☆ 4.8 Article

Comparative analysis of the repertoire of insulin-reactive B cells in type 1 diabetes-prone and resistant mice

FRONTIERS IN IMMUNOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Immunology

Role of inhibitory signaling in peripheral B cell tolerance*

Andrew Getahun

Summary: This review article focuses on the B cell-intrinsic mechanisms that prevent the activation of autoreactive B cells in the periphery. It discusses the establishment of inhibitory signaling circuits, specifically the Lyn-SHIP-1-SHP-1 axis, and how disruptions of these circuits can contribute to the development of autoimmunity.

IMMUNOLOGICAL REVIEWS (2022)

添加到收藏夹

Article Chemistry, Inorganic & Nuclear

Magnetic Enrichment of SARS-CoV-2 Antigen-Binding B Cells for Analysis of Transcriptome and Antibody Repertoire

Maureen Banach et al.

Summary: This study introduced a new method to efficiently enrich SARS-CoV-2 antigen-binding B cells, which is essential for understanding their transcriptional profile and antibody repertoire, and further studying the immune response to SARS-CoV-2 vaccines.

MAGNETOCHEMISTRY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Single-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation

Robin D. Lee et al.

Summary: The integration of external signals and B-lymphoid transcription factor activities in B cell lineage commitment leads to alternating cycles of proliferation and differentiation, generating a diverse repertoire of mature B cells. Using single-cell transcriptomics/proteomics, differential gene networks across B cell development have been identified and correlated with subtypes of B cell leukemia. Unique transcriptional signatures have been revealed that refine pre-B cell expansion stages into pre-BCR-dependent and pre-BCR-independent proliferative phases, with distinct expression kinetics of various biological modalities characterized across B cell development. The underlying heterogeneity of developing B cells has been demonstrated, highlighting developmental nodes linked to B cell transformation.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Immunology

Single-Cell Transcriptomic Analyses Define Distinct Peripheral B Cell Subsets and Discrete Development Pathways

Alexander Stewart et al.

Summary: The separation of B cells into different subsets has provided insights into their diverse functions in immune responses. Advances in single-cell techniques have enabled a deeper understanding of B cell characteristics and functions, though challenges remain. This study offers a reference single-cell dataset for better classification of functional B cell subsets in peripheral blood, highlighting the complexity and diversity of B cell populations.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Multidisciplinary Sciences

Preventing type 1 diabetes in childhood

Colin M. Dayan et al.

Summary: Recent studies have shown that monitoring pancreatic islet autoantibodies and genetic risk assessment can identify most children who will develop T1D, with immunotherapy and primary prevention methods showing success in delaying disease progression. By shifting focus towards early diagnosis and b cell preservation, a future without daily insulin injections for children with T1D is anticipated.

SCIENCE (2021)

添加到收藏夹

Review Cell Biology

Non-Antibody-Secreting Functions of B Cells and Their Contribution to Autoimmune Disease

Andrew Getahun et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 35 (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

The cis-Regulatory Atlas of the Mouse Immune System

Hideyuki Yoshida et al.

CELL (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

High-Throughput Mapping of B Cell Receptor Sequences to Antigen Specificity

Ian Setliff et al.

CELL (2019)

添加到收藏夹

Article Endocrinology & Metabolism

Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles

Mia J. Smith et al.

DIABETES (2018)

添加到收藏夹

Article Immunology

Anti-Insulin B Cells Are Poised for Antigen Presentation in Type 1 Diabetes

Jamie L. Felton et al.

JOURNAL OF IMMUNOLOGY (2018)

添加到收藏夹

Article Endocrinology & Metabolism

Silencing of high-affinity insulin-reactive B lymphocytes by anergy and impact of the NOD genetic background in mice

Mia J. Smith et al.

DIABETOLOGIA (2018)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Cell Hashing with barcoded antibodies enables multiplexing and doublet detection for single cell genomics

Marlon Stoeckius et al.

GENOME BIOLOGY (2018)

添加到收藏夹

Review Urology & Nephrology

B cells in type 1 diabetes mellitus and diabetic kidney disease

Mia J. Smith et al.

NATURE REVIEWS NEPHROLOGY (2017)

添加到收藏夹

Article Endocrinology & Metabolism

B-Lymphocytes Expressing an Ig Specificity Recognizing the Pancreatic β-Cell Autoantigen Peripherin Are Potent Contributors to Type 1 Diabetes Development in NOD Mice

Caroline M. Leeth et al.

DIABETES (2016)

添加到收藏夹

Article Medicine, General & Internal

B Cell Receptor Affinity for Insulin Dictates Autoantigen Acquisition and B Cell Functionality in Autoimmune Diabetes

Thomas A. Packard et al.

JOURNAL OF CLINICAL MEDICINE (2016)

添加到收藏夹

Article Immunology

Targeting Anti-Insulin B Cell Receptors Improves Receptor Editing in Type 1 Diabetes-Prone Mice

Rachel H. Bonami et al.

JOURNAL OF IMMUNOLOGY (2015)

添加到收藏夹

Article Endocrinology & Metabolism

Loss of Anergic B Cells in Prediabetic and New-Onset Type 1 Diabetic Patients

Mia J. Smith et al.

DIABETES (2015)

添加到收藏夹

Review Immunology

Dual immunoglobulin light chain B cells: Trojan horses of autoimmunity?

Roberta Pelanda

CURRENT OPINION IN IMMUNOLOGY (2014)

添加到收藏夹

Article Immunology

Light chain editors of anti-DNA receptors in human B cells

Olga Kalinina et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2014)

添加到收藏夹

Review Endocrinology & Metabolism

Zinc and insulin in pancreatic beta-cells

Yang V. Li

ENDOCRINE (2014)

添加到收藏夹

Article Medicine, General & Internal

Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children

Anette G. Ziegler et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

添加到收藏夹

Article Immunology

B Lymphocyte Original Sin in the Bone Marrow Enhances Islet Autoreactivity in Type 1 Diabetes-Prone Nonobese Diabetic Mice

Rachel A. Henry-Bonami et al.

JOURNAL OF IMMUNOLOGY (2013)

添加到收藏夹

Article Endocrinology & Metabolism

Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes

Zhuo Fu et al.

CURRENT DIABETES REVIEWS (2013)

添加到收藏夹

Article Endocrinology & Metabolism

B-Cell Cross-Presentation of Autologous Antigen Precipitates Diabetes

Eliana Marino et al.

DIABETES (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Endogenous antigen tunes the responsiveness of naive B cells but not T cells

Julie Zikherman et al.

NATURE (2012)

添加到收藏夹

Article Genetics & Heredity

Vκ polymorphisms in NOD mice are spread throughout the entire immunoglobulin kappa locus and are shared by other autoimmune strains

Rachel A. Henry et al.

IMMUNOGENETICS (2010)

添加到收藏夹

Article Immunology

Low-valency, but not monovalent, antigens trigger the B-cell antigen receptor (BCR)

Susana Minguet et al.

INTERNATIONAL IMMUNOLOGY (2010)

添加到收藏夹

Article Endocrinology & Metabolism

Pancreatic Islet Autoantibodies as Predictors of Type 1 Diabetes in the Diabetes Prevention Trial-Type 1

Tihamer Orban et al.

DIABETES CARE (2009)

添加到收藏夹

Article Biochemical Research Methods

Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen

Kenneth Smith et al.

NATURE PROTOCOLS (2009)

添加到收藏夹

Article Medicine, General & Internal

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

Mark D. Pescovitz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

添加到收藏夹

Article Medicine, Research & Experimental

Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice

Chang-Yun Hu et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

添加到收藏夹

Article Immunology

Tertiary lymphoid structures in the pancreas promote selection of B lymphocytes in autoimmune diabetes

Peggy L. Kendall et al.

JOURNAL OF IMMUNOLOGY (2007)

添加到收藏夹

Article Immunology

Identification of anergic B cells within a wild-type repertoire

Kevin T. Merrell et al.

IMMUNITY (2006)

添加到收藏夹

Article Immunology

Uncoupling of anergy from developmental arrest in anti-insulin B cells supports the development of autoimmune diabetes

CA Acevedo-Suárez et al.

JOURNAL OF IMMUNOLOGY (2005)

添加到收藏夹

Article Endocrinology & Metabolism

Investigation of the role of B-cells in type 1 diabetes in the NOD mouse

FS Wong et al.

DIABETES (2004)

添加到收藏夹

Article Immunology

Editors and editing of anti-DNA receptors

H Li et al.

IMMUNITY (2001)

添加到收藏夹

Article Immunology

Cutting edge: B cell specificity contributes to the outcome of diabetes in nonobese diabetic mice

C Hulbert et al.

JOURNAL OF IMMUNOLOGY (2001)

添加到收藏夹

Article Immunology

Anergy and not clonal ignorance determines the fate of B cells that recognize a physiological autoantigen

M Rojas et al.

JOURNAL OF IMMUNOLOGY (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.