A multi-scale probabilistic atlas of the human connectome

The human brain is a complex system that can be efficiently represented as a network of structural connectivity. Many imaging studies would benefit from such network information, which is not always available. In this work, we present a whole-brain multi-scale structural connectome atlas. This tool has been derived from a cohort of 66 healthy subjects imaged with optimal technology in the setting of the Human Connectome Project. From these data we created, using extensively validated diffusion-data processing, tractography and gray-matter parcellation tools, a multi-scale probabilistic atlas of the human connectome. In addition, we provide user-friendly and accessible code to match this atlas to individual brain imaging data to extract connection-specific quantitative information. This can be used to associate individual imaging findings, such as focal white-matter lesions or regional alterations, to specific connections and brain circuits. Accordingly, network-level consequences of regional changes can be analyzed even in absence of diffusion and tractography data. This method is expected to broaden the accessibility and lower the yield for connectome research.

Automated summary

In this work, a whole-brain multi-scale structural connectome atlas is presented, which can provide valuable network information for imaging studies. This tool is derived from healthy subject data, using extensively validated processing and segmentation tools, and it offers user-friendly code to extract connection-specific quantitative information from individual brain imaging data. This method contributes to analyzing the network-level consequences of regional changes.