☆ 4.6 Article

A comprehensive analysis of G-protein-signaling modulator 2 as a prognostic and diagnostic marker for pan-cancer

FRONTIERS IN GENETICS (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Oncology

Identification of G-protein signaling modulator 2 as a diagnostic and prognostic biomarker of pancreatic adenocarcinoma: an exploration of its regulatory mechanisms

Xintong Zhou et al.

Summary: This study identified GPSM2 as a potential prognostic factor and therapeutic target for pancreatic adenocarcinoma, showing its overexpression in correlation with patient history, disease stage, and tumor grade. GPSM2 was found to influence immune cell infiltration in the tumor microenvironment and targeting GPSM2 and its downstream genes may extend patient survival.

JOURNAL OF GASTROINTESTINAL ONCOLOGY (2021)

添加到收藏夹

Article Immunology

Kinase activity profiling reveals contribution of G-protein signaling modulator 2 deficiency to impaired regulatory T cell migration in rheumatoid arthritis

Anja Meyer et al.

Summary: The study found significantly altered post-translational phosphorylation of kinase related proteins, including GPSM2, PTK6, and VTNC, in CD4+ T cells from rheumatoid arthritis (RA) patients, with GPSM2 being revealed to promote Treg cell migration in healthy individuals. Treatment with interleukin-6 receptor blocking antibodies can restore GPSM2 expression and improve Treg cell migration in RA patients. This highlights the potential of multiplex kinase activity arrays for identifying RA-related proteins as potential targets for novel treatments.

JOURNAL OF AUTOIMMUNITY (2021)

添加到收藏夹

Article Oncology

Tumor mutation burden in connection with immune-related survival in uterine corpus endometrial carcinoma

Ling Zhao et al.

Summary: The study identified several clinically significant differential immune genes and established relevant prognostic models for UCEC, providing a basis for molecular analysis of TMB and immune cells in UCEC. The results also confirmed potential prognostic and immune-related genes, while adding clinical conditions for further analysis to confirm the identity of genes and clinical elements-based models.

CANCER CELL INTERNATIONAL (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Non-coding RNAs regulation of macrophage polarization in cancer

Swati Mohapatra et al.

Summary: Noncoding RNA transcripts, as important regulators in the tumor microenvironment, play crucial roles in modulating macrophage polarization and influencing tumor progression and clinical outcomes. More research is needed to further understand the mechanisms underlying these processes and the potential therapeutic implications.

MOLECULAR CANCER (2021)

添加到收藏夹

Review Oncology

The Role of Cancer-Associated Fibroblasts in Cancer Invasion and Metastasis

Paris Jabeen Asif et al.

Summary: Metastasis in cancer is closely associated with cancer-associated fibroblasts (CAFs), which play a key role in cancer progression by contributing to extracellular matrix deposition and remodeling, extensive crosstalk with cancer cells, epithelial-to-mesenchymal transition (EMT), invasion, metastasis, and therapy resistance. Understanding the role of CAFs in the process of metastasis, particularly in colorectal cancer (CRC) with high stromal infiltration, is crucial for developing targeted therapeutics and advancing research in this field.

CANCERS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Identifying GPSM Family Members as Potential Biomarkers in Breast Cancer: A Comprehensive Bioinformatics Analysis

Huy-Hoang Dang et al.

Summary: The study identifies significant differential expression of GPSMs in breast cancer, with associations with tumor progression and prognosis, particularly GPSM2 linked to worse distant metastasis-free survival and GPSM3 correlated with immune cell infiltration.

BIOMEDICINES (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Ubiquitin signaling in cell cycle control and tumorigenesis

Fabin Dang et al.

Summary: Cell cycle progression relies on the activation of cyclin-dependent kinases, regulated in part by ubiquitin-mediated proteolysis. Dysregulated proteolytic control can lead to uncontrolled cell proliferation and tumorigenesis. Targeting E3 ubiquitin ligases involved in cell cycle regulation may offer novel therapeutic strategies for cancer treatment.

CELL DEATH AND DIFFERENTIATION (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Loss of G-protein-signaling modulator 2 accelerates proliferation of lung adenocarcinoma via EGFR signaling pathway

Mingming Deng et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2020)

添加到收藏夹

Article Oncology

Knockdown of G-protein-signaling modulator 2 promotes metastasis of non-small-cell lung cancer by inducing the expression of Snail

Mingming Deng et al.

CANCER SCIENCE (2020)

添加到收藏夹

Article Oncology

GPSM2 Serves as an Independent Prognostic Biomarker for Liver Cancer Survival

Dingquan Yang et al.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis

Zefang Tang et al.

NUCLEIC ACIDS RESEARCH (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

G-protein-signaling modulator 2 expression and role in a CD133+ pancreatic cancer stem cell subset

Sheng-Chun Dang et al.

ONCOTARGETS AND THERAPY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

Jianfang Liu et al.

CELL (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cancer-related circulating and tumor-associated neutrophils - subtypes, sources and function

Merav E. Shaul et al.

FEBS JOURNAL (2018)

添加到收藏夹

Article Oncology

High expression of G-protein signaling modulator 2 in hepatocellular carcinoma facilitates tumor growth and metastasis by activating the PI3K/AKT signaling pathway

Xiao-Qin He et al.

TUMOR BIOLOGY (2017)

添加到收藏夹

Review Oncology

Tumor endothelial cells accelerate tumor metastasis

Nako Maishi et al.

CANCER SCIENCE (2017)

添加到收藏夹

Review Biotechnology & Applied Microbiology

New methods in the diagnosis of cancer and gene therapy of cancer based on nanoparticles

M. A. Zaimy et al.

CANCER GENE THERAPY (2017)

添加到收藏夹

Review Multidisciplinary Sciences

Cancer Genome Landscapes

Bert Vogelstein et al.

SCIENCE (2013)

添加到收藏夹

Article Genetics & Heredity

GPSM2 Mutations Cause the Brain Malformations and Hearing Loss in Chudley-McCullough Syndrome

Dan Doherty et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2012)

添加到收藏夹

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

添加到收藏夹

Article Oncology

Critical Roles of LGN/GPSM2 Phosphorylation by PBK/TOPK in Cell Division of Breast Cancer Cells

Chikako Fukukawa et al.

GENES CHROMOSOMES & CANCER (2010)

添加到收藏夹

Article Cell Biology

The G-protein regulatory (GPR) motif-containing Leu-Gly-Asn-enriched protein (LGN) and Giα3 influence cortical positioning of the mitotic spindle poles at metaphase in symmetrically dividing mammalian cells

Joe B. Blumer et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2006)

添加到收藏夹

Article Cell Biology

A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization

QS Du et al.

NATURE CELL BIOLOGY (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.