Biomaterials in Orthopedic Devices: Current Issues and Future Perspectives

Article Biochemistry & Molecular Biology

Cerium Oxide Nanoparticles Promote Osteoplastic Precursor Differentiation by Activating the Wnt Pathway

Junchao Luo et al.

Summary: CeO2 nanoparticles promote the differentiation of precursor osteoblasts by activating the Wnt pathway and enhancing matrix mineralization.

BIOLOGICAL TRACE ELEMENT RESEARCH (2023)

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Review Materials Science, Multidisciplinary

Biodegradable Mg-based alloys: biological implications and restorative opportunities

Xiao Lin et al.

Summary: This review systematically summarizes and analyzes the biological effects and related mechanisms of Mg-based alloy degradation on biological systems. The restorative potential of Mg-based alloys for tissue repair and regeneration is also summarized, along with discussions on biosafety evaluation and design strategies.

INTERNATIONAL MATERIALS REVIEWS (2023)

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Review Biochemistry & Molecular Biology

Active Materials for 3D Printing in Small Animals: Current Modalities and Future Directions for Orthopedic Applications

Parastoo Memarian et al.

Summary: The successful clinical application of bone tissue engineering requires customized implants based on the receiver's bone anatomy and defect characteristics. 3D printing in small animal orthopedics has emerged as a valuable approach in fabricating individualized implants, improving performance and precision. This review discusses the application of 3D printing in small animal orthopedics, along with the techniques and materials used.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Chemistry, Physical

Magnesium-Based Alloys Used in Orthopedic Surgery

Iulian Antoniac et al.

Summary: This paper provides a detailed overview of the development and manufacturing techniques of magnesium-based alloys as orthopedic temporary implants. It covers the physiological and toxicological effects of alloying elements, mechanical properties, osteogenesis, angiogenesis, and biocompatibility of these alloys. The article also discusses in vitro experiments, animal testing, and clinical translation.

MATERIALS (2022)

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Review Engineering, Biomedical

Biomaterialomics: Data science-driven pathways to develop fourth-generation biomaterials

Bikramjit Basu et al.

Summary: This leading opinion review paper emphasizes the integration of data science concepts and algorithms with biomaterials science. It also highlights the need for a mathematically rigorous cross-disciplinary framework that allows for systematic quantitative exploration and curation of critical biomaterials knowledge, driven by the concept of "biomaterialomics" which integrates multi-omics data and high-dimensional analysis with artificial intelligence tools like machine learning. The formulation of this approach has been demonstrated for patient-specific implants, additive manufacturing, and bioelectronic medicine.

ACTA BIOMATERIALIA (2022)

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Article Psychology, Clinical

Biomechanical in vitro analysis of a novel flexible implant for pubic symphysis disruption using an ultra-high molecular weight polyethylene fiber cord

Nico Hinz et al.

Summary: A novel flexible implant for repairing pubic symphysis disruptions using ultra-high molecular weight polyethylene fiber cords was developed and tested biomechanically. The eye splice fixation method was identified as mechanically optimal, and the flexible implant was proven to withstand physiological forces acting on the pubic symphysis.

CLINICAL PSYCHOLOGY REVIEW (2022)

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Article Polymer Science

Smart 3D Printed Hydrogel Skin Wound Bandages: A Review

Filmon Tsegay et al.

Summary: Wounds can become chronic and even lead to mortality. However, 3D printed wound dressings loaded with various items such as antibiotics and antibacterial nanoparticles have emerged as a promising solution for accelerating wound healing.

POLYMERS (2022)

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Review Polymer Science

A Review of Recent Advances in Natural Polymer-Based Scaffolds for Musculoskeletal Tissue Engineering

Jingzhi Fan et al.

Summary: The musculoskeletal system is crucial for movement, organ protection, support, hematopoiesis, and postural stability. Damage to or loss of musculoskeletal tissues greatly affects quality of life. Natural polymers have shown great potential in tissue engineering for musculoskeletal repair.

POLYMERS (2022)

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Review Polymer Science

Functional Ultra-High Molecular Weight Polyethylene Composites for Ligament Reconstructions and Their Targeted Applications in the Restoration of the Anterior Cruciate Ligament

Sonia B. Wahed et al.

Summary: The selection of biomaterials for biomedical implants is a significant challenge. UHMWPE and its composites are widely used due to their biocompatibility and high wear resistance. However, issues such as wear debris and oxidative degradation exist in UHMWPE implants, necessitating surface functionalization to enhance their performance.

POLYMERS (2022)

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Review Biotechnology & Applied Microbiology

Application and Development of Modern 3D Printing Technology in the Field of Orthopedics

Binglong Li et al.

Summary: 3D printing technology, combined with various adhesive materials, is widely used in multidisciplinary fields such as orthopedics. Despite some shortcomings and challenges, continuous development of advanced materials in 3D printing technology offers a broad outlook for future development.

BIOMED RESEARCH INTERNATIONAL (2022)

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Review Infectious Diseases

Current Knowledge on Biomaterials for Orthopedic Applications Modified to Reduce Bacterial Adhesive Ability

Valeria Allizond et al.

Summary: A significant challenge in orthopedics is the design of biomaterial devices that can substitute or repair tissues and control bone repair. This review provides an overview of recent research into biomaterial modifications to reduce bacterial adhesive ability, focusing on metallic materials, polymers, and composites. Close interdisciplinary collaboration is needed to modify biomaterial structures and improve their antibacterial properties and resistance to infection.

ANTIBIOTICS-BASEL (2022)

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Article

BONE DEFECT MANAGEMENT AND AUGMENTATION OF DISTAL FEMORAL FRACTURES WITH POLYMETHYLMETHACRYLATE BONE CEMENT

Sebastián Corró et al.

Journal of Musculoskeletal Research (2022)

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Article Biotechnology & Applied Microbiology

Insight on recent development in metallic biomaterials: Strategies involving synthesis, types and surface modification for advanced therapeutic and biomedical applications

S. Thanigaivel et al.

Summary: Metallic biomaterials are widely used in the medical field, but increased use of these implants can lead to various problems. To improve the usability of bio-inert metals like titanium and cobalt-based alloys, their appearance needs to be altered. This review discusses the applications, synthesis, and characteristics of metallic biomaterials, as well as strategies for surface and bulk modification to enhance their biointegration, mechanical strength, flexibility, and biocompatibility.

BIOCHEMICAL ENGINEERING JOURNAL (2022)

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Article Materials Science, Coatings & Films

Evaluation of corrosion resistant, antimicrobial and cytocompatible behaviour of cobalt based metallosurfactants self-assembled monolayers on 316L stainless steel surface

Harshal Mehta et al.

Summary: The present research aims to develop a more economic and ecological way to improve the biocompatibility of medical-grade stainless steel. By functionalizing 316L stainless steel with self-assembled monolayers of cost-effective Cobalt-based metallosurfactants, superior corrosion and bacterial protection are provided without compromising the cytocompatibility of the surface, making them promising candidates for biomedical applications.

SURFACE & COATINGS TECHNOLOGY (2022)

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Article

Osteotomy after medial malleolus fracture fixed with magnesium screws ZX00 - A case report

Patrick Holweg et al.

Trauma Case Reports (2022)

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Review Engineering, Biomedical

Biological evaluation of preceramic organosilicon polymers for various healthcare and biomedical engineering applications: A review

Adel Francis

Summary: The article discusses the research on preceramic organosilicon polymers and composites for bone tissue regeneration and medical engineering implants. It highlights surface modifications, biological evaluations, in vitro and in vivo studies, showcasing the versatility and wide range of applications of these materials.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2021)

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Review Materials Science, Composites

Oxide Bioceramic Composites in Orthopedics and Dentistry

Corrado Piconi et al.

Summary: Ceramic composites based on alumina and zirconia have been widely used in orthopedic joint replacements and in dentistry in this century. The excellent mechanical properties of these composites allow for innovative device designs in joint replacements and dental implants.

JOURNAL OF COMPOSITES SCIENCE (2021)

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Article Polymer Science

New and novel stabilisation approach for radiation-crosslinked Ultrahigh Molecular Weight Polyethylene (XL-UHMWPE) targeted for use in orthopeadic implants

C. Jefferies et al.

Summary: Maintenance of stability in XL-UHMWPE materials is crucial for long-term use of orthopaedic joint implants, and the use of novel reactive antioxidants can effectively enhance their oxidative stability and prevent premature failure.

POLYMER DEGRADATION AND STABILITY (2021)

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Article Engineering, Biomedical

Osseointegration of additive manufacturing Ti-6Al-4V and Co-Cr-Mo alloys, with and without surface functionalization with hydroxyapatite and type I collagen

Silvia Brogini et al.

Summary: The study investigated the osseointegration process of Ti-6Al-4V and Co-Cr-Mo implants with different coatings implanted into rabbit lateral femoral condyles. The results showed good biocompatibility of the additive manufacturing materials, with hydroxyapatite coating promoting bone-to-implant contact while collagen did not significantly improve osseointegration.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2021)

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Article Green & Sustainable Science & Technology

Recent advances in biopolymeric composite materials: Future sustainability of bone-implant

Bankole Oladapo et al.

Summary: This research summary focuses on the outcome of a critical review on the medical applications of poly-ether-ether-ketone (PEEK) and its composite materials, including 3D printing and interface healing process. Utilizing the Scopus database and Google search, peer-reviewed papers from the past twelve years were examined. The findings could enhance sustainability and understanding of osteointegration models for PEEK and its composites in the medical and scientific community.

RENEWABLE & SUSTAINABLE ENERGY REVIEWS (2021)

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Review Chemistry, Multidisciplinary

PEEK (Polyether-ether-ketone) and its composite materials in orthopedic implantation

Hongyun Ma et al.

Summary: The article discusses the challenges of large bone defects caused by tumors and traumas, the development of orthopedic implants and bone tissue engineering materials, with a focus on the research progress and advantages of PEEK materials, and their successful clinical applications and achievements.

ARABIAN JOURNAL OF CHEMISTRY (2021)

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Review Engineering, Chemical

Biomaterials and Their Biomedical Applications: From Replacement to Regeneration

Silvia Todros et al.

Summary: The history of biomaterials can be traced back to ancient times when humans used exogenous materials to facilitate wound healing and restore damaged tissues and organs. Nowadays, there is a wide variety of biomaterials available for both maintaining and restoring bodily functions, driven by emerging clinical needs.

PROCESSES (2021)

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Article Engineering, Electrical & Electronic

Micro engraving on 316L stainless steel orthopedic implant using fiber laser

Suvranshu Pattanayak et al.

Summary: The study adopted a multi-response optimization approach and grey relational analysis to improve the quality of fiber laser-based micro engraving grooves, identifying laser power and pulse frequency as the most significant factors for controlling groove quality. Improvements in groove quality were observed under optimized engraving conditions.

OPTICAL FIBER TECHNOLOGY (2021)

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Review Medicine, Research & Experimental

Orthopedic surgery in hemophilic patients with musculoskeletal disorders: A systematic review

Oana Viola Badulescu et al.

Summary: Hemophilia is a hereditary coagulopathy caused by dysfunction of factor VIII or IX, leading to increased bleeding predisposition. Although prophylaxis using coagulation factors has significantly improved the quality of life for hemophilic patients, they still face risks of progressive joint bleeding and secondary motor deficiency. Orthopedic management, including conservative or surgical techniques, is essential in treating osteoarticular complications in hemophilic patients.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Review Metallurgy & Metallurgical Engineering

Biodegradable Mg alloys for orthopedic implants - A review

Violeta Tsakiris et al.

Summary: In the past decade, there has been significant growth in the market for alloys used for implants, especially in orthopedic implants. Research on biodegradable magnesium-based alloys has made great strides in the medical industry due to the desire to improve quality of life and reduce costs.

JOURNAL OF MAGNESIUM AND ALLOYS (2021)

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Review Engineering, Mechanical

Biomedical materials: A review of titanium based alloys

F. A. Anene et al.

Summary: Titanium alloys are highly valued in the biomedical field for their excellent mechanical properties, corrosion resistance, and biocompatibility. With the increasing demand for implants, there is an urgent need to accelerate research and development of biomaterials, with titanium alloys playing a crucial role in implant production.

PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART C-JOURNAL OF MECHANICAL ENGINEERING SCIENCE (2021)

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Article Orthopedics

Ultra-high molecular weight polyethylene (UHMWPE) for hip and knee arthroplasty: The present and the future

Alessandro Bistolfi et al.

Summary: This study reviewed the advances and clinical performance of polyethylene in total joint arthroplasty, highlighting recent innovations such as crosslinking UHMWPE and adding vitamin-E. The findings suggest that these innovations can improve the performance of both the hip and knee, with the potential for long-term survivorship.

JOURNAL OF ORTHOPAEDICS (2021)

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Review Cell & Tissue Engineering

On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook

Carolina Montoya et al.

Summary: The demand for biomaterials to promote repair, replacement, or restoration of hard and soft tissues is increasing due to population aging. This review redefines the concept of "Smart Biomaterial" and discusses recent advances in hard tissue repair and regeneration. It proposes four degrees of smartness and surveys the applications of smart biomaterials in hard tissues, along with discussing limitations in translation from basic research to clinical utilization.

BONE RESEARCH (2021)

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Article Materials Science, Multidisciplinary

Microstructure, wear resistance, and corrosion performance of Ti35Zr28Nb alloy fabricated by powder metallurgy for orthopedic applications

Wei Xu et al.

JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY (2020)

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Review Materials Science, Multidisciplinary

Medical devices biomaterials - A review

A. J. Festas et al.

PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART L-JOURNAL OF MATERIALS-DESIGN AND APPLICATIONS (2020)

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Review Engineering, Biomedical

Biomaterials and biocompatibility: An historical overview

Elia Marin et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2020)

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Review Polymer Science

Natural and Synthetic Polymers for Bone Scaffolds Optimization

Francesca Donnaloja et al.

POLYMERS (2020)

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Article Chemistry, Multidisciplinary

Antibacterial and Osteoconductive Effects of Chitosan/Polyethylene Oxide (PEO)/Bioactive Glass Nanofibers for Orthopedic Applications

Francesco Boschetto et al.

APPLIED SCIENCES-BASEL (2020)

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Review Nanoscience & Nanotechnology

The Advances of Ceria Nanoparticles for Biomedical Applications in Orthopaedics

Hongru Li et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Review Medicine, Research & Experimental

Current practices in haemophilic patients undergoing orthopedic surgery - a systematic review

Oana Viola Badulescu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

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Review Engineering, Multidisciplinary

Metal Oxide Nanoparticles as Biomedical Materials

Maria P. Nikolova et al.

BIOMIMETICS (2020)

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Review Orthopedics

Hybrid fracture fixation systems developed for orthopaedic applications: A general review

Li Tian et al.

JOURNAL OF ORTHOPAEDIC TRANSLATION (2019)

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Article Orthopedics

Comparison of three different internal fixation implants in treatment of femoral neck fracturea finite element analysis

Jia Li et al.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2019)

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Article Orthopedics

Surgical Considerations for Osteoporosis in Ankle Fracture Fixation

Raymond Y. Hsu et al.

ORTHOPEDIC CLINICS OF NORTH AMERICA (2019)

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Review Materials Science, Biomaterials

Review on titanium and titanium based alloys as biomaterials for orthopaedic applications

Manmeet Kaur et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Review Materials Science, Multidisciplinary

Fused Deposition Modelling as a Potential Tool for Antimicrobial Dialysis Catheters Manufacturing: New Trends vs. Conventional Approaches

Essyrose Mathew et al.

COATINGS (2019)

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Article Materials Science, Biomaterials

Au nanoparticle-decorated aragonite microdumbbells for enhanced antibacterial and anticancer activities

Aniruddha Samanta et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Review Engineering, Chemical

Anodization of titanium alloys for orthopedic applications

Merve Izmir et al.

FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING (2019)

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Review Engineering, Biomedical

Key terminology in biomaterials and biocompatibility

Laleh Ghasemi-Mobarakeh et al.

CURRENT OPINION IN BIOMEDICAL ENGINEERING (2019)

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Review Orthopedics

Internal Fixation of Osteoporotic Bone

Kevin D. Grant et al.

JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS (2018)

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Proceedings Paper Materials Science, Multidisciplinary

Composite Polymer in Orthopedic Implants: A Review

Mohammad Saad et al.

MATERIALS TODAY-PROCEEDINGS (2018)

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Review Chemistry, Multidisciplinary

Polymers and Ceramics Biomaterials in Orthopedics and Dentistry: A Review Article

Tamer M. Hamdy

EGYPTIAN JOURNAL OF CHEMISTRY (2018)

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Review Engineering, Biomedical

Synthetic polymeric biomaterials for wound healing: a review

Mariam Mir et al.

PROGRESS IN BIOMATERIALS (2018)

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Article Critical Care Medicine

Surgical treatment of osteoporotic fractures: An update on the principles of management

Eyal Yaacobi et al.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2017)

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Article Chemistry, Multidisciplinary

Silver Nanoparticles in Orthopedic Applications: New Insights on Their Effects on Osteogenic Cells

Sara Castiglioni et al.

NANOMATERIALS (2017)

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Article Critical Care Medicine

The use of augmentation techniques in osteoporotic fracture fixation

Christian Kammerlander et al.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2016)

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Editorial Material Materials Science, Multidisciplinary

Fourth-generation biomedical materials

Chengyun Ning et al.

MATERIALS TODAY (2016)

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Review Biochemistry & Molecular Biology

Future Prospects for Scaffolding Methods and Biomaterials in Skin Tissue Engineering: A Review

Atul A. Chaudhari et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Article Orthopedics

Internal fixation of fragility fractures of the femoral neck Ex vivo biomechanical studies

Trude Basso

ACTA ORTHOPAEDICA (2015)

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Review Pharmacology & Pharmacy

Peripheral nerve regeneration: Experimental strategies and future perspectives

Alessandro Faroni et al.

ADVANCED DRUG DELIVERY REVIEWS (2015)

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Review Engineering, Biomedical

Polymeric heart valves for surgical implantation, catheter-based technologies and heart assist devices

Deon Bezuidenhout et al.

BIOMATERIALS (2015)

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Article Critical Care Medicine

PMMA-augmented SI screw: a biomechanical analysis of stiffness and pull-out force in a matched paired human cadaveric model

Stephan Grechenig et al.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2015)

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Review Materials Science, Multidisciplinary

Metallic implant biomaterials

Qizhi Chen et al.

MATERIALS SCIENCE & ENGINEERING R-REPORTS (2015)

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Review Chemistry, Physical

Biodegradable Materials for Bone Repair and Tissue Engineering Applications

Zeeshan Sheikh et al.

MATERIALS (2015)

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Review Orthopedics

New biomaterials for orthopedic implants

Kevin L. Ong et al.

ORTHOPEDIC RESEARCH AND REVIEWS (2015)

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Review Chemistry, Medicinal

A Comprehensive Review of Advanced Biopolymeric Wound Healing Systems

Naeema Mayet et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2014)

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Review Materials Science, Multidisciplinary

Material processing of hydroxyapatite and titanium alloy (HA/Ti) composite as implant materials using powder metallurgy: A review

Amir Arifin et al.

MATERIALS & DESIGN (2014)

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Article Orthopedics

The Effect of Fracture Stability on the Performance of Locking Plate Fixation in Periprosthetic Femoral Fractures

Mehran Moazen et al.

JOURNAL OF ARTHROPLASTY (2013)

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Article Engineering, Biomedical

Regulation of UHMWPE biomaterials in total hip arthroplasty

Michael J. Kasser

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2013)

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Review Biochemistry & Molecular Biology

Recent Insights Into the Biomedical Applications of Shape-memory Polymers

Maria C. Serrano et al.

MACROMOLECULAR BIOSCIENCE (2012)

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Article Orthopedics

Fragility fractures of the pelvis

Gillian L. S. Soles et al.

CURRENT REVIEWS IN MUSCULOSKELETAL MEDICINE (2012)

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Review Engineering, Biomedical

Bioactive and Biodegradable Nanocomposites and Hybrid Biomaterials for Bone Regeneration

Bedilu A. Allo et al.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2012)

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Article Orthopedics

Augmented Tendon Achilles Repair Using a Tissue Reinforcement Scaffold: A Biomechanical Study

Eric Giza et al.

FOOT & ANKLE INTERNATIONAL (2011)

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Article Orthopedics

Impaired Wound-Healing, Local Eczema, and Chronic Inflammation Following Titanium Osteosynthesis in a Nickel and Cobalt-Allergic Patient

Peter Thomas et al.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2011)

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Article Engineering, Biomedical

Characterization of commercial rigid polyurethane foams used as bone analogs for implant testing

Kayla L. Calvert et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2010)

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Article Materials Science, Multidisciplinary

Polymeric biomaterials for load-bearing medical devices

Lisa Pruitt et al.

JOM (2009)

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Article Orthopedics

Complications of titanium and stainless steel elastic nail fixation of pediatric femoral fractures

Eric J. Wall et al.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2008)

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Article Biophysics

Compressive and shear properties of commercially available polyurethane foams

MS Thompson et al.

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME (2003)

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Review Engineering, Biomedical

Bone cements and fillers: A review

SM Kenny et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2003)

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Review Materials Science, Composites

Biomedical applications of polymer-composite materials: a review

S Ramakrishna et al.

COMPOSITES SCIENCE AND TECHNOLOGY (2001)

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Article Dentistry, Oral Surgery & Medicine

Substitutes for human cadaveric hone in maxillofacial rigid fixation research

TL Bredbenner et al.

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY (2000)

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Biomaterials in Orthopedic Devices: Current Issues and Future Perspectives

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