih Haslak et al.
Summary: A new disease called multisystem inflammatory syndrome in children has emerged in the era of 2019 coronavirus disease, which, although rare, appears to be highly fatal. Understanding the pathogenesis and establishing appropriate treatment regimes are urgent needs.
TURKISH ARCHIVES OF PEDIATRICS
(2021)
