☆ 4.8 Review

Macrophage autophagy in macrophage polarization, chronic inflammation and organ fibrosis

FRONTIERS IN IMMUNOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Rheumatology

METTL3-mediated m6A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression

Xiang Chen et al.

Summary: This study revealed the significant increase of senescent FLSs with OA progression, impacting autophagy and SASP expression. METTL3 negatively regulated autophagy-related genes, promoting FLS senescence. Inhibiting METTL3 could attenuate FLS senescence, offering a potential therapeutic strategy for OA.

ANNALS OF THE RHEUMATIC DISEASES (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Tissue geometry drives deterministic organoid patterning

N. Gjorevski et al.

Summary: This study describes a method for controlling the formation of epithelial organoids, making the stochastic process more deterministic by spatial and temporal control. By using bioengineering techniques, researchers successfully controlled the formation and patterning of intestinal organoids, and identified the underlying mechanisms of epithelial patterning.

SCIENCE (2022)

添加到收藏夹

Review Cell Biology

Mitophagy in degenerative joint diseases

Kai Sun et al.

Summary: Mitochondrial dysfunction is crucial in the development of intervertebral disc degeneration and osteoarthritis. Targeting mitophagy pathways may offer promising therapeutic strategies for degenerative joint diseases.

AUTOPHAGY (2021)

添加到收藏夹

Article Immunology

USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy

Tao Liu et al.

Summary: The study reveals that USP19 acts as an anti-inflammatory switch promoting M2-like macrophage polarization and inhibiting inflammatory responses by affecting NLRP3 activity through various mechanisms.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Bioengineering Approaches for the Advanced Organoid Research

Sang Ah Yi et al.

Summary: Recent advances in 3D cell culture technology have enabled scientists to generate stem cell derived organoids that mimic the structural and functional characteristics of native organs. Current technologies are striving to identify essential factors for controlling organoid development processes, while there is a growing demand for engineering dynamic environments to generate reproducible and reliable organoids. Innovative biomaterial-based and advanced engineering-based approaches have been incorporated into conventional organoid culture methods to facilitate research development.

ADVANCED MATERIALS (2021)

添加到收藏夹

Article Cell Biology

Chaperone-mediated autophagy controls the turnover of E3 ubiquitin ligase MARCHF5 and regulates mitochondrial dynamics

Tiejian Nie et al.

Summary: This study demonstrates the critical role of chaperone-mediated autophagy (CMA) in maintaining proper mitochondria dynamics. Loss of this regulatory control may occur in Parkinson's disease (PD), leading to impaired mitochondria function. Increasing CMA activity promotes MARCHF5 turnover, reduces mitochondria fragmentation, and alleviates mitochondrial dysfunction under oxidative stress.

AUTOPHAGY (2021)

添加到收藏夹

Article Oncology

Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer

Yuanyuan Zhang et al.

Summary: The study indicates that high levels of baseline CXCL13(+) T cells are associated with effective responses to combination therapy in triple-negative breast cancer patients. These cells increase following combination therapy but decrease after monotherapy, highlighting their importance in predicting treatment outcomes.

CANCER CELL (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis

Daniel Wendisch et al.

Summary: Analysis of pulmonary immune responses and lung pathology in patients with COVID-19 ARDS revealed an accumulation of profibrotic macrophages and similarities with macrophage populations in idiopathic pulmonary fibrosis. Exposure to SARS-CoV-2 induced a profibrotic phenotype in human monocytes, suggesting a mechanistic link between the virus and fibroproliferative ARDS.

CELL (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Macrophage Autophagy and Silicosis: Current Perspective and Latest Insights

Shiyi Tan et al.

Summary: Silicosis is a pressing public health issue globally, with autophagy playing a crucial role in disease progression and potentially providing therapeutic targets through regulating macrophage apoptosis. Exogenous chemicals like lipopolysaccharides or natural product ingredients may have either detrimental or beneficial effects on silicosis fibrosis by modulating macrophage autophagy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

ER-Phagy, ER Homeostasis, and ER Quality Control: Implications for Disease

Susan Ferro-Novick et al.

Summary: ER-phagy, the process of lysosomal degradation of endoplasmic reticulum fragments by autophagy, occurs under normal and stress conditions. The discovery of multiple ER-phagy receptors has led to studies on the functions of ER-phagy receptors and their role in maintaining ER homeostasis and quality control. ER-phagy plays a crucial role in alleviating ER expansion induced by ER stress and acts as an alternative disposal pathway for misfolded proteins, which may explain the connection between ER-phagy and disease.

TRENDS IN BIOCHEMICAL SCIENCES (2021)

添加到收藏夹

Article Cell Biology

Lymphangiogenesis in renal fibrosis arises from macrophages via VEGF-C/VEGFR3-dependent autophagy and polarization

Ying Zhang et al.

Summary: This study demonstrated a close relationship between lymphangiogenesis and renal fibrosis, with M1 macrophages predominately transdifferentiating into LECs. The VEGF-C/VEGFR3 signaling pathway was found to downregulate macrophage autophagy, promoting M1 macrophage polarization. These results suggest that M1 macrophages play a role in promoting lymphangiogenesis in renal fibrosis microenvironment, with VEGF-C/VEGFR3 pathway activating macrophage M1 polarization by suppressing macrophage autophagy.

CELL DEATH & DISEASE (2021)

添加到收藏夹

Article Cell Biology

Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response

Se-Jin Jeong et al.

Summary: The autophagy-lysosome system is crucial for recycling dysfunctional components in cells, and trehalose, a natural disaccharide, has the ability to induce autophagy by potentially affecting lysosomal function. This suggests that trehalose could serve as a therapeutic target for diseases associated with dysfunctional autophagy.

AUTOPHAGY (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Virus infection induced pulmonary fibrosis

Wei Jie Huang et al.

Summary: Pulmonary fibrosis, the end stage of various lung diseases, may be triggered by virus infection, but the specific mechanisms are not fully understood. Studying the relationship between pulmonary fibrosis and various viruses, as well as the infection mechanisms, may provide insights into potential anti-fibrotic treatment targets.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Organoid models: assessing lung cell fate decisions and disease responses

Derek C. Liberti et al.

Summary: Organoids derived from various lung cell types offer a reproducible model for understanding complex signals driving cell fate decisions in a regenerative context. Integrating organoid assays with in vivo modeling helps explore responses of different niches and compartments in the respiratory system to acute and chronic lung diseases. Strategic implementation and improvement of organoid techniques provide exciting opportunities to identify new therapeutic approaches for lung disease states.

TRENDS IN MOLECULAR MEDICINE (2021)

添加到收藏夹

Article Biology

Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy

Vinay V. Eapen et al.

Summary: The study investigates the lysophagy process by examining the proteomic landscape of lysosome-associated proteins during lysophagy. It reveals the crucial role of TAX1BP1 in driving lysophagic flux and provides a resource for further research on lysophagy.

ELIFE (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Quercetin attenuates neurotoxicity induced by iron oxide nanoparticles

Akram Bardestani et al.

Summary: Iron oxide nanoparticles (IONPs) have been proposed as targeted carriers to deliver therapeutic molecules in the central nervous system (CNS), but they may damage neural tissue. Quercetin (QC) has neuroprotective effects, but poor solubility and low bioavailability have led to the development of QC-involved nanoparticles. Combining quercetin with superparamagnetic iron oxide nanoparticles (QCSPIONs) can improve cognitive dysfunction and promote neurogenesis without toxicity by inhibiting protein aggregation and acting against iron overload.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

添加到收藏夹

Article Cell & Tissue Engineering

Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly

Veronica Krenn et al.

Summary: Viral infection in early pregnancy can lead to microcephaly, with distinct mechanisms observed in Zika virus and herpes simplex virus-induced brain organoid models. This study highlights the importance of organoid models in understanding virus-specific mechanisms and immune responses associated with virus-induced microcephaly.

CELL STEM CELL (2021)

添加到收藏夹

Review Immunology

Macrophage Polarization and Its Role in Liver Disease

Cheng Wang et al.

Summary: Macrophages play a crucial role in liver diseases, with their polarization being significantly important in the initiation and progression of liver diseases. Macrophage polarization involves various molecular mechanisms, including multiple signaling pathways. Further research on macrophage polarization is essential for understanding and treating liver diseases effectively.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Cell Biology

Autophagy in Viral Infection and Pathogenesis

Shan Liang et al.

Summary: Autophagy, as a crucial cellular process, plays a vital role in cellular metabolism and viral infections, but viruses can also manipulate autophagy for their own benefit. Understanding the function of host autophagy in viral infections and pathogenesis helps in developing more specific therapeutic strategies.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Review Cell Biology

Cell Cycle Dysregulation and Renal Fibrosis

Yun-Shan Wu et al.

Summary: Precise regulation of cell cycle is crucial for tissue homeostasis and development, while dysregulation of renal cell cycle is closely associated with renal fibrosis. Understanding and treating cell cycle dysregulation in renal cells is essential for the potential therapeutic strategies to halt or reverse renal fibrosis progression.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Article Cell Biology

Hypoxic glioma-derived exosomes promote M2-like macrophage polarization by enhancing autophagy induction

Jianye Xu et al.

Summary: The study reveals that glioma-derived exosomes may promote glioma proliferation and migration by inducing autophagy and M2-like macrophage polarization, leading to the formation of an immunosuppressive microenvironment. IL-6 and miR-155-3p could be novel biomarkers for diagnosing glioma, while treatments targeting autophagy and the STAT3 pathway may contribute to antitumor immunotherapy.

CELL DEATH & DISEASE (2021)

添加到收藏夹

Review Immunology

The Role of Macrophages in the Pathogenesis of SARS-CoV-2-Associated Acute Respiratory Distress Syndrome

Anna Kosyreva et al.

Summary: Macrophages play a crucial role in COVID-19, especially in cases complicated by ARDS. Macrophage activation syndrome is predominantly caused by massive activation of macrophages. Reprogrammed macrophages with stable pro- or anti-inflammatory phenotypes may have potential utility in the treatment of ARDS.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Cell Biology

Autophagy and the hallmarks of aging

Susmita Kaushik et al.

Summary: Autophagy, as an essential cellular process, plays a crucial role in cellular quality control and proteostasis. Dysfunction of autophagy with age contributes significantly to the loss of proteostasis in aging organisms. The diverse functions of different types of autophagy and their interactions with other aging determinants place autophagy at the center of the aging process.

AGEING RESEARCH REVIEWS (2021)

添加到收藏夹

Review Cell Biology

The Role of Rapamycin in Healthspan Extension via the Delay of Organ Aging

Yan Zhang et al.

Summary: Anti-aging is a complex global challenge, and rapamycin can prolong healthy lifespan by inhibiting the mTOR pathway, although current evidence for its effectiveness in lifespan extension is not yet comprehensive. This drug has significant anti-aging effects on multiple organ systems.

AGEING RESEARCH REVIEWS (2021)

添加到收藏夹

Review Cell Biology

Mechanisms of Selective Autophagy

Trond Lamark et al.

Summary: Selective autophagy is the degradation of specific intracellular components via selective autophagy receptors, which interact with autophagy-related proteins and may or may not depend on ubiquitin labeling of the cargo.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 37 (2021)

添加到收藏夹

Editorial Material Cell Biology

Chaperone-mediated autophagy: a gatekeeper of neuronal proteostasis

Mathieu Bourdenx et al.

Summary: Different types of autophagy have distinct contributions to maintenance of cellular proteostasis, with chaperone-mediated autophagy (CMA) playing a key role in preserving the metastable proteome. Loss of CMA exacerbates proteotoxicity in neurodegenerative conditions like Alzheimer's disease, while pharmacological enhancement of CMA shows promise in improving behavior and pathology in AD mouse models.

AUTOPHAGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Autophagy in major human diseases

Daniel J. Klionsky et al.

Summary: Autophagy is crucial for maintaining cellular and organismal homeostasis, and dysfunction in autophagy is implicated in the pathogenesis of major human disorders across various organ systems.

EMBO JOURNAL (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

FBXO2/SCF ubiquitin ligase complex directs xenophagy through recognizing bacterial surface glycan

Akihiro Yamada et al.

Summary: FBXO2 acts as a specific substrate receptor for recognizing the GlcNAc side chains of GAS surface carbohydrates and promoting ubiquitin-mediated xenophagy. The SCF components are essential for the ubiquitin-mediated xenophagy against GAS.

EMBO REPORTS (2021)

添加到收藏夹

Article Cell Biology

MicroRNA-205-5p targets E2F1 to promote autophagy and inhibit pulmonary fibrosis in silicosis through impairing SKP2-mediated Beclin1 ubiquitination

Qingzeng Qian et al.

Summary: The study elucidated that miR-205-5p targeted E2F1, thereby inhibiting SKP2-mediated Beclin1 ubiquitination to promote macrophage autophagy and inhibit pulmonary fibrosis in mice with silicosis.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells

Maria Casanova-Acebes et al.

Summary: Macrophages play a crucial role in shaping the tumor microenvironment and tumor immunity, with tissue-resident macrophages identified as key contributors to early lung cancer progression. Targeting tissue-resident macrophages may offer new possibilities for prevention and treatment of early lung cancer lesions.

NATURE (2021)

添加到收藏夹

Article Biochemical Research Methods

Intestinal organoid cocultures with microbes

Jens Puschhof et al.

Summary: This protocol outlines methods for co-culturing human small intestinal and colon organoids with microbes, including microinjection and exposure to bacteria. It provides detailed protocols for assessing cell viability and growth kinetics, as well as spatial relationships using microscopy techniques. Considerations for evaluating the impact of bacteria on gene expression and mutations through sequencing are also discussed.

NATURE PROTOCOLS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

LRRK2 plays essential roles in maintaining lung homeostasis and preventing the development of pulmonary fibrosis

Yujie Tian et al.

Summary: LRRK2 deficiency results in aggravated pulmonary fibrosis by causing dysfunction of alveolar type II epithelial cells and promoting profibrotic immune responses.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Article Multidisciplinary Sciences

The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-I

Yiwen Zhang et al.

Summary: COVID-19, caused by SARS-CoV-2, significantly differs from SARS in its clinical and pathological characteristics. The viral protein ORF8 of SARS-CoV-2 interacts with MHC-I molecules, leading to their down-regulation and impairment of antigen presentation system, proposing ORF8 inhibition as a potential strategy for improving immune surveillance.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Review Immunology

Inflammasomes and Fibrosis

Wen-Juan Zhang et al.

Summary: Fibrosis is the final common pathway of inflammatory diseases in various organs, and inflammasomes, especially NLRP3, play a crucial role in this process. Inflammasomes can be activated through classical and non-classical pathways, with the former being better understood.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Immunology

Critical Role of Synovial Tissue-Resident Macrophage and Fibroblast Subsets in the Persistence of Joint Inflammation

Samuel Kemble et al.

Summary: This review focuses on discussing the disease persistence pathways of rheumatoid arthritis and treating the disease through regulating specific cellular behaviors. The article reveals the heterogeneity of tissue resident synovial cells and how they function in joint inflammation. Finally, specific targeted therapeutic strategies against pathogenic subsets of fibroblasts in RA are proposed.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Single-Cell RNA Sequencing of Peripheral Blood Reveals Immune Cell Signatures in Alzheimer's Disease

Hui Xu et al.

Summary: This study explored the characteristics of peripheral immune cells in Alzheimer's disease by profiling single-cell transcriptome and immune repertoire sequencing. Five immune cell subsets were identified in AD patients, with alterations in cell subset proportion and gene expression patterns. High-frequency amplification clonotypes were found in T and B cells, suggesting a potential role of adaptive immune response in the pathogenesis of AD.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Immunology

Macrophages: The Good, the Bad, and the Gluttony

Ewan R. A. Ross et al.

Summary: Macrophages play critical roles in sterile inflammation and autoimmune diseases, particularly in the pathophysiology of diseases like rheumatoid arthritis. Imbalance in macrophage homeostasis contributes to chronic inflammation, and therapeutic strategies targeting macrophage plasticity are being explored. Apoptotic cell-derived extracellular vesicles may play a role in regulating macrophage phenotype and are a potential target for new therapeutic approaches.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Immunology

Roles of Macrophage Polarization and Macrophage-Derived miRNAs in Pulmonary Fibrosis

Amit Kishore et al.

Summary: This review highlights the significant impact of macrophage polarization on the development and progression of lung fibrosis by regulating the production and function of inflammatory and fibrogenic mediators. It also emphasizes the role of miRNAs in regulating lung injury and fibrotic responses, with extracellular exosomal-miRNAs potentially promoting disease progression, particularly those derived from M2 macrophages.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Immunology

Macrophages in lung fibrosis

Tatsuro Ogawa et al.

Summary: Pulmonary fibrosis is a lung disease characterized by excessive accumulation of extracellular matrix, leading to thickening of alveolar walls possibly due to dysfunction of type II alveolar epithelial cells. There is no known curative treatment for this condition, and the prognosis is poor.

INTERNATIONAL IMMUNOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing

Cornelius H. L. Kuerten et al.

Summary: Using single-cell RNA sequencing and multiplexed imaging, this study reveals the cellular complexity of the TME in HNSCC patients, exploring inflammatory status, stromal heterogeneity, and immune checkpoint receptor-ligand interactions.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Cell Biology

ESCRT, not intralumenal fragments, sorts ubiquitinated vacuole membrane proteins for degradation

Xi Yang et al.

Summary: Studies have shown that in yeast cells, the degradation process of vacuole membrane proteins does not involve intralumenal fragments, but rather relies on ESCRT for sorting into the lumen. This provides a new insight for reconstituting the degradation mechanism of vacuole membrane proteins.

JOURNAL OF CELL BIOLOGY (2021)

添加到收藏夹

Review Gastroenterology & Hepatology

Molecular and cellular mechanisms of liver fibrosis and its regression

Tatiana Kisseleva et al.

Summary: Chronic liver injury results in liver inflammation and fibrosis, which can be reversed by eliminating activated myofibroblasts and resorbing the fibrous scar. Understanding the molecular mechanisms underlying liver fibrosis and its reversibility can lead to the identification of new therapeutic targets for liver fibrosis treatment.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

添加到收藏夹

Review Oncology

Ferroptosis is a type of autophagy-dependent cell death

Borong Zhou et al.

SEMINARS IN CANCER BIOLOGY (2020)

添加到收藏夹

Review Genetics & Heredity

Autophagy in aging and longevity

Shi Q. Wong et al.

HUMAN GENETICS (2020)

添加到收藏夹

Article Cell Biology

Disrupting the TRIB3-SQSTM1 interaction reduces liver fibrosis by restoring autophagy and suppressing exosome-mediated HSC activation

Xiao-Wei Zhang et al.

AUTOPHAGY (2020)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Targeting metabolic dysregulation for fibrosis therapy

Xiao Zhao et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

添加到收藏夹

Article Cell Biology

Araloside C attenuates atherosclerosis by modulating macrophage polarization via Sirt1-mediated autophagy

Yun Luo et al.

Aging-US (2020)

添加到收藏夹

Review Cell Biology

Autophagy and Macrophage Functions: Inflammatory Response and Phagocytosis

Ming-Yue Wu et al.

CELLS (2020)

添加到收藏夹

Article Cell Biology

LC3-associated phagocytosis protects against inflammation and liver fibrosis via immunoreceptor inhibitory signaling

JingHong Wan et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

添加到收藏夹

Article Cell Biology

TRIM29 mediates lung squamous cell carcinoma cell metastasis by regulating autophagic degradation of E-cadherin

Weifeng Xu et al.

AGING-US (2020)

添加到收藏夹

Review Cell Biology

Microautophagy - distinct molecular mechanisms handle cargoes of many sizes

Sebastian Schuck

JOURNAL OF CELL SCIENCE (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Trehalose alleviates apoptosis by protecting the autophagy-lysosomal system in alveolar macrophages during human silicosis

Shiyi Tan et al.

LIFE SCIENCES (2020)

添加到收藏夹

Review Medicine, General & Internal

Autophagy in Human Diseases

Noboru Mizushima et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Review Multidisciplinary Sciences

Fibrosis: from mechanisms to medicines

Neil C. Henderson et al.

NATURE (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Developmental pathways in the pathogenesis of lung fibrosis

Diptiman Chanda et al.

MOLECULAR ASPECTS OF MEDICINE (2019)

添加到收藏夹

Article Cell Biology

LC3-associated phagocytosis at a glance

Bradlee L. Heckmann et al.

JOURNAL OF CELL SCIENCE (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Docosahexaenoic acid enhances M2 macrophage polarization via the p38 signaling pathway and autophagy

Aki Kawano et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

添加到收藏夹

Review Urology & Nephrology

Macrophages: versatile players in renal inflammation and fibrosis

Patrick Ming-Kuen Tang et al.

NATURE REVIEWS NEPHROLOGY (2019)

添加到收藏夹

Article Immunology

The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation

Freya R. Svedberg et al.

NATURE IMMUNOLOGY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer's Disease

Bradlee L. Heckmann et al.

CELL (2019)

添加到收藏夹

Article Immunology

Gata6+ Pericardial Cavity Macrophages Relocate to the Injured Heart and Prevent Cardiac Fibrosis

Justin F. Deniset et al.

IMMUNITY (2019)

添加到收藏夹

Review Immunology

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages

Marco Orecchioni et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Cell Biology

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis

Ki Wung Chung et al.

CELL METABOLISM (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Biological Functions of Autophagy Genes: A Disease Perspective

Beth Levine et al.

CELL (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Dioscin Alleviates Crystalline Silica-Induced Pulmonary Inflammation and Fibrosis through Promoting Alveolar Macrophage Autophagy

Sitong Du et al.

THERANOSTICS (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Mitophagy-dependent macrophage reprogramming protects against kidney fibrosis

Divya Bhatia et al.

JCI INSIGHT (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Employing Macrophage-Derived Microvesicle for Kidney-Targeted Delivery of Dexamethasone: An Efficient Therapeutic Strategy against Renal Inflammation and Fibrosis

Tao-Tao Tang et al.

THERANOSTICS (2019)

添加到收藏夹

Review Physiology

Mechanisms of Renal Fibrosis

Benjamin D. Humphreys

ANNUAL REVIEW OF PHYSIOLOGY, VOL 80 (2018)

添加到收藏夹

Review Cell Biology

Autophagy and inflammation in chronic respiratory disease

Alexandra C. Racanelli et al.

AUTOPHAGY (2018)

添加到收藏夹

Article Pharmacology & Pharmacy

Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization

Hong Lu et al.

BIOCHEMICAL PHARMACOLOGY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

Sarah Pickles et al.

CURRENT BIOLOGY (2018)

添加到收藏夹

Review Immunology

Implications of macrophage polarization in autoimmunity

Samanta C. Funes et al.

IMMUNOLOGY (2018)

添加到收藏夹

Article Cell Biology

Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy

Jakob Mejlvang et al.

JOURNAL OF CELL BIOLOGY (2018)

添加到收藏夹

Review Cell Biology

Macrophage plasticity, polarization, and function in health and disease

Abbas Shapouri-Moghaddam et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Inflammation and fibrosis

Matthias Mack

MATRIX BIOLOGY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

The human heart contains distinct macrophage subsets with divergent origins and functions

Geetika Bajpai et al.

NATURE MEDICINE (2018)

添加到收藏夹

Review Cell Biology

Mechanism and medical implications of mammalian autophagy

Ivan Dikic et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

添加到收藏夹

Article Immunology

Spermine Alleviates Acute Liver Injury by Inhibiting Liver-Resident Macrophage Pro-Inflammatory Response Through ATG5-Dependent Autophagy

Shun Zhou et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Immunology

CD5L Promotes M2 Macrophage Polarization through Autophagy-Mediated Upregulation of ID3

Lucia Sanjurjo et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance

Larissa D. Cunha et al.

CELL (2018)

添加到收藏夹

Article Multidisciplinary Sciences

The intralumenal fragment pathway mediates ESCRT-independent surface transporter down-regulation

Erin Kate McNally et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Oncology

USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability

Min Wu et al.

ONCOTARGET (2017)

添加到收藏夹

Review Immunology

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

Eleni Vergadi et al.

JOURNAL OF IMMUNOLOGY (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

LC3-Associated Phagocytosis and Inflammation

Bradlee L. Heckmann et al.

JOURNAL OF MOLECULAR BIOLOGY (2017)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Biological Phenotypes of Heart Failure With Preserved Ejection Fraction

Gavin A. Lewis et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

添加到收藏夹

Article Oncology

Rapamycin regulates macrophage activation by inhibiting NLRP3 inflammasome-p38 MAPK-NFκB pathways in autophagy- and p62-dependent manners

Jung Hwa Ko et al.

ONCOTARGET (2017)

添加到收藏夹

Article Medicine, Research & Experimental

Dioscin Exerts Protective Effects Against Crystalline Silica-induced Pulmonary Fibrosis in Mice

Chao Li et al.

THERANOSTICS (2017)

添加到收藏夹

Article Medicine, General & Internal

Idiopathic pulmonary fibrosis

Fernando J. Martinez et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

添加到收藏夹

Review Cell Biology

Autophagy-monitoring and autophagy-deficient mice

Akiko Kuma et al.

AUTOPHAGY (2017)

添加到收藏夹

Review Oncology

Targeting autophagy in cancer

Jean M. Mulcahy Levy et al.

NATURE REVIEWS CANCER (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Molecular definitions of autophagy and related processes

Lorenzo Galluzzi et al.

EMBO JOURNAL (2017)

添加到收藏夹

Article Gastroenterology & Hepatology

Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β

Ghulam Ilyas et al.

JOURNAL OF HEPATOLOGY (2016)

添加到收藏夹

Article Immunology

Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract

Junji Xing et al.

NATURE IMMUNOLOGY (2016)

添加到收藏夹

Article Pharmacology & Pharmacy

Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure

Forrest Jessop et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)

添加到收藏夹

Article Cell Biology

Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization

Kun Liu et al.

AUTOPHAGY (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Organelle-Specific Initiation of Autophagy

Valentina Sica et al.

MOLECULAR CELL (2015)

添加到收藏夹

Article Neurosciences

Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy

Valerie Uytterhoeven et al.

NEURON (2015)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Inhibition of Toll-like receptor 2 reduces cardiac fibrosis by attenuating macrophage-mediated inflammation

Lei Wang et al.

CARDIOVASCULAR RESEARCH (2014)

添加到收藏夹

Article Endocrinology & Metabolism

Adiponectin Suppresses Angiotensin II-Induced Inflammation and Cardiac Fibrosis through Activation of Macrophage Autophagy

Guan-Ming Qi et al.

ENDOCRINOLOGY (2014)

添加到收藏夹

Article Immunology

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

Slava Epelman et al.

IMMUNITY (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Characterization of the Deubiquitinating Activity of USP19 and Its Role in Endoplasmic Reticulum-associated Degradation

Jin-Gu Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

添加到收藏夹

Article Gastroenterology & Hepatology

Macrophage heterogeneity in liver injury and fibrosis

Frank Tacke et al.

JOURNAL OF HEPATOLOGY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart

Kory J. Lavine et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Autophagy and genomic integrity

A. T. Vessoni et al.

CELL DEATH AND DIFFERENTIATION (2013)

添加到收藏夹

Article Medicine, General & Internal

Association of Fibrosis With Mortality and Sudden Cardiac Death in Patients With Nonischemic Dilated Cardiomyopathy

Ankur Gulati et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2

Yasuhiro Maejima et al.

NATURE MEDICINE (2013)

添加到收藏夹

Letter Medicine, General & Internal

Autophagy in Human Health and Disease REPLY

Augustine M. K. Choi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

添加到收藏夹

Review Medicine, General & Internal

MECHANISMS OF DISEASE Autophagy in Human Health and Disease

Augustine M. K. Choi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

Microautophagy: lesser-known self-eating

Wen-wen Li et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

Thomas A. Wynn et al.

NATURE MEDICINE (2012)

添加到收藏夹

Review Cell Biology

Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease

Dong Fan et al.

FIBROGENESIS & TISSUE REPAIR (2012)

添加到收藏夹

Review Biochemistry & Molecular Biology

Autophagy: Renovation of Cells and Tissues

Noboru Mizushima et al.

CELL (2011)

添加到收藏夹

Article Cell Biology

Microautophagy of Cytosolic Proteins by Late Endosomes

Ranjit Sahu et al.

DEVELOPMENTAL CELL (2011)

添加到收藏夹

Review Immunology

Protective and pathogenic functions of macrophage subsets

Peter J. Murray et al.

NATURE REVIEWS IMMUNOLOGY (2011)

添加到收藏夹

Article Cell Biology

Inhibition of autophagy in the heart induces age-related cardiomyopathy

Manabu Taneike et al.

AUTOPHAGY (2010)

添加到收藏夹

Review Oncology

Autophagy: cellular and molecular mechanisms

Danielle Glick et al.

JOURNAL OF PATHOLOGY (2010)

添加到收藏夹

Article Multidisciplinary Sciences

Circulating mitochondrial DAMPs cause inflammatory responses to injury

Qin Zhang et al.

NATURE (2010)

添加到收藏夹

Review Physiology

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

Brinda Ravikumar et al.

PHYSIOLOGICAL REVIEWS (2010)

添加到收藏夹

Review Gastroenterology & Hepatology

Macrophages: Master Regulators of Inflammation and Fibrosis

Thomas A. Wynn et al.

SEMINARS IN LIVER DISEASE (2010)

添加到收藏夹

Review Genetics & Heredity

Regulation Mechanisms and Signaling Pathways of Autophagy

Congcong He et al.

ANNUAL REVIEW OF GENETICS (2009)

添加到收藏夹

Review Biochemistry & Molecular Biology

Autophagy in the pathogenesis of disease

Beth Levine et al.

CELL (2008)

添加到收藏夹

Review Oncology

Cellular and molecular mechanisms of fibrosis

T. A. Wynn

JOURNAL OF PATHOLOGY (2008)

添加到收藏夹

Review Multidisciplinary Sciences

Autophagy fights disease through cellular self-digestion

Noboru Mizushima et al.

NATURE (2008)

添加到收藏夹

Article Immunology

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Veit Hornung et al.

NATURE IMMUNOLOGY (2008)

添加到收藏夹

Article Biochemistry & Molecular Biology

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

Atsuko Nakai et al.

NATURE MEDICINE (2007)

添加到收藏夹

Review Cell Biology

Self-eating and self-killing: crosstalk between autophagy and apoptosis

M. Chiara Maiuri et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Cardiovascular magnetic resonance, fibrosis, and prognosis in dilated cardiomyopathy

Ravi G. Assomull et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2006)

添加到收藏夹

Review Immunology

Fibrosis in heart disease:: understanding the role of transforming growth factor-β1 in cardiomyopathy, valvular disease and arrhythmia

R Khan et al.

IMMUNOLOGY (2006)

添加到收藏夹

Article Transplantation

Macrophages contribute to the initiation of ischaemic acute renal failure in rats

SK Jo et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2006)

添加到收藏夹

Article Cell Biology

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

M Komatsu et al.

JOURNAL OF CELL BIOLOGY (2005)

添加到收藏夹

Review Immunology

Fibrotic disease and the TH1/TH2 paradigm

TA Wynn

NATURE REVIEWS IMMUNOLOGY (2004)

添加到收藏夹

Article Multidisciplinary Sciences

The role of autophagy during the early neonatal starvation period

A Kuma et al.

NATURE (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.