期刊
CARCINOGENESIS
卷 37, 期 2, 页码 108-118出版社
OXFORD UNIV PRESS
DOI: 10.1093/carcin/bgv167
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资金
- Israel Science Foundation
- I-Core Foundation
- Israeli Ministry of Health
- National Network of Excellence in Neuroscience-TEVA Ltd.
- European Foundation for the Study of Diabetes [MSD 2014_1] Funding Source: researchfish
SIRT6, a member of the mammalian sirtuins family, functions as a mono-ADP-ribosyl transferase and NAD(+)-dependent deacylase of both acetyl groups and long-chain fatty acyl groups. SIRT6 regulates diverse cellular functions such as transcription, genome stability, telomere integrity, DNA repair, inflammation and metabolic related diseases such as diabetes, obesity and cancer. In this review, we will discuss the implication of SIRT6 in the biology of cancer and the relevance to organism homeostasis and lifespan.
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