期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.842468
关键词
SARS-CoV-2; COVID-19; mucosal immunity; IgA; severe infection; inflammatory cytokine
类别
资金
- Agence Nationale de la Recherche (France)
- Fondation pour la Recherche Medicale (FRM, France)
- China Scholarship Council
- FRM
- Line Renaud-Loulou Gaste fund
- [ANR-20-COVI-0024]
This study found that the mucosal IgG and IgA antibody response in the lungs plays a significant role in the outcome of COVID-19. These antibodies persist even after the virus is cleared. Fatal COVID-19 cases have higher levels of mucosal antibodies, but their neutralizing activity decreases over time.
The role of the mucosal pulmonary antibody response in coronavirus disease 2019 (COVID-19) outcome remains unclear. Here, we found that in bronchoalveolar lavage (BAL) samples from 48 patients with severe COVID-19-infected with the ancestral Wuhan virus, mucosal IgG and IgA specific for S1, receptor-binding domain (RBD), S2, and nucleocapsid protein (NP) emerged in BAL containing viruses early in infection and persist after virus elimination, with more IgA than IgG for all antigens tested. Furthermore, spike-IgA and spike-IgG immune complexes were detected in BAL, especially when the lung virus has been cleared. BAL IgG and IgA recognized the four main RBD variants. BAL neutralizing titers were higher early in COVID-19 when virus replicates in the lung than later in infection after viral clearance. Patients with fatal COVID-19, in contrast to survivors, developed higher levels of mucosal spike-specific IgA than IgG but lost neutralizing activities over time and had reduced IL-1 beta in the lung. Altogether, mucosal spike and NP-specific IgG and S1-specific IgA persisting after lung severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) clearance and low pulmonary IL-1 beta correlate with COVID-19 fatal outcome. Thus, mucosal SARS-CoV-2-specific antibodies may have adverse functions in addition to protective neutralization.
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