4.7 Review

Expert consensus on the bone repair strategy for osteoporotic fractures in China

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Zhen Geng et al.

Summary: This study showed that Sr incorporation in titanium implants can improve osseointegration, new bone formation, and mineralization. Implants with high Sr content were found to be more favorable for cell spreading, proliferation, osteogenic differentiation, and extracellular matrix mineralization. The competitive effect of osteogenic activity and apatite-forming ability on bone-implant osseointegration was proposed, providing a new strategy for implant design.

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Qianmin Gao et al.

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Shuangshuang Chen et al.

Summary: The repair and regeneration of bone defects caused by various factors have always been a key issue in clinical practice. Bone tissue engineering technology has greatly accelerated the speed and quality of bone regeneration by providing functional scaffold materials and seed cells. However, the complicated bone metabolism mechanism poses challenges to research in bone regeneration. Organoids, as a new concept, show promising application prospects in organ development, drug screening, and mechanism study.

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Neutrophil-erythrocyte hybrid membrane-coated hollow copper sulfide nanoparticles for targeted and photothermal/anti-inflammatory therapy of osteoarthritis

Xu Xue et al.

Summary: This study presents a new type of nanoparticle for treating osteoarthritis, which achieves targeted delivery and anti-inflammatory treatment through cell membrane modification and photothermal responsive drug release. It exhibits significant therapeutic efficacy for osteoarthritis in vivo.

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Epidemiology and outcomes of tibial plateau fractures in adults aged 60 and over treated in the United Kingdom

Richard L. Donovan et al.

Summary: This study investigated the epidemiology, treatment, and outcomes of tibial plateau fractures in patients aged over 60 years. The majority of these fractures in older adults are caused by low-energy falls. The treatment is relatively conservative, and the benefits of surgical intervention for this patient group remain controversial.

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A bone-targeted engineered exosome platform delivering siRNA to treat osteoporosis

Yongzhi Cui et al.

Summary: The complex pathogenesis of osteoporosis makes it difficult to treat with conventional therapies. Researchers have developed an exosome delivery system based on exosomes secreted by mesenchymal stem cells derived from induced pluripotent stem cells. By modifying a bone-targeting peptide, the system can specifically deliver siRNA to osteoblasts and enhance therapeutic effects.

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Exosome-Laden Hydrogels: A Novel Cell-free Strategy for In-situ Bone Tissue Regeneration

Jinru Sun et al.

Summary: In-situ bone tissue regeneration is a method that utilizes special properties of biomaterials, cell external microenvironment, and regenerative potential to induce bone reconstruction. Hydrogel, with its 3D network structure and ability to mimic the native extracellular matrix, is widely used. Exosomes, which play a role in various physiological processes, have been explored for bone regeneration. This review discusses the drawbacks of traditional bone tissue engineering, challenges in exosome delivery, and the advantages of exosome-laden hydrogels for in-situ bone tissue regeneration. It also explores the encapsulation strategies of hydrogel and exosomes, and the research progress and prospects of bioactive hydrogel composite system for continuous exosome delivery in in-situ bone repair.

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Xu Xue et al.

Summary: Bone tissue engineering provides promising tools for the treatment of bone-related diseases using biomimetic hydrogels. This article discusses the fabrication of biomimetic hydrogels using thermal sensitive polymers, mineral ions, chemically triggered agents, photo crosslinking initiators, and enzyme triggers. These hydrogels accelerate bone regeneration and the article also highlights key factors influencing therapeutic effects.

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Rational Design of Multifunctional CuS Nanoparticle-PEG Composite Soft Hydrogel-Coated 3D Hard Polycaprolactone Scaffolds for Efficient Bone Regeneration

Xu Xue et al.

Summary: A CuS-PEG-PCL scaffold with excellent photothermal properties and stable elasticity was designed for efficient bone regeneration. The scaffold released dexamethasone sodium phosphate (Dexp) and promoted osteogenic differentiation of bone cells through controlled release and mild heating.

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Incidence of subsequent osteoporotic fractures after distal radius fractures and mortality of the subsequent distal radius fractures: a retrospective analysis of claims data of the Korea National Health Insurance Service

H. -S. Jung et al.

Summary: A better understanding of the features of subsequent fractures after distal radius fracture (DRF) is important for the prevention of further osteoporotic fractures. This study in South Korea found that the cumulative incidence of subsequent osteoporotic fractures increased over time and that the mortality rates of subsequent DRFs were lower than those of first-time DRFs, with women having higher risk of subsequent fractures.

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RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss

Yan Hu et al.

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Yan Hu et al.

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Prevalence of Osteoporosis and Fracture in China The China Osteoporosis Prevalence Study

Linhong Wang et al.

Summary: The prevalence of osteoporosis and vertebral fracture are high in adult population in mainland China, with similar rates of vertebral and clinical fractures in men and women.

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Summary: Given the progressive ageing of Western populations, the fragility fractures market is experiencing a growing socioeconomic impact. Fragility fractures, common in the elderly, have negative effects on their quality of life, autonomy, disability rate, and life expectancy. Targeting fragile patients before the occurrence of fractures remains a significant challenge, with current diagnostic tools having limitations.

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Summary: Glass polyalkenoate cements (GPCs) are being studied as potential bone adhesives, with GPCs containing strontium (Sr) and zinc (Zn) showing stimulating effects on osteogenic differentiation. Different types of GPCs have varying effects on the osteogenic differentiation of bone cells, with some leading to elevated markers while others inhibiting differentiation.

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Opportunistic Screening Using Low-Dose CT and the Prevalence of Osteoporosis in China: A Nationwide, Multicenter Study

Xiaoguang Cheng et al.

Summary: This study explored the feasibility of opportunistic screening for osteoporosis using LDCT in a large population cohort of Chinese men and women. The prevalence of osteoporosis in Chinese population over 50 years old was found to be 29.0% for women and 13.5% for men, with geographical and age-related variations observed. Further cohort studies are needed to evaluate the clinical utility of such screening in terms of fracture prevention and national health economic analyses.

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