Deposition of Fluoresceine-Doped HAp Coatings via High-Velocity Suspension Flame Spraying

In current medicine, joint revision surgery plays an important role in the treatment of degenerative joint diseases. Infections of the artificial joints are an iatrogenic, accompanying symptom after joint replacement procedures. A new approach is to functionalize the bioactive coatings of the implants by infiltrating them with anti-inflammatory drugs. This work aims at a one-step approach in manufacturing drug-doped, porous hydroxyapatite coatings by high-velocity suspension flame spraying (HVSFS). Thermal exposure of the temperature-sensitive drugs is critical. Therefore, a new process setup, combining one axial and one radial suspension line, is used for coating deposition. The lower dwell time of the suspension in the flame through radial injection helps in controlling the temperature exposition of the contained drug to the flame. Additionally, the influence of the powder morphology, used as a carrier for the drug in the suspension, is investigated by carrying out spray experiments with suspensions from three different granule types. To analyze the temperature exposition within the coating process, fluoresceine was used as a model drug, as the decomposition of the organic, fluorescing molecules can be easily controlled by fluorescence intensity measurements. It could be shown that the deposition of temperature-sensitive organic molecules is possible without degrading the molecular structure by a modified HVSFS process. This knowledge offers new possibilities in the cost-effective one-step manufacturing of functionalized, anti-inflammatory bioceramic coatings on orthopaedic implants.

Automated summary

Joint revision surgery is important in the treatment of degenerative joint diseases, but infections of artificial joints are a common issue. A new approach using anti-inflammatory drugs in bioactive coatings of implants has been developed. The study investigates the influence of powder morphology and temperature exposure during the coating process. The results show that a modified process allows for the deposition of temperature-sensitive organic molecules without degrading their structure, providing new possibilities for cost-effective manufacturing of functionalized, anti-inflammatory bioceramic coatings on orthopaedic implants.