期刊
FRONTIERS IN GENETICS
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2022.929231
关键词
exosomes; cardiovascular; cardio; miRNA; treatment
资金
- National Natural Science Foundation of China, China [81970399]
- project of Jilin Key Laboratory Construction Project, China [20190901008JC]
- project of Jilin Province Health Science and technology capacity improvement, China [2021JC043]
This review discusses the role of exosomes and the biomolecules they contain in the prevention, diagnosis, and treatment of cardiovascular diseases. By examining the results of published studies, the review reveals the mechanisms of exosomal miRNAs in various cardiovascular diseases.
Cardiovascular diseases are the most common diseases threatening the health of the elderly, and the incidence and mortality rates associated with cardiovascular diseases remain high and are increasing gradually. Studies on the treatment and prevention of cardiovascular diseases are underway. Currently, several research groups are studying the role of exosomes and biomolecules incorporated by exosomes in the prevention, diagnosis, and treatment of clinical diseases, including cardiovascular diseases. Now, based on the results of published studies, this review discusses the characteristics, separation, extraction, and identification of exosomes, specifically the role of exosomal miRNAs in atherosclerosis, myocardial injury and infarction, heart failure, aortic dissection, myocardial fibrosis, ischemic reperfusion, atrial fibrillation, and other diseases. We believe that the observations noted in this article will aid in the prevention, diagnosis, and treatment of cardiovascular diseases.
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