期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.982773
关键词
long non-coding RNA; osteoarthritis; pathogenesis; biomarkers; therapeutic strategies
类别
资金
- General Research Fund [24121622]
- Area of Excellence [AoE/M-402/20]
- Research Matching Grant Scheme, University Grants Committee, Hong Kong
- Chinese University of Hong Kong, Hong Kong
- Innovation and Technology Fund [PRP/090/20FX]
- American Society for Bone and Mineral Research
This review summarizes the role of lncRNAs in osteoarthritis (OA), focusing on extensively studied lncRNAs such as H19, GAS5, MALAT1, XIST, and HOTAIR. The potential translational value of these lncRNAs as therapeutic targets for OA is also discussed.
Osteoarthritis (OA) is a prevalent joint disease, which is associated with progressive articular cartilage loss, synovial inflammation, subchondral sclerosis and meniscus injury. The molecular mechanism underlying OA pathogenesis is multifactorial. Long non-coding RNAs (lncRNAs) are non-protein coding RNAs with length more than 200 nucleotides. They have various functions such as modulating transcription and protein activity, as well as forming endogenous small interfering RNAs (siRNAs) and microRNA (miRNA) sponges. Emerging evidence suggests that lncRNAs might be involved in the pathogenesis of OA which opens up a new avenue for the development of new biomarkers and therapeutic strategies. The purpose of this review is to summarize the current clinical and basic experiments related to lncRNAs and OA with a focus on the extensively studied H19, GAS5, MALAT1, XIST and HOTAIR. The potential translational value of these lncRNAs as therapeutic targets for OA is also discussed.
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