Microbial dysbiosis and childhood asthma development: Integrated role of the airway and gut microbiome, environmental exposures, and host metabolic and immune response

Article Respiratory System

Nasopharyngeal metatranscriptome profiles of infants with bronchiolitis and risk of childhood asthma: a multicentre prospective study

Yoshihiko Raita et al.

Summary: Through transcriptome and clustering analysis, we identified biologically distinct metatranscriptome profiles with differential risks of asthma in infant bronchiolitis.

EUROPEAN RESPIRATORY JOURNAL (2022)

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Article Allergy

Association of the gut microbiome and metabolome with wheeze frequency in childhood asthma

Kathleen Lee-Sarwar et al.

Summary: This study analyzed the relationship between gut microbiome and metabolome and wheeze frequency in children with asthma. The results showed that specific microbial taxa and metabolites were associated with high wheeze proportion in children. This finding suggests the impact of the gut microbiome on asthma morbidity in children.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Cell Biology

Early-life infection of the airways with Streptococcus pneumoniae exacerbates HDM-induced asthma in a murine model

Dan Peng et al.

Summary: Respiratory tract infection early in life may play a role in the development of asthma. This study using a mouse model suggests that early life infection with Streptococcus pneumoniae may exacerbate allergic asthma induced by house dust mite allergen in adulthood. These findings contribute to our understanding and prevention of asthma.

CELLULAR IMMUNOLOGY (2022)

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Article Allergy

Metabolome subtyping of severe bronchiolitis in infancy and risk of childhood asthma

Zhaozhong Zhu et al.

Summary: This study uses metabolome analysis to identify biologically distinct metabotypes in infants with severe bronchiolitis, including a metabotype characterized by high inflammatory amino acids and low polyunsaturated fatty acids that is at significantly increased risk for developing asthma.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Allergy

Exclusive breast-feeding, the early-life microbiome and immune response, and common childhood respiratory illnesses

Christian Rosas-Salazar et al.

Summary: Exclusive breast-feeding has a protective causal role in reducing the risk of lower respiratory tract infections, asthma, and allergic rhinitis in childhood. This association may be mediated through its impact on the early-life upper respiratory tract and gut microbiome, as well as the immune response in infancy.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Allergy

Nasopharyngeal airway dual-transcriptome of infants with severe bronchiolitis and risk of childhood asthma: A multicenter prospective study

Zhaozhong Zhu et al.

Summary: By studying infants with bronchiolitis, this research found an interplay between airway microbiome, host response, and asthma development.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Review Immunology

Early-Life Lung and Gut Microbiota Development and Respiratory Syncytial Virus Infection

Kazuma Yagi et al.

Summary: Several environmental factors can impact the development of early-life microbiota, which in turn affects the occurrence of respiratory tract infections and diseases. The role of gut and lung microbiota in airway diseases, particularly in the context of respiratory syncytial virus (RSV) infection, is of increasing interest.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Allergy

Farm living and allergic rhinitis from childhood to young adulthood: Prospective results of the GABRIEL study

Sonja Strieker et al.

Summary: Growing up on a farm is associated with a reduced prevalence of respiratory allergies in childhood, and this protective effect persists into early adulthood. Continuous exposure to farm living during puberty does not enhance the protective effect.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Respiratory System

Nasopharyngeal lipidomic endotypes of infants with bronchiolitis and risk of childhood asthma: a multicentre prospective study

Michimasa Fujiogi et al.

Summary: This multicentre prospective cohort study integrated clinical, virus and lipidomics data to identify different endotypes of bronchiolitis and examined their relationship with subsequent asthma risk.

THORAX (2022)

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Review Biochemistry & Molecular Biology

Microbiota in health and diseases

Kaijian Hou et al.

Summary: The role of microbiota in health and disease is significant, contributing to homeostasis and immune regulation. Dysbiosis of microbiota can lead to disease progression, associated with dysregulation of community composition, modulation of host immune response, and induction of chronic inflammation. Clinical approaches utilizing microbiota, such as microbiota modulation and fecal microbial transplantation, can be effective for disease treatment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Immunology

Antibiotic Treatments During Infancy, Changes in Nasal Microbiota, and Asthma Development: Population-based Cohort Study

Laura Toivonen et al.

Summary: Early exposures to antibiotics were associated with increased risk of asthma; the effect was partly mediated by longitudinal changes in the nasal airway microbiota.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Allergy

Investigating asthma heterogeneity through shared and distinct genetics: Insights from genome-wide cross-trait analysis

Zhaozhong Zhu et al.

Summary: Asthma is a complex respiratory disease with heterogeneous mechanisms influenced by shared and distinct genetic factors. Large-scale GWAS studies have revealed shared and unique genetic components between asthma subtypes, highlighting the genetic basis of the disease's heterogeneity. Analytic approaches such as genome-wide cross-trait analysis provide insights into the genetic architecture of asthma and can be applied to other complex traits.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

Developmental patterns in the nasopharyngeal microbiome during infancy are associated with asthma risk

Howard H. F. Tang et al.

Summary: The developmental trajectories of the nasopharyngeal microbiome in early life and the composition of the microbiome during illnesses are associated with the risk of childhood asthma. A Staphylococcus-dominant microbiome in early infancy is linked to an increased risk of recurrent wheezing and persistent asthma, while detection of rhinoviruses and predominance of Moraxella during wheezing illnesses are associated with asthma that persists throughout later childhood.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

Urbanized microbiota in infants, immune constitution, and later risk of atopic diseases

Jenni Lehtimaki et al.

Summary: The study found an association between urbanization and an increased risk of asthma and aeroallergen sensitization in infants. Differences in airway and gut microbiota composition were observed between urban and rural infants, with the urbanized microbiota structure being linked to an increased risk of asthma.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

Advances in asthma: New understandings of asthma's natural history, risk factors, underlying mechanisms, and clinical management

Rachel L. Miller et al.

Summary: In the past two years, there has been significant growth in high-quality asthma research, leading to new understandings of asthma incidence, natural history, risk factors, and potential therapeutic interventions. The progress in understanding mechanisms of asthma development and exacerbations, as well as advancements in diagnostic tools and precision approaches, have been immense and impactful. Though further knowledge on novel therapeutics and different asthma phenotypes is needed, these recent advancements offer promising avenues for future asthma management.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

The intersect of genetics, environment, and microbiota in asthma-perspectives and challenges

Howard H. F. Tang et al.

Summary: Asthma pathogenesis involves interactions between genetics, environment, and microbiota, including factors like endotoxin, pattern recognition systems, allergen exposure, host gut and airway microbiota, viral infections, etc. Challenges for future research include integrating multiomic data and defining asthma endotypes.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Agriculture, Multidisciplinary

Both living and dead Faecalibacterium prausnitzii alleviate house dust mite-induced allergic asthma through the modulation of gut microbiota and short-chain fatty acid production

Wenbing Hu et al.

Summary: The study found that Faecalibacterium prausnitzii has potential as a probiotic agent for allergic asthma prevention by modulating gut microbiota and short-chain fatty acid production.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2021)

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Article Respiratory System

Multi-omics links IL-6 trans-signalling with neutrophil extracellular trap formation and Haemophilus infection in COPD

Sofia Winslow et al.

Summary: The study identified a subset of COPD patients with IL-6TS pathway activation, characterized by persistent neutrophilic inflammation, impaired respiratory function, and increased nitrite levels in lung tissue, suggesting that chronic colonization with Haemophilus may be a driving force for these patients.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Article Allergy

Pediatric asthma incidence rates in the United States from 1980 to 2017

Christine C. Johnson et al.

Summary: The study found that asthma incidence rates in US children varied significantly by age, sex, parental asthma history, race/ethnicity, and calendar year, with the highest rates observed in the 0-4 year age group, especially between 1995 and 1999.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Immunology

Novel Anti-Cytokine Strategies for Prevention and Treatment of Respiratory Allergic Diseases

Ekaterina O. Gubernatorova et al.

Summary: Asthma is a heterogeneous inflammatory disease characterized by airflow obstruction, wheezing, eosinophilia, and neutrophilia. Targeting different inflammatory patterns with therapeutic antibodies against cytokines has shown promising results. Combining pharmacological inhibition of multiple pathogenic cytokines may be more effective in treating asthma compared to targeting a single cytokine.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Medicine, General & Internal

Relationship of Soluble Interleukin-6 Receptors With Asthma: A Mendelian Randomization Study

Yoshihiko Raita et al.

Summary: Genetically-instrumented soluble interleukin-6 receptor level was found to be significantly associated with a higher risk of overall asthma and its phenotypes, suggesting a potentially important role of interleukin-6 pathways in the pathobiology of asthma.

FRONTIERS IN MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Bifidobacteria-mediated immune system imprinting early in life

Bethany M. Henrick et al.

Summary: Early immune-microbe interactions play a role in the development of allergies, asthma, and inflammatory diseases. Breastfeeding promotes healthier immune-microbe relationships by providing necessary nutrients to beneficial microbes. The lack of bifidobacteria and genes required for HMO utilization can lead to systemic inflammation and immune dysregulation in early life.

CELL (2021)

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Article Allergy

Integrated-omics endotyping of infants with rhinovirus bronchiolitis and risk of childhood asthma

Yoshihiko Raita et al.

Summary: By analyzing clinical, RV species, nasopharyngeal microbiome, cytokine, and metabolome data, we identified 4 distinct endotypes of RV bronchiolitis, with infants in one endotype characterized by RV-C infection, Moraxella-dominant microbiota, and high T2 cytokine response showing a higher risk for developing recurrent wheeze and asthma.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Integrated omics endotyping of infants with respiratory syncytial virus bronchiolitis and risk of childhood asthma

Yoshihiko Raita et al.

Summary: The study integrated clinical, virus, airway microbiome, transcriptome, and metabolome data of infants hospitalized with RSV bronchiolitis and identified four endotypes with differential risks for developing asthma.

NATURE COMMUNICATIONS (2021)

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Correction Microbiology

A probiotic has differential effects on allergic airway inflammation in A/J and C57BL/6 mice and is correlated with the gut microbiome (vol 9, 134, 2021)

Mateus B. Casaro et al.

MICROBIOME (2021)

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Review Immunology

Constitutive immune mechanisms: mediators of host defence and immune regulation

Soren R. Paludan et al.

Summary: This review compares and contrasts the inducible and constitutive mechanisms of immunosurveillance, showing the effectiveness and potential risks of immune responses, as well as the importance of maintaining homeostasis through a variety of immune mechanisms.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Allergy

Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank

Zhaozhong Zhu et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Allergy

Increased Moraxella and Streptococcus species abundance after severe bronchiolitis is associated with recurrent wheezing

Jonathan M. Mansbach et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Review Immunology

The Role of Lung and Gut Microbiota in the Pathology of Asthma

Weronika Barcik et al.

IMMUNITY (2020)

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Review Immunology

Dysbiosis of the gut and lung microbiome has a role in asthma

Karin Hufnagl et al.

SEMINARS IN IMMUNOPATHOLOGY (2020)

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Review Immunology

The Gut-Lung Axis in Health and Respiratory Diseases: A Place for Inter-Organ and Inter-Kingdom Crosstalks

Raphael Enaud et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Review Microbiology

The Cross-Talk Between Gut Microbiota and Lungs in Common Lung Diseases

Dapeng Zhang et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Article Critical Care Medicine

Decreasing antibiotic use, the gut microbiota, and asthma incidence in children: evidence from population-based and prospective cohort studies

David M. Patrick et al.

LANCET RESPIRATORY MEDICINE (2020)

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Review Immunology

Microbiome Composition and Its Impact on the Development of Allergic Diseases

Diego G. Peroni et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Allergy

Association of asthma and its genetic predisposition with the risk of severe COVID-19

Zhaozhong Zhu et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Review Microbiology

Lung Microbiome Participation in Local Immune Response Regulation in Respiratory Diseases

Juan Alberto Lira-Lucio et al.

MICROORGANISMS (2020)

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Article Pediatrics

Longitudinal Changes in Early Nasal Microbiota and the Risk of Childhood Asthma

Laura Toivonen et al.

PEDIATRICS (2020)

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Article Multidisciplinary Sciences

Systematic analysis of infectious disease outcomes by age shows lowest severity in school-age children

Judith R. Glynn et al.

SCIENTIFIC DATA (2020)

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Article Multidisciplinary Sciences

Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children

Marja Roslund et al.

SCIENCE ADVANCES (2020)

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Article Cell Biology

Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma

Jakob Stokholm et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma

Martin Depner et al.

NATURE MEDICINE (2020)

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Review Immunology

The Role of Butyrate in Attenuating Pathobiont-Induced Hyperinflammation

Jiezhong Chen et al.

IMMUNE NETWORK (2020)

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Review Immunology

Microbes, metabolites, and the gut-lung axis

Anh Thu Dang et al.

MUCOSAL IMMUNOLOGY (2019)

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Article Critical Care Medicine

Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies

Milton Pividori et al.

LANCET RESPIRATORY MEDICINE (2019)

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Review Immunology

Commensal Bacteria: An Emerging Player in Defense Against Respiratory Pathogens

Rabia Khan et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Pediatrics

Epidemiology of Asthma in Children and Adults

Shyamaii C. Dharmage et al.

FRONTIERS IN PEDIATRICS (2019)

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Article Microbiology

Elevated faecal 12,13-diHOME concentration in neonates at high risk for asthma is produced by gut bacteria and impedes immune tolerance

Sophia R. Levan et al.

NATURE MICROBIOLOGY (2019)

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Article Respiratory System

Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis

Zhaozhong Zhu et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

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Article Multidisciplinary Sciences

Infant airway microbiota and topical immune perturbations in the origins of childhood asthma

Jonathan Thorsen et al.

NATURE COMMUNICATIONS (2019)

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Review Critical Care Medicine

Childhood Asthma: Advances Using Machine Learning and Mechanistic Studies

Sejal Saglani et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

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Editorial Material Respiratory System

Metabolomics in the prevention and management of asthma

Zhaozhong Zhu et al.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2019)

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Article Genetics & Heredity

Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct

Manuel A. R. Ferreira et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2019)

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Article Genetics & Heredity

A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases

Zhaozhong Zhu et al.

NATURE GENETICS (2018)

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Article Multidisciplinary Sciences

Maturation of the gut microbiome and risk of asthma in childhood

Jakob Stokholm et al.

NATURE COMMUNICATIONS (2018)

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Article Allergy

Early-life farm exposures and adult asthma and atopy in the Agricultural Lung Health Study

John S. House et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Review Allergy

Airway microbial dysbiosis in asthmatic patients: A target for prevention and treatment?

Kian Fan Chung

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Article Immunology

IL-17 and TNF-α Are Key Mediators Of Moraxella catarrhalis Triggered Exacerbation of Allergic Airway Inflammation

Safa Alnahas et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Allergy

Microbes and asthma: Opportunities for intervention

Hermelijn H. Smits et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

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Article Biochemistry & Molecular Biology

Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation

Kei E. Fujimura et al.

NATURE MEDICINE (2016)

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Article Medicine, General & Internal

Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children

Michelle M. Stein et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Article Microbiology

Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype

Leopoldo N. Segal et al.

NATURE MICROBIOLOGY (2016)

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Article Microbiology

The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma Development

Shu Mei Teo et al.

CELL HOST & MICROBE (2015)

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Article Cell Biology

Early infancy microbial and metabolic alterations affect risk of childhood asthma

Marie-Claire Arrieta et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

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Article Microbiology

Plasmacytoid Dendritic Cells Mediate Anti-inflammatory Responses to a Gut Commensal Molecule via Both Innate and Adaptive Mechanisms

Suryasarathi Dasgupta et al.

CELL HOST & MICROBE (2014)

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Article Allergy

Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children

Susan V. Lynch et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

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Article Biochemistry & Molecular Biology

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

Aurelien Trompette et al.

NATURE MEDICINE (2014)

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Article Biochemistry & Molecular Biology

Lung microbiota promotes tolerance to allergens in neonates via PD-L1

Eva S. Gollwitzer et al.

NATURE MEDICINE (2014)

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Article Multidisciplinary Sciences

Commensal bacteria protect against food allergen sensitization

Andrew T. Stefka et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Review Cell Biology

Recognition of Streptococcus pneumoniae by the innate immune system

Uwe Koppe et al.

CELLULAR MICROBIOLOGY (2012)

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Article Allergy

Dehydroxymethylepoxyquinomicin (DHMEQ), a novel NF-kappaB inhibitor, inhibits allergic inflammation and airway remodelling in murine models of asthma

K. Shimizu et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2012)

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Article Respiratory System

Combined Haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma

Ama-Tawiah Essilfie et al.

THORAX (2012)

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Article Biochemistry & Molecular Biology

Innate Immunity in the Respiratory Epithelium

Dane Parker et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2011)

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Review Immunology

The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases

Helena Tlaskalova-Hogenova et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2011)

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Article Allergy

Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age

Hans Bisgaard et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2011)

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Review Microbiology

Bacterial manipulation of innate immunity to promote infection

Lautaro Diacovich et al.

NATURE REVIEWS MICROBIOLOGY (2010)

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Article Immunology

Farm living: effects on childhood asthma and allergy

Erika von Mutius et al.

NATURE REVIEWS IMMUNOLOGY (2010)

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Article Medicine, General & Internal

Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study

Hans Bisgaard et al.

BRITISH MEDICAL JOURNAL (2010)

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Review Medicine, General & Internal

Asthma: epidemiology, etiology and risk factors

Padmaja Subbarao et al.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2009)

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Review Allergy

Asthma: a syndrome composed of heterogeneous diseases

Larry Borish et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2008)

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Review Biochemistry & Molecular Biology

Signaling to NF-κB by Toll-like receptors

Taro Kawai et al.

TRENDS IN MOLECULAR MEDICINE (2007)

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Article Multidisciplinary Sciences

The Human Microbiome Project

Peter J. Turnbaugh et al.

NATURE (2007)

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Article Medicine, General & Internal

Childhood asthma after bacterial colonization of the airway in neonates

Hans Bisgaard et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

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Review Allergy

Manipulation of signaling to control allergic inflammation

John Colgan et al.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2007)

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Microbial dysbiosis and childhood asthma development: Integrated role of the airway and gut microbiome, environmental exposures, and host metabolic and immune response

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