期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.915094
关键词
immune checkpoint blockade; combination therapy; T cell response; resistance mechanisms; immunotherapy
类别
资金
- National Natural Science Foundation of China [81821002]
- Sichuan Science and Technology Program [2018YJ0609]
Immune checkpoint blockade has revolutionized cancer treatment, but drug resistance limits its effectiveness. This study investigates the mechanisms of resistance and proposes strategies to enhance the efficacy of immune checkpoint blockade.
Immune checkpoint blockade (ICB) has rapidly transformed the treatment paradigm for various cancer types. Multiple single or combinations of ICB treatments have been approved by the US Food and Drug Administration, providing more options for patients with advanced cancer. However, most patients could not benefit from these immunotherapies due to primary and acquired drug resistance. Thus, a better understanding of the mechanisms of ICB resistance is urgently needed to improve clinical outcomes. Here, we focused on the changes in the biological functions of CD8(+) T cells to elucidate the underlying resistance mechanisms of ICB therapies and summarized the advanced coping strategies to increase ICB efficacy. Combinational ICB approaches and individualized immunotherapies require further in-depth investigation to facilitate longer-lasting efficacy and a more excellent safety of ICB in a broader range of patients.
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