期刊
FRONTIERS IN CHEMISTRY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2022.897578
关键词
moenomycin; combination; Helicobacter; antibiotics; penicillin-binding protein knockout
资金
- Summit Program of Academia Sinica
- National Research Program for Biopharmaceuticals, Taiwan
Combining moenomycin A with clarithromycin or metronidazole shows a synergistic effect in eradicating multidrug-resistant Helicobacter pylori, with a near 95% success rate. Moenomycin A-non-susceptible strains of H. pylori with transglycosylase deletion exhibit slower growth and impaired biofilm formation compared to the parental strain.
Current treatment of Helicobacter pylori involves a triple therapy comprising one proton pump inhibitor and two other antibiotics; however, the outcomes are limited due to the existence of antibiotic resistant strains. We previously reported that moenomycin A, a cell-wall transglycosylase inhibitor, is highly active against multidrug-resistant Helicobacter pylori. Herein we show that combination of moenomycin A with the protein synthesis inhibitor clarithromycin or metronidazole can synergistically achieve almost 95% eradication of multidrug-resistant Helicobacter pylori. We also found that the moenomycin A-non-susceptible strains of Helicobacter pylori with deletion of transglycosylase exhibit moenomycin A hyposensitivity, faster growth and impaired biofilm formation compared to the parental strain. Overall, the combination of moenomycin A and clarithromycin or metronidazole to achieve a synergistic effect on different targets is a promising treatment for multidrug-resistant Helicobacter pylori.
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