Association of TNF-α, TGF-β1, amphiregulin, IL-2, and EGFR WITH pulmonary fibrosis in COVID-19

Article Medicine, General & Internal

Novel signaling pathways regulate SARS-CoV and SARS-CoV-2 infectious disease

Li-Chin Cheng et al.

Summary: This study utilized a holistic bioinformatics approach to study gene signatures of SARS-CoV and SARS-CoV-2 infected cells, revealing up-regulation of several cytokine genes and differential regulation of pathways related to chemokines, cytokines, inflammation, and immune responses. The analysis also showed enrichment of TNF- and IL-17-related signaling and predicted downstream networks involved in leukocyte recruitment, activation, and survival after coronavirus infection. These findings provide important evidence for transcript regulation and downstream signaling in SARS-CoV and SARS-CoV-2 infections.

MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Serum levels of the IgA isotype switch factor TGF-β1 are elevated in patients with COVID-19

Er-yi Wang et al.

Summary: The study found that serum levels of TGF-beta 1 significantly increased in the early and middle stages of COVID-19 and were correlated with the levels of SARS-CoV-2-specific IgA and the APACHE II score in patients with severe disease. The findings suggest TGF-beta 1 may play a key role in COVID-19, based on the genetic association of the TGF-beta 1 activator THBS3 with severe COVID-19 identified by the COVID-19 Host Genetics Initiative.

FEBS LETTERS (2021)

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Article Health Care Sciences & Services

Investigation into molecular mechanisms and high-frequency core TCM for pulmonary fibrosis secondary to COVID-19 based on network pharmacology and data mining

Mei-Xiang Yu et al.

Summary: This study systematically identified the molecular mechanisms of PF secondary to COVID-19 and high-frequency core TCM targeting strategies. The molecular mechanisms were mainly related to TNF signaling pathway, cytokine-cytokine receptor interaction pathway, and NF-kappa B signaling pathway. Key targets such as IL-6, TNF, and IL-1 beta were identified, along with high-frequency core TCM including quercetin, epigallocatechin-3-gallate, emodin, triptolide, resveratrol, and Polygonum cuspidatum.

ANNALS OF PALLIATIVE MEDICINE (2021)

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Review Immunology