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Poor clinical outcome in metastatic melanoma is associated with a microRNA-modulated immunosuppressive tumor microenvironment
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JOURNAL OF TRANSLATIONAL MEDICINE (2020)
Accurate estimation of cell composition in bulk expression through robust integration of single-cell information
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NATURE COMMUNICATIONS (2020)
Effect of the topical administration of N-(2-(4-bromophenylamino)-5-(trifluoromethyl)phenyl)nicotinamide compound in a murine subcutaneous melanoma model
Juliana Alves do Vale et al.
ANTI-CANCER DRUGS (2020)
Molecular principles of metastasis: a hallmark of cancer revisited
Jawad Fares et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)
Serine/arginine protein-specific kinase 2 promotes the development and progression of pancreatic cancer by downregulating Numb and p53
Guosen Wang et al.
FEBS JOURNAL (2019)
Enhanced expression of SRPK2 contributes to aggressive progression and metastasis in prostate cancer
Yang Jia Zhuo et al.
BIOMEDICINE & PHARMACOTHERAPY (2018)
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Andrew Butler et al.
NATURE BIOTECHNOLOGY (2018)
Antimetastatic effect of the pharmacological inhibition of serine/arginine-rich protein kinases (SRPK) in murine melanoma
Gabriela Alves Moreira et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
Livnat Jerby-Arnon et al.
CELL (2018)
SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform
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CELL CHEMICAL BIOLOGY (2018)
Single-cell RNA sequencing technologies and bioinformatics pipelines
Byungjin Hwang et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2018)
The crucial role of SRPK1 in IGF-1-induced EMT of human gastric cancer
Hong Wang et al.
ONCOTARGET (2017)
Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation
Sreerama Chaitanya Sridhara et al.
CELL REPORTS (2017)
Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling
Gina Lee et al.
CELL (2017)
Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease
Jennifer Batson et al.
ACS CHEMICAL BIOLOGY (2017)
Serine-arginine protein kinase 1 (SRPK1), a determinant of angiogenesis, is upregulated in prostate cancer and correlates with disease stage and invasion
Nicholas Bullock et al.
JOURNAL OF CLINICAL PATHOLOGY (2016)
TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data
Antonio Colaprico et al.
NUCLEIC ACIDS RESEARCH (2016)
SRPK2 promotes the growth and migration of the colon cancer cells
Jian Wang et al.
GENE (2016)
Serine-arginine protein kinase 1 promotes a cancer stem cell-like phenotype through activation of Wnt/β-catenin signalling in NSCLC
Liyun Gong et al.
JOURNAL OF PATHOLOGY (2016)
Expression of SRPK1 in gliomas and its role in glioma cell lines viability
Ioanna Sigala et al.
TUMOR BIOLOGY (2016)
Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant
Wies van Roosmalen et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays antitumor activity against melanoma in vitro and in vivo
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SCIENTIFIC REPORTS (2015)
Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340)
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PLOS ONE (2015)
Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice
Satoshi Morooka et al.
MOLECULAR PHARMACOLOGY (2015)
Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma
M. V. Gammons et al.
BRITISH JOURNAL OF CANCER (2014)
Movers and shakers: cell cytoskeleton in cancer metastasis
C. M. Fife et al.
BRITISH JOURNAL OF PHARMACOLOGY (2014)
Both Decreased and Increased SRPK1 Levels Promote Cancer by Interfering with PHLPP- Mediated Dephosphorylation of Akt
Pingping Wang et al.
MOLECULAR CELL (2014)
Improved vectors and genome-wide libraries for CRISPR screening
Neville E. Sanjana et al.
NATURE METHODS (2014)
Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells
Vania Goncalves et al.
RNA (2014)
DNA targeting specificity of RNA-guided Cas9 nucleases
Patrick D. Hsu et al.
NATURE BIOTECHNOLOGY (2013)
Topical Antiangiogenic SRPK1 Inhibitors Reduce Choroidal Neovascularization in Rodent Models of Exudative AMD
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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2013)
The Akt-SRPK-SR Axis Constitutes a Major Pathway in Transducing EGF Signaling to Regulate Alternative Splicing in the Nucleus
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MOLECULAR CELL (2012)
Elevated Expression of the Serine-Arginine Protein Kinase 1 Gene in Ovarian Cancer and Its Role in Cisplatin Cytotoxicity In Vitro
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PLOS ONE (2012)
Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones
Xiang-Yang Zhong et al.
GENES & DEVELOPMENT (2009)
mRNA-Seq whole-transcriptome analysis of a single cell
Fuchou Tang et al.
NATURE METHODS (2009)
Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1
Sung-Wuk Jang et al.
CANCER RESEARCH (2008)
Serine-arginine protein kinase 1 overexpression is associated with tumorigenic imbalance in mitogen-activated protein kinase pathways in breast, colonic, and pancreatic carcinomas
Gregory M. Hayes et al.
CANCER RESEARCH (2007)
Targeting the RNA splicing machinery as a novel treatment strategy for pancreatic carcinoma
GM Hayes et al.
CANCER RESEARCH (2006)
Resistance to platinum-containing chemotherapy in testicular germ cell tumors is associated with downregulation of the protein kinase SRPK1
PW Schenk et al.
NEOPLASIA (2004)