期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.1059133
关键词
high-throughput sequencing technologies; EBV therapeutics; EBV animal models; molecular mechanisms of EBV-host interactions; EBV-associated diseases and cancers; EBV vaccines
类别
资金
- extramural research programs of the NIH [R35GM138283]
- Showalter Trust
- Intramural Research Programs of the National Institute of Diabetes and Digestive and Kidney Diseases [ZIA/DK075149]
EBV is a prevalent virus with a high infection rate, which is associated with cancer and autoimmune diseases. Despite some available treatments, their efficacy and safety are still unclear. Therefore, studying the mechanisms and therapeutic methods related to EBV-associated diseases is crucial for the development of novel effective treatments.
EBV is a prevalent virus, infecting >90% of the world's population. This is an oncogenic virus that causes similar to 200,000 cancer-related deaths annually. It is, in addition, a significant contributor to the burden of autoimmune diseases. Thus, EBV represents a significant public health burden. Upon infection, EBV remains dormant in host cells for long periods of time. However, the presence or episodic reactivation of the virus increases the risk of transforming healthy cells to malignant cells that routinely escape host immune surveillance or of producing pathogenic autoantibodies. Cancers caused by EBV display distinct molecular behaviors compared to those of the same tissue type that are not caused by EBV, presenting opportunities for targeted treatments. Despite some encouraging results from exploration of vaccines, antiviral agents and immune- and cell-based treatments, the efficacy and safety of most therapeutics remain unclear. Here, we provide an up-to-date review focusing on underlying immune and environmental mechanisms, current therapeutics and vaccines, animal models and emerging technologies to study EBV-associated diseases that may help provide insights for the development of novel effective treatments.
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