The Association of Prenatal C-Reactive Protein Levels With Childhood Asthma and Atopy

BACKGROUND: The pathogenesis of childhood asthma is complex, and determinants of risk may begin in utero.OBJECTIVE: To describe the association of systemic prenatal inflammation, measured by plasma C-reactive protein (CRP), with childhood asthma, eczema, and allergic rhinitis.METHODS: A total of 522 maternal-offspring pairs from the Vitamin D Antenatal Asthma Reduction Trial were included. Prenatal plasma CRP level was measured between 10 and 18 weeks of gestation and between 32 and 38 weeks of gestation. Offspring asthma, eczema, and allergic rhinitis were assessed quarterly between birth and age 6 years. We performed mediation analyses of prenatal CRP on the association between several maternal characteristics and offspring asthma.RESULTS: Elevated early and late prenatal CRP and an increase in CRP from early to late pregnancy were associated with asthma by age 6 years (early: adjusted odds ratio [aOR], 1.76, 95% CI, 1.12-2.82, P = .02; late: aOR, 2.45, 95% CI, 1.47-4.18, P < .001; CRP increase: aOR, 2.06, 95% CI, 1.26-3.39, P < .004). Prenatal CRP and childhood asthma associations were strengthened among offspring with atopic asthma (early: aOR, 3.78, 95% CI, 1.49-10.64, P = .008; late: aOR, 4.84, 95% CI, 1.68-15.50, P [ .005; CRP increase: aOR, 3.01, 95% CI, 1.06-9.16, P = .04).

Automated summary

Prenatal systemic inflammation, as measured by plasma CRP, is associated with childhood asthma, eczema, and allergic rhinitis. Elevated early and late prenatal CRP and an increase in CRP from early to late pregnancy are linked to the development of childhood asthma. This association is particularly strong for children with atopic asthma.