期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.988536
关键词
B cells; antibody; COVID-19; SARS-CoV-2; memory B cells; vaccination
类别
资金
- HUST Academic Frontier Youth Team
- [2018QYTD10]
This review summarizes the importance of B cells in SARS-CoV-2 infection and immune responses, as well as their role in vaccination. It provides insights for medical workers and researchers on the interaction between B cells and the virus.
B cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the positive function and pathological response of B cells in SARS-CoV-2 infection and re-infection. Then, we structure the immunity responses that B cells mediated in peripheral tissues. Furthermore, we discuss the role of B cells during vaccination including the effectiveness of antibodies and memory B cells, viral evolution mechanisms, and future vaccine development. This review might help medical workers and researchers to have a better understanding of the interaction between B cells and SARS-CoV-2 and broaden their vision for future investigations.
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