GNB3 c.825c>T polymorphism influences T-cell but not antibody response following vaccination with the mRNA-1273 vaccine

Article Cell Biology

Polymorphism of the HLA system and weak antibody response to BNT162b2 mRNA vaccine

Roberto Crocchiolo et al.

Summary: The HLA system polymorphism has been extensively studied in COVID-19 infection, but there is no data about its role in vaccine response. This study found that certain HLA alleles and haplotypes, along with age, are associated with a weaker antibody response after the BNT162b2 mRNA vaccine. These findings provide insights into tracking potentially susceptible individuals, but further research is needed to confirm and dissect the role of HLA polymorphism in response to anti-COVID-19 vaccines.

HLA (2022)

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Article Immunology

Differential T-Cell Immunity to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in mRNA-1273-and BNT162b2-Vaccinated Individuals

Kathleen M. E. Gallagher et al.

Summary: Breakthrough cases among vaccinated individuals highlight the importance of long-term immunity against SARS-CoV-2 and its variants. Antibody levels and anti-spike T-cell responses decrease over time and are lower in those vaccinated with BNT162b2 compared to mRNA-1273. T-cell responses to variants remain relatively unaffected.

CLINICAL INFECTIOUS DISEASES (2022)

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Article Immunology

HLA Class II Polymorphism and Humoral Immunity Induced by the SARS-CoV-2 mRNA-1273 Vaccine

Juan Francisco Gutierrez-Bautista et al.

Summary: This study investigates the association between HLA-Class II typing and the intensity of humoral response to the SARS-CoV2 mRNA 1273 vaccine. The findings suggest a possible relationship between HLA-DRB1*07:01 allele and HLA-DRB1*07:01 similar to DQA1*02:01 similar to DQB1*02:02 haplotype with higher antibody production 30 days after the administration of the second dose of mRNA-1273.

VACCINES (2022)

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Letter Medicine, General & Internal

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

Alicia T. Widge et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Letter Medicine, General & Internal

Differential Kinetics of Immune Responses Elicited by Covid-19 Vaccines

Ai-ris Y. Collier et al.

Summary: The kinetics of immune response to Covid-19 vaccines were studied, showing varying peak levels and durations of response for different vaccines. However, the response levels correlating with protection have not been defined yet.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Rheumatology

SARS-CoV-2 vaccination responses in untreated, conventionally treated and anticytokine-treated patients with immune-mediated inflammatory diseases

David Simon et al.

Summary: Immune response against SARS-CoV-2 is delayed and reduced in patients with immune-mediated inflammatory diseases, regardless of treatment.

ANNALS OF THE RHEUMATIC DISEASES (2021)

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Article Rheumatology

Immunogenicity and safety of anti-SARS-CoV-2 mRNA vaccines in patients with chronic inflammatory conditions and immunosuppressive therapy in a monocentric cohort

Ulf M. Geisen et al.

Summary: In this study, the efficacy and safety of anti-SARS-CoV-2 mRNA vaccines in immunosuppressed patients were compared with healthy controls. The results showed that all study participants developed antibodies, with lower IgG titres in patients compared to controls. Side effects were minimal and no disease flares were observed, demonstrating the efficiency and safety of mRNA vaccines in this cohort despite its small size.

ANNALS OF THE RHEUMATIC DISEASES (2021)

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Article Immunology

Humoral and Cellular Vaccination Responses against SARS-CoV-2 in Hematopoietic Stem Cell Transplant Recipients

Monika Lindemann et al.

Summary: The cellular response to SARS-CoV-2 vaccination and infection in HSCT recipients remains unclear. The study found that HSCT patients vaccinated twice had significantly higher SARS-CoV-2 IgG antibodies compared to pre-vaccination. However, their ELISpot responses were reduced to less than 33% of controls. Female patients and healthy controls showed higher antibody responses post-vaccination, while cellular immunity was diminished in patients regardless of sex.

VACCINES (2021)

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Letter Medicine, General & Internal

Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19

Nicole Doria-Rose et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Letter Medicine, General & Internal

Comparison of SARS-CoV-2 Antibody Response Following Vaccination With BNT162b2 and mRNA-1273

Deborah Steensels et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Infectious Diseases

Immunogenicity of mRNA-1273 COVID vaccine after 6 months surveillance in health care workers; a third dose is necessary

Marie Tre-Hardy et al.

Summary: A study on mRNA-1273 vaccine recipients showed a significant decrease in antibody levels after 6 months, especially in individuals who had not previously been vaccinated. In a supply-limited environment, it is recommended to prioritize the third dose for seronegative individuals prior to vaccination.

JOURNAL OF INFECTION (2021)

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Review Immunology

SARS-CoV-2 Vaccines Based on the Spike Glycoprotein and Implications of New Viral Variants

Daniel Martinez-Flores et al.

Summary: COVID-19, caused by SARS-CoV-2, affects the respiratory system and has resulted in over 2 million deaths worldwide. Vaccines targeting the S glycoprotein have been developed, but the emergence of new variants could impact their effectiveness.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

Mechanisms of SARS-CoV-2 Transmission and Pathogenesis

Andrew G. Harrison et al.

TRENDS IN IMMUNOLOGY (2020)

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Article Virology

Role of G protein β3 subunit C825T and HLA class II polymorphisms in the immune response after HBV vaccination

M Lindemann et al.

VIROLOGY (2002)

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GNB3 c.825c>T polymorphism influences T-cell but not antibody response following vaccination with the mRNA-1273 vaccine

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