Characterization and evaluation of cytotoxic effect, antioxidant and antimicrobial activities of zinc oxide nanoparticles derived from Justicia adhatoda

The current study describes a green synthesis method for preparing zinc oxide nanoparticles (ZnO-NPs) using Justicia adhatoda to investigate the different pathogen and toxic assays. Synthesized nanoparticles are hexagonal and 40 nm in size. The antifungal activity of ZnO-NPs was analyzed against three strains: Aspergillus fumigatus, Aspergillus flavus, and Aspergillus niger. The antimicrobial activity of ZnO-NPs as tested against Bacillus, Escherichia coli, and Staphylococcus aureus. The ZnO-NPs produced exhibited significant free radical scavenging effects of 200 mu g/mL-73.12%. ZnO-NPs were evaluated against MCF-7 human breast cancer cells at an LD50 concentration of 50 mu g/mL. The results showed that biosynthesized ZnO-NPs have efficient inhibitory activity against fungal and bacterial strains and cytotoxicity against human MCF-7 breast cancer cell lines.

Automated summary

This study describes a green synthesis method using Justicia adhatoda to prepare zinc oxide nanoparticles (ZnO-NPs) and investigates their antifungal, antimicrobial, and anticancer activities. The synthesized ZnO-NPs exhibit significant inhibitory effects against fungal and bacterial strains, as well as cytotoxicity against human breast cancer cells.