☆ 4.8 Review

Membranous nephropathy: Clearer pathology and mechanisms identify potential strategies for treatment

FRONTIERS IN IMMUNOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Urology & Nephrology

Recurrence of Anti-Semaphorin 3B?Mediated Membranous Nephropathy after Kidney Transplantation

Marc Fila et al.

Summary: This study reports the first case of early recurrence after transplantation of membranous nephropathy associated with antibodies directed at semaphorin 3B. The findings provide strong evidence that anti-semaphorin 3B antibodies are pathogenic and should be carefully monitored in patients with membranous nephropathy. Furthermore, the study supports the efficacy of rituximab in treating the disease.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

添加到收藏夹

Article Urology & Nephrology

Molecular Characterization of Membranous Nephropathy

Rachel Sealfon et al.

Summary: Using gene expression data from the kidney tissue, MN patients can be accurately distinguished from other kidney disease patients. By analyzing the gene expression differences between MN patients and other glomerulonephropathy patients, specific gene modules related to MN can be identified in a kidney-specific functional network, indicating upregulation of podocyte-expressed genes in MN.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

添加到收藏夹

Article Urology & Nephrology

Hematopoietic Stem Cell Transplant-M embranous Nephropathy Is Associated with Protocadherin FAT1

Sanjeev Sethi et al.

Summary: In this study, a novel antigen associated with membranous nephropathy (MN) in patients receiving hematopoietic stem cell transplant (HSCT) was identified using laser microdissection and tandem mass spectrometry (MS/MS). The antigen, called FAT1, was detected in the glomeruli of patients with PLA2R-negative MN. Further studies confirmed the presence of FAT1-associated MN in a majority of HSCT-related MN cases. This study provides valuable insights into the pathogenesis of MN in HSCT patients and may contribute to the development of targeted therapies.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

添加到收藏夹

Article Urology & Nephrology

Complement C3a and C3a Receptor Activation Mediates Podocyte Injuries in the Mechanism of Primary Membranous Nephropathy

Shuang Gao et al.

Summary: This study investigates the role of C3a and C3a receptor (C3aR) in the pathogenesis of primary membranous nephropathy (MN). It demonstrates that C3a anaphylatoxin is a crucial effector of complement-mediated podocyte damage in MN, and blocking C3aR may be a potentially viable treatment for this disease.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Discovery of anti-Formin-like 1 protein (FMNL1) antibodies in membranous nephropathy and other glomerular diseases

Maurizio Bruschi et al.

Summary: Evidence has shown that autoantibodies targeting podocytes can cause membranous nephropathy. In this study, a high-density peptide array was used to identify a panel of proteins reactive to sera of membranous nephropathy patients. The protein FMNL1, expressed by macrophages in the tissues of membranous nephropathy patients, was found to have high levels of anti-FMNL1 IgG4 in the sera of these patients. This autoantibody was associated with lack of remission of proteinuria and was also observed in other glomerular disease conditions. These findings suggest a broader role of this autoantibody in different glomerular diseases.

SCIENTIFIC REPORTS (2022)

添加到收藏夹

Article Urology & Nephrology

Netrin G1 Is a Novel Target Antigen in Primary Membranous Nephropathy

Linda Reinhard et al.

Summary: This study identified a novel target antigen, Netrin G1 (NTNG1), in primary membranous nephropathy (MN) and confirmed the presence of NTNG1 autoantibodies in MN patients. The findings expand our understanding of the pathogenesis in MN and have important implications for further research on the clinical role of NTNG1 autoantibodies.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

添加到收藏夹

Article Urology & Nephrology

Podocyte expression of human phospholipase A2 receptor 1 causes immune-mediated membranous nephropathy in mice

Nicola M. Tomas et al.

Summary: This study successfully generated a transgenic mouse line expressing full-length human PLA2R1 in podocytes, which developed membranous nephropathy with characteristics similar to human disease. The mouse model provides a useful tool for evaluating antigen-specific treatment strategies and advancing our understanding of the autoimmune pathogenesis of membranous nephropathy.

KIDNEY INTERNATIONAL (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Structure of PLA2R reveals presentation of the dominant membranous nephropathy epitope and an immunogenic patch

Maryline Fresquet et al.

Summary: Membranous nephropathy is an autoimmune kidney disease caused by autoantibodies targeting antigens present on glomerular podocytes. This study provides insights into the structure and key residues of the phospholipase A2 receptor (PLA2R) involved in autoantibody binding, and suggests potential drug targets for membranous nephropathy.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

添加到收藏夹

Article Urology & Nephrology

Fumarate modulates phospholipase A2 receptor autoimmunity-induced podocyte injury in membranous nephropathy

Hyung Ah Jo et al.

Summary: The downstream mechanisms leading to podocyte injury following phospholipase A2 receptor (PLA2R) autoimmunity are still unclear. However, studies have found that fumarate may play a role in this process and could potentially serve as a target for the treatment of PLA2R-associated membranous nephropathy.

KIDNEY INTERNATIONAL (2021)

添加到收藏夹

Article Urology & Nephrology

HLA-D and PLA2R1 risk alleles associate with recurrent primary membranous nephropathy in kidney transplant recipients

Lena Berchtold et al.

Summary: The study identified genetic variants in HLA-D and PLA2R1 genes associated with recurrence of primary membranous nephropathy. Specifically, donor expression of certain SNPs in these genes was predictive of recurrence, while recipient expression was not. A genetic risk score based on these SNPs can help identify patients at high risk of recurrence.

KIDNEY INTERNATIONAL (2021)

添加到收藏夹

Article Urology & Nephrology

NELL1 is a target antigen in malignancy-associated membranous nephropathy

Tiffany N. Caza et al.

Summary: Patients with membranous nephropathy associated with malignancy were found to have unique NELL1 immune complexes in kidney biopsy tissue, with characteristic histopathology of incomplete capillary loop staining and IgG1 predominance. These NELL1-positive cases also showed a higher association with concurrent malignancy compared to other known types of membranous nephropathy.

KIDNEY INTERNATIONAL (2021)

添加到收藏夹

Article Urology & Nephrology

Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus nephritis

Tiffany N. Caza et al.

Summary: Research has identified neural cell adhesion molecule 1 (NCAM1) as a target antigen in some cases of membranous lupus nephritis and rare cases of primary membranous nephropathy, colocalizing with IgG in glomerular immune deposits. Circulating antibodies to NCAM1 have been detected in serum of patients with NCAM1-associated membranous nephropathy, suggesting diagnostic significance. Future studies are needed to determine whether anti-NCAM1 antibody levels correlate with disease activity or response to therapy.

KIDNEY INTERNATIONAL (2021)

添加到收藏夹

Article Urology & Nephrology

In Patients with Membranous Lupus Nephritis, Exostosin-Positivity and Exostosin-Negativity Represent Two Different Phenotypes

Aishwarya Ravindran et al.

Summary: In membranous lupus nephritis, EXT1/EXT2-positive patients have more favorable kidney biopsy findings with less chronicity, while EXT1/EXT2-negative patients are more likely to progress to ESKD. This suggests that the presence of EXT1/EXT2 is associated with better renal outcomes.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

添加到收藏夹

Review Urology & Nephrology

New 'Antigens' in Membranous Nephropathy

Sanjeev Sethi

Summary: Membranous nephropathy is a disease caused by immune complex deposition along the glomerular basement membrane, with PLA2R and THSD7A being the main antigens. New mass spectrometry techniques have led to the discovery of four novel types of MN, each with distinct clinical and pathologic features. Additional studies are needed to understand the pathophysiology, treatment response, and outcomes of these new MN subtypes.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Follicular regulatory T cells produce neuritin to regulate B cells

Paula Gonzalez-Figueroa et al.

Summary: Regulatory T cells produce neuritin to suppress B cell-driven autoimmunity and IgE-mediated allergies. Lack of these T cells or neuritin leads to the emergence of autoantibodies and excessive IgE.

CELL (2021)

添加到收藏夹

Article Urology & Nephrology

Contactin-1 is a novel target antigen in membranous nephropathy associated with chronic inflammatory demyelinating polyneuropathy

Moglie Le Quintrec et al.

Summary: Primary membranous nephropathy (MN) is an autoimmune glomerular disease with PLA2R1 as the main targeted antigen in 80% of cases, while the antigenic target remains undefined in 20% cases. A study discovered that contactin 1 is a novel common antigenic target in MN associated with chronic inflammatory demyelinating polyneuropathy.

KIDNEY INTERNATIONAL (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PL A2R1-associated membranous nephropathy

George Haddad et al.

Summary: In primary membranous nephropathy, anti-PLA2R1 IgG4 can induce podocyte injury by activating the lectin pathway. The study results indicate that aberrantly glycosylated IgG4 directly binds to mannose-binding lectin and induces proteolysis of synaptopodin and NEPH1 proteins through two distinct proteolytic pathways.

JOURNAL OF CLINICAL INVESTIGATION (2021)

添加到收藏夹

Letter Urology & Nephrology

Limited Significance of Antifactor H Antibodies in Patients with Membranous Nephropathy

Amit Sethi et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

添加到收藏夹

Article Urology & Nephrology

Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy

Laith Farah Al-Rabadi et al.

Summary: The study identified serine protease HTRA1 as a novel podocyte antigen in primary membranous nephropathy (MN) patients. Anti-HTRA1 antibodies in patients with HTRA1-associated MN were predominantly IgG4 and seemed to correlate with clinical disease activity. Screening of 118 quadruple-negative patients revealed a 4.2% prevalence of HTRA1-associated MN.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

添加到收藏夹

Article Urology & Nephrology

Protocadherin 7?Associated Membranous Nephropathy

Sanjeev Sethi et al.

Summary: Membranous nephropathy (MN) can be caused by antibodies targeting different antigens in the glomerular basement membrane (GBM), such as PLA2R, THSD7A, NELL1, SEMA3B, and now, the novel protein PCHD7. PCHD7 appears to define a distinct type of MN with specific characteristics in terms of staining pattern and antibody reactivity.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

添加到收藏夹

Review Urology & Nephrology

A conceptual framework linking immunology, pathology, and clinical features in primary membranous nephropathy

Gabriel B. Lerner et al.

Summary: Primary membranous nephropathy is a leading cause of adult nephrotic syndrome. The identification of PLA2R as a target antigen and the ability to measure circulating autoantibodies has provided new insights into the humoral aspect of the disease. Additionally, the detection and monitoring of autoantibody levels are crucial for guiding disease management.

KIDNEY INTERNATIONAL (2021)

添加到收藏夹

Article Urology & Nephrology

The STARMEN trial indicates that alternating treatment with corticosteroids and cyclophosphamide is superior to sequential treatment with tacrolimus and rituximab in primary membranous nephropathy

Gema Fernandez-Juarez et al.

Summary: The study found that a cyclical corticosteroid-cyclophosphamide regimen was more effective in inducing persistent remission in patients with primary membranous nephropathy compared to sequential therapy with tacrolimus and rituximab, with a higher rate of complete remission. Overall, treatment with corticosteroid-cyclophosphamide resulted in a significantly greater number of patients achieving remission.

KIDNEY INTERNATIONAL (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Life-extended glycosylated IL-2 promotes Treg induction and suppression of autoimmunity

Aner Ottolenghi et al.

Summary: The study extended the half-life of IL-2 by flanking its core with sequences from the NCR2 receptor, creating a modified IL-2 called S2A. S2A significantly enhanced induction of Tregs in vivo but did not reduce the metastatic capacity of melanoma in a mouse model, showing promising therapeutic effects in autoimmune models.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Letter Medicine, General & Internal

CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus

Dimitrios Mougiakakos et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

添加到收藏夹

Article Immunology

Single-Cell Profiling Reveals Transcriptional Signatures and Cell-Cell Crosstalk in Anti-PLA2R Positive Idiopathic Membranous Nephropathy Patients

Jie Xu et al.

Summary: Utilizing single-cell RNA sequencing, this study analyzed kidney samples from IMN patients and healthy controls, identifying different cell types, differentially expressed genes, and intercellular interactions. Genes involved in inflammation and immune response regulation were enriched in most kidney parenchymal cells. The extensive communication of mesangial cells in IMN was highlighted as being of great importance.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

The Diagnostic and Prognostic Potential of the B-Cell Repertoire in Membranous Nephropathy

Zuhui Su et al.

Summary: Membranous nephropathy (MN) is a common autoimmune glomerular disease that requires renal tissue biopsy for diagnosis, indicating the need for new diagnostic and prognostic monitoring methods. High-throughput sequencing analysis revealed abnormalities in multiple aspects of the immunoglobulin heavy chain in patients, with certain gene transcripts and parameters showing potential for predicting therapeutic effects.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Urology & Nephrology

Transforming Growth Factor Beta Receptor 3 (TGFBR3)-Associated Membranous Nephropathy

Tiffany N. Caza et al.

Summary: A novel biomarker, TGFBR3, expressed in a subset of patients with MLN, was found to be a distinct form of MN significantly enriched in MLN. Diagnosis of TGFBR3-associated MN can alert clinicians to search for underlying autoimmune diseases and guide treatment decisions to improve patient prognosis.

KIDNEY360 (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

sPLA2-IB and PLA2R mediate insufficient autophagy and contribute to podocyte injury in idiopathic membranous nephropathy by activation of the p38MAPK/mTOR/ULK1ser757 signaling pathway

Liyan Yang et al.

Summary: This study found that IMN patients with nephrotic-range proteinuria have significantly higher levels of sPLA2-IB and fewer autophagosomes than those with non-nephrotic-range proteinuria. In vitro experiments demonstrated that sPLA2-IB induced insufficient autophagy in podocytes and promoted podocyte injury through activation of the mTOR/ULK1 signaling pathway. Additionally, inhibition of p38 MAPK abrogated sPLA2-IB-induced autophagy and mTOR/ULK1 activation.

FASEB JOURNAL (2021)

添加到收藏夹

Article Immunology

Autoantigens PLA2R and THSD7A in membranous nephropathy share a common epitope motif in the N-terminal domain

M. Fresquet et al.

JOURNAL OF AUTOIMMUNITY (2020)

添加到收藏夹

Article Urology & Nephrology

A novel mouse model of phospholipase A2 receptor 1-associated membranous nephropathy mimics podocyte injury in patients

Catherine Meyer-Schwesinger et al.

KIDNEY INTERNATIONAL (2020)

添加到收藏夹

Article Urology & Nephrology

Neural epidermal growth factor-like 1 protein (NELL-1) associated membranous nephropathy

Sanjeev Sethi et al.

KIDNEY INTERNATIONAL (2020)

添加到收藏夹

Review Pathology

Molecular Pathogenesis of Membranous Nephropathy

Pierre Ronco et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 15, 2020 (2020)

添加到收藏夹

Article Urology & Nephrology

Clinical Relevance of Domain-Specific Phospholipase A2 Receptor 1 Antibody Levels in Patients with Membranous Nephropathy

Linda Reinhard et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Megalin: A bridge connecting kidney, the renin-angiotensin system, and atherosclerosis

Masayoshi Kukida et al.

PHARMACOLOGICAL RESEARCH (2020)

添加到收藏夹

Article Urology & Nephrology

Association of HLA Typing and Alloimmunity With Posttransplantation Membranous Nephropathy: A Multicenter Case Series

Ibrahim Batal et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2020)

添加到收藏夹

Article Surgery

Reversing donor-specific antibody responses and antibody-mediated rejection with bortezomib and belatacept in mice and kidney transplant recipients

Dharmendra Jain et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2020)

添加到收藏夹

Article Immunology

Neutralizing Anti-Rituximab Antibodies and Relapse in Membranous Nephropathy Treated With Rituximab

Sonia Boyer-Suavet et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis

Jingyuan Xie et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Generation of a conditional transgenic mouse model expressing human Phospholipase A2 Receptor 1

Sara Jaber et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Immunology

The Landscape and Prognosis Potential of the T-Cell Repertoire in Membranous Nephropathy

Yu Zhang et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Editorial Material Urology & Nephrology

Megalin/lipoprotein receptor-related protein 2 autoimmunity and kidney disease

Maria V. Perez-Gomez et al.

CLINICAL KIDNEY JOURNAL (2020)

添加到收藏夹

Article Urology & Nephrology

The association of anti-PLA2R with clinical manifestations and outcomes in idiopathic membranous nephropathy: a meta-analysis

Si-jie Rao et al.

INTERNATIONAL UROLOGY AND NEPHROLOGY (2020)

添加到收藏夹

Article Urology & Nephrology

Regulatory B Cells Are Reduced and Correlate With Disease Activity in Primary Membranous Nephropathy

Raja Ramachandran et al.

KIDNEY INTERNATIONAL REPORTS (2020)

添加到收藏夹

Article Urology & Nephrology

Proteomic Analysis of Complement Proteins in Membranous Nephropathy

Aishwarya Ravindran et al.

KIDNEY INTERNATIONAL REPORTS (2020)

添加到收藏夹

Article Urology & Nephrology

A comprehensive phenotypic and functional immune analysis unravels circulating anti-PLA2R antibody secreting cells in membranous nephropathy patients

Chiara Cantarelli et al.

Kidney International Reports (2020)

添加到收藏夹

Article Urology & Nephrology

Semaphorin 3B-associated membranous nephropathy is a distinct type of disease predominantly present in pediatric patients

Sanjeev Sethi et al.

KIDNEY INTERNATIONAL (2020)

添加到收藏夹

Article Medicine, General & Internal

Two-Year, Randomized, Controlled Trial of Belimumab in Lupus Nephritis

Richard Furie et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Review Immunology

The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy

Zhaocheng Dong et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2020)

添加到收藏夹

Review Immunology

Chimeric Antigen Receptor Based Therapy as a Potential Approach in Autoimmune Diseases: How Close Are We to the Treatment?

Muhammad Sadeqi Nezhad et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Immunology

Th17-Immune Response in Patients With Membranous Nephropathy Is Associated With Thrombosis and Relapses

Marion Cremoni et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Medicine, General & Internal

Ofatumumab for multirelapsing membranous nephropathy complicated by rituximab-induced serum-sickness

Manuel Alfredo Podesta et al.

BMJ CASE REPORTS (2020)

添加到收藏夹

Article Physiology

Effect of Glomerular Mannose-Binding Lectin Deposition on the Prognosis of Idiopathic Membranous Nephropathy

Ying Zhang et al.

KIDNEY & BLOOD PRESSURE RESEARCH (2020)

添加到收藏夹

Meeting Abstract Rheumatology

ALTERNATIVE RENAL RESPONSE DEFINITIONS IN A RANDOMIZED, CONTROLLED TRIAL OF OBINUTUZUMAB FOR PROLIFERATIVE LUPUS NEPHRITIS

Z. Amoura et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

添加到收藏夹

Article Urology & Nephrology

Exostosin 1/Exostosin 2-Associated Membranous Nephropathy

Sanjeev Sethi et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2019)

添加到收藏夹

Article Immunology

Regulatory T cells engineered with a novel insulin-specific chimeric antigen receptor as a candidate immunotherapy for type 1 diabetes

Michel Tenspolde et al.

JOURNAL OF AUTOIMMUNITY (2019)

添加到收藏夹

Article Medicine, General & Internal

Rituximab or Cyclosporine in the Treatment of Membranous Nephropathy

F. C. Fervenza et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Opposing T cell responses in experimental autoimmune encephalomyelitis

Naresha Saligrama et al.

NATURE (2019)

添加到收藏夹

Article Urology & Nephrology

LDL Receptor-Related Protein 2 (Megalin) as a Target Antigen in Human Kidney Anti-Brush Border Antibody Disease

Christopher P. Larsen et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

添加到收藏夹

Article Urology & Nephrology

Phospholipase A2 Receptor 1 Epitope Spreading at Baseline Predicts Reduced Likelihood of Remission of Membranous Nephropathy

Barbara Seitz-Polski et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

添加到收藏夹

Article Transplantation

Glomerular mannose-binding lectin deposition in intrinsic antigen-related membranous nephropathy

Norifumi Hayashi et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Human anti-thrombospondin type 1 domain-containing 7A antibodies induce membranous nephropathy through activation of lectin complement pathway

Zheng Wang et al.

BIOSCIENCE REPORTS (2018)

添加到收藏夹

Article Urology & Nephrology

The Most N-Terminal Region of THSD7A Is the Predominant Target for Autoimmunity in THSD7A-Associated Membranous Nephropathy

Larissa Seifert et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

添加到收藏夹

Article Cell Biology

A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes

Markus M. Rinschen et al.

CELL REPORTS (2018)

添加到收藏夹

Article Immunology

Alternative Pathway Is Essential for Glomerular Complement Activation and Proteinuria in a Mouse Model of Membranous Nephropathy

Wentian Luo et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Review Medicine, Research & Experimental

A Review of Obinutuzumab (GA101), a Novel Type II Anti-CD20 Monoclonal Antibody, for the Treatment of Patients with B-Cell Malignancies

Kensei Tobinai et al.

ADVANCES IN THERAPY (2017)

添加到收藏夹

Article Urology & Nephrology

An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy

Elion Hoxha et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

添加到收藏夹

Article Urology & Nephrology

MHC Class II Risk Alleles and Amino Acid Residues in Idiopathic Membranous Nephropathy

Zhao Cui et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

添加到收藏夹

Article Urology & Nephrology

A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy

Nicola M. Tomas et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

添加到收藏夹

Article Urology & Nephrology

B- and T-cell subpopulations in patients with severe idiopathic membranous nephropathy may predict an early response to rituximab

Michelle Rosenzwajg et al.

KIDNEY INTERNATIONAL (2017)

添加到收藏夹

Review Urology & Nephrology

Membranous nephropathy: integrating basic science into improved clinical management

Daniel C. Cattran et al.

KIDNEY INTERNATIONAL (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

Joshua D. Ooi et al.

NATURE (2017)

添加到收藏夹

Review Urology & Nephrology

Treatment of membranous nephropathy: time for a paradigm shift

Piero Ruggenenti et al.

NATURE REVIEWS NEPHROLOGY (2017)

添加到收藏夹

Article Pediatrics

Bortezomib in the treatment of antibody-mediated rejection in pediatric kidney transplant recipients: A multicenter Midwest Pediatric Nephrology Consortium study

Sarah Kizilbash et al.

PEDIATRIC TRANSPLANTATION (2017)

添加到收藏夹

Article Oncology

Inhibition of tumor necrosis factor signaling attenuates renal immune cell infiltration in experimental membranous nephropathy

Yen-Sung Huang et al.

ONCOTARGET (2017)

添加到收藏夹

Article Immunology

Higher frequencies of circulating ICOS+, IL-21+ T follicular helper cells and plasma cells in patients with new-onset membranous nephropathy

Zhihui Zhang et al.

AUTOIMMUNITY (2017)

添加到收藏夹

Article Urology & Nephrology

Primary Membranous Nephropathy

William G. Couser

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

添加到收藏夹

Article Urology & Nephrology

Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease

Young-Hyun You et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

添加到收藏夹

Article Urology & Nephrology

Epitope Spreading of Autoantibody Response to PLA2R Associates with Poor Prognosis in Membranous Nephropathy

Barbara Seitz-Polski et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

添加到收藏夹

Review Immunology

New insights into immune mechanisms underlying response to Rituximab in patients with membranous nephropathy: A prospective study and a review of the literature

D. Roccatello et al.

AUTOIMMUNITY REVIEWS (2016)

添加到收藏夹

Article Pharmacology & Pharmacy

Increased ratio of ICOS+/PD-1+ follicular helper T cells positively correlates with the development of human idiopathic membranous nephropathy

Xu Shi et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2016)

添加到收藏夹

Article Medicine, Research & Experimental

Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy

Nicola M. Tomas et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

添加到收藏夹

Article Urology & Nephrology

Phospholipase A2 Receptor-Related Membranous Nephropathy and Mannan-Binding Lectin Deficiency

Stephane Bally et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

添加到收藏夹

Article Pathology

THSD7A staining of membranous glomerulopathy in clinical practice reveals cases with dual autoantibody positivity

Christopher P. Larsen et al.

MODERN PATHOLOGY (2016)

添加到收藏夹

Letter Medicine, General & Internal

A Mechanism for Cancer-Associated Membranous Nephropathy

Elion Hoxha et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

Christoph T. Ellebrecht et al.

SCIENCE (2016)

添加到收藏夹

Article Immunology

Recurrent Membranous Nephropathy After Kidney Transplantation: Treatment and Long-Term Implications

Ayelet Grupper et al.

TRANSPLANTATION (2016)

添加到收藏夹

Article Urology & Nephrology

Renal Phospholipase A(2) Receptor in Hepatitis B Virus-Associated Membranous Nephropathy

Qionghong Xie et al.

AMERICAN JOURNAL OF NEPHROLOGY (2015)

添加到收藏夹

Article Surgery

Anti-Phospholipase A2 Receptor Antibodies in Recurrent Membranous Nephropathy

A. Kattah et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2015)

添加到收藏夹

Article Immunology

B cells expressing IFN-γ suppress Treg-cell differentiation and promote autoimmune experimental arthritis

Susan A. Olalekan et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2015)

添加到收藏夹

Article Urology & Nephrology

Anti-Phospholipase A2 Receptor Antibody Titer Predicts Post-Rituximab Outcome of Membranous Nephropathy

Piero Ruggenenti et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

添加到收藏夹

Article Immunology

Antiphospholipase A2 Receptor Antibody Levels Predict the Risk of Posttransplantation Recurrence of Membranous Nephropathy

Luis F. Quintana et al.

TRANSPLANTATION (2015)

添加到收藏夹

Article Urology & Nephrology

Identification of a Major Epitope Recognized by PLA2R Autoantibodies in Primary Membranous Nephropathy

Maryline Fresquet et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

添加到收藏夹

Article Medicine, General & Internal

Serum with phospholipase A2 receptor autoantibodies interferes with podocyte adhesion to collagen

Andrej Skoberne et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2014)

添加到收藏夹

Article Urology & Nephrology

Bortezomib therapy for nephrotic syndrome due to idiopathic membranous nephropathy

Choli Hartono et al.

JOURNAL OF NEPHROLOGY (2014)

添加到收藏夹

Article Medicine, General & Internal

Thrombospondin Type-1 Domain-Containing 7A in Idiopathic Membranous Nephropathy

Nicola M. Tomas et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Circulating TNF Receptors Are Significant Prognostic Biomarkers for Idiopathic Membranous Nephropathy

Su Mi Lee et al.

PLOS ONE (2014)

添加到收藏夹

Article Multidisciplinary Sciences

The Diagnosis Accuracy of PLA2R-AB in the Diagnosis of Idiopathic Membranous Nephropathy: A Meta-Analysis

Yu Du et al.

PLOS ONE (2014)

添加到收藏夹

Article Immunology

Tissue-Specific Host Recognition by Complement Factor H Is Mediated by Differential Activities of Its Glycosaminoglycan-Binding Regions

Simon J. Clark et al.

JOURNAL OF IMMUNOLOGY (2013)

添加到收藏夹

Article Pathology

IgG subclass staining in renal biopsies with membranous glomerulonephritis indicates subclass switch during disease progression

Cheng Cheng Huang et al.

MODERN PATHOLOGY (2013)

添加到收藏夹

Review Urology & Nephrology

The Role of Complement in Membranous Nephropathy

Hong Ma et al.

SEMINARS IN NEPHROLOGY (2013)

添加到收藏夹

Article Urology & Nephrology

Coexistence of Different Circulating Anti-Podocyte Antibodies in Membranous Nephropathy

Corrado Murtas et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2012)

添加到收藏夹

Article Immunology

Murine Membranous Nephropathy: Immunization with α3(IV) Collagen Fragment Induces Subepithelial Immune Complexes and FcγR-Independent Nephrotic Syndrome

Jun-Jun Zhang et al.

JOURNAL OF IMMUNOLOGY (2012)

添加到收藏夹

Article Immunology

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

Moa Fransson et al.

JOURNAL OF NEUROINFLAMMATION (2012)

添加到收藏夹

Article Urology & Nephrology

CD8+ Regulatory T Cells Induced by T Cell Vaccination Protect Against Autoimmune Nephritis

Yuan Min Wang et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2012)

添加到收藏夹

Article Urology & Nephrology

Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy

Elion Hoxha et al.

KIDNEY INTERNATIONAL (2012)

添加到收藏夹

Article Surgery

Autoantibodies Specific for the Phospholipase A2 Receptor in Recurrent and De Novo Membranous Nephropathy

H. Debiec et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2011)

添加到收藏夹

Article Urology & Nephrology

Anti-Phospholipase A2 Receptor Antibodies Correlate with Clinical Status in Idiopathic Membranous Nephropathy

Julia M. Hofstra et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)

添加到收藏夹

Article Immunology

Nephrotic Syndrome and Subepithelial Deposits in a Mouse Model of Immune-Mediated Anti-Podocyte Glomerulonephritis

Catherine Meyer-Schwesinger et al.

JOURNAL OF IMMUNOLOGY (2011)

添加到收藏夹

Article Medicine, Research & Experimental

Correlation between B Lymphocyte Abnormality and Disease Activity in Patients with Idiopathic Membranous Nephropathy

B. Wang et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2011)

添加到收藏夹

Article Medicine, General & Internal

Risk HLA-DQA1 and PLA(sub 2)R1 Alleles in Idiopathic Membranous Nephropathy.

Horia C. Stanescu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

添加到收藏夹

Article Medicine, Research & Experimental

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

Bjoern Hartleben et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

添加到收藏夹

Article Urology & Nephrology

Autoimmunity in Membranous Nephropathy Targets Aldose Reductase and SOD2

Marco Prunotto et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)

添加到收藏夹

Article Transplantation

Long-term outcome of renal transplantation in patients with idiopathic membranous glomerulonephritis (MN)

Gabriella Moroni et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2010)

添加到收藏夹

Letter Medicine, General & Internal

PLA2R Autoantibodies and Recurrent Membranous Nephropathy after Transplantation

Rolf Stahl et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

添加到收藏夹

Article Oncology

A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCH-L1) in podocyte process formation and podocyte injury in human glomerulopathies

C. Meyer-Schwesinger et al.

JOURNAL OF PATHOLOGY (2009)

添加到收藏夹

Article Medicine, General & Internal

M-Type Phospholipase A(sub 2) Receptor as Target Antigen in Idiopathic Membranous Nephropathy.

Laurence H. Beck et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

添加到收藏夹

Article Surgery

Recurrent idiopathic membranous nephropathy after kidney transplantation: A surveillance biopsy study

T. S. Dabade et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2008)

添加到收藏夹

Article Gastroenterology & Hepatology

Redirection of regulatory T cells with predetermined specificity for the treatment of experimental colitis in mice

Eran Elinav et al.

GASTROENTEROLOGY (2008)

添加到收藏夹

Article Biochemistry & Molecular Biology

Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy

Tomohiro Kabuta et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

添加到收藏夹

Article Immunology

CD4+FoxP3+ regulatory T cells confer infectious tolerance in a TGF-β-dependent manner

John Andersson et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

添加到收藏夹

Article Urology & Nephrology

Intramolecular epitope spreading in Heymann nephritis

Pallavi Shah et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2007)

添加到收藏夹

Article Urology & Nephrology

A new mouse model of immune-mediated podocyte injury

T. N. Meyer et al.

KIDNEY INTERNATIONAL (2007)

添加到收藏夹

Article Immunology

Induction of passive Heymann nephritis in complement component 6-deficient PVG rats

S. Timothy Spicer et al.

JOURNAL OF IMMUNOLOGY (2007)

添加到收藏夹

Article Urology & Nephrology

A randomized, controlled trial of steroids and cyclophosphamide in adults with nephrotic syndrome caused by idiopathic membranous nephropathy

Vivekanand Jha et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2007)

添加到收藏夹

Article Oncology

Expression of neutral endopeptidase (NEP/CD10) on pancreatic tumor cell lines, pancreatitis and pancreatic tumor tissues

Mabruk Erhuma et al.

INTERNATIONAL JOURNAL OF CANCER (2007)

添加到收藏夹

Article Urology & Nephrology

Autocrine class 3 semaphorin system regulates slit diaphragm proteins and podocyte survival

F Guan et al.

KIDNEY INTERNATIONAL (2006)

添加到收藏夹

Review Physiology

Experimental membranous nephropathy redux

AV Cybulsky et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2005)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Human netrin-G1 isoforms show evidence of differential expression

JMA Meerabux et al.

GENOMICS (2005)

添加到收藏夹

Article Urology & Nephrology

Th2 cytokines increase and stimulate B cells to produce IgG4 in idiopathic membranous nephropathy

A Kuroki et al.

KIDNEY INTERNATIONAL (2005)

添加到收藏夹

Article Immunology

Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis

V Viglietta et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2004)

添加到收藏夹

Article Transplantation

Up-regulated interleukin-4 production by peripheral T-helper cells in idiopathic membranous nephropathy

K Masutani et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2004)

添加到收藏夹

Article Immunology

Conformation and glycosylation of a Megalin fragment correlate with nephritogenicity in Heymann nephritis

A Tramontano et al.

JOURNAL OF IMMUNOLOGY (2004)

添加到收藏夹

Article Immunology

Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy

MR Ehrenstein et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2004)

添加到收藏夹

Article Medicine, General & Internal

Role of truncating mutations in MME gene in fetomaternal alloimmunisation and antenatal glomerulopathies

H Debiec et al.

LANCET (2004)

添加到收藏夹

Article Immunology

Quantification of regulatory T cells in patients with systemic lupus erythematosus

JC Crispin et al.

JOURNAL OF AUTOIMMUNITY (2003)

添加到收藏夹

Article Urology & Nephrology

Rat glomerular epithelial cells produce and bear factor H on their surface that is up-regulated under complement attack

GH Ren et al.

KIDNEY INTERNATIONAL (2003)

添加到收藏夹

Article Urology & Nephrology

Podocyte changes after induction of acute albuminuria in mice by anti-aminopeptidase A mAb

HBPM Dijkman et al.

NEPHRON EXPERIMENTAL NEPHROLOGY (2003)

添加到收藏夹

Article Immunology

Infectious tolerance:: Human CD25+ regulatory T cells convey suppressor activity to conventional CD4+ T helper cells

H Jonuleit et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2002)

添加到收藏夹

Article Medicine, General & Internal

Brief report - Antenatal membranous glomerulonephritis due to anti-neutral endopeptidase antibodies

H Debiec et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

添加到收藏夹

Article Urology & Nephrology

Predominance of type-2 immune response in idiopathic membranous nephropathy - Cytoplasmic cytokine analysis

K Hirayama et al.

NEPHRON (2002)

添加到收藏夹

Article Urology & Nephrology

Cyclosporine in patients with steroid-resistant membranous nephropathy: A randomized trial

DC Cattran et al.

KIDNEY INTERNATIONAL (2001)

添加到收藏夹

Article Urology & Nephrology

No complement receptor 1 stumps on podocytes in human glomerulopathies

S Moll et al.

KIDNEY INTERNATIONAL (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.