☆ 4.8 Review

Exhaust the exhausters: Targeting regulatory T cells in the tumor microenvironment

FRONTIERS IN IMMUNOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Oncology

Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments

Shogo Kumagai et al.

Summary: In highly glycolytic tumors, regulatory T (Treg) cells have higher PD-1 expression compared to effector T cells. Under low-glucose conditions, Treg cells actively absorb lactic acid through monocarboxylate transporter 1 (MCT1), promoting the expression of PD-1, while PD-1 expression by effector T cells is dampened. PD-1 blockade invigorates PD-1-expressing Treg cells, resulting in treatment failure.

CANCER CELL (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Hypoxia-driven immunosuppression by Treg and type-2 conventional dendritic cells in HCC

Sheena Suthen et al.

Summary: This study analyzed the immune landscapes of hypoxic regions in hepatocellular carcinoma (HCC) and identified enriched immune subsets, including regulatory T cells, M2 macrophages, and HLA-DRlo cDC2, in hypoxia-high tumor regions. In contrast, hypoxia-low tumor regions showed an abundance of active granzyme B-hi PD-1(lo) CD8(+) T cells, indicating a relatively active immune landscape. The up-regulation of cancer-associated genes in tumor tissues and immunosuppressive genes in tumor-infiltrating leukocytes supported a highly pro-tumorigenic network in hypoxic HCC.

HEPATOLOGY (2022)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Key chemokines direct migration of immune cells in solid tumors

Karan Kohli et al.

Summary: Immune cell infiltration into solid tumors and their interactions with chemokine receptors play a crucial role in tumor growth and the balance between effector and immunosuppressive cells. This review discusses the implications of dysregulated chemokine signaling in the tumor microenvironment and the potential for targeting chemokine signaling in cancer immunotherapy.

CANCER GENE THERAPY (2022)

添加到收藏夹

Review Oncology

Immune-checkpoint inhibitors: long-term implications of toxicity

Douglas B. Johnson et al.

Summary: Immune-checkpoint inhibitors have improved outcomes for advanced-stage solid tumour patients, but they also carry the risk of chronic toxicities that can affect patients' quality of life. While evidence on chronic toxicities is limited, emerging evidence suggests that they may be more common than previously thought. These toxicities can affect various organ systems and may even lead to fatal outcomes. Research on the effects of immune-checkpoint blockade on other immune processes is also important for cancer survivors.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

添加到收藏夹

Article Immunology

FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor Microenvironment by Inducing CCR4 Expression in Breast Cancer

Tania Sarkar et al.

Summary: Tumor-infiltrating T-regulatory cells play a significant role in immunotherapy resistance, and the chemokine receptor CCR4 is involved in regulating their infiltration. The transcription activator FOXP3 not only activates CCR4 but also regulates T-regulatory cell infiltration in the tumor microenvironment. Genetic ablation of FOXP3 reduces tumor size and restores anti-tumor immunity, while overexpression of FOXP3 increases tumor infiltration and progression.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Oncology

Tumor-associated Tregs obstruct antitumor immunity by promoting T cell dysfunction and restricting clonal diversity in tumor-infiltrating CD8+T cells

David Noyes et al.

Summary: This study demonstrates that the accumulation of Tregs contributes to the dysfunction and clonal constriction of tumor-infiltrating CD8 +T cells. The dysfunctional phenotype of CD8 +T cells is reversed upon reduction of Tregs, and this is mediated by Treg-expressed CTLA-4.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

添加到收藏夹

Review Biology

GARP: A Key Target to Evaluate Tumor Immunosuppressive Microenvironment

Alexanne Bouchard et al.

Summary: GARP is widely expressed in cancer and plays a crucial role in the TGF-beta pathway, promoting cancer progression and contributing to immune evasion. Its potential as a predictive and therapeutic biomarker in real time assessment through molecular imaging is also highlighted.

BIOLOGY-BASEL (2021)

添加到收藏夹

Article Immunology

PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance

Catherine L. Tan et al.

Summary: Studies have shown that PD-1-deficient T reg cells exhibit enhanced immunosuppressive function through reduced signaling through the PI3K-AKT pathway. This finding demonstrates that cell-intrinsic PD-1 restraint of T reg cells is a significant mechanism by which PD-1 inhibitory signals regulate T cell tolerance and autoimmunity.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Effect of Hypoxia on the Expression of CXC Chemokines and CXC Chemokine Receptors-A Review of Literature

Jan Korbecki et al.

Summary: Hypoxia plays a crucial role in the tumor microenvironment, affecting cancer processes. Changes in CXC chemokine expression induced by hypoxia have implications for angiogenesis, lymphangiogenesis, and recruitment of various cells to the tumor niche. Targeting the CXC chemokine system with drugs has potential in cancer therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Review Immunology

The Therapeutic Potential of Regulatory T Cells: Challenges and Opportunities

Fatemeh Bayati et al.

Summary: Regulatory T cells (Tregs) are a subgroup of CD4(+) T cells that play a key role in immune tolerance regulation, preventing autoimmunity and aiding tumor evasion of immune recognition. Their therapeutic potential in transplantation, autoimmune diseases, and cancer therapy is being actively studied for improving treatment options.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Immunology

Tumor Hypoxia Regulates Immune Escape/Invasion: Influence on Angiogenesis and Potential Impact of Hypoxic Biomarkers on Cancer Therapies

Raefa Abou Khouzam et al.

Summary: The environmental and metabolic pressures in the tumor microenvironment have a significant impact on tumor development, especially hypoxia-triggered events that promote growth, enhance resistance to the immune response, and stimulate angiogenesis. Normalizing tumor vasculature can restore integrity, increase perfusion, alleviate hypoxia, and reshape anti-tumor immunity, offering potential in achieving stable vascular normalization for mature and functional blood vessels.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Oncology

Differences in TCR repertoire and T cell activation underlie the divergent outcomes of antitumor immune responses in tumor-eradicating versus tumor-progressing hosts

Rachel A. Woolaver et al.

Summary: The study reveals that intrinsic differences in the TCR repertoire of TILs and their different transcriptional trajectories may underlie the heterogeneous antitumor immune responses in different hosts. Antitumor immune responses are highly individualized and different hosts employ different TCR specificities against the same tumors, which may have important implications for developing personalized cancer immunotherapy.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

添加到收藏夹

Review Oncology

Metabolic profiles of regulatory T cells in the tumour microenvironment

Disha Rao et al.

Summary: Metabolic reprogramming in cancer cells leads to the formation of a tumour microenvironment characterized by nutrient restriction, hypoxia, acidity, and oxidative stress, unfavorable for effector T cells but conducive for immune-suppressive functions of Tregs. Tregs rely on oxidative phosphorylation for their functions and have metabolic adaptations in the tumour microenvironment. Targeting pathways responsible for Tregs' adaptation in the tumour microenvironment can improve anti-tumour immunity in preclinical models.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

添加到收藏夹

Letter Immunology

Autocrine transforming growth factor β1 in regulatory T cell biology-gone but not missed

Maria Velegraki et al.

IMMUNITY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours

Roberta Zappasodi et al.

Summary: By blocking CTLA-4, metabolic fitness and immune cell infiltration in tumours, especially those with low glycolytic activity, can be enhanced. This improves therapeutic outcomes, particularly in tumours with defective glycolysis, by destabilizing T-reg cells and promoting the activity of tumour-specific CD8(+) T cells.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

McLane J. Watson et al.

Summary: T-reg cells exhibit broad heterogeneity in glucose metabolism within normal and transformed tissues, utilizing an alternative metabolic pathway to maintain their suppressive function and proliferation. Glucose uptake is correlated with poorer suppressive function and long-term instability, while high-glucose conditions impair T-reg cell function and stability. Additionally, T-reg cells upregulate pathways involved in the metabolism of lactic acid, with lactate uptake being dispensable for peripheral T-reg cells but required intratumorally for slowed tumor growth and increased response to immunotherapy.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Lipid signalling enforces functional specialization of Treg cells in tumours

Seon Ah Lim et al.

Summary: Regulatory T cells play a crucial role in immune tolerance and immunosuppression in the tumor microenvironment. Inhibiting lipid synthesis dependent on SREBPs in T-reg cells can enhance antitumor immune responses without autoimmune toxicity, and deletion of SCAP in these cells inhibits tumor growth and enhances immunotherapy. SCAP and SREBPs signaling regulate lipid synthesis and inhibitory receptor signaling in T-reg cells, pointing to new ways of targeting these cells for cancer therapy.

NATURE (2021)

添加到收藏夹

Article Cell Biology

Prevalence of intratumoral regulatory T cells expressing neuropilin-1 is associated with poorer outcomes in patients with cancer

Christopher A. Chuckran et al.

Summary: Despite the success of immune checkpoint blockade therapy, targeting regulatory T cells (T-regs) within the tumor microenvironment remains a challenge due to the need for specificity to avoid systemic inflammation. Neuropilin-1 (NRP1) is preferentially expressed by intratumoral T-regs and may indicate higher disease burden in patients. NRP1 marks a transient activation state of human T-regs driven by continuous T cell receptor signaling and interleukin-2 exposure.

SCIENCE TRANSLATIONAL MEDICINE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients

Maria Xydia et al.

Summary: Regulatory T cells in breast cancer do not show clonal relationship with their circulating counterpart, but share a common origin with intratumoral antigen-experienced conventional T cells.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression

Enja Schneider et al.

Summary: Immune cells at sites of inflammation are continuously activated by local antigens and cytokines, and regulatory mechanisms must be enacted to control inflammation. Human effector CD8 T cells contribute to adenosine production by releasing CD73-containing extracellular vesicles, which suppress immune responses independently of regulatory T cells. The study suggests that these extracellular vesicles derived from CD8 T cells serve as intrinsic regulators of immune responses in inflamed tissues.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Oncology

Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy

Helena Van Damme et al.

Summary: Regulatory T cells (Tregs) play a role in antitumor immunotherapy, but lack of selectivity for tumor-infiltrating Tregs can lead to adverse effects. CCR8-specific nanobodies were developed to selectively deplete tumor-promoting Tregs in mouse and human tumors, synergizing with anti-PD-1 therapy and reducing tumor growth through NK cell-dependent mechanisms. Targeting CCR8 may be an effective and safe strategy for antitumor immunotherapy.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

添加到收藏夹

Article Immunology

A Novel TGF-β Risk Score Predicts the Clinical Outcomes and Tumour Microenvironment Phenotypes in Bladder Cancer

Zhi Liu et al.

Summary: In this study, a TGF-beta signature was constructed and validated to predict prognosis and TME phenotypes for BLCA. The TGF-beta risk score could assist in individual precision treatment for BLCA.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function

Sarah K. Whiteside et al.

Summary: CCR8 function is not essential for Treg cell accumulation and immunosuppressive function within tumors, suggesting that depletion of CCR8(+) Treg cells rather than blockade of CCR8 function may be a more promising avenue for selective immunotherapy.

IMMUNOLOGY (2021)

添加到收藏夹

Review Oncology

Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy

Kai Tang et al.

Summary: IDO1 is an important heme enzyme involved in cancer immune escape, associated with poor prognosis in various cancers, and currently undergoing clinical trials with multiple drugs. The development of IDO1 degraders using PROTAC technology presents a novel therapeutic approach.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

添加到收藏夹

Article Oncology

High TGF-β signature predicts immunotherapy resistance in gynecologic cancer patients treated with immune checkpoint inhibition

Ying Ni et al.

Summary: This study focused on immune checkpoint inhibitor resistance in gynecological cancer patients. It found that immune-related toxicity predicted ICI treatment response, while objective clinical response was a key predictor of survival outcomes. The TGF-beta signaling pathway was identified as playing a significant role in immunotherapy failure, with a 6-gene TGF-beta score showing promise in predicting ICI treatment outcomes, particularly in ovarian cancer.

NPJ PRECISION ONCOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas

Zohreh Amoozgar et al.

Summary: In this study, researchers found that treatment with an agonistic anti-GITR antibody converts tumor infiltrating regulatory T cells to effector cells, overcoming resistance to PD1 blockade in preclinical models of GBM.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Review Oncology

Cytokine-based Cancer Immunotherapy: Challenges and Opportunities for IL-10

Kathrine S. Rallis et al.

Summary: Cancer immunotherapy is a rapidly evolving research field, with cytokines considered as a potential therapy but only IFN-alpha and IL-2 approved by the FDA. Challenges with cytokine-based cancer therapies include high toxicity and low efficacy, but advancements in molecular engineering offer potential for optimization in the future.

ANTICANCER RESEARCH (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop

Francesco Marangoni et al.

Summary: The study reveals that T regulatory cells interact with tumor-associated conventional dendritic cells to receive activation signals and self-regulate their function through a CTLA-4- and CD28-dependent feedback loop. CTLA-4 blockade may lead to Treg cell hyper-proliferation and impact therapeutic benefits in cancer patients.

CELL (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

CD39 Regulation and Functions in T Cells

Eleonora Timperi et al.

Summary: CD39, along with CD73, plays a crucial role in converting adenosine triphosphate into an immunosuppressive form of adenosine in the tumor microenvironment. Environmental and genetic factors shape the expression of CD39, which has significant functions in regulating T cell activities. Studies from preclinical models to clinical trials have contributed essential insights into novel combinatorial approaches for cancer treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Immunology

Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity

Yugang Guo et al.

Summary: The study demonstrates that a half-life-extended IL-10-Fc fusion protein can enhance the function of terminally exhausted CD8(+) tumor-infiltrating lymphocytes by promoting oxidative phosphorylation, leading to improved response to cancer immunotherapy.

NATURE IMMUNOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells

Murat Tekguc et al.

Summary: Regulatory T cells reduce the expression of CD80/CD86 on antigen-presenting cells through CTLA-4-dependent trogocytosis, inhibiting T cell immune responses. This mechanism can have dual suppressive effects, limiting CD80/CD86 costimulation to naive T cells and increasing free PD-L1 available for the inhibition of PD-1-expressing effector T cells.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Article Immunology

Novel anti-GARP antibody DS-1055a augments anti-tumor immunity by depleting highly suppressive GARP+ regulatory T cells

Kazuki Satoh et al.

Summary: Regulatory T (Treg) cells play a crucial role in maintaining self-tolerance but can inhibit anti-tumor immunity, hindering effective immune responses against cancer. Targeting glycoprotein A repetitions predominant (GARP) can deplete Treg cells and activate effector T cells, showing potential for enhancing anti-tumor immunity in cancer immunotherapy.

INTERNATIONAL IMMUNOLOGY (2021)

添加到收藏夹

Review Oncology

Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer

Chunxiao Li et al.

Summary: Macrophages play a crucial role in the tumor microenvironment, where they can be polarized into tumor-associated macrophages (TAMs). The abundance of TAMs in tumors is closely linked with poor prognosis, leading to investigations into therapeutic strategies targeting TAMs. These strategies include inhibiting macrophage recruitment to tumors, repolarizing TAMs towards an anti-tumor phenotype, and inducing macrophage-mediated destruction of cancer cells. As tumor immunotherapy gains more importance, new anti-tumor strategies focusing on TAMs are being discussed.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

添加到收藏夹

Review Immunology

Regulatory T Cell Development

Peter A. Savage et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 38 (2020)

添加到收藏夹

Article Oncology

Enhanced Lipid Accumulation and Metabolism Are Required for the Differentiation and Activation of Tumor-Associated Macrophages

Pan Su et al.

CANCER RESEARCH (2020)

添加到收藏夹

Article Immunology

CTLA-4: From mechanism to autoimmune therapy

Arezoo Hosseini et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

添加到收藏夹

Article Immunology

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

Haiping Wang et al.

NATURE IMMUNOLOGY (2020)

添加到收藏夹

Article Cell Biology

Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β

Alessandra Metelli et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

添加到收藏夹

Article Cell Biology

Treg-Cell-Derived IL-35-Coated Extracellular Vesicles Promote Infectious Tolerance

Jeremy A. Sullivan et al.

CELL REPORTS (2020)

添加到收藏夹

Article Immunology

An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells

Shogo Kumagai et al.

IMMUNITY (2020)

添加到收藏夹

Article Oncology

Genetically driven CD39 expression shapes human tumor-infiltrating CD8+ T-cell functions

Daniela Gallerano et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

添加到收藏夹

Review Oncology

Neuropilin-1: a checkpoint target with unique implications for cancer immunology and immunotherapy

Christopher A. Chuckran et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

添加到收藏夹

Article Immunology

Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding

Lawrence P. Andrews et al.

SCIENCE IMMUNOLOGY (2020)

添加到收藏夹

Article Immunology

Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells

Teresa Manzo et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

添加到收藏夹

Review Oncology

Identifying and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors

Vid Leko et al.

CANCER CELL (2020)

添加到收藏夹

Article Cell Biology

Regulatory T cells: Master thieves of the immune system

Billur Akkaya et al.

CELLULAR IMMUNOLOGY (2020)

添加到收藏夹

Review Oncology

Towards new horizons: characterization, classification and implications of the tumour antigenic repertoire

Sebastian P. Haen et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

添加到收藏夹

Article Immunology

Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity

Jacob A. Turner et al.

IMMUNITY (2020)

添加到收藏夹

Article Immunology

The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies

Shogo Kumagai et al.

NATURE IMMUNOLOGY (2020)

添加到收藏夹

Article Immunology

PD-1+Tregcells: a foe in cancer immunotherapy?

Halil-Ibrahim Aksoylar et al.

NATURE IMMUNOLOGY (2020)

添加到收藏夹

Review Multidisciplinary Sciences

Revisiting the PD-1 pathway

Nikolaos Patsoukis et al.

SCIENCE ADVANCES (2020)

添加到收藏夹

Meeting Abstract Oncology

The CD25 antibody RG6292 selectively depletes Tregs while preserving IL-2 signaling and CTL activity for tumor control

Maria Amann et al.

CANCER RESEARCH (2020)

添加到收藏夹

Article Oncology

CD25-Treg-depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity

Isabelle Solomon et al.

NATURE CANCER (2020)

添加到收藏夹

Article Cell Biology

GARP promotes the proliferation and therapeutic resistance of bone sarcoma cancer cells through the activation of TGF-β

Ana Belen Carrillo-Galvez et al.

CELL DEATH & DISEASE (2020)

添加到收藏夹

Article Oncology

Tumors establish resistance to immunotherapy by regulating T-reg recruitment via CCR4

Lisa A. Marshall et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

添加到收藏夹

Article Oncology

GARP Dampens Cancer Immunity by Sustaining Function and Accumulation of Regulatory T Cells in the Colon

Mohammad Salem et al.

CANCER RESEARCH (2019)

添加到收藏夹

Article Immunology

Cutting Edge: IL-27 Attenuates Autoimmune Neuroinflammation via Regulatory T Cell/Lag3-Dependent but IL-10-Independent Mechanisms In Vivo

Dongkyun Kim et al.

JOURNAL OF IMMUNOLOGY (2019)

添加到收藏夹

Article Immunology

Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion

Deepali Sawant et al.

NATURE IMMUNOLOGY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Rational design of anti-GITR-based combination immunotherapy

Roberta Zappasodi et al.

NATURE MEDICINE (2019)

添加到收藏夹

Article Multidisciplinary Sciences

PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

Takahiro Kamada et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

添加到收藏夹

Article Oncology

Targeting Tumors with IL-10 Prevents Dendritic Cell-Mediated CD8+ T Cell Apoptosis

Jian Qiao et al.

CANCER CELL (2019)

添加到收藏夹

Article Immunology

Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ

Chang Liu et al.

IMMUNITY (2019)

添加到收藏夹

Article Chemistry, Medicinal

Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment

Jeffrey J. Jackson et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

添加到收藏夹

Article Oncology

IL-10 secreted by cancer-associated macrophages regulates proliferation and invasion in gastric cancer cells via c-Met/STAT3 signaling

Ling Chen et al.

ONCOLOGY REPORTS (2019)

添加到收藏夹

Review Immunology

Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment

Heidi Harjunpaa et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Review Immunology

CIITA-Driven MHC Class II Expressing Tumor Cells as Antigen Presenting Cell Performers: Toward the Construction of an Optimal Anti-tumor Vaccine

Roberto S. Accolla et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Immunology

CD4+ T cell exhaustion revealed by high PD-1 and LAG-3 expression and the loss of helper T cell function in chronic hepatitis B

Yuejiao Dong et al.

BMC IMMUNOLOGY (2019)

添加到收藏夹

Review Immunology

Helios: still behind the clouds

Angela M. Thornton et al.

IMMUNOLOGY (2019)

添加到收藏夹

Review Oncology

Tumor neoantigens: from basic research to clinical applications

Tao Jiang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

添加到收藏夹

Article Oncology

Pegilodecakin combined with pembrolizumab or nivolumab for patients with advanced solid tumours (IVY): a multicentre, multicohort, open-label, phase 1b trial

Aung Naing et al.

LANCET ONCOLOGY (2019)

添加到收藏夹

Article Immunology

Different Expression Characteristics of LAG3 and PD-1 in Sepsis and Their Synergistic Effect on T Cell Exhaustion: A New Strategy for Immune Checkpoint Blockade

Bailin Niu et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Blocking TGF-β Signaling To Enhance The Efficacy Of Immune Checkpoint Inhibitor

Xianguang Bai et al.

ONCOTARGETS AND THERAPY (2019)

添加到收藏夹

Article Immunology

Regulatory T cells mediate specific suppression by depleting peptide-MHC class II from dendritic cells

Billur Akkaya et al.

NATURE IMMUNOLOGY (2019)

添加到收藏夹

Review Oncology

T-Regulatory Cells In Tumor Progression And Therapy

Amit Verma et al.

CANCER MANAGEMENT AND RESEARCH (2019)

添加到收藏夹

Review Immunology

Lymphocyte-activation gene 3 (LAG3): The next immune checkpoint receptor

Elisa Ruffo et al.

SEMINARS IN IMMUNOLOGY (2019)

添加到收藏夹

Review Immunology

Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation

Ludger Klein et al.

NATURE REVIEWS IMMUNOLOGY (2019)

添加到收藏夹

Article Immunology

Tumor-infiltrating human CD4(+) regulatory T cells display a distinct TCR repertoire and exhibit tumor and neoantigen reactivity

Mojgan Ahmadzadeh et al.

SCIENCE IMMUNOLOGY (2019)

添加到收藏夹

Review Oncology

Immunoregulatory functions and the therapeutic implications of GARP-TGF-β in inflammation and cancer

Alessandra Metelli et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

添加到收藏夹

Review Cell Biology

Contextual determinants of TGFβ action in development, immunity and cancer

Charles J. David et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth

Ilenia Pacella et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization

Chih-Chan Lee et al.

NATURE COMMUNICATIONS (2018)

添加到收藏夹

Article Immunology

Increased Mitochondrial Biogenesis and Reactive Oxygen Species Production Accompany Prolonged CD4(+) T Cell Activation

Billur Akkaya et al.

JOURNAL OF IMMUNOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types

Angela M. Magnuson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

添加到收藏夹

Review Immunology

CTLA-4 and PD-1 Control of T-Cell Motility and Migration: Implications for Tumor Immunotherapy

Monika C. Brunner-Weinzierl et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Review Immunology

Revisiting IL-2: Biology and therapeutic prospects

Abul K. Abbas et al.

SCIENCE IMMUNOLOGY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Extracellular purines, purinergic receptors and tumor growth

F. Di Virgilio et al.

ONCOGENE (2017)

添加到收藏夹

Article Immunology

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

Frederick Arce Vargas et al.

IMMUNITY (2017)

添加到收藏夹

Review Endocrinology & Metabolism

SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology

Hitoshi Shimano et al.

NATURE REVIEWS ENDOCRINOLOGY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

CCR8+FOXp3+ Treg cells as master drivers of immune regulation

Yiftah Barsheshet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression

Chongbiao Huang et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Article Oncology

Human Tumor Antigens Yesterday, Today, and Tomorrow

Olivera J. Finn

CANCER IMMUNOLOGY RESEARCH (2017)

添加到收藏夹

Article Oncology

GITR ligand fusion protein agonist enhances the tumor antigen-specific CD8 T-cell response and leads to long-lasting memory

Nick M. Durham et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Tumor-derived factors affecting immune cells

Vincenzo Russo et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2017)

添加到收藏夹

Article Cell Biology

Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments

Alessia Angelin et al.

CELL METABOLISM (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity

Abigail E. Overacre-Delgoffe et al.

CELL (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Metabolic Instruction of Immunity

Michael D. Buck et al.

CELL (2017)

添加到收藏夹

Article Immunology

LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes

Qianxia Zhang et al.

SCIENCE IMMUNOLOGY (2017)

添加到收藏夹

Article Immunology

An IL-27/Lag3 axis enhances Foxp3(+) regulatory T cell-suppressive function and therapeutic efficacy

J-s Do et al.

MUCOSAL IMMUNOLOGY (2016)

添加到收藏夹

Article Immunology

Interleukin-35 Limits Anti-Tumor Immunity

Meghan E. Tumis et al.

IMMUNITY (2016)

添加到收藏夹

Article Immunology

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells

Marco De Simone et al.

IMMUNITY (2016)

添加到收藏夹

Article Immunology

Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer

George Plitas et al.

IMMUNITY (2016)

添加到收藏夹

Article Oncology

Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (AM0010) in Patients With Advanced Solid Tumors

Aung Naing et al.

JOURNAL OF CLINICAL ONCOLOGY (2016)

添加到收藏夹

Review Oncology

The future of cancer treatment: immunomodulation, CARs and combination immunotherapy

Danny N. Khalil et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2016)

添加到收藏夹

Review Cell Biology

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

Weiping Zou et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

添加到收藏夹

Review Immunology

Metabolic pathways in T cell activation and lineage differentiation

Luis Almeida et al.

SEMINARS IN IMMUNOLOGY (2016)

添加到收藏夹

Article Oncology

A key role of GARP in the immune suppressive tumor microenvironment

Susanne A. Hahn et al.

ONCOTARGET (2016)

添加到收藏夹

Article Oncology

IL-10 secreted by M2 macrophage promoted tumorigenesis through interaction with JAK2 in glioma

Ling Qi et al.

ONCOTARGET (2016)

添加到收藏夹

Article Oncology

Hypoxia-induced CCL28 promotes recruitment of regulatory T cells and tumor growth in liver cancer

Li Ren et al.

ONCOTARGET (2016)

添加到收藏夹

Article Medicine, Research & Experimental

PD-1 marks dysfunctional regulatory T cells in malignant gliomas

Daniel E. Lowther et al.

JCI INSIGHT (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

Chih-Hao Chang et al.

CELL (2015)

添加到收藏夹

Article Oncology

Regulatory T cells-derived IL-35 promotes the growth of adult acute myeloid leukemia blasts

Qianshan Tao et al.

INTERNATIONAL JOURNAL OF CANCER (2015)

添加到收藏夹

Article Immunology

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity

Alison M. Paterson et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

添加到收藏夹

Review Immunology

Control of Regulatory T Cell Migration, Function, and Homeostasis

Daniel J. Campbell

JOURNAL OF IMMUNOLOGY (2015)

添加到收藏夹

Review Immunology

Confusing signals: Recent progress in CTLA-4 biology

Lucy S. K. Walker et al.

TRENDS IN IMMUNOLOGY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo

Huey-Wen Hsiao et al.

NATURE COMMUNICATIONS (2015)

添加到收藏夹

Review Medicine, General & Internal

PI3K/AKT signaling pathway and cancer: an updated review

Miriam Martini et al.

ANNALS OF MEDICINE (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

IL-35 promotes pancreas cancer growth through enhancement of proliferation and inhibition of apoptosis: Evidence for a role as an autocrine growth factor

Michael B. Nicholl et al.

CYTOKINE (2014)

添加到收藏夹

Review Immunology

tTregs, pTregs, and iTregs: similarities and differences

Ethan M. Shevach et al.

IMMUNOLOGICAL REVIEWS (2014)

添加到收藏夹

Article Medicine, Research & Experimental

Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction

Christian A. Bauer et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

添加到收藏夹

Article Immunology

Release of Active TGF-β1 from the Latent TGF-β1/GARP Complex on T Regulatory Cells Is Mediated by Integrin β8

Justin P. Edwards et al.

JOURNAL OF IMMUNOLOGY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Thymocyte apoptosis drives the intrathymic generation of regulatory T cells

Joanne E. Konkel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation

Hongmei Fu et al.

NATURE COMMUNICATIONS (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease

Amos A. Fatokun et al.

AMINO ACIDS (2013)

添加到收藏夹

Review Immunology

Metabolic Regulation of T Lymphocytes

Nancie J. MacIver et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 (2013)

添加到收藏夹

Article Immunology

Modulation of Treg cells/T effector function by GITR signaling is context-dependent

Amal Ephrem et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2013)

添加到收藏夹

Review Immunology

Treg and CTLA-4: Two intertwining pathways to immune tolerance

Lucy S. K. Walker

JOURNAL OF AUTOIMMUNITY (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis

Greg M. Delgoffe et al.

NATURE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Intratumor Hypoxia Promotes Immune Tolerance by Inducing Regulatory T Cells via TGF-β1 in Gastric Cancer

Bin Deng et al.

PLOS ONE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans

Daisuke Sugiyama et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells

Sven Malchow et al.

SCIENCE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

E. L. Pearce et al.

SCIENCE (2013)

添加到收藏夹

Review Oncology

The roles of TGFβ in the tumour microenvironment

Michael Pickup et al.

NATURE REVIEWS CANCER (2013)

添加到收藏夹

Review Immunology

Regulatory T Cells: Mechanisms of Differentiation and Function

Steven Z. Josefowicz et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 30 (2012)

添加到收藏夹

Article Oncology

Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape

Seng-Ryong Woo et al.

CANCER RESEARCH (2012)

添加到收藏夹

Article Oncology

IL-10 Directly Activates and Expands Tumor-Resident CD8+ T Cells without De Novo Infiltration from Secondary Lymphoid Organs

Jan Emmerich et al.

CANCER RESEARCH (2012)

添加到收藏夹

Article Oncology

The T-cell Receptor Repertoire of Tumor-Infiltrating Regulatory T Lymphocytes Is Skewed Toward Public Sequences

Alexander Sainz-Perez et al.

CANCER RESEARCH (2012)

添加到收藏夹

Article Immunology

Trogocytosis of CD80 and CD86 by induced regulatory T cells

Peng Gu et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2012)

添加到收藏夹

Review Immunology

Modulation of GITR for cancer immunotherapy

David A. Schaer et al.

CURRENT OPINION IN IMMUNOLOGY (2012)

添加到收藏夹

Review Immunology

mTOR, metabolism, and the regulation of T-cell differentiation and function

Adam T. Waickman et al.

IMMUNOLOGICAL REVIEWS (2012)

添加到收藏夹

Review Immunology

Metabolic switching and fuel choice during T-cell differentiation and memory development

Gerritje J. W. van der Windt et al.

IMMUNOLOGICAL REVIEWS (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

Eric T. Clambey et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

添加到收藏夹

Article Oncology

IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance

John B. Mumm et al.

CANCER CELL (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

Eric V. Dang et al.

CELL (2011)

添加到收藏夹

Article Immunology

Autocrine Transforming Growth Factor-β1 Promotes In Vivo Th17 Cell Differentiation

Ilona Gutcher et al.

IMMUNITY (2011)

添加到收藏夹

Article Immunology

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

Ryan D. Michalek et al.

JOURNAL OF IMMUNOLOGY (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

Andrea Facciabene et al.

NATURE (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

Omar S. Qureshi et al.

SCIENCE (2011)

添加到收藏夹

Article Cell Biology

Cross Talk among TGF-β Signaling Pathways, Integrins, and the Extracellular Matrix

John S. Munger et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

添加到收藏夹

Article Immunology

B7/CD28 in central tolerance: costimulation promotes maturation of regulatory T cell precursors and prevents their clonal deletion

Maria Hinterberger et al.

FRONTIERS IN IMMUNOLOGY (2011)

添加到收藏夹

Article Oncology

Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy

David Coe et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2010)

添加到收藏夹

Article Oncology

Regulatory T cells in tumor immunity

Hiroyoshi Nishikawa et al.

INTERNATIONAL JOURNAL OF CANCER (2010)

添加到收藏夹

Article Immunology

Blockade of CCL1 Inhibits T Regulatory Cell Suppressive Function Enhancing Tumor Immunity without Affecting T Effector Responses

Dominique B. Hoelzinger et al.

JOURNAL OF IMMUNOLOGY (2010)

添加到收藏夹

Article Immunology

Smad2 and Smad3 Are Redundantly Essential for the TGF-β-Mediated Regulation of Regulatory T Plasticity and Th1 Development

Tomohito Takimoto et al.

JOURNAL OF IMMUNOLOGY (2010)

添加到收藏夹

Review Cell Biology

How specificity for self-peptides shapes the development and function of regulatory T cells

Donald M. Simons et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2010)

添加到收藏夹

Article Immunology

IL-35-mediated induction of a potent regulatory T cell population

Lauren W. Collison et al.

NATURE IMMUNOLOGY (2010)

添加到收藏夹

Review Immunology

The regulation of IL-10 production by immune cells

Margarida Saraiva et al.

NATURE REVIEWS IMMUNOLOGY (2010)

添加到收藏夹

Article Oncology

Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome

Michael Gobert et al.

CANCER RESEARCH (2009)

添加到收藏夹

Review Immunology

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

Ethan M. Shevach

IMMUNITY (2009)

添加到收藏夹

Review Immunology

Control of Regulatory T Cell Lineage Commitment and Maintenance

Steven Z. Josefowicz et al.

IMMUNITY (2009)

添加到收藏夹

Review Oncology

Targeting the mTOR Signaling Network for Cancer Therapy

Funda Meric-Bernstam et al.

JOURNAL OF CLINICAL ONCOLOGY (2009)

添加到收藏夹

Article Immunology

Affinity-Based Selection of Regulatory T Cells Occurs Independent of Agonist-Mediated Induction of Foxp3 Expression

Lance M. Relland et al.

JOURNAL OF IMMUNOLOGY (2009)

添加到收藏夹

Article Immunology

The impact of negative selection on thymocyte migration in the medulla

Marie Le Borgne et al.

NATURE IMMUNOLOGY (2009)

添加到收藏夹

Article Hematology

FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions

Mojgan Ahmadzadeh et al.

BLOOD (2008)

添加到收藏夹

Review Biochemistry & Molecular Biology

Role and regulation of prolyl hydroxylase domain proteins

G-H Fong et al.

CELL DEATH AND DIFFERENTIATION (2008)

添加到收藏夹

Article Immunology

Reaulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces

Yuri P. Rubtsov et al.

IMMUNITY (2008)

添加到收藏夹

Article Immunology

CD4+FoxP3+ regulatory T cells confer infectious tolerance in a TGF-β-dependent manner

John Andersson et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

添加到收藏夹

Article Immunology

Immunosurveillance of Lung Melanoma Metastasis in EBI-3-Deficient Mice Mediated by CD8+ T Cells

Kerstin A. Sauer et al.

JOURNAL OF IMMUNOLOGY (2008)

添加到收藏夹

Article Multidisciplinary Sciences

CTLA-4 control over Foxp3+ regulatory T cell function

Kajsa Wing et al.

SCIENCE (2008)

添加到收藏夹

Article Immunology

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

Yukiko Tone et al.

NATURE IMMUNOLOGY (2008)

添加到收藏夹

Article Immunology

CD4+ CD25+ Foxp3+ regulatory T cells induce cytokine deprivation -mediated apoptosis of effector CD4+ T cells

Pushpa Pandiyan et al.

NATURE IMMUNOLOGY (2007)

添加到收藏夹

Article Multidisciplinary Sciences

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

Lauren W. Collison et al.

NATURE (2007)

添加到收藏夹

Article Immunology

Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance

Xuefang Cao et al.

IMMUNITY (2007)

添加到收藏夹

Article Hematology

Expression of ectonucleotidase CD39 by Foxp3+ Treg cells:: hydrolysis of extracellular ATP and immune suppression

Giovanna Borsellino et al.

BLOOD (2007)

添加到收藏夹

Article Immunology

Altering the distribution of Foxp3+ regulatory T cells results in tissue-specific inflammatory disease

Blythe D. Sather et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2007)

添加到收藏夹

Article Immunology

Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4(+) T cells

Jamie Wong et al.

JOURNAL OF IMMUNOLOGY (2007)

添加到收藏夹

Article Multidisciplinary Sciences

A2A adenosine receptor protects tumors from antitumor T cells

Akio Ohta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

添加到收藏夹

Article Immunology

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

Weihong Liu et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

添加到收藏夹

Article Oncology

Specific recruitment of CC chemokine receptor 4-positive regulatory T cells in Hodgkin lymphoma fosters immune privilege

Takashi Ishida et al.

CANCER RESEARCH (2006)

添加到收藏夹

Article Hematology

Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2

M Murga et al.

BLOOD (2005)

添加到收藏夹

Article Immunology

Cutting edge:: TGF-β induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

MC Fantini et al.

JOURNAL OF IMMUNOLOGY (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

TJ Curiel et al.

NATURE MEDICINE (2004)

添加到收藏夹

Article Immunology

Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors

CS Hsieh et al.

IMMUNITY (2004)

添加到收藏夹

Article Immunology

Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells

F Kanamaru et al.

JOURNAL OF IMMUNOLOGY (2004)

添加到收藏夹

Article Immunology

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3

WJ Chen et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)

添加到收藏夹

Review Biochemistry & Molecular Biology

TGF-β:: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression

WJ Chen et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2003)

添加到收藏夹

Article Immunology

CTLA-4-Ig regulates tryptophan catabolism in vivo

U Grohmann et al.

NATURE IMMUNOLOGY (2002)

添加到收藏夹

Article Immunology

Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4+CD25+ regulatory T cells

A Iellem et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2001)

添加到收藏夹

Article Genetics & Heredity

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

ME Brunkow et al.

NATURE GENETICS (2001)

添加到收藏夹

Article Genetics & Heredity

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

CL Bennett et al.

NATURE GENETICS (2001)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.