期刊
FRONTIERS IN NEUROLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fneur.2022.972590
关键词
focal to bilateral tonic-clonic seizure; diffusion MRI; track-weighted imaging; tensor-based imaging; focal epilepsy; white matter; microstructural
资金
- UCB
We compared white matter differences between patients with and without focal to bilateral tonic-clonic seizures (FBTCS) and control participants using a neural network based tract segmentation model. We found significant alterations in white matter regions of patients with focal epilepsy compared to controls. Patients without FBTCS showed increased disruption in specific white matter tracts, while the FBTCS group had measurements more similar to healthy controls. These findings help identify specific tracts that may serve as predictive biomarkers for patients likely to develop FBTCS.
We examined the white matter of patients with and without focal to bilateral tonic-clonic seizures (FBTCS), and control participants. A neural network based tract segmentation model (Tractseg) was used to isolate tract-specific, track-weighted tensor-based measurements from the tracts of interest. We compared the group differences in the track-weighted tensor-based measurements derived from whole and hemispheric tracts. We identified several regions that displayed significantly altered white matter in patients with focal epilepsy compared to controls. Furthermore, patients without FBTCS showed significantly increased white matter disruption in the inferior fronto-occipital fascicle and the striato-occipital tract. In contrast, the track-weighted tensor-based measurements from the FBTCS cohort exhibited a stronger resemblance to the healthy controls (compared to the non-FBTCS group). Our findings revealed marked alterations in a range of subcortical tracts considered critical in the genesis of seizures in focal epilepsy. Our novel application of tract-specific, track-weighted tensor-based measurements to a new clinical dataset aided the elucidation of specific tracts that may act as a predictive biomarker to distinguish patients likely to develop FBTCS.
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