Epigenetic modifications and targeted therapy in pediatric acute myeloid leukemia

Acute myeloid leukemia (AML) is a hematological malignancy resulting from the genetic alterations and epigenetic dysregulations of the hematopoietic progenitor cells. One-third of children with AML remain at risk of relapse even though outcomes have improved in recent decades. Epigenetic dysregulations have been identified to play a significant role during myeloid leukemogenesis. In contrast to genetic changes, epigenetic modifications are typically reversible, opening the door to the development of epigenetic targeted therapy. In this review, we provide an overview of the landscape of epigenetic alterations and describe the current progress that has been made in epigenetic targeted therapy, and pay close attention to the potential value of epigenetic abnormalities in the precision and combinational therapy of pediatric AML.

Automated summary

This review discusses the genetic alterations and epigenetic dysregulations of hematopoietic progenitor cells in acute myeloid leukemia (AML), emphasizing the role of epigenetic abnormalities in leukemogenesis. The current progress in epigenetic targeted therapy and its potential value in precision and combinational therapy for pediatric AML are also described.