☆ 4.6 Article

The soldiers needed to be awakened: Tumor-infiltrating immune cells

FRONTIERS IN GENETICS (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。
Review Medicine, Research & Experimental

The immunomodulatory role of all-trans retinoic acid in tumor microenvironment

Guoshu Bi et al.

Summary: All-trans retinoic acid (ATRA), an essential nutrient for human beings, plays important roles in multiple biological processes. It regulates the transcription of target genes and has both differentiation-inducing and immunoregulatory effects in cancer immunology and immunotherapy. The combination of ATRA with other therapeutic approaches has been extensively studied for its potential clinical significance in cancer treatment.

CLINICAL AND EXPERIMENTAL MEDICINE (2023)

添加到收藏夹
Article Hematology

Systemic IL-15 promotes allogeneic cell rejection in patients treated with natural killer cell adoptive therapy

Melissa M. Berrien-Elliott et al.

Summary: Using IL-15 for allogeneic cellular therapy may paradoxically limit therapeutic efficacy as it accelerates CD8 T-cell activation, leading to rejection of donor NK cells.

BLOOD (2022)

添加到收藏夹
Article Oncology

CD103+CD8+ tissue-resident memory T cell infiltration predicts clinical outcome and adjuvant therapeutic benefit in muscle-invasive bladder cancer

Kaifeng Jin et al.

Summary: CD103(+)CD8(+) T-RM cells play a crucial role in anti-tumour immunity and serve as an ideal prognostic biomarker for bladder cancer patients.

BRITISH JOURNAL OF CANCER (2022)

添加到收藏夹
Article Oncology

Distribution, phenotype, functional and clinical relevance of CD8+CD103+ tissue-resident memory T cells in human gastric cancer

Yang Shen et al.

Summary: In gastric cancer, tumor-infiltrating CD8(+)CD103(+) tissue-resident memory T cells are decreased compared to non-tumor tissues and show impaired cytolytic function. Restoring the function of these cells through PD-1 blockade and 4-1BB co-stimulation may be a promising strategy for treating gastric cancer and improving patient survival.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2022)

添加到收藏夹
Review Oncology

Understanding resistance to immune checkpoint inhibitors in advanced breast cancer

Paolo Tarantino et al.

Summary: The addition of immune checkpoint inhibitors to frontline chemotherapy has improved survival for advanced TNBC patients. However, resistance often develops and outcomes remain poor. Understanding the immune landscape of BC subtypes, developing new biomarkers, and exploring combination strategies tailored to patient and tumor immunophenotype may help overcome resistance to ICIs.

EXPERT REVIEW OF ANTICANCER THERAPY (2022)

添加到收藏夹
Article Immunology

TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures

Ricardo A. Chaurio et al.

Summary: Regulation of PD-1 expression on Tfh cells affects Tfh cell differentiation. Inhibiting SATB1 expression promotes Tfh cell differentiation and enhances immune responses. Transfer of Tfh cells can induce TLS formation and inhibit tumor growth.

IMMUNITY (2022)

添加到收藏夹
Review Oncology

Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies

Nisha Kumari et al.

Summary: Cancer immunotherapy has had limited success, but nanoparticles have emerged as crucial tools in targeting tumor-associated macrophages (TAMs) and improving therapy outcomes. Current strategies include restricting TAMs survival, inhibiting TAMs recruitment, and repolarizing tumor-supportive TAMs to an antitumor phenotype.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

添加到收藏夹
Article Immunology

Dependence on Bcl6 and Blimp1 drive distinct differentiation of murine memory and follicular helper CD4+ T cells

Thomas Ciucci et al.

Summary: This study reveals that Bcl6 promotes the differentiation of memory cells primarily by repressing Blimp1, while it does not promote the differentiation of Tfh cells. These findings uncover distinct mechanisms underlying the differentiation of memory and Tfh CD4(+) cells and identify the Bcl6-Blimp1 axis as a potential target for promoting long-term memory T cell differentiation.

JOURNAL OF EXPERIMENTAL MEDICINE (2022)

添加到收藏夹
Article Biochemistry & Molecular Biology

Engineered exosomes as an in situ DC-primed vaccine to boost antitumor immunity in breast cancer

Lanxiang Huang et al.

Summary: By loading immunogenic cell death inducers into breast cancer-derived exosomes, a DC vaccine called HELA-Exos was created. HELA-Exos exhibited high efficacy in inducing immune cell death in breast cancer cells and activating immune responses that suppressed tumor growth.

MOLECULAR CANCER (2022)

添加到收藏夹
Review Immunology

The fellowship of regulatory and tissue-resident memory cells

Leandro Barros et al.

Summary: T cells located in non-lymphoid tissues, including CD8(+) Trm cells and CD4(+) Treg cells, have functions beyond immune defence, involving tissue homeostasis and repair. They form a multicellular communication network and have potential implications for future therapies.

MUCOSAL IMMUNOLOGY (2022)

添加到收藏夹
Review Immunology

Tissue resident memory T cells in the respiratory tract

Ming Z. M. Zheng et al.

Summary: Tissue-resident memory (Trm) cells in the respiratory tract play a crucial role in local immune responses against infections. Factors influencing the development, longevity, and immune surveillance of Trm cells were discussed, along with vaccination regimes harnessing these cells as new strategies to combat future global pandemics.

MUCOSAL IMMUNOLOGY (2022)

添加到收藏夹
Review Multidisciplinary Sciences

Tertiary lymphoid structures in cancer

Ton N. Schumacher et al.

Summary: This article discusses the current knowledge on TLSs in cancer, focusing on the drivers of TLS formation, the function and contribution of TLSs to the antitumor immune response, and the potential of TLSs as therapeutic targets in human cancers.

SCIENCE (2022)

添加到收藏夹
Article Pathology

TGFB1 mRNA expression is associated with poor prognosis and specific features of inflammation in ccRCC

Taishi Takahara et al.

Summary: This study investigated the association between TGFB1 expression and clinicopathological features in ccRCC. The results showed that TGFB1 was significantly upregulated in ccRCC tissue and correlated with tumor grade, relapse-free survival, and distant metastasis. TGFB1 expression was also associated with the number of PD-L1-positive cells in the tumor stroma and the formation of tertiary lymphoid structures.

VIRCHOWS ARCHIV (2022)

添加到收藏夹
Article Biotechnology & Applied Microbiology

Future prospects for cancer immunotherapy-Strategies for ineffective cancers

Satoshi Wada et al.

Summary: With the recent Nobel Prize recognition, cancer immunotherapy has gained significant attention and is expected to be a key development in the future. Immune checkpoint inhibitors, a new class of drugs with a different mechanism than traditional chemotherapy, have shown promise in shrinking tumors and improving long-term survival rates. However, their efficacy alone is still limited, leading to ongoing clinical trials focusing on combination therapies for improved outcomes. Another promising approach is CAR T-cell therapy, which has received approval for B-cell hematopoietic tumors. This article outlines the future prospects of cancer immunotherapy, highlighting strategies for combating ineffective cancer treatments.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2022)

添加到收藏夹
Article Oncology

Immunomodulation of T- and NK-cell Responses by a Bispecific Antibody Targeting CD28 Homolog and PD-L1

Madhu Ramaswamy et al.

CANCER IMMUNOLOGY RESEARCH (2022)

添加到收藏夹
Review Immunology

Regulating Histone Deacetylase Signaling Pathways of Myeloid-Derived Suppressor Cells Enhanced T Cell-Based Immunotherapy

Adeleye O. Adeshakin et al.

Summary: Immunotherapy is a promising approach to improve cancer treatment by addressing the immunosuppressive tumor microenvironment. The accumulation of immunosuppressive cells in the tumor microenvironment limits the effectiveness of this treatment. Recent studies have shown that inhibiting histone deacetylase expression on myeloid cells can reduce their immunosuppressive effect, sensitizing tumors to immune checkpoint inhibitors.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹
Article Immunology

Follicular Helper T-Cell-Based Classification of Endometrial Cancer Promotes Precise Checkpoint Immunotherapy and Provides Prognostic Stratification

Yi Chen et al.

Summary: Through studying the transcriptome features of endometrial cancer patients, we identified T follicular helper-like cells (Tfh) as an important factor with potential clinical application in anti-PD-1 treatment. We constructed a Tfh Infiltration Risk Model (TIRM) and found that it outperformed existing models in predicting the prognosis of EC patients.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹
Article Oncology

Single-cell transcriptome analysis revealed a suppressive tumor immune microenvironment in EGFR mutant lung adenocarcinoma

Lei Yang et al.

Summary: This study investigates the immune microenvironment of EGFR-mutant and EGFR wild-type lung adenocarcinomas (LUADs) using single-cell transcriptome sequencing and multiplex immunohistochemistry. The results show that EGFR-mutant LUAD lacks CD8(+) tissue-resident memory (TRM) cells and has less crosstalk between T cells and other cell types compared to EGFR wild-type LUAD. These findings contribute to a better understanding of the immune landscape of EGFR-mutant LUAD at the single-cell level and suggest that the lack of CD8(+) TRM cells may be a key factor in the suppressive TME of EGFR-mutant LUAD.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

添加到收藏夹
Review Oncology

Potential Role of CXCL13/CXCR5 Signaling in Immune Checkpoint Inhibitor Treatment in Cancer

Ching-Hung Hsieh et al.

Summary: Immunotherapy, particularly through the CXCL13/CXCR5 signaling axis, plays a crucial role in cancer treatment by influencing patient prognosis and immune cell activation for antitumor responses. Targeting this axis has significant therapeutic implications in cancer immunotherapy, especially in enhancing lymphocyte infiltration and activation against tumor antigens.

CANCERS (2022)

添加到收藏夹
Article Oncology

Immune Microenvironment Characteristics of Urachal Carcinoma and Its Implications for Prognosis and Immunotherapy

Xinke Zhang et al.

Summary: Urachal carcinoma (UrC) is a rare tumor with no effective treatment. This study analyzed the immune microenvironment of UrC and found that CD8+ T cell density is associated with PD-L1 and PD1 expression. PD-L1 positive expression on immune cells is related to increased PD1 expression. High peritumoral CD8+ T cell density is associated with worse prognosis. The number of tertiary lymphoid structures (TLS) may be a predictive and prognostic biomarker for UrC. Targeting the PD-1/PD-L1 checkpoint could be a potential therapeutic strategy for UrC.

CANCERS (2022)

添加到收藏夹
Review Cell Biology

Plasmacytoid Dendritic Cells and Cancer Immunotherapy

Chunmei Fu et al.

Summary: Although clinical trials of dendritic cell-based vaccines have been disappointing, recent studies have shown that cross-priming mediated by dendritic cells plays a critical role in generating anti-tumor immunity. This supports further development of dendritic cell vaccines as immunotherapy. Recent clinical studies have also shown promise with naturally circulating dendritic cells and dendritic cell-derived exosomes as cancer vaccines.

CELLS (2022)

添加到收藏夹
Review Cell Biology

A review of signaling and transcriptional control in T follicular helper cell differentiation

Andrew P. Hart et al.

Summary: T follicular helper (Tfh) cells play a critical role in adaptive immunity, supporting germinal center B cell survival, antibody class switching, and plasma cell maturation. The differentiation of Tfh is regulated by signals and transcription factors, and further research is needed to understand the dysregulation of Tfh in autoimmune diseases.

JOURNAL OF LEUKOCYTE BIOLOGY (2022)

添加到收藏夹
Article Engineering, Biomedical

Polarization of tumor-associated macrophages by TLR7/8 conjugated radiosensitive peptide hydrogel for overcoming tumor radioresistance

Yumin Zhang et al.

Summary: This study aimed to overcome radioresistance in tumors by regulating the polarization of tumor-associated macrophages (TAMs) using a toll-like receptor agonist TLR7/8a conjugated with a radiosensitive peptide hydrogel (Smac-TLR7/8 hydrogel). The results showed that the Smac-TLR7/8 hydrogel effectively polarized TAMs into an anti-tumor M1 phenotype upon gamma-ray radiation. The repolarization of TAMs promoted tumor necrosis factor secretion, activated the anti-tumor immune response, and inhibited tumor growth. Furthermore, TAMs repolarization enhanced the efficacy of PD1-blockade by increasing tumor infiltrating lymphocytes (TILs) and decreasing Treg cells in solid tumors.

BIOACTIVE MATERIALS (2022)

添加到收藏夹
Article Multidisciplinary Sciences

Tertiary lymphoid structure and decreased CD8+ cell infiltration in minimally invasive adenocarcinoma

Jin Wang et al.

Summary: This study reveals the adaptive characteristics of the tumor microenvironment (TME) in early lung adenocarcinoma, including high CD4(+) T cell infiltration, high B-cell activation, and low CD8(+) T cell infiltration. Multiplex immunohistochemistry staining confirms the formation of tertiary lymphoid structures (TLS) and the enrichment of follicular regulatory T cells (Tfr) in TLS follicles, which may contribute to the attenuated anti-tumor immunity in early lung adenocarcinoma.

ISCIENCE (2022)

添加到收藏夹
Article Engineering, Biomedical

Exploiting autophagy-regulative nanomaterials for activation of dendritic cells enables reinforced cancer immunotherapy

Ying-Hua Guan et al.

Summary: Dendritic cells (DCs) play a critical role in regulating immune response and anti-tumor process. However, immunosuppressive cells and factors in the tumor microenvironment pose challenges to DC function. Therefore, designing nanomaterials to regulate DC autophagy is important for enhancing immune function.

BIOMATERIALS (2022)

添加到收藏夹
Editorial Material Hematology

N-803: a double-edged sword in haplo-NK therapy Comment

Daniela Pende et al.

Summary: In this study, the authors found that haploidentical natural killer (NK) cell therapy using IL-15/N-803 support had decreased clinical activity due to accelerated host T-cell-mediated rejection, which limited the persistence of NK cells.

BLOOD (2022)

添加到收藏夹
Editorial Material Oncology

Intratumoral plasma cells More than a predictive marker of response to anti-PD-L1 treatment in lung cancer?

Jean-Lu Teillauo et al.

Summary: Increased plasma cell signatures are found to be predictive of extended overall survival in non-small-cell lung cancer patients treated with a PD-L1 inhibitor, and these cells are associated with the presence of tertiary lymphoid structures.

CANCER CELL (2022)

添加到收藏夹
Article Oncology

Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells

Carmen M. Anadon et al.

Summary: This study reveals that tissue-resident memory (TRM) cells are the main type of T cells infiltrating ovarian cancer. These TRM cells, specifically the progenitor TRMstem cells, play a crucial role in predicting the outcome of ovarian cancer. The findings suggest that ovarian cancer is immunogenic, but only a small portion of tumor-infiltrating T cells have tumor antigen reactivity.

CANCER CELL (2022)

添加到收藏夹
Article Cell Biology

BMDCs induce the generation of the CD103+CD8+ tissue-resident memory T cell subtype, which amplifies local tumor control in the genital tract

Yuheng Huang et al.

Summary: Tissue-resident memory T (Trm) cells play an important role in antitumor immunity. This study shows that cervicovaginal vaccination can generate Trm cells in the genital tract, which can result in CD8+ T cell expansion and cytokine production upon reencountering the same antigen, effectively controlling tumor growth.

CELLULAR IMMUNOLOGY (2022)

添加到收藏夹
Article Gastroenterology & Hepatology

The tumour microenvironment shapes innate lymphoid cells in patients with hepatocellular carcinoma

Bernd Heinrich et al.

Summary: Our study shows that the cytokine milieu in liver cancer controls the composition of ILCs and the outcome of HCC. Specific cytokine changes can alter ILC composition in the tumor, induce plasticity, and modify ILC function.

GUT (2022)

添加到收藏夹
Review Immunology

Mechanisms of induction of regulatory B cells in the tumour microenvironment and their contribution to immunosuppression and pro-tumour responses

Fabian Flores-Borja et al.

Summary: This article discusses the induction of regulatory B cells in the tumour microenvironment and their role in suppressing anti-tumour responses. The article also explores the therapeutic implications of inhibiting Bregs in cancer. It highlights the importance of understanding the heterogeneity of Bregs and their interactions with other immune cells and the tumour itself in developing potential therapeutic tools to promote anti-tumour responses.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2022)

添加到收藏夹
Article Immunology

Heterogeneity of tissue resident memory T cells

Spela Konjar et al.

Summary: CD8(+) tissue-resident memory T (TRM) cells, found in non-lymphoid organs in mice and humans, play important roles in tissue homeostasis, defense against infections and cancer. TRM cells have common characteristics but show tissue-specific differences in response to local circumstances, interactions with surrounding cells, and available metabolites.

IMMUNOLOGY LETTERS (2022)

添加到收藏夹
Article Immunology

T follicular cells: The regulators of germinal center homeostasis

Filipa Ribeiro et al.

Summary: This article reviews the development and biology of T follicular cell subsets, with a special emphasis on the metabolic regulation of Tfh cells, contributing to a better understanding of GC responses.

IMMUNOLOGY LETTERS (2022)

添加到收藏夹
Article Oncology

The TLR7/8 agonist R848 optimizes host and tumor immunity to improve therapeutic efficacy in murine lung cancer

Jianchun Zhou et al.

Summary: Treatment with TLR7 agonist R848 has shown effectiveness in lung cancer by targeting macrophages and activating immune responses, resulting in reduced tumor burden and prolonged survival. R848 treatment promotes the activation of DCs and NK cells, increases T helper cell-associated cytokines, and alters the proportion of immune cells in the tumor microenvironment.

INTERNATIONAL JOURNAL OF ONCOLOGY (2022)

添加到收藏夹
Review Biochemistry & Molecular Biology

Current status and perspectives of regulatory T cell-based therapy

Guojun Qu et al.

Summary: CD4(+)FOXP3(+) regulatory T (Treg) cells play a vital role in maintaining immune homeostasis, and Treg cell-based therapies have shown promise in various diseases. Current challenges in Treg cell therapy include emerging clinical trials like CAR-Treg cell therapy and new strategies in engineering Treg cells.

JOURNAL OF GENETICS AND GENOMICS (2022)

添加到收藏夹
Review Oncology

Immunosuppressive cells in cancer: mechanisms and potential therapeutic targets

Yan Tie et al.

Summary: Immunotherapies are effective for treating advanced cancers, but some patients are resistant to these therapies. Targeting immunosuppressive cells and related signals is a promising strategy to enhance the efficacy of immunotherapies.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

添加到收藏夹
Review Immunology

Innate lymphoid cells and cancer

Nicolas Jacquelot et al.

Summary: Innate lymphoid cells (ILCs) play a role in immune responses and have been found to have pleiotropic effects in various tissues, including both tissue repair and immunopathology toward allergens and promotion of tumorigenesis. Recent studies suggest that non-NK ILCs might be harnessed for anti-tumor responses. Gabrielle Belz and colleagues review the influence of ILCs on cancer immune responses.

NATURE IMMUNOLOGY (2022)

添加到收藏夹
Editorial Material Immunology

Tfh cells induce intratumoral tertiary lymphoid structures

Lisa Schmidleithner et al.

Summary: A recent study reveals that repression of Satb1 in CD4(+) T cells can drive intratumoral TLS formation, resulting in reduced tumor growth.

TRENDS IN IMMUNOLOGY (2022)

添加到收藏夹
Editorial Material Immunology

Editorial: Germinal Centers in Lymphoid and Non-Lymphoid Tissues: Adaptive and Evolving Structures

Michel Cogne et al.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹
Article Immunology

Tumor-Resident T Cells, Associated With Tertiary Lymphoid Structure Maturity, Improve Survival in Patients With Stage III Lung Adenocarcinoma

Hua Zhao et al.

Summary: In this study, the relationship between tumor-resident memory T cells (T-RM) and the maturity of tertiary lymphoid structures (TLS) in lung adenocarcinoma (LUAD) patients was investigated. It was found that the proportion of T-RM within TLSs was significantly higher than outside and it was positively correlated with patient survival. Furthermore, the proportions of CD4(+)CD103(+) T-RM and CD8(+)CD103(+) T-RM increased with the maturity of TLSs.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹
Article Oncology

PD-L1 blockade potentiates the antitumor effects of ALA-PDT and optimizes the tumor microenvironment in cutaneous squamous cell carcinoma

Qingyu Zeng et al.

Summary: The study found that PD-L1 blockade enhances the antitumor effects of ALA-PDT in cSCC and optimizes the tumor microenvironment. The combination therapy of antibody and photodynamic therapy induces immunogenic cell death and stimulates systemic immune response, preventing tumor recurrence. Additionally, the combination therapy can recruit lymphoid aggregates and promote tumor-infiltrating lymphocyte-mediated antitumor immunity.

ONCOIMMUNOLOGY (2022)

添加到收藏夹
Review Oncology

Tissue-resident memory T cells in gastrointestinal cancer immunology and immunotherapy: ready for prime time?

Syrine Abdeljaoued et al.

Summary: Tissue-resident memory T (T-RM) cells are immune cells that patrol the tissue microenvironment and coordinate anti-tumor immune responses. Recent studies have shown that these cells play a crucial role in cancer immunosurveillance and are associated with positive responses to immunotherapy and better clinical outcomes in cancer patients. This review provides an overview of the advances and recent findings in the phenotype, transcriptional and epigenetic regulation of T-RM cells in cancer, with a focus on gastrointestinal tumors. The clinical implications of T-RM cells in these types of tumors are also highlighted.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

添加到收藏夹
Review Oncology

The Role of Type-2 Conventional Dendritic Cells in the Regulation of Tumor Immunity

Yasuyuki Saito et al.

Summary: This review outlines the role of type-2 conventional dendritic cells (cDC2s) in antitumor immunity and summarizes the latest progress in cancer vaccination and cDC2-targeted cancer immunotherapy.

CANCERS (2022)

添加到收藏夹
Review Immunology

Human dendritic cells in cancer

Egle Kvedaraite et al.

Summary: In this review, the authors discuss the antitumor and tolerogenic responses of dendritic cells (DCs) in cancer, as well as the contributions of different subsets and the recently described mature DCs enriched in immunoregulatory molecules across human tumors.

SCIENCE IMMUNOLOGY (2022)

添加到收藏夹
Review Medicine, Research & Experimental

CD39-A bright target for cancer immunotherapy

Shuwei Guo et al.

Summary: The ATP-adenosine pathway plays a key role in regulating immune response in the tumor microenvironment. Inhibition of eADO generation and intervention of its receptors can restore the antitumor immune function of immune cells. CD39 antagonists enhance antitumor immunity by stabilizing extracellular ATP and preventing adenosine accumulation. Understanding the role of CD39 in immune regulation and therapeutic strategies targeting this pathway is currently a focus of research.

BIOMEDICINE & PHARMACOTHERAPY (2022)

添加到收藏夹
Article Pharmacology & Pharmacy

Cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs); where do they stand in tumorigenesis and how they can change the face of cancer therapy?

Mahboubeh Tajaldini et al.

Summary: The tumor microenvironment (TME) plays a crucial role in cancer metastasis and drug resistance. Tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) regulate angiogenesis, tumor metastasis, and drug resistance by manipulating the composition and organization of extracellular matrix (ECM). Targeting TAMs and CAFs is essential for enhancing the effectiveness of anti-cancer agents.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

添加到收藏夹
Editorial Material Immunology

Big fish in small ponds: Narrow repertoires of stem-like tissue-resident T cells yield great power in anti-tumor immunity

Kellie N. Smith

Summary: A recent study identifies a population of stem-like tissue-resident memory T cells in metastatic ovarian cancer that are responsible for the majority of anti-tumor T cell immunity, providing insights for improving therapeutic response.

IMMUNITY (2022)

添加到收藏夹
Review Immunology

The complex role of tumor-infiltrating macrophages

Anthos Christofides et al.

Summary: This article reviews the characteristics of tumor-associated macrophages (TAMs) and discusses the mechanisms that contribute to their pathological adaptations to the tumor microenvironment. TAMs play a crucial role in the tumor microenvironment and are closely associated with cancer progression.

NATURE IMMUNOLOGY (2022)

添加到收藏夹
Article Multidisciplinary Sciences

Inhibition of myeloid-derived suppressive cell function with all-trans retinoic acid enhanced anti-PD-L1 efficacy in cervical cancer

Yun Liang et al.

Summary: PD-1/PD-L1 inhibitor treatments are not very effective in advanced cervical cancer patients. However, a study has shown that all-trans retinoic acid (ATRA) can differentiate myeloid-derived suppressor cells (MDSCs) into mature myeloid cells. This research aimed to investigate whether ATRA could enhance PD-L1 blockade-mediated tumor immunotherapy by suppressing the function of MDSCs. The results showed that ATRA effectively abrogated the suppressive activity of MDSCs and enhanced the efficacy of anti-PD-L1 cancer immunotherapy in cervical cancer.

SCIENTIFIC REPORTS (2022)

添加到收藏夹
Editorial Material Immunology

Editorial: Versatile Roles for B Cells in Tumor Immunity

Peter Brossart

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹
Article Oncology

Cardamonin suppresses pro-tumor function of macrophages by decreasing M2 polarization on ovarian cancer cells via mTOR inhibition

Huajiao Chen et al.

Summary: Cardamonin inhibits the pro-tumor function of tumor-associated macrophages (TAMs) in ovarian cancer by suppressing M2 polarization via mTOR inhibition, suggesting its potential as a therapeutic agent for ovarian cancer.

MOLECULAR THERAPY-ONCOLYTICS (2022)

添加到收藏夹
Review Oncology

Therapeutic targeting of regulatory T cells in cancer

Feng Shan et al.

Summary: The success of immunotherapy in oncology highlights the important role of the immune system in cancer development. Regulatory T cells (Tregs) play multiple roles in the tumor microenvironment, particularly in suppressing T cell activation. Understanding the subpopulations of Tregs and their functions within the complex networks of the tumor microenvironment is crucial for the development of next-generation immunotherapies.

TRENDS IN CANCER (2022)

添加到收藏夹
Review Immunology

Role of CD4+CD25+FOXP3+ TReg cells on tumor immunity

Agustinus Darmadi Hariyanto et al.

Summary: Regulator T cells are crucial in maintaining immune tolerance and homeostasis, but their activation can hinder anti-tumor immunity. Removing or suppressing these T-Reg cells can enhance the immune response against tumors, although it may lead to autoimmune diseases. Targeted therapies focused on dominant effector T-Reg cells in tumor tissues are being explored to improve tumor immunity.

IMMUNOLOGICAL MEDICINE (2022)

添加到收藏夹
Review Immunology

CD8+ T cell differentiation and dysfunction in cancer

Mary Philip et al.

Summary: The article discusses the dysfunctional states of CD8(+) T cells in tumors and their impact on response and resistance to immunotherapy. The authors emphasize the heterogeneity of T cell states in tumors and the challenge of predicting which patients will respond to immunotherapeutic interventions.

NATURE REVIEWS IMMUNOLOGY (2022)

添加到收藏夹
Review Medicine, General & Internal

Cellular immunotherapies for cancer

Conall Hayes

Summary: Immunotherapies have become a major tool in fighting cancer by enhancing or utilizing the immune system to combat malignant cells. Cellular immunotherapies, which involve administering living cells to patients, have seen significant advancements since 2010.

IRISH JOURNAL OF MEDICAL SCIENCE (2021)

添加到收藏夹
Review Biochemistry & Molecular Biology

NK cells and ILCs in tumor immunotherapy

Simona Sivori et al.

Summary: Innate immune cells, especially NK cells, play an important role in tumor immunotherapy by controlling tumor growth and metastasis. Various approaches have been developed, such as using IL-15 to improve NK cell function and utilizing NK cell engagers to activate NK cells. Additionally, NK cells may express inhibitory checkpoints like PD-1, which can be targeted for therapeutic use against certain tumors.

MOLECULAR ASPECTS OF MEDICINE (2021)

添加到收藏夹
Article Biology

Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cells

Jennifer L. Vella et al.

Summary: Dendritic cells play a crucial role in supporting T-RM responses to melanoma, with their close interaction being essential for maintaining immune protection. Chemotaxis and adhesion mediated by the CXCR6/CXCL16 axis are critical for T-RM migration and persistence in the skin, with the interaction between CXCR6-expressing T-RM cells and CXCL16-expressing APCs being pivotal for sustaining T-RM cell-mediated tumor protection.

LIFE SCIENCE ALLIANCE (2021)

添加到收藏夹
Review Oncology

Exploring the NK cell platform for cancer immunotherapy

Jacob A. Myers et al.

Summary: NK cells have innate potential to kill cancer cells, leading to the development of various NK cell-based therapies for cancer treatment. The main focus of NK cell therapy research is on optimizing sources of therapeutic NK cells and enhancing their cytotoxicity and persistence in the body.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

添加到收藏夹
Review Immunology

Cytokine Regulation and Function in T Cells

Chen Dong

Summary: T lymphocytes play a key role in cellular immunity, with significant heterogeneity in CD4(+) T cells leading to the identification of various subsets with unique roles in immunity and pathology. Understanding cytokine regulation and function has provided innovative treatment options for many human diseases.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 39 (2021)

添加到收藏夹
Review Cell Biology

IL-6 as a major regulator of MDSC activity and possible target for cancer immunotherapy

Rebekka Weber et al.

Summary: MDSC are crucial cells generated during tumor progression that suppress the anti-tumor functions of T and NK cells. IL-6 plays a key role in regulating the accumulation and activation of MDSC, as well as stimulating tumor cell proliferation and survival. This cytokine has pleiotropic effects on immune cell populations involved in tumor development and is a potential target for tumor immunotherapy to block MDSC-mediated immunosuppression in cancer patients.

CELLULAR IMMUNOLOGY (2021)

添加到收藏夹
Article Biochemistry & Molecular Biology

Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses

Can Cui et al.

Summary: The study found that the enrichment of TFH cell transcriptional signature in lung adenocarcinoma patients is correlated with GC B cell signature and prolonged survival. Interactions between tumor-specific TFH and GC B cells are crucial for tumor control and effector CD8 T cell function.

CELL (2021)

添加到收藏夹
Article Immunology

B cells and cancer: To B or not to B?

Wolf Herman Fridman et al.

Summary: Recent studies have suggested that B cells in the tumor microenvironment may play a significant role in presenting tumor-associated antigens to T cells and producing antibodies that enhance antigen presentation, ultimately impacting cancer clinical outcomes. Immune complexes formed by B cells can also have deleterious effects through inflammation, angiogenesis, and immunosuppression via macrophage and complement activation.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

添加到收藏夹
Review Oncology

NK cell-based cancer immunotherapy: from basic biology to clinical development

Sizhe Liu et al.

Summary: NK cells, as a specialized immune effector cell type, play a critical role in immune activation against abnormal cells. Unlike T cell activation, NK cell activation is governed by interactions between NK receptors and target cells, leading to significant attention in cancer immunotherapy. Many efforts are focused on developing and engineering NK cell-based cancer immunotherapy.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

添加到收藏夹
Review Oncology

Advances in the development of personalized neoantigen-based therapeutic cancer vaccines

Eryn Blass et al.

Summary: Immunotherapy has revolutionized cancer treatment with the development of immune-checkpoint inhibitors and personalized neoantigen vaccines. These vaccines trigger specific T cell responses against individual patient's tumors, showing promising tumor-specific immunogenicity and antitumor activity.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

添加到收藏夹
Article Multidisciplinary Sciences

CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells

Mario Bunse et al.

Summary: The study demonstrates that CAR-T cells targeting CXCR5 effectively inhibit tumor growth by depleting both B cells and follicular T helper cells in lymphoma models, suggesting a promising treatment strategy for nodal B-NHLs.

NATURE COMMUNICATIONS (2021)

添加到收藏夹
Review Oncology

Outlook for New CAR-Based Therapies with a Focus on CAR NK Cells: What Lies Beyond CAR-Engineered T Cells in the Race against Cancer

May Daher et al.

Summary: CAR engineering has transformed the field of cellular therapy for cancer treatment by redirecting the specificity of immune effector cells. The use of natural killer (NK) cells as platforms for CAR engineering has emerged as a safe and effective alternative to traditional CAR-T cells. Expanding this strategy beyond T lymphocytes may lead to safer and more effective off-the-shelf cellular therapy products to combat cancer.

CANCER DISCOVERY (2021)

添加到收藏夹
Article Oncology

CXCL13 shapes immunoactive tumor microenvironment and enhances the efficacy of PD-1 checkpoint blockade in high-grade serous ovarian cancer

Moran Yang et al.

Summary: This study reveals the critical role of CXCL13 in shaping the antitumor microenvironment by facilitating the maintenance of CXCR5(+)CD8(+) T cells in TLSs, and supports a clinical investigation for a combination of CXCL13 and PD-1 blockade therapy in HGSC.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

添加到收藏夹
Article Cell Biology

Interleukin-33 modulates immune responses in cutaneous melanoma in a context-specific way

Liang Peng et al.

Summary: The study investigated the role of IL-33 in human cutaneous melanoma, revealing its association with better prognosis and more active immune responses in metastasis sub-cohorts, while not serving as a prognostic factor in the primary melanoma sub-cohort. Moreover, the cellular sources of IL-33 may determine its distinct effects.

AGING-US (2021)

添加到收藏夹
Article Biochemistry & Molecular Biology

HDAC inhibition potentiates anti-tumor activity of macrophages and enhances anti-PD-L1-mediated tumor suppression

Xiaolei Li et al.

Summary: Pharmacological modulation of macrophage phenotype by HDAC inhibitors can reshape the tumor immune microenvironment, enhance anti-tumor immune responses, and improve the efficacy of immunotherapies in various tumors.

ONCOGENE (2021)

添加到收藏夹
Review Immunology

Tolerogenic Immunotherapy: Targeting DC Surface Receptors to Induce Antigen-Specific Tolerance

Charlotte Castenmiller et al.

Summary: Dendritic cells play key roles in regulating immune responses by inducing either inflammatory or tolerogenic reactions. Research interest is growing in defining tolerance-inducing receptors on DCs for developing new immunotherapeutic strategies. Targeting strategies such as antigen-carbohydrate conjugates and antibody-antigen fusion proteins aim to induce a tolerogenic DC phenotype.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹
Article Oncology

Type 2 Innate Lymphoid Cells Protect against Colorectal Cancer Progression and Predict Improved Patient Survival

Qiutong Huang et al.

Summary: Colorectal cancer is the second leading cause of cancer-related deaths globally. The study shows that specialized type 2 innate lymphoid cells (ILC2) infiltrate colorectal tumors and their presence is associated with reduced tumor burden and improved overall survival. This highlights the potential of ILC2 as a new therapeutic approach to improve clinical outcomes in colorectal cancer.

CANCERS (2021)

添加到收藏夹
Review Peripheral Vascular Disease

High endothelial venules (HEVs) in immunity, inflammation and cancer

Lucas Blanchard et al.

Summary: High endothelial venules (HEVs) are essential for lymphocyte circulation and immune surveillance in lymph nodes and secondary lymphoid organs. These specialized blood vessels expand during inflammation and play important roles in chronic inflammatory diseases. MECA-79(+) tumor-associated HEVs also play crucial roles in promoting lymphocyte entry into tumors in cancer immunotherapy.

ANGIOGENESIS (2021)

添加到收藏夹
Review Immunology

Innate myeloid cells in the tumor microenvironment

Vikas Duhan et al.

Summary: Cancer immunotherapies are increasingly approved in the clinic, but only a fraction of patients benefit long-term. Understanding the mechanisms of immunotherapeutic resistance is critical for broader utility and benefit of cancer immunotherapy. Tumor infiltrating myeloid cells play a critical role in regulating anti-tumor lymphocyte effector cells in the tumor microenvironment.

CURRENT OPINION IN IMMUNOLOGY (2021)

添加到收藏夹
Review Immunology

Engineered CAR-Macrophages as Adoptive Immunotherapies for Solid Tumors

Christopher Sloas et al.

Summary: Cellular immunotherapies, particularly using macrophages as adoptive cell therapies, show promise in treating solid tumors. Engineered CAR macrophages (CAR-M) have the potential for effective treatment against solid malignancies, highlighting the importance of manipulating immune cell function in cancer therapy.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹
Review Immunology

Vascular Microenvironment, Tumor Immunity and Immunotherapy

Zachary Lamplugh et al.

Summary: Immunotherapy shows promise in cancer treatment, but solid tumor T cell-based immunotherapy faces challenges due to lack of universal tumor-specific antigens and an immunosuppressive tumor microenvironment. The vascular microenvironment plays a crucial role in inducing immune-hostile conditions and resistance to immunotherapy in tumors.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹
Article Gastroenterology & Hepatology

Group-2 Innate Lymphoid Cells Promote HCC Progression Through CXCL2-Neutrophil-Induced Immunosuppression

Xingyuan Xu et al.

Summary: The study revealed that ILC2s were highly enriched in human HCC and significantly correlated with tumor recurrence, progression-free survival, and overall survival in patients. The HCC-associated ILC2s were identified as an immune regulatory cell type that promotes tumor development, suggesting potential new treatments for HCC by targeting these cells.

HEPATOLOGY (2021)

添加到收藏夹
Article Immunology

The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

Alvaro de Mingo Pulido et al.

Summary: Blockade of the inhibitory receptor TIM-3 has shown efficacy in clinical trials of cancer immunotherapy, specifically in enhancing antitumor immunity in mammary carcinomas by increasing CXCL9 expression by cDC1 cells. This increased expression required type I interferons and extracellular DNA, with DNA uptake and efficacy of TIM-3 blockade being dependent on HMGB1 and galectin-9-induced cell surface clustering of TIM-3, suggesting a potential mechanism for TIM-3 immunotherapy.

IMMUNITY (2021)

添加到收藏夹
Article Oncology

CXCR6 by increasing retention of memory CD8+ T cells in the ovarian tumor microenvironment promotes immunosurveillance and control of ovarian cancer

Ravikumar Muthuswamy et al.

Summary: Resident memory CD8 T cells, characterized by their ability to reside in peripheral tissues, play a crucial role in adaptive sentinel activity and amplifying immune responses. The study focused on the chemotactic mechanisms governing the localization, retention, and residency of memory CD8 T cells in the ovarian tumor microenvironment. Results indicated that CXCR6 is a key marker for resident memory tumor-specific CD8 T cells, with its deficiency resulting in reduced retention in tumor tissues and poor control of ovarian cancer. Further research is needed to explore the potential of utilizing CXCR6 to enhance resident memory responses in cancer.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

添加到收藏夹
Review Biochemistry & Molecular Biology

PD-1/PD-L1 in Cancer: Pathophysiological, Diagnostic and Therapeutic Aspects

Enrico Munari et al.

Summary: Immune evasion is a crucial strategy adopted by tumor cells to promote survival and metastasis, with PD-1 playing a major role in inhibiting immune responses. Targeting the PD-1/PD-L1 axis has been a significant breakthrough in cancer treatment, representing unprecedented success in various cancer types. Further research on mechanisms regulating PD-1 expression and signaling in tumors is needed to improve therapeutic efficacy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹
Review Oncology

The Dual Role of Innate Lymphoid and Natural Killer Cells in Cancer. from Phenotype to Single-Cell Transcriptomics, Functions and Clinical Uses

Stefania Roma et al.

Summary: Innate lymphoid cells (ILCs), including natural killer (NK) cells, play a crucial role in inflammation and cancer. NK cells have anti-tumor activity and potential for cellular therapy. The tissue niche and single-cell RNA sequencing influence the classification and function of ILCs.

CANCERS (2021)

添加到收藏夹
Review Oncology

Integrin αE(CD103)β7 in Epithelial Cancer

Johanna C. Hoffmann et al.

Summary: The focus of research and clinical developments in cancer is on the immune system, particularly on the role of CD103 β(7) integrin expressing tumor infiltrating T lymphocytes in epithelial tumors. The interaction between CD103 and E-cadherin appears to play a significant role in the immunological synapse and can influence patient prognosis. Further exploration of this receptor in solid tumors may lead to more effective therapies.

CANCERS (2021)

添加到收藏夹
Review Immunology

Tissue-resident memory T cells in tumor immunity and immunotherapy

Karolina Okla et al.

Summary: Tissue-resident memory T cells (TRM) reside in peripheral tissues, patrol their surroundings, and rapidly respond to alarming signals. These features enable them to potentially serve as critical players in antitumor surveillance and immunity.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

添加到收藏夹
Article Oncology

Targeting the CSF1/CSF1R axis is a potential treatment strategy for malignant meningiomas

Jacky Yeung et al.

Summary: Malignant meningiomas are enriched with immunosuppressive myeloid cells. Treatment with anti-CSF1/CSF1R antibodies may be an effective normalization cancer immunotherapy for malignant meningiomas.

NEURO-ONCOLOGY (2021)

添加到收藏夹
Article Multidisciplinary Sciences

PPAR? drives IL-33-dependent ILC2 pro-tumoral functions

Giuseppe Ercolano et al.

Summary: The expression of PPARγ in ILC2s sustains type-2 cytokines secretion and supports their pro-tumorigenic role in preclinical cancer models. Pharmacologic inhibition or genetic deletion of PPARγ in ILC2s significantly impair IL-33-induced Type-2 cytokine production and mitochondrial fitness.

NATURE COMMUNICATIONS (2021)

添加到收藏夹
Article Oncology

Short-course IL-15 given as a continuous infusion led to a massive expansion of effective NK cells: implications for combination therapy with antitumor antibodies

Sigrid P. Dubois et al.

Summary: The study demonstrated that administering IL-15 as CIV-5 significantly expanded NK cells with increased cytotoxic functions. There were no dose-limiting toxicities in the CIV-5 regimen, and a substantial increase in CD8(+) T cells was observed.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

添加到收藏夹
Review Cell Biology

TGF-β: Many Paths to CD103+ CD8 T Cell Residency

Zhijuan Qiu et al.

Summary: CD8 tissue-resident memory T (T-RM) cells are a subset of memory CD8 T cells that primarily reside in nonlymphoid tissues, providing front-line protective immunity against infections and cancers. They can be divided into CD103(-) T-RM cells and CD103(+) T-RM cells. TGF-beta plays a critical role in the development and maintenance of CD103(+) CD8 T-RM cells, and the review highlights the importance of TGF-beta in regulating this unique subset of memory CD8 T cells for potential vaccine design improvements.

CELLS (2021)

添加到收藏夹
Review Cell Biology

Role of the CCL2-CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting

Maosen Xu et al.

Summary: The chemokine ligand CCL2 and its receptor CCR2 play crucial roles in the initiation and progression of cancer by promoting tumor cell growth, migration, and recruitment of immunosuppressive cells. Studies have shown that therapeutic strategies targeting the CCL2-CCR2 axis are promising in combating cancer.

CELL PROLIFERATION (2021)

添加到收藏夹
Review Immunology

Natural killer cell engagers in cancer immunotherapy: Next generation of immuno-oncology treatments

Olivier Demaria et al.

Summary: Immuno-oncology is revolutionizing cancer treatment by inducing the immune system to recognize and eliminate tumor cells. Despite successes, alternative strategies are needed to broaden and strengthen anti-tumor immune responses.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

添加到收藏夹
Review Immunology

Memory B cells and plasma cells: The differentiative continuum of humoral immunity

Michael P. Cancro et al.

Summary: Immunological memory involves lasting antibody titers and memory T and B cells. Memory B cells are critical for generating plasma cells in the secondary response, showing heterogeneity and defined by specific markers.

IMMUNOLOGICAL REVIEWS (2021)

添加到收藏夹
Review Biochemistry & Molecular Biology

Exploiting B Cell Transfer for Cancer Therapy: Engineered B Cells to Eradicate Tumors

Audrey Page et al.

Summary: Immunotherapy strategies utilizing B cells have shown promising results in reducing tumor growth and enhancing antitumoral immune responses. By modifying B cells through various methods such as increasing antigen presentation or antibody secretion, their therapeutic role can be enhanced for potential cancer treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹
Review Biochemistry & Molecular Biology

Tumor-Associated Macrophages: Combination of Therapies, the Approach to Improve Cancer Treatment

Pedram Moeini et al.

Summary: Macrophages, crucial cells of the innate immune system, play a significant role in cancer progression and therapy failure by transforming into tumor-associated macrophages (TAMs) within the tumor microenvironment. This review aims to explore the advantages and disadvantages of TAMs in the immune system.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹
Article Biochemistry & Molecular Biology

All-trans-retinoic acid restores CD4+T cell response after sepsis by inhibiting the expansion and activation of myeloid-derived suppressor cells

Tao Liu et al.

Summary: ATRA can reduce the frequency and activity of MDSCs in the spleen of mice by regulating the expression of arginase-1 and iNOS, as well as the secretion of immune-suppressive cytokines. The administration of ATRA ultimately decreased mortality in CLP-surviving mice with secondary infection, potentially due to the restoration of CD4+ T cell function.

MOLECULAR IMMUNOLOGY (2021)

添加到收藏夹
Article Immunology

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

Susan N. Christo et al.

Summary: Tissue-resident memory T (T-RM) cells are non-recirculating cells distributed throughout the body, and their properties, durability, and malleability are influenced by the tissue in which they are generated. Unequal responsiveness to TGF beta plays a major role in driving diversity in T-RM cell function.

NATURE IMMUNOLOGY (2021)

添加到收藏夹
Article Immunology

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

Nicolas Jacquelot et al.

Summary: ILC2s play a critical role in melanoma immunity by producing cytokines that enhance antitumor responses. High infiltration of ILC2s in melanoma is associated with good clinical prognosis, but their antitumor functions may be restricted by programmed cell death protein-1.

NATURE IMMUNOLOGY (2021)

添加到收藏夹
Article Biochemistry & Molecular Biology

An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer

Paula Voabil et al.

Summary: A study using patient-derived tumor fragments as an ex vivo platform showed that the reactivation of tumor-infiltrating immune cells after PD-1 blockade could predict clinical outcomes. Tumor-resident T cells were identified as crucial in the immunological response, and a subgroup of tumors was found to be unresponsive to PD-1 blockade. Additionally, the presence of tertiary lymphoid structures in baseline tumors correlated with the capacity for intratumoral immune cell reactivation.

NATURE MEDICINE (2021)

添加到收藏夹
Article Pathology

Immune checkpoints and cancer development: Therapeutic implications and future directions

Saber Mehdizadeh et al.

Summary: Immune checkpoint inhibitors have played a prominent role in reducing anti-tumor immune responses in cancer immunotherapy. Recent studies have focused on finding antibodies against other inhibitory immune checkpoints in the tumor microenvironment.

PATHOLOGY RESEARCH AND PRACTICE (2021)

添加到收藏夹
Review Immunology

Tissue-specific differentiation of CD8+ resident memory T cells

Kun Yang et al.

Summary: CD8(+) tissue-resident memory T (T-RM) cells exhibit heterogeneity across different tissues, influenced by the activity of tissue-specific molecules; transforming growth factor (TGF)-beta plays a significant role in the generation of T-RM heterogeneity.

TRENDS IN IMMUNOLOGY (2021)

添加到收藏夹
Article Oncology

Key sunitinib-related biomarkers for renal cell carcinoma

Yun Peng et al.

Summary: This study identified key immune-related genes and hub genes associated with sunitinib and immune infiltration in clear cell RCC (ccRCC), providing insights into sunitinib resistance and potential biomarkers or drug targets for ccRCC.

CANCER MEDICINE (2021)

添加到收藏夹
Review Immunology

Lineage Reprogramming of Effector Regulatory T Cells in Cancer

Michael L. Dixon et al.

Summary: Regulatory T-cells, particularly effector Tregs (eTregs), play a crucial role in maintaining self-tolerance and tissue homeostasis, with potential implications in tumor development. Understanding the mechanisms that modulate the stability and suppressive function of tumoral Tregs, such as eTregs and T-FR cells, can lead to the development of more effective cancer immunotherapies that target the tumor microenvironment while minimizing systemic side effects.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹
Review Oncology

Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies

Hiroyoshi Nishikawa et al.

Summary: With the widespread use of immunotherapies in cancer treatment, understanding the immune landscape in the tumor microenvironment has become crucial. Regulatory T cells (Tregs) play a key role in cancer immunity but also contribute to immune evasion by tumor cells. Targeting Tregs is considered a crucial aspect of cancer immunotherapy, especially in tumors with abundant Treg presence.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

添加到收藏夹
Article Oncology

Follicular helper-T cells restore CD8+-dependent antitumor immunity and anti-PD-L1/PD-1 efficacy

Julie Niogret et al.

Summary: Tfh cells play an important role in antitumor immune response, especially in a CD8(+)-dependent manner, by producing interleukin-21 to support the function of exhausted T cells. Their accumulation in tumor sites and draining lymph nodes is closely associated with treatment efficacy and patient survival.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

添加到收藏夹
Article Oncology

Follicular Helper T Cells Remodel the Immune Microenvironment of Pancreatic Cancer via Secreting CXCL13 and IL-21

Xuan Lin et al.

Summary: The immunosuppressive microenvironment in PDAC is closely related to poor prognosis. Tfh cells promote an immunoactive tumor microenvironment by secreting CXCL13 and IL-21, correlating with better patient prognosis. However, the anti-tumor function of Tfh cells is inhibited by the PD-L1/PD-1 signaling pathway, which can be reversed by neoadjuvant chemotherapy.

CANCERS (2021)

添加到收藏夹
Review Cell Biology

B Cell Orchestration of Anti-tumor Immune Responses: A Matter of Cell Localization and Communication

Gabriela Sarti Kinker et al.

Summary: B cells in the tumor microenvironment play diverse roles in modulating anti-tumor immune responses, especially within TLS formed during lymphoid neogenesis. The interaction between B cells and antigen-experienced and exhausted CD8(+) T cells is associated with improved response to immune checkpoint blockade in certain types of tumors. Conversely, the distribution and organization of B cells in the tumor microenvironment may lead to immune-regulatory functions.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹
Review Oncology

Holding our breath: the promise of tissue-resident memory T cells in lung cancer

Claire Marceaux et al.

Summary: T cell memory plays a critical role in controlling infections and anti-tumor responses, with T-RM-like TILs in lung cancer being associated with better survival outcomes and potentially contributing to anti-tumor responses.

TRANSLATIONAL LUNG CANCER RESEARCH (2021)

添加到收藏夹
Article Medicine, Research & Experimental

Functional Th1-oriented T follicular helper cells that infiltrate human breast cancer promote effective adaptive immunity

Gregory Noel et al.

Summary: This study found that T follicular helper (Tfh) cells in breast cancer play a key role in the formation of tertiary lymphoid structures (TLS), with active and functional Tfh TILs in TLS being associated with positive clinical outcomes in patients. The balance between functional Tfh TILs and functional T follicular regulatory (Tfr) TILs dictates the activity of tumor-associated TLS.

JOURNAL OF CLINICAL INVESTIGATION (2021)

添加到收藏夹
Review Biochemistry & Molecular Biology

iPSC-Derived Natural Killer Cells for Cancer Immunotherapy

Peter Karagiannis et al.

Summary: The discovery of human pluripotent stem cells (PSCs) has led to the exploration of induced pluripotent stem cells (iPSCs) as a potential universal cell source for therapies, including cancer immunotherapies using natural killer (NK cells). iPSCs offer advantages in quality and flexibility compared to primary NK cells, and there are various protocols for genetic modification and differentiation into NK cells. However, there are challenges that need to be addressed before iPSC-based NK cell immunotherapies can become mainstream in clinical settings.

MOLECULES AND CELLS (2021)

添加到收藏夹
Article Cell Biology

Single-cell transcriptomic landscape reveals tumor specific innate lymphoid cells associated with colorectal cancer progression

Jingjing Qi et al.

Summary: Innate lymphoid cells (ILCs) are tissue-resident lymphocytes without antigen-specific receptors, and their roles in cancer immunity and immunotherapy are still unclear. Studies have identified tumor-specific ILC subsets in colorectal cancer (CRC) patients, with SLAMF1 potentially serving as an anti-tumor biomarker.

CELL REPORTS MEDICINE (2021)

添加到收藏夹
Review Biochemistry & Molecular Biology

CD47/SIRPα pathway mediates cancer immune escape and immunotherapy

Xiao Jia et al.

Summary: Immune evasion of cancer cells is mediated by the SIRPα-CD47 axis, but blocking the CD47-SIRPα interaction can enhance phagocytic clearance of cancer cells, activate immune responses, promote antigen presentation, and ultimately activate antitumor immune responses.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

添加到收藏夹
Review Biochemistry & Molecular Biology

Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis

Jihyun Kim et al.

Summary: Innate lymphoid cells (ILCs) are a recently discovered family of immune cells with three groups based on functions and cytokine production. They play a frontline role in host defense, interact with various cells, and are involved in the development of inflammatory diseases.

MOLECULES AND CELLS (2021)

添加到收藏夹
Article Oncology

Tertiary lymphoid structures and B lymphocytes in cancer prognosis and response to immunotherapies

N. Jacquelot et al.

Summary: Tertiary lymphoid structures (TLS) are ectopic cellular aggregates resembling secondary lymphoid organs. Found in solid tumors, TLS exhibit varying degrees of maturation and are composed of diverse immune cell types that actively drive the immune response against tumor development and progression. Their role, prognostic value, and potential for immunotherapeutic targeting are discussed in this review.

ONCOIMMUNOLOGY (2021)

添加到收藏夹
Article Oncology

Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer

Andrew J. Gunderson et al.

Summary: PDAC tumors show T cell inflamed phenotypes, with some tumors having early-stage TLS which correlates with higher survival rates.

ONCOIMMUNOLOGY (2021)

添加到收藏夹
Review Biochemistry & Molecular Biology

Targeting tumor-associated macrophages to synergize tumor immunotherapy

Xiaonan Xiang et al.

Summary: Tumor-associated macrophages (TAMs) play a significant role in tumor immunotherapies, with potential therapeutic value in enhancing treatment outcomes.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

添加到收藏夹
Review Oncology

Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion

Suchit Jhunjhunwala et al.

Summary: This review discusses the importance of antigen presentation in the success of immune checkpoint inhibition therapy and mechanisms by which tumors evade immune recognition. Tumors evade immune recognition by modulating antigen expression and altering antigen presentation.

NATURE REVIEWS CANCER (2021)

添加到收藏夹
Review Immunology

T follicular helper cell subsets: a potential key player in autoimmunity

Izumi Kurata et al.

Summary: Follicular helper T (Tfh) cells play a crucial role in promoting B cell maturation and antigen-specific antibody production. Dysregulation of Tfh activities can contribute to pathogenic autoantibody production in autoimmune diseases. Recent studies have identified three distinct subpopulations with effector functions in Tfh cells: Tfh1, Tfh2, and Tfh17 cells.

IMMUNOLOGICAL MEDICINE (2021)

添加到收藏夹
Article Biochemistry & Molecular Biology

Progression or suppression: Two sides of the innate lymphoid cells in cancer

S. Haleh Hosseini et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2020)

添加到收藏夹
Article Oncology

Efficacy of third-party chimeric antigen receptor modified peripheral blood natural killer cells for adoptive cell therapy of B-cell precursor acute lymphoblastic leukemia

C. Quintarelli et al.

LEUKEMIA (2020)

添加到收藏夹
Article Biochemistry & Molecular Biology

CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis

Hui Yang et al.

MOLECULAR CANCER (2020)

添加到收藏夹
Review Biochemistry & Molecular Biology

Chemokines and their receptors promoting the recruitment of myeloid-derived suppressor cells into the tumor

Bao-Hua Li et al.

MOLECULAR IMMUNOLOGY (2020)

添加到收藏夹
Article Multidisciplinary Sciences

B cells are associated with survival and immunotherapy response in sarcoma

Florent Petitprez et al.

NATURE (2020)

添加到收藏夹
Article Multidisciplinary Sciences

Tertiary lymphoid structures improve immunotherapy and survival in melanoma

Rita Cabrita et al.

NATURE (2020)

添加到收藏夹
Article Multidisciplinary Sciences

ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity

John Alec Moral et al.

NATURE (2020)

添加到收藏夹
Article Oncology

CXCR1 Expression to Improve Anti-Cancer Efficacy of Intravenously Injected CAR-NK Cells in Mice with Peritoneal Xenografts

Yu Yang Ng et al.

MOLECULAR THERAPY-ONCOLYTICS (2020)

添加到收藏夹
Article Oncology

Interferon gamma inhibits CXCL8-CXCR2 axis mediated tumor-associated macrophages tumor trafficking and enhances anti-PD1 efficacy in pancreatic cancer

Mingjie Zhang et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

添加到收藏夹
Article Cell Biology

Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s

Marek Wagner et al.

CELL REPORTS (2020)

添加到收藏夹
Article Cell Biology

Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy

Bo He et al.

CELL REPORTS (2020)

添加到收藏夹
Article Oncology

Characterization of CD103+ CD8+ tissue-resident T cells in esophageal squamous cell carcinoma: may be tumor reactive and resurrected by anti-PD-1 blockade

Lu Han et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

添加到收藏夹
Article Cell Biology

Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer

Shuo Wang et al.

CELL RESEARCH (2020)

添加到收藏夹
Article Oncology

Early Hepatic Lesions Display Immature Tertiary Lymphoid Structures and Show Elevated Expression of Immune Inhibitory and Immunosuppressive Molecules

Maxime Meylan et al.

CLINICAL CANCER RESEARCH (2020)

添加到收藏夹
Article Biochemistry & Molecular Biology

Tumor-associated macrophages

Luca Cassetta et al.

CURRENT BIOLOGY (2020)

添加到收藏夹
Review Biochemistry & Molecular Biology

Interferon regulatory factor 8 governs myeloid cell development

Xueli Xia et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2020)

添加到收藏夹
Article Immunology

Pulmonary Group 2 Innate Lymphoid Cell Phenotype Is Context Specific: Determining the Effect of Strain, Location, and Stimuli

Lewis J. Entwistle et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹
Review Immunology

Helper Innate Lymphoid Cells in Human Tumors: A Double-Edged Sword?

Nicola Tumino et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹
Review Immunology

Pleiotropic Role and Bidirectional Immunomodulation of Innate Lymphoid Cells in Cancer

Zhengwen An et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹
Article Oncology

Helper T cell-dominant tertiary lymphoid structures are associated with disease relapse of advanced colorectal cancer

Kyoko Yamaguchi et al.

ONCOIMMUNOLOGY (2020)

添加到收藏夹
Article Cell Biology

CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling

Renlun Huang et al.

CELL DEATH & DISEASE (2020)

添加到收藏夹
Article Biotechnology & Applied Microbiology

Human chimeric antigen receptor macrophages for cancer immunotherapy

Michael Klichinsky et al.

NATURE BIOTECHNOLOGY (2020)

添加到收藏夹
Article Immunology

Eomes Expression Defines Group 1 Innate Lymphoid Cells During Metastasis in Human and Mouse

Riva Verma et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹
Review Immunology

The New Era of Cancer Immunotherapy: Targeting Myeloid-Derived Suppressor Cells to Overcome Immune Evasion

Paola De Cicco et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹
Article Oncology

CD103+tumor-resident CD8+T cell numbers underlie improved patient survival in oropharyngeal squamous cell carcinoma

Rehana Hewavisenti et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

添加到收藏夹
Review Biochemistry & Molecular Biology

Natural killer cells in cancer biology and therapy

Song-Yang Wu et al.

MOLECULAR CANCER (2020)

添加到收藏夹
Article Multidisciplinary Sciences

cDC1 prime and are licensed by CD4+T cells to induce anti-tumour immunity

Stephen T. Ferris et al.

NATURE (2020)

添加到收藏夹
Review Oncology

The adenosine pathway in immuno-oncology

Bertrand Allard et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

添加到收藏夹
Review Oncology

Ambiguous roles and potential therapeutic strategies of innate lymphoid cells in different types of tumor

Shijie Wang et al.

ONCOLOGY LETTERS (2020)

添加到收藏夹
Article Biochemistry & Molecular Biology

Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial

Nick van Dijk et al.

NATURE MEDICINE (2020)

添加到收藏夹
Review Immunology

Tissue-Specific Features of Innate Lymphoid Cells

Isabel Meininger et al.

TRENDS IN IMMUNOLOGY (2020)

添加到收藏夹
Article Dentistry, Oral Surgery & Medicine

Prognostic value of tertiary lymphoid structure and tumour infiltrating lymphocytes in oral squamous cell carcinoma

Qunxing Li et al.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2020)

添加到收藏夹
Article Cell Biology

CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response

Shannon K. Bromley et al.

CELL REPORTS (2020)

添加到收藏夹
Article Oncology

NK-Cell-Mediated Targeting of Various Solid Tumors Using a B7-H3 Tri-Specific Killer Engager In Vitro and In Vivo

Daniel A. Vallera et al.

CANCERS (2020)

添加到收藏夹
Review Immunology

Resident Memory T Cells and Their Effect on Cancer

Daniel J. Craig et al.

VACCINES (2020)

添加到收藏夹
Review Medicine, Research & Experimental

WNT/β-catenin signaling in the development of liver cancers

Shuai He et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

添加到收藏夹
Review Immunology

Cytokine-Mediated Regulation of Innate Lymphoid Cell Plasticity in Gut Mucosal Immunity

Carlo De Salvo et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹
Review Immunology

Glioblastoma Immunotherapy Targeting the Innate Immune Checkpoint CD47-SIRPα Axis

Jinyang Hu et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹
Review Oncology

Group 2 Innate Lymphoid Cells: A Double-Edged Sword in Cancer?

Enrico Maggi et al.

CANCERS (2020)

添加到收藏夹
Article Oncology

CD25-Treg-depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity

Isabelle Solomon et al.

NATURE CANCER (2020)

添加到收藏夹
Article Oncology

Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets

Nina Bhardwaj et al.

NATURE CANCER (2020)

添加到收藏夹
Review Biochemistry & Molecular Biology

Resident Memory T Cells and Their Role within the Liver

Sonia Ghilas et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹
Article Cell Biology

iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti-PD-1 therapy

Frank Cichocki et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

添加到收藏夹
Review Biochemistry & Molecular Biology

CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of the Ligands of Receptors CCR1, CCR2, CCR3, and CCR4

Jan Korbecki et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹
Review Immunology

Regulatory T Cells in Tumor Microenvironment and Approach for Anticancer Immunotherapy

Jung-Ho Kim et al.

IMMUNE NETWORK (2020)

添加到收藏夹
Article Cell Biology

Targeting IL-10 Family Cytokines for the Treatment of Human Diseases

Xiaoting Wang et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2019)

添加到收藏夹
Article Gastroenterology & Hepatology

Intra-tumoral tertiary lymphoid structures are associated with a low risk of early recurrence of hepatocellular carcinoma

Julien Calderaro et al.

JOURNAL OF HEPATOLOGY (2019)

添加到收藏夹
Article Pathology

Presence of tertiary lymphoid structures determines the level of tumor-infiltrating lymphocytes in primary breast cancer and metastasis

Miseon Lee et al.

MODERN PATHOLOGY (2019)

添加到收藏夹
Article Cell Biology

Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression

Pieter Goossens et al.

CELL METABOLISM (2019)

添加到收藏夹
Review Immunology

Human NK cells: surface receptors, inhibitory checkpoints, and translational applications

Simona Sivori et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2019)

添加到收藏夹
Article Gastroenterology & Hepatology

Blocking Triggering Receptor Expressed on Myeloid Cells-1-Positive Tumor-Associated Macrophages Induced by Hypoxia Reverses Immunosuppression and Anti-Programmed Cell Death Ligand 1 Resistance in Liver Cancer

Qinchuan Wu et al.

HEPATOLOGY (2019)

添加到收藏夹
Article Medicine, Research & Experimental

Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance

Daisuke Muraoka et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

添加到收藏夹
Article Oncology

First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers

Branimir Sikic et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

添加到收藏夹
Article Multidisciplinary Sciences

Comparative analysis reveals a role for TGF-β in shaping the residency-related transcriptional signature in tissue-resident memory CD8+ T cells

Artika P. Nath et al.

PLOS ONE (2019)

添加到收藏夹
Article Biochemistry & Molecular Biology

Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity

Mikhail Binnewies et al.

CELL (2019)

添加到收藏夹
Article Immunology

Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy

Melvyn T. Chow et al.

IMMUNITY (2019)

添加到收藏夹
Review Immunology

T Follicular Helper Cell Biology: A Decade of Discovery and Diseases

Shane Crotty

IMMUNITY (2019)

添加到收藏夹
Article Medicine, Research & Experimental

Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells

Takahiro Kamiya et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

添加到收藏夹
Article Immunology

Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion

Deepali Sawant et al.

NATURE IMMUNOLOGY (2019)

添加到收藏夹
Review Immunology

Hide and seek: Plasticity of innate lymphoid cells in cancer

Tobias Bald et al.

SEMINARS IN IMMUNOLOGY (2019)

添加到收藏夹
Article Gastroenterology & Hepatology

Cytokines derived from innate lymphoid cells assist Helicobacter hepaticus to aggravate hepatocellular tumorigenesis in viral transgenic mice

Xiao Han et al.

GUT PATHOGENS (2019)

添加到收藏夹
Article Oncology

A Gene Signature Predicting Natural Killer Cell Infiltration and Improved Survival in Melanoma Patients

Joseph Cursons et al.

CANCER IMMUNOLOGY RESEARCH (2019)

添加到收藏夹
Article Oncology

Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen

Stefanie K. Wculek et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

添加到收藏夹
Article Oncology

Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation

Alex M. Jaeger et al.

CLINICAL CANCER RESEARCH (2019)

添加到收藏夹
Article Oncology

Coexistence of regulatory B cells and regulatory T cells in tumor-infiltrating lymphocyte aggregates is a prognostic factor in patients with breast cancer

Emi Ishigami et al.

BREAST CANCER (2019)

添加到收藏夹
Article Immunology

NK cells switch from granzyme B to death receptor-mediated cytotoxicity during serial killing

Isabel Prager et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

添加到收藏夹
Article Immunology

Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues

Marina Cella et al.

NATURE IMMUNOLOGY (2019)

添加到收藏夹
Article Hematology

The effects of monoclonal anti-CD47 on RBCs, compatibility testing, and transfusion requirements in refractory acute myeloid leukemia

C. K. Brierley et al.

TRANSFUSION (2019)

添加到收藏夹
Article Oncology

β-Catenin Activation Promotes Immune Escape and Resistance to Anti-PD-1 Therapy in Hepatocellular Carcinoma

Marina Ruiz de Galarreta et al.

CANCER DISCOVERY (2019)

添加到收藏夹
Review Immunology

The Natural Cytotoxicity Receptors in Health and Disease

Alexander David Barrow et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹
Article Oncology

Interleukin-15 Enhances Anti-GD2 Antibody-Mediated Cytotoxicity in an Orthotopic PDX Model of Neuroblastoma

Rosa Nguyen et al.

CLINICAL CANCER RESEARCH (2019)

添加到收藏夹
Review Oncology

Tumor-derived exosomes, myeloid-derived suppressor cells, and tumor microenvironment

Xinyu Tian et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

添加到收藏夹
Article Immunology

The Obese Liver Environment Mediates Conversion of NK Cells to a Less Cytotoxic ILC1-Like Phenotype

Antonia O. Cuff et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹
Article Chemistry, Multidisciplinary

CSF1R-and SHP2-Inhibitor-Loaded Nanoparticles Enhance Cytotoxic Activity and Phagocytosis in Tumor-Associated Macrophages

Anujan Ramesh et al.

ADVANCED MATERIALS (2019)

添加到收藏夹
Article Biochemistry & Molecular Biology

B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer

Daniel P. Hollern et al.

CELL (2019)

添加到收藏夹
Article Medicine, Research & Experimental

Hedgehog signaling promotes tumor-associated macrophage polarization to suppress intratumoral CD8+ T cell recruitment

Amy J. Petty et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

添加到收藏夹
Article Oncology

Blood-derived dendritic cell vaccinations induce immune responses that correlate with clinical outcome in patients with chemo-naive castration-resistant prostate cancer

Harm Westdorp et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

添加到收藏夹
Article Oncology

NK Cells Expressing a Chimeric Activating Receptor Eliminate MDSCs and Rescue Impaired CAR-T Cell Activity against Solid Tumors

Robin Parihar et al.

CANCER IMMUNOLOGY RESEARCH (2019)

添加到收藏夹
Review Immunology

Therapeutic Potential of Natural Killer Cells in Gastric Cancer

Yu Du et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹
Review Engineering, Multidisciplinary

FOXP3 and Its Cofactors as Targets of Immunotherapies

Yasuhiro Nagai et al.

ENGINEERING (2019)

添加到收藏夹
Review Immunology

Are Conventional Type 1 Dendritic Cells Critical for Protective Antitumor Immunity and How?

Jean-Charles Cancel et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹
Review Immunology

CAR T Cells for Solid Tumors: New Strategies for Finding, Infiltrating, and Surviving in the Tumor Microenvironment

Marina Martinez et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹
Review Oncology

Tertiary lymphoid structures in the era of cancer immunotherapy

Catherine Sautes-Fridman et al.

NATURE REVIEWS CANCER (2019)

添加到收藏夹
Article Hematology

Novel CD19-targeted TriKE restores NK cell function and proliferative capacity in CLL

Martin Felices et al.

BLOOD ADVANCES (2019)

添加到收藏夹
Review Biochemistry & Molecular Biology

Metabolism and TAM functions-it takes two to tango

Massimiliano Mazzone et al.

FEBS JOURNAL (2018)

添加到收藏夹
Article Oncology

Maturation of tertiary lymphoid structures and recurrence of stage II and III colorectal cancer

Florian Posch et al.

ONCOIMMUNOLOGY (2018)

添加到收藏夹
Article Oncology

Activated innate lymphoid cell populations accumulate in human tumour tissues

Maryam Salimi et al.

BMC CANCER (2018)

添加到收藏夹
Article Oncology

TIM-3 Regulates CD103(+) Dendritic Cell Function and Response to Chemotherapy in Breast Cancer

Alvaro de Mingo Pulido et al.

CANCER CELL (2018)

添加到收藏夹
Article Oncology

Blockade of Myeloid-Derived Suppressor Cell Expansion with All-Trans Retinoic Acid Increases the Efficacy of Antiangiogenic Therapy

Raimund Bauer et al.

CANCER RESEARCH (2018)

添加到收藏夹
Article Biochemistry & Molecular Biology

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

Jan P. Boettcher et al.

CELL (2018)

添加到收藏夹
Article Cell & Tissue Engineering

Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity

Ye Li et al.

CELL STEM CELL (2018)

添加到收藏夹
Article Oncology

CD103+ Tumor-Resident CD8+ T Cells Are Associated with Improved Survival in Immunotherapy-Naive Melanoma Patients and Expand Significantly During Anti-PD-1 Treatment

Jarem Edwards et al.

CLINICAL CANCER RESEARCH (2018)

添加到收藏夹
Article Oncology

A Pilot Trial of Lirilumab With or Without Azacitidine for Patients With Myelodysplastic Syndrome

Fevzi Firat Yalniz et al.

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2018)

添加到收藏夹
Article Immunology

Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity

Sabine Hoves et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

添加到收藏夹
Review Immunology

Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment

Suzanne Ostrand-Rosenberg et al.

JOURNAL OF IMMUNOLOGY (2018)

添加到收藏夹
Article Oncology

Vascular targeting of LIGHT normalizes blood vessels in primary brain cancer and induces intratumoural high endothelial venules

Bo He et al.

JOURNAL OF PATHOLOGY (2018)

添加到收藏夹
Review Immunology

Tissue-resident memory T cells at the center of immunity to solid tumors

Derk Amsen et al.

NATURE IMMUNOLOGY (2018)

添加到收藏夹
Article Biochemistry & Molecular Biology

Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

Peter Savas et al.

NATURE MEDICINE (2018)

添加到收藏夹
Article Biochemistry & Molecular Biology

A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments

Kevin C. Barry et al.

NATURE MEDICINE (2018)

添加到收藏夹
Article Multidisciplinary Sciences

Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity

Lucas Ferrari de Andrade et al.

SCIENCE (2018)

添加到收藏夹
Review Immunology

Orchestration of intestinal homeostasis and tolerance by group 3 innate lymphoid cells

Hugo A. Penny et al.

SEMINARS IN IMMUNOPATHOLOGY (2018)

添加到收藏夹
Article Multidisciplinary Sciences

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGF beta enhance the efficacy of cancer immunotherapy

Rajani Ravi et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹
Article Biology

Chimeric antigen receptors that trigger phagocytosis

Meghan A. Morrissey et al.

ELIFE (2018)

添加到收藏夹
Article Immunology

STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer

Hulin Ma et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2018)

添加到收藏夹
Article Immunology

TLR-3 Stimulation Skews M2 Macrophages to M1 Through IFN-αβ Signaling and Restricts Tumor Progression

Aurobind Vidyarthi et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹
Review Immunology

Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion

Flavia Castro et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹
Article Oncology

In situ delivery of allogeneic natural killer cell (NK) combined with Cetuximab in liver metastases of gastrointestinal carcinoma: A phase I clinical trial

O. Adotevi et al.

ONCOIMMUNOLOGY (2018)

添加到收藏夹
Article Oncology

Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade

Rikke B. Holmgaard et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

添加到收藏夹
Article Engineering, Biomedical

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

Christopher B. Rodell et al.

NATURE BIOMEDICAL ENGINEERING (2018)

添加到收藏夹
Article Oncology

Inhibition of Casein Kinase 2 Disrupts Differentiation of Myeloid Cells in Cancer and Enhances the Efficacy of Immunotherapy in Mice

Ayumi Hashimoto et al.

CANCER RESEARCH (2018)

添加到收藏夹
Review Biochemistry & Molecular Biology

Innate Lymphoid Cells: 10 Years On

Eric Vivier et al.

CELL (2018)

添加到收藏夹
Article Immunology

Targeting myeloid-derived suppressor cells using all-trans retinoic acid in melanoma patients treated with Ipilimumab

Richard P. Tobin et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2018)

添加到收藏夹
Article Multidisciplinary Sciences

Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism

Kairui Mao et al.

NATURE (2018)

添加到收藏夹
Review Gastroenterology & Hepatology

Inflammasomes in the gastrointestinal tract: infection, cancer and gut microbiota homeostasis

Si Ming Man

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

添加到收藏夹
Article Oncology

SD-101 in Combination with Pembrolizumab in Advanced Melanoma: Results of a Phase Ib, Multicenter Study

Antoni Ribas et al.

CANCER DISCOVERY (2018)

添加到收藏夹
Review Immunology

Genealogy, Dendritic Cell Priming, and Differentiation of Tissue-esident Memory CD8+ T Cells

Michel Enamorado et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹
Review Immunology

Tumor Resident Memory T Cells: New Players in Immune Surveillance and Therapy

Nina Dumauthioz et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹
Article Oncology

Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus-Derived Vectors Fosters Dendritic Cell-Mediated T-cell Cross-Priming

Alfonso R. Sanchez-Paulete et al.

CANCER RESEARCH (2018)

添加到收藏夹
Article Biochemistry & Molecular Biology

NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines

Nadine van Montfoort et al.

CELL (2018)

添加到收藏夹
Article Biochemistry & Molecular Biology

Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells

Pascale Andre et al.

CELL (2018)

添加到收藏夹
Article Biochemistry & Molecular Biology

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

Moshe Sade-Feldman et al.

CELL (2018)

添加到收藏夹
Article Immunology

B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen

Sheng Hong et al.

IMMUNITY (2018)

添加到收藏夹
Article Immunology

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

Christopher S. Garris et al.

IMMUNITY (2018)

添加到收藏夹
Article Oncology

Entinostat Converts Immune-Resistant Breast and Pancreatic Cancers into CheckpointResponsive Tumors by Reprogramming Tumor-Infiltrating MDSCs

Brian J. Christmas et al.

CANCER IMMUNOLOGY RESEARCH (2018)

添加到收藏夹
Article Immunology

Antigen Specificity and Clinical Significance of IgG and IgA Autoantibodies Produced in situ by Tumor-Infiltrating B Cells in Breast Cancer

Soizic Garaud et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹
Article Immunology

A Highly Active Form of XCL1/Lymphotactin Functions as an Effective Adjuvant to Recruit Cross-Presenting Dendritic Cells for Induction of Effector and Memory CD8+ T Cells

Kazuhiko Matsuo et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹
Review Immunology

Natural killer cells and other innate lymphoid cells in cancer

Laura Chiossone et al.

NATURE REVIEWS IMMUNOLOGY (2018)

添加到收藏夹
Review Oncology

The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity

Jan P. Boettcher et al.

TRENDS IN CANCER (2018)

添加到收藏夹
Article Oncology

The class I/IV HDAC inhibitor mocetinostat increases tumor antigen presentation, decreases immune suppressive cell types and augments checkpoint inhibitor therapy

David Briere et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2018)

添加到收藏夹
Article Oncology

Germinal Centers Determine the Prognostic Relevance of Tertiary Lymphoid Structures and Are Impaired by Corticosteroids in Lung Squamous Cell Carcinoma

Karina Silina et al.

CANCER RESEARCH (2018)

添加到收藏夹
Article Biotechnology & Applied Microbiology

TGF-β-responsive CAR-T cells promote anti-tumor immune function

Andrew J. Hou et al.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2018)

添加到收藏夹
Article Immunology

Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy

Amira A. Barkal et al.

NATURE IMMUNOLOGY (2018)

添加到收藏夹
Article Oncology

CCR5(+) Myeloid-Derived Suppressor Cells Are Enriched and Activated in Melanoma Lesions

Carolin Blattner et al.

CANCER RESEARCH (2018)

添加到收藏夹
Article Medicine, Research & Experimental

Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages

Sean P. Arlauckas et al.

THERANOSTICS (2018)

添加到收藏夹
Article Gastroenterology & Hepatology

Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma

Xiaoguang Li et al.

GUT (2017)

添加到收藏夹
Article Immunology

Liver-infiltrating CD11b(-)CD27(-) NK subsets account for NK-cell dysfunction in patients with hepatocellular carcinoma and are associated with tumor progression

Qiong-Fang Zhang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2017)

添加到收藏夹
Article Oncology

Selective Targeting of Myeloid-Derived Suppressor Cells in Cancer Patients Using DS-8273a, an Agonistic TRAIL-R2 Antibody

George A. Dominguez et al.

CLINICAL CANCER RESEARCH (2017)

添加到收藏夹
Article Oncology

A Strong B-cell Response Is Part of the Immune Landscape in Human High-Grade Serous Ovarian Metastases

Anne Montfort et al.

CLINICAL CANCER RESEARCH (2017)

添加到收藏夹
Correction Multidisciplinary Sciences

PI3Kγ is a molecular switch that controls immune suppression (vol 539, pg 437, 2016)

Megan M. Kaneda et al.

NATURE (2017)

添加到收藏夹
Article Oncology

Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non-Small Cell Lung Cancer

Valsamo Anagnostou et al.

CANCER DISCOVERY (2017)

添加到收藏夹
Article Oncology

CD40-activated B cells induce anti-tumor immunity in vivo

Kerstin Wennhold et al.

ONCOTARGET (2017)

添加到收藏夹
Review Pharmacology & Pharmacy

High-dose interleukin-2 (IL-2) for the treatment of melanoma: safety considerations and future directions

Stephen Marabondo et al.

EXPERT OPINION ON DRUG SAFETY (2017)

添加到收藏夹
Article Immunology

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

Frederick Arce Vargas et al.

IMMUNITY (2017)

添加到收藏夹
Article Immunology

CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin

Stanley Cheuk et al.

IMMUNITY (2017)

添加到收藏夹
Review Immunology

The Broad Spectrum of Human Natural Killer Cell Diversity

Aharon G. Freud et al.

IMMUNITY (2017)

添加到收藏夹
Article Oncology

PD-L1 induced by IFN-γ from tumor-associated macrophages via the JAK/STAT3 and PI3K/AKT signaling pathways promoted progression of lung cancer

Xiaohui Zhang et al.

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2017)

添加到收藏夹
Article Medicine, Research & Experimental

CD56bright NK cells exhibit potent antitumor responses following IL-15 priming

Julia A. Wagner et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

添加到收藏夹
Article Medicine, Research & Experimental

ILC2-modulated T cell-to-MDSC balance is associated with bladder cancer recurrence

Mathieu F. Chevalier et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

添加到收藏夹
Article Immunology

Tissue microenvironment dictates the fate and tumorsuppressive function of type 3 ILCs

Kathrin Nussbaum et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

添加到收藏夹
Review Immunology

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

Eleni Vergadi et al.

JOURNAL OF IMMUNOLOGY (2017)

添加到收藏夹
Article Biochemistry & Molecular Biology

The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2

Torsten Hartwig et al.

MOLECULAR CELL (2017)

添加到收藏夹
Review Biochemistry & Molecular Biology

T memory stem cells in health and disease

Luca Gattinoni et al.

NATURE MEDICINE (2017)

添加到收藏夹
Article Oncology

Distinct Tertiary Lymphoid Structure Associations and Their Prognostic Relevance in HER2 Positive and Negative Breast Cancers

Xia Liu et al.

ONCOLOGIST (2017)

添加到收藏夹
Article Multidisciplinary Sciences

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

Alexandra-Chloe Villani et al.

SCIENCE (2017)

添加到收藏夹
Article Cell Biology

Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation

Elizabeth Allen et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

添加到收藏夹
Article Multidisciplinary Sciences

Interconnected subsets of memory follicular helper T cells have different effector functions

Assia Asrir et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹
Article Multidisciplinary Sciences

Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis

Sara Trabanelli et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹
Article Multidisciplinary Sciences

Induction of resident memory T cells enhances the efficacy of cancer vaccine

Mevyn Nizard et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹
Article Oncology

Engineering of Anti-CD133 Trispecific Molecule Capable of Inducing NK Expansion and Driving Antibody-Dependent Cell-Mediated Cytotoxicity

Jorg U. Schmohl et al.

CANCER RESEARCH AND TREATMENT (2017)

添加到收藏夹
Article Cell Biology

Protein Kinase C Epsilon Cooperates with PTEN Loss for Prostate Tumorigenesis through the CXCL13-CXCR5 Pathway

Rachana Garg et al.

CELL REPORTS (2017)

添加到收藏夹
Article Microbiology

IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection

Rajesh M. Valanparambil et al.

PLOS PATHOGENS (2017)

添加到收藏夹
Article Oncology

Antigen-Presenting Intratumoral B Cells Affect CD4+ TIL Phenotypes in Non-Small Cell Lung Cancer Patients

Tullia C. Bruno et al.

CANCER IMMUNOLOGY RESEARCH (2017)

添加到收藏夹
Article Oncology

Treg Depletion Licenses T Cell-Driven HEV Neogenesis and Promotes Tumor Destruction

Emily J. Colbeck et al.

CANCER IMMUNOLOGY RESEARCH (2017)

添加到收藏夹
Article Oncology

Combination of CD40 Agonism and CSF-1R Blockade Reconditions Tumor-Associated Macrophages and Drives Potent Antitumor Immunity

Karla R. Wiehagen et al.

CANCER IMMUNOLOGY RESEARCH (2017)

添加到收藏夹
Article Oncology

Myeloid-Derived Suppressor Cells

Dmitry I. Gabrilovich

CANCER IMMUNOLOGY RESEARCH (2017)

添加到收藏夹
Article Immunology

A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression

Maria de la Luz Garcia-Hernandez et al.

FRONTIERS IN IMMUNOLOGY (2017)

添加到收藏夹
Article Immunology

A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma

Juliane Wagner et al.

FRONTIERS IN IMMUNOLOGY (2017)

添加到收藏夹
Article Oncology

Tadalafil has biologic activity in human melanoma. Results of a pilot trial with Tadalafil in patients with metastatic Melanoma (TaMe)

Jessica C. Hassel et al.

ONCOIMMUNOLOGY (2017)

添加到收藏夹
Article Oncology

CD103+tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+T cells associated with prognostic benefit and therapy response in cervical cancer

Fenne L. Komdeur et al.

ONCOIMMUNOLOGY (2017)

添加到收藏夹
Review Oncology

Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy

Michael A. Cannarile et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2017)

添加到收藏夹
Article Oncology

Paxillin Binding to the Cytoplasmic Domain of CD103 Promotes Cell Adhesion and Effector Functions for CD8+ Resident Memory T Cells in Tumors

Ludiane Gauthier et al.

CANCER RESEARCH (2017)

添加到收藏夹
Article Immunology

De novo induction of intratumoral lymphoid structures and vessel normalization enhances immunotherapy in resistant tumors

Anna Johansson-Percival et al.

NATURE IMMUNOLOGY (2017)

添加到收藏夹
Article Hematology

Phase 1 clinical trial using mbIL21 ex vivo-expanded donor-derived NK cells after haploidentical transplantation

Stefan O. Ciurea et al.

BLOOD (2017)

添加到收藏夹
Article Immunology

Modification of anti-tumor immunity by tolerogenic dendritic cells

Liying Chen et al.

AUTOIMMUNITY (2017)

添加到收藏夹
Article Biochemistry & Molecular Biology

Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation

Shuo Wang et al.

CELL (2017)

添加到收藏夹
Article Immunology

SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling

Victor S. Cortez et al.

NATURE IMMUNOLOGY (2017)

添加到收藏夹
Article Oncology

Entinostat Neutralizes Myeloid-Derived Suppressor Cells and Enhances the Antitumor Effect of PD-1 Inhibition in Murine Models of Lung and Renal Cell Carcinoma

Ashley Orillion et al.

CLINICAL CANCER RESEARCH (2017)

添加到收藏夹
Review Immunology

Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy

Nisha Nagarsheth et al.

NATURE REVIEWS IMMUNOLOGY (2017)

添加到收藏夹
Article Immunology

Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells

Yulong Gao et al.

NATURE IMMUNOLOGY (2017)

添加到收藏夹
Article Immunology

Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer

Anusha-Preethi Ganesan et al.

NATURE IMMUNOLOGY (2017)

添加到收藏夹
Article Medicine, Research & Experimental

CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer

Chunyan Gu-Trantien et al.

JCI INSIGHT (2017)

添加到收藏夹
Article Oncology

Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy

Stefani Spranger et al.

CANCER CELL (2017)

添加到收藏夹
Article Immunology

Targeting latency-associated peptide promotes antitumor immunity

Galina Gabriely et al.

SCIENCE IMMUNOLOGY (2017)

添加到收藏夹
Article Oncology

RORγt+ Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers

Sheeba Irshad et al.

CANCER RESEARCH (2017)

添加到收藏夹
Review Biochemistry & Molecular Biology

The Principles of Engineering Immune Cells to Treat Cancer

Wendell A. Lim et al.

CELL (2017)

添加到收藏夹
Review Oncology

Targeting TGF-β Signaling in Cancer

Selcuk Colak et al.

TRENDS IN CANCER (2017)

添加到收藏夹
Review Immunology

Group 3 innate lymphoid cells: regulating host-commensal bacteria interactions in inflammation and cancer

Jeremy Goc et al.

INTERNATIONAL IMMUNOLOGY (2016)

添加到收藏夹
Review Immunology

Follicular Helper T Cells

Carola G. Vinuesa et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 34 (2016)

添加到收藏夹
Article Oncology

Critical Role for CD103+/CD141+ Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma

Edward W. Roberts et al.

CANCER CELL (2016)

添加到收藏夹
Article Oncology

TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment

Marie Boutet et al.

CANCER RESEARCH (2016)

添加到收藏夹
Article Oncology

Myeloid-Derived Suppressor Cells Express Bruton's Tyrosine Kinase and Can Be Depleted in Tumor-Bearing Hosts by Ibrutinib Treatment

Andrew Stiff et al.

CANCER RESEARCH (2016)

添加到收藏夹
Article Oncology

CSF1 Overexpression Promotes High-Grade Glioma Formation without Impacting the Polarization Status of Glioma-Associated Microglia and Macrophages

Ishani De et al.

CANCER RESEARCH (2016)

添加到收藏夹
Article Biochemistry & Molecular Biology

Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy

Jianjun Gao et al.

CELL (2016)

添加到收藏夹
Article Biochemistry & Molecular Biology

Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells

Saida Dadi et al.

CELL (2016)

添加到收藏夹
Article Oncology

Tumor-infiltrating lymphocyte subsets and tertiary lymphoid structures in pulmonary metastases from colorectal cancer

Thomas Schweiger et al.

CLINICAL & EXPERIMENTAL METASTASIS (2016)

添加到收藏夹
Article Oncology

Tumor-Infiltrating Plasma Cells Are Associated with Tertiary Lymphoid Structures, Cytolytic T-Cell Responses, and Superior Prognosis in Ovarian Cancer

David R. Kroeger et al.

CLINICAL CANCER RESEARCH (2016)

添加到收藏夹
Article Oncology

IL15 Trispecific Killer Engagers (TriKE) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing Persistence, In Vivo Expansion, and Enhanced Function

Daniel A. Vallera et al.

CLINICAL CANCER RESEARCH (2016)

添加到收藏夹
Letter Hematology

Innate lymphoid cells are expanded and functionally altered in chronic lymphocytic leukemia

Iris de Weerdt et al.

HAEMATOLOGICA (2016)

添加到收藏夹
Article Immunology

Interleukin-35 Limits Anti-Tumor Immunity

Meghan E. Tumis et al.

IMMUNITY (2016)

添加到收藏夹
Review Immunology

Tertiary lymphoid structures, drivers of the anti-tumor responses in human cancers

Marie-Caroline Dieu-Nosjean et al.

IMMUNOLOGICAL REVIEWS (2016)

添加到收藏夹
Article Nanoscience & Nanotechnology

Manipulating the NF-κB pathway in macrophages using mannosylated, siRNA-delivering nanoparticles can induce immunostimulatory and tumor cytotoxic functions

Ryan A. Ortega et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2016)

添加到收藏夹
Article Immunology

Intratumorally Establishing Type 2 Innate Lymphoid Cells Blocks Tumor Growth

Juyang Kim et al.

JOURNAL OF IMMUNOLOGY (2016)

添加到收藏夹
Article Immunology

An essential role for the IL-2 receptor in Treg cell function

Takatoshi Chinen et al.

NATURE IMMUNOLOGY (2016)

添加到收藏夹
Review Immunology

Targeting natural killer cells in cancer immunotherapy

Camille Guillerey et al.

NATURE IMMUNOLOGY (2016)

添加到收藏夹
Article Biochemistry & Molecular Biology

Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers

Takuro Saito et al.

NATURE MEDICINE (2016)

添加到收藏夹
Article Cell Biology

Spatially selective depletion of tumor-associated regulatory T cells with near-infrared photoimmunotherapy

Kazuhide Sato et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

添加到收藏夹
Article Cell Biology

Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia

Rizwan Romee et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

添加到收藏夹
Article Oncology

B lymphocytes as direct antigen-presenting cells for anti-tumor DNA vaccines

Viswa Teja Colluru et al.

ONCOTARGET (2016)

添加到收藏夹
Letter Hematology

Innate lymphoid cells are expanded and functionally altered in chronic lymphocytic leukemia

Iris de Weerdt et al.

HAEMATOLOGICA (2016)

添加到收藏夹
Article Immunology

Very late antigen-1 Marks Functional Tumor-resident cD8 T cells and correlates with survival of Melanoma Patients

Timothy Murray et al.

FRONTIERS IN IMMUNOLOGY (2016)

添加到收藏夹
Article Oncology

NKp30 isoforms and NKp46 transcripts in metastatic melanoma patients: Unique NKp30 pattern in rare melanoma patients with favorable evolution

Meriem Messaoudene et al.

ONCOIMMUNOLOGY (2016)

添加到收藏夹
Article Oncology

Single dose denileukin diftitox does not enhance vaccine-induced T cell responses or effectively deplete Tregs in advanced melanoma: immune monitoring and clinical results of a randomized phase II trial

Jason J. Luke et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2016)

添加到收藏夹
Review Oncology

NK cells and cancer: you can teach innate cells new tricks

Maelig G. Morvan et al.

NATURE REVIEWS CANCER (2016)

添加到收藏夹
Article Medicine, Research & Experimental

B cell repertoire expansion occurs in meningeal ectopic lymphoid tissue

Klaus Lehmann-Horn et al.

JCI INSIGHT (2016)

添加到收藏夹
Article Medicine, Research & Experimental

Vaccine-generated lung tissue-resident memory T cells provide heterosubtypic protection to influenza infection

Kyra D. Zens et al.

JCI INSIGHT (2016)

添加到收藏夹
Article Hematology

Adaptive Natural Killer Cell and Killer Cell Immunoglobulin-Like Receptor-Expressing T Cell Responses are Induced by Cytomegalovirus and Are Associated with Protection against Cytomegalovirus Reactivation after Allogeneic Donor Hematopoietic Cell Transplantation

Zachary B. Davis et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2015)

添加到收藏夹
Article Oncology

Intratumoral tertiary lymphoid organ is a favourable prognosticator in patients with pancreatic cancer

N. Hiraoka et al.

BRITISH JOURNAL OF CANCER (2015)

添加到收藏夹
Article Biochemistry & Molecular Biology

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

Elizabeth M. Steinert et al.

CELL (2015)

添加到收藏夹
Article Biochemistry & Molecular Biology

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

Santiago Zelenay et al.

CELL (2015)

添加到收藏夹
Review Biochemistry & Molecular Biology

Human dendritic cell subsets and function in health and disease

Meredith O'Keeffe et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2015)

添加到收藏夹
Article Oncology

TLR9-Targeted STAT3 Silencing Abrogates Immunosuppressive Activity of Myeloid-Derived Suppressor Cells from Prostate Cancer Patients

Dewan M. S. Hossain et al.

CLINICAL CANCER RESEARCH (2015)

添加到收藏夹
Article Oncology

A Phase I Trial of the Anti-KIR Antibody IPH2101 and Lenalidomide in Patients with Relapsed/Refractory Multiple Myeloma

Don M. Benson et al.

CLINICAL CANCER RESEARCH (2015)

添加到收藏夹
Article Immunology

ICOS maintains the T follicular helper cell phenotype by down-regulating Kruppel-like factor 2

Jan P. Weber et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

添加到收藏夹
Article Immunology

Cutting Edge: CD69 Interference with Sphingosine-1-Phosphate Receptor Function Regulates Peripheral T Cell Retention

Laura K. Mackay et al.

JOURNAL OF IMMUNOLOGY (2015)

添加到收藏夹
Article Oncology

Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer

Michele Mondini et al.

MOLECULAR CANCER THERAPEUTICS (2015)

添加到收藏夹
Article Multidisciplinary Sciences

TH17 cells transdifferentiate into regulatory T cells during resolution of inflammation

Nicola Gagliani et al.

NATURE (2015)

添加到收藏夹
Article Immunology

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

Shlomi Finkin et al.

NATURE IMMUNOLOGY (2015)

添加到收藏夹
Article Multidisciplinary Sciences

A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

Beatriz M. Carreno et al.

SCIENCE (2015)

添加到收藏夹
Article Cell Biology

Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients

Michaela Semeraro et al.

Science Translational Medicine (2015)

添加到收藏夹
Article Multidisciplinary Sciences

Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints

M. E. Mikucki et al.

NATURE COMMUNICATIONS (2015)

添加到收藏夹
Article Multidisciplinary Sciences

NCR+ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures

Paolo Carrega et al.

NATURE COMMUNICATIONS (2015)

添加到收藏夹
Article Oncology

CD40 controls CXCR5-induced recruitment of myeloid-derived suppressor cells to gastric cancer

Yixin Ding et al.

ONCOTARGET (2015)

添加到收藏夹
Review Oncology

NKG2D Receptor and Its Ligands in Host Defense

Lewis L. Lanier

CANCER IMMUNOLOGY RESEARCH (2015)

添加到收藏夹
Article Oncology

Angels and demons: Th17 cells represent a beneficial response, while neutrophil IL-17 is associated with poor prognosis in squamous cervical cancer

Simone Punt et al.

ONCOIMMUNOLOGY (2015)

添加到收藏夹
Review Oncology

Tumor-induced myeloid dysfunction and its implications for cancer immunotherapy

Michelle N. Messmer et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2015)

添加到收藏夹
Article Immunology

Therapeutic DC vaccination with IL-2 as a consolidation therapy for ovarian cancer patients: a phase I/II trial

Soyoung Baek et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2015)

添加到收藏夹
Article Oncology

Tadalafil Reduces Myeloid-Derived Suppressor Cells and Regulatory T Cells and Promotes Tumor Immunity in Patients with Head and Neck Squamous Cell Carcinoma

Donald T. Weed et al.

CLINICAL CANCER RESEARCH (2015)

添加到收藏夹
Article Multidisciplinary Sciences

T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction

Dan Liu et al.

NATURE (2015)

添加到收藏夹
Article Multidisciplinary Sciences

Serum IL-10 Predicts Worse Outcome in Cancer Patients: A Meta-Analysis

Shuai Zhao et al.

PLOS ONE (2015)

添加到收藏夹
Article Multidisciplinary Sciences

CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells

Jianfeng Han et al.

SCIENTIFIC REPORTS (2015)

添加到收藏夹
Review Immunology

Perforin and granzymes: function, dysfunction and human pathology

Ilia Voskoboinik et al.

NATURE REVIEWS IMMUNOLOGY (2015)

添加到收藏夹
Review Oncology

S100 proteins in cancer

Anne R. Bresnick et al.

NATURE REVIEWS CANCER (2015)

添加到收藏夹
Article Critical Care Medicine

Presence of B Cells in Tertiary Lymphoid Structures Is Associated with a Protective Immunity in Patients with Lung Cancer

Claire Germain et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)

添加到收藏夹
Article Hematology

Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease

J. Marius Munneke et al.

BLOOD (2014)

添加到收藏夹
Article Oncology

Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

Jeremy Goc et al.

CANCER RESEARCH (2014)

添加到收藏夹
Article Oncology

Occurrence of Tertiary Lymphoid Tissue Is Associated with T-Cell Infiltration and Predicts Better Prognosis in Early-Stage Colorectal Cancers

Giuseppe Di Caro et al.

CLINICAL CANCER RESEARCH (2014)

添加到收藏夹
Article Oncology

Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions

Yong-Chen Lu et al.

CLINICAL CANCER RESEARCH (2014)

添加到收藏夹
Review Immunology

Tissue-Resident Memory T Cells

Jason M. Schenkel et al.

IMMUNITY (2014)

添加到收藏夹
Review Cell Biology

Natural cytotoxicity receptors and their ligands

Philip H. Kruse et al.

IMMUNOLOGY AND CELL BIOLOGY (2014)

添加到收藏夹
Article Medicine, Research & Experimental

TGF-β prevents T follicular helper cell accumulation and B cell autoreactivity

Mark J. McCarron et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

添加到收藏夹
Article Medicine, Research & Experimental

ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis

Thomas Condamine et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

添加到收藏夹
Article Biochemistry & Molecular Biology

Generation of a new therapeutic peptide that depletes myeloid-derived suppressor cells in tumor-bearing mice

Hong Qin et al.

NATURE MEDICINE (2014)

添加到收藏夹
Article Oncology

Ectopic lymphoid structures in primary cutaneous melanoma

Andrea Ladanyi et al.

PATHOLOGY & ONCOLOGY RESEARCH (2014)

添加到收藏夹
Article Multidisciplinary Sciences

Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis

Arthur Mortha et al.

SCIENCE (2014)

添加到收藏夹
Article Cell Biology

Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy

Steven L. Highfill et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

添加到收藏夹
Article Cell Biology

Intramuscular Therapeutic Vaccination Targeting HPV16 Induces T Cell Responses That Localize in Mucosal Lesions

Leonel Maldonado et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

添加到收藏夹
Review Immunology

NK cell self tolerance, responsiveness and missing self recognition

Nataliya Shifrin et al.

SEMINARS IN IMMUNOLOGY (2014)

添加到收藏夹
Article Oncology

Immunotherapy Converts Nonimmunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation

Eric R. Lutz et al.

CANCER IMMUNOLOGY RESEARCH (2014)

添加到收藏夹
Article Oncology

Reprogramming Tumor-Infiltrating Dendritic Cells for CD103+CD8+ Mucosal T-cell Differentiation and Breast Cancer Rejection

Te-Chia Wu et al.

CANCER IMMUNOLOGY RESEARCH (2014)

添加到收藏夹
Review Immunology

Early BCR events and antigen captutre, processing, and loading on MHC class II on B cells

Ana M. Avelos et al.

FRONTIERS IN IMMUNOLOGY (2014)

添加到收藏夹
Article Oncology

A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition

Efstratios Stratikos et al.

FRONTIERS IN ONCOLOGY (2014)

添加到收藏夹
Article Gastroenterology & Hepatology

Targeting Interleukin-4 Receptor Alpha by Hybrid Peptide for Novel Biliary Tract Cancer Therapy

Kahori Seto et al.

INTERNATIONAL JOURNAL OF HEPATOLOGY (2014)

添加到收藏夹
Article Immunology

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

David Masopust et al.

JOURNAL OF IMMUNOLOGY (2014)

添加到收藏夹
Review Immunology

Regulation of Ligands for the NKG2D Activating Receptor

David H. Raulet et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 (2013)

添加到收藏夹
Article Hematology

Adenosine production by human B cells and B cell-mediated suppression of activated T cells

Zenichiro Saze et al.

BLOOD (2013)

添加到收藏夹
Article Oncology

Natural Human Plasmacytoid Dendritic Cells Induce Antigen-Specific T-Cell Responses in Melanoma Patients

Jurjen Tel et al.

CANCER RESEARCH (2013)

添加到收藏夹
Article Oncology

A Chimeric Receptor with NKG2D Specificity Enhances Natural Killer Cell Activation and Killing of Tumor Cells

Yu-Hsiang Chang et al.

CANCER RESEARCH (2013)

添加到收藏夹
Article Cell Biology

A novel role of hematopoietic CCL5 in promoting triple-negative mammary tumor progression by regulating generation of myeloid-derived suppressor cells

Yan Zhang et al.

CELL RESEARCH (2013)

添加到收藏夹
Article Oncology

PI3K/AKT Signaling Is Essential for Communication between Tissue-Infiltrating Mast Cells, Macrophages, and Epithelial Cells in Colitis-Induced Cancer

Mohammad W. Khan et al.

CLINICAL CANCER RESEARCH (2013)

添加到收藏夹
Article Oncology

Characteristics and Clinical Impacts of the Immune Environments in Colorectal and Renal Cell Carcinoma Lung Metastases: Influence of Tumor Origin

Romain Remark et al.

CLINICAL CANCER RESEARCH (2013)

添加到收藏夹
Article Oncology

Targeting Natural Killer Cells to Acute Myeloid Leukemia In Vitro with a CD16 x 33 Bispecific Killer Cell Engager and ADAM17 Inhibition

Andres Wiernik et al.

CLINICAL CANCER RESEARCH (2013)

添加到收藏夹
Article Immunology

Human Inflammatory Dendritic Cells Induce Th17 Cell Differentiation

Elodie Segura et al.

IMMUNITY (2013)

添加到收藏夹
Article Immunology

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

Yuting Ma et al.

IMMUNITY (2013)

添加到收藏夹
Article Immunology

Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure

Jing He et al.

IMMUNITY (2013)

添加到收藏夹
Article Immunology

Transforming Growth Factor-β Signaling Controls the Formation and Maintenance of Gut-Resident Memory T Cells by Regulating Migration and Retention

Nu Zhang et al.

IMMUNITY (2013)

添加到收藏夹
Article Immunology

Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model

Stefanie Kirchberger et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

添加到收藏夹
Article Immunology

Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells

Cara N. Skon et al.

NATURE IMMUNOLOGY (2013)

添加到收藏夹
Article Immunology

Human type 1 innate lymphoid cells accumulate in inflamed mucosa! tissues

Jochem H. Bernink et al.

NATURE IMMUNOLOGY (2013)

添加到收藏夹
Article Immunology

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

Laura K. Mackay et al.

NATURE IMMUNOLOGY (2013)

添加到收藏夹
Article Cell Biology

Mucosal Imprinting of Vaccine-Induced CD8+ T Cells Is Crucial to Inhibit the Growth of Mucosal Tumors

Federico Sandoval et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

添加到收藏夹
Article Oncology

Plasmacytoid Dendritic Cells Support Melanoma Progression by Promoting Th2 and Regulatory Immunity through OX40L and ICOSL

Caroline Aspord et al.

CANCER IMMUNOLOGY RESEARCH (2013)

添加到收藏夹
Article Immunology

Innate lymphoid cells - a proposal for uniform nomenclature

Hergen Spits et al.

NATURE REVIEWS IMMUNOLOGY (2013)

添加到收藏夹
Article Hematology

A phase 1 trial of the anti-KIR antibody IPH2101 in patients with relapsed/refractory multiple myeloma

Don M. Benson et al.

BLOOD (2012)

添加到收藏夹
Article Oncology

Neogenesis of Lymphoid Structures and Antibody Responses Occur in Human Melanoma Metastases

Arcadi Cipponi et al.

CANCER RESEARCH (2012)

添加到收藏夹
Article Oncology

CCR5 Antagonist Blocks Metastasis of Basal Breast Cancer Cells

Marco Velasco-Velazquez et al.

CANCER RESEARCH (2012)

添加到收藏夹
Review Immunology

CD4(+)T Cells: Differentiation and Functions

Rishi Vishal Luckheeram et al.

CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2012)

添加到收藏夹
Article Immunology

The Transcription Factors T-bet and Eomes Control Key Checkpoints of Natural Killer Cell Maturation

Scott M. Gordon et al.

IMMUNITY (2012)

添加到收藏夹
Article Immunology

PGE2-Driven Induction and Maintenance of Cancer-Associated Myeloid-Derived Suppressor Cells

Natasa Obermajer et al.

IMMUNOLOGICAL INVESTIGATIONS (2012)

添加到收藏夹
Article Immunology

Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts

Alexandre P. A. Theocharides et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2012)

添加到收藏夹
Article Genetics & Heredity

Transcript signature predicts tissue NK cell content and defines renal cell carcinoma subgroups independent of TNM staging

Judith Eckl et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2012)

添加到收藏夹
Article Oncology

Targeting Interleukin-4 Receptor α with Hybrid Peptide for Effective Cancer Therapy

Liying Yang et al.

MOLECULAR CANCER THERAPEUTICS (2012)

添加到收藏夹
Article Immunology

The development and fate of follicular helper T cells defined by an IL-21 reporter mouse

Katja Luethje et al.

NATURE IMMUNOLOGY (2012)

添加到收藏夹
Article Gastroenterology & Hepatology

Hepatocellular carcinoma and macrophage interaction induced tumor immunosuppression via Treg requires TLR4 signaling

Jing Yang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2012)

添加到收藏夹
Editorial Material Oncology

Tumor high endothelial venules (HEVs) predict lymphocyte infiltration and favorable prognosis in breast cancer

Ludovic Martinet et al.

ONCOIMMUNOLOGY (2012)

添加到收藏夹
Article Oncology

Profound Coordinated Alterations of Intratumoral NK Cell Phenotype and Function in Lung Carcinoma

Sophia Platonova et al.

CANCER RESEARCH (2011)

添加到收藏夹
Article Oncology

COX-2 Blockade Suppresses Gliomagenesis by Inhibiting Myeloid-Derived Suppressor Cells

Mitsugu Fujita et al.

CANCER RESEARCH (2011)

添加到收藏夹
Article Oncology

The Two Faces of Interferon-γ in Cancer

M. Raza Zaidi et al.

CLINICAL CANCER RESEARCH (2011)

添加到收藏夹
Article Medicine, Research & Experimental

Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity

Emilie Mamessier et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

添加到收藏夹
Article Immunology

Human Dendritic Cell Subsets from Spleen and Blood Are Similar in Phenotype and Function but Modified by Donor Health Status

Diana Mittag et al.

JOURNAL OF IMMUNOLOGY (2011)

添加到收藏夹
Article Multidisciplinary Sciences

Resident Memory T Cells (TRM) Are Abundant in Human Lung: Diversity, Function, and Antigen Specificity

Rahul Purwar et al.

PLOS ONE (2011)

添加到收藏夹
Article Hematology

siRNA silencing of PD-L1 and PD-L2 on dendritic cells augments expansion and function of minor histocompatibility antigen-specific CD8+ T cells

Willemijn Hobo et al.

BLOOD (2010)

添加到收藏夹
Article Oncology

Effects of Siltuximab on the IL-6-Induced Signaling Pathway in Ovarian Cancer

Yuqi Guo et al.

CLINICAL CANCER RESEARCH (2010)

添加到收藏夹
Article Biochemistry & Molecular Biology

CD69 Suppresses Sphingosine 1-Phosophate Receptor-1 (S1P1) Function through Interaction with Membrane Helix 4

Alexander J. Bankovich et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

添加到收藏夹
Article Immunology

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

Michelle A. Linterman et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

添加到收藏夹
Article Immunology

Dynamic T cell migration program provides resident memory within intestinal epithelium

David Masopust et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

添加到收藏夹
Article Cell Biology

Tumor-mediated induction of myeloid-derived suppressor cells and M2-polarized macrophages by altering intracellular PGE2 catabolism in myeloid cells

Evgeniy Eruslanov et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2010)

添加到收藏夹
Article Immunology

IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46

Maya Eisenring et al.

NATURE IMMUNOLOGY (2010)

添加到收藏夹
Article Multidisciplinary Sciences

CD8+T Cell Priming by Dendritic Cell Vaccines Requires Antigen Transfer to Endogenous Antigen Presenting Cells

Alice W. Yewdall et al.

PLOS ONE (2010)

添加到收藏夹
Article Oncology

Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome

Michael Gobert et al.

CANCER RESEARCH (2009)

添加到收藏夹
Article Biochemistry & Molecular Biology

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

Siddhartha Jaiswal et al.

CELL (2009)

添加到收藏夹
Article Oncology

Dendritic Cell Vaccination Combined with CTLA4 Blockade in Patients with Metastatic Melanoma

Antoni Ribas et al.

CLINICAL CANCER RESEARCH (2009)

添加到收藏夹
Article Immunology

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

Di Yu et al.

IMMUNITY (2009)

添加到收藏夹
Article Immunology

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

Makoto Miyara et al.

IMMUNITY (2009)

添加到收藏夹
Article Immunology

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

Thomas Gebhardt et al.

NATURE IMMUNOLOGY (2009)

添加到收藏夹
Article Multidisciplinary Sciences

Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival

Dusan Bogunovic et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

添加到收藏夹
Article Multidisciplinary Sciences

Bcl6 Mediates the Development of T Follicular Helper Cells

Roza I. Nurieva et al.

SCIENCE (2009)

添加到收藏夹
Article Immunology

Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

Roza I. Nurieva et al.

IMMUNITY (2008)

添加到收藏夹
Article Oncology

Long-term survival for patients with non-small-cell lung cancer with intratumoral lymphoid structures

Marie-Caroline Dieu-Nosjean et al.

JOURNAL OF CLINICAL ONCOLOGY (2008)

添加到收藏夹
Article Immunology

Expression of a soluble TGF-beta receptor by tumor cells enhances dendritic cell/tumor fusion vaccine efficacy

Min Zhang et al.

JOURNAL OF IMMUNOLOGY (2008)

添加到收藏夹
Review Immunology

IL-10: The master regulator of immunity to infection

Kevin N. Couper et al.

JOURNAL OF IMMUNOLOGY (2008)

添加到收藏夹
Article Immunology

Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells

Pratima Sinha et al.

JOURNAL OF IMMUNOLOGY (2008)

添加到收藏夹
Article Immunology

Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance

Xuefang Cao et al.

IMMUNITY (2007)

添加到收藏夹
Article Immunology

Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response

Pratima Sinha et al.

JOURNAL OF IMMUNOLOGY (2007)

添加到收藏夹
Article Immunology

αEβ7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis

Audrey Le Floc'h et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2007)

添加到收藏夹
Review Immunology

Activation, coactivation, and costimulation of resting human natural killer cells

Yenan T. Bryceson et al.

IMMUNOLOGICAL REVIEWS (2006)

添加到收藏夹
Review Biochemistry & Molecular Biology

Both integrated and differential regulation of components of the IL-2/IL-2 receptor system

Hyoung Pyo Kim et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2006)

添加到收藏夹
Article Multidisciplinary Sciences

Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells

Matthew A. Williams et al.

NATURE (2006)

添加到收藏夹
Review Oncology

Myeloid suppressor cells in cancer: Recruitment, phenotype, properties, and mechanisms of immune suppression

P Serafini et al.

SEMINARS IN CANCER BIOLOGY (2006)

添加到收藏夹
Article Immunology

CD4+ CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-β-dependent manner

F Ghiringhelli et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

添加到收藏夹
Article Multidisciplinary Sciences

T cell immunity using transgenic B lymphocytes

M Gerloni et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

添加到收藏夹
Review Immunology

Central memory and effector memory T cell subsets: Function, generation, and maintenance

F Sallusto et al.

ANNUAL REVIEW OF IMMUNOLOGY (2004)

添加到收藏夹
Article Oncology

Renal cell carcinoma-infiltrating natural killer cells express differential repertoires of activating and inhibitory receptors and are inhibited by specific HLA class I allotypes

JS Schleypen et al.

INTERNATIONAL JOURNAL OF CANCER (2003)

添加到收藏夹
Article Immunology

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases

S Zompi et al.

NATURE IMMUNOLOGY (2003)

添加到收藏夹
Review Immunology

Induction of tolerogenic DCs: 'you are what you eat'

K Mahnke et al.

TRENDS IN IMMUNOLOGY (2003)

添加到收藏夹
Review Immunology

Cancer immunoediting: from immunosurveillance to tumor escape

GP Dunn et al.

NATURE IMMUNOLOGY (2002)

添加到收藏夹
Article Immunology

Subspecialization of CXCR5+ T cells:: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells

CH Kim et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2001)

添加到收藏夹
Article Multidisciplinary Sciences

Preferential localization of effector memory cells in nonlymphoid tissue

D Masopust et al.

SCIENCE (2001)

添加到收藏夹
Article Immunology

Resting B lymphocytes as APC for naive T lymphocytes: Dependence on CD40 ligand/CD40

DE Evans et al.

JOURNAL OF IMMUNOLOGY (2000)

添加到收藏夹
研讨会 海报 问题 讨论圈 基金 期刊 论文 科研社交 资讯集成 审稿人 关于我们 常见问题 移动App 隐私条款 使用条款
© Peeref 2019-2024. All rights reserved.