期刊
FRONTIERS IN ENDOCRINOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2022.971960
关键词
bone mineral density; insulin; insulinemia; insulin resistance; osteoporosis
资金
- Taichung Veterans General Hospital
- [TCVGH-1093504C]
- [TCVGH-1097316C]
- [TCVGH-1097327D]
- [TCVGH-1103502C]
- [TCVGH-1113502C]
This study investigated the relationship between insulin resistance, beta-cell secretion, and bone mineral density (BMD) and osteoporosis. The results showed that insulin resistance was positively associated with osteoporosis in individuals with high beta-cell secretion, while beta-cell secretion was negatively associated with osteoporosis in individuals with low insulin resistance. These findings suggest that the relationship between beta-cell secretion and BMD/osteoporosis changes as insulin resistance increases.
We investigated the associations of insulin resistance and beta-cell secretion with bone mineral density (BMD) and osteoporosis using data from the National Health and Nutrition Examination Survey. Data on BMD assessed using dual-energy x-ray absorptiometry from 5292 participants were analyzed. Insulin resistance and beta-cell secretion were assessed using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and beta-cell function (HOMA-beta), respectively. We divided the study population into four groups according to HOMA-IR (<2 vs. >= 2) and HOMA-beta (<100 vs. >= 100). BMD and T score at the lumbar spine, hip joint, and femur were used for analyses. Osteoporosis was defined as a T score <= -2.5. Logistic regression analyses were conducted to examine the associations of HOMA-IR and HOMA-beta with osteoporosis, and the joint effects of HOMA-IR and HOMA-beta on osteoporosis. We found a positive association between HOMA-IR and osteoporosis in participants with a HOMA-beta >= 100 (OR 8.773, 95% CI 2.160-35.637, p=0.002 at the femoral neck). A negative association between HOMA-beta and osteoporosis was noted in those with a HOMA-IR <2 (OR 0.183, 95% CI 0.038-0.882, p=0.034 at the femoral neck). Compared with participants who had HOMA-IR <2 and HOMA-beta <100, those with HOMA-IR <2 and HOMA-beta >= 100 had a lower risk of osteoporosis (OR 0.126, 95% CI 0.020-0.805, p=0.032 at the femoral neck). In conclusion, the association between HOMA-beta and BMD/osteoporosis changed as HOMA-IR increased. HOMA-beta was negatively associated with osteoporosis when HOMA-IR <2. The association was not significant when HOMA-IR >= 2.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据