期刊
FRONTIERS IN PSYCHIATRY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fpsyt.2022.995956
关键词
schizophrenia; long non-coding RNAs; pathophysiology; biomarker; therapy
类别
资金
- National Natural Science Foundation of China
- Shanxi Provincial Science and Technology Achievements Transformation and Guidance Project
- Shanxi Provincial Department of Education University Science and Technology Innovation Plan Project
- Shanxi Provincial Science and Technology Innovation Team of Multidisciplinary Diagnosis and Treatment of Cognitive Impairment
- Shanxi Scholarship Council of China
- [82271546]
- [81701326]
- [81971601]
- [201904D131020]
- [202010203]
- [201705D131027]
- [2022-190]
This review summarizes the involvement of long non-coding RNAs in the pathogenesis of schizophrenia and discusses their potential as biomarkers and therapeutic targets.
Schizophrenia (SZ) is a severe psychiatric disorder which is contributed by both genetic and environmental factors. However, at present, its specific pathogenesis is still not very clear, and there is a lack of objective and reliable biomarkers. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) are involved in the pathophysiology of several psychiatric disorders, including SZ, and hold promise as potential biomarkers and therapeutic targets for psychiatric disorders. In this review, we summarize and discuss the role of lncRNAs in the pathogenesis of SZ and their potential value as biomarkers and therapeutic targets.
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