4.8 Review

Targeting inflammation and immune activation to improve CTLA4-Ig-based modulation of transplant rejection

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Medicinal

Jakinibs of All Trades: Inhibiting Cytokine Signaling in Immune-Mediated Pathologies

Madison Alexander et al.

Summary: Over the past 25 years, inhibiting Janus kinases (JAKs) has been a successful approach for treating immune and inflammatory disorders. Multiple JAK inhibitors (jakinibs) have been approved in 80 countries for diseases such as rheumatoid arthritis, ulcerative colitis, and atopic dermatitis. In addition, two jakinibs have shown promising efficacy in treating hospitalized COVID-19 patients, suggesting potential applications in infectious diseases and hyperinflammatory syndromes. The development of more selective JAK-targeting and organ-selective delivery methods has further expanded the clinical applications of jakinibs. Safety and pharmacokinetic studies have also been conducted to solidify the benefits and limitations of jakinib use.

PHARMACEUTICALS (2022)

Article Immunology

Impact of Belatacept Conversion on Renal Function, Histology, and Gene Expression in Kidney Transplant Patients With Chronic Active Antibody-mediated Rejection

Dhiren Kumar et al.

Summary: In patients with chronic active antibody-mediated rejection (caAMR), conversion to belatacept alone was associated with stabilization in renal function and improvement in inflammation, without the need for intensive salvage immunosuppressive therapies.

TRANSPLANTATION (2021)

Review Chemistry, Multidisciplinary

Intra-Organ Delivery of Nanotherapeutics for Organ Transplantation

Bilal Hussain et al.

Summary: The targeted delivery of therapeutics through nanoparticles offers promising potential in increasing efficacy and reducing side effects. While current efforts have primarily focused on cancer therapy, the introduction of nanotherapeutics in immunology and transplantation fields is underway. Research on utilizing nanotherapeutics in organ transplantation shows promise but requires further studies to address physiological challenges in effective delivery.

ACS NANO (2021)

Article Surgery

A short course of Tofacitinib sustains the immunoregulatory effect of CTLA4-Ig in the presence of inflammatory cytokines and promotes long-term survival of murine cardiac allografts

Marcos Iglesias et al.

Summary: Research shows that the combination of JAK/STAT inhibitor Tofacitinib and CTLA4-Ig can enhance the regulatory effect on transplant recipients, offering a promising strategy for improved management of transplanted patients.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

Article Rheumatology

Filgotinib in combination with methotrexate or as monotherapy versus methotrexate monotherapy in patients with active rheumatoid arthritis and limited or no prior exposure to methotrexate: the phase 3, randomised controlled FINCH 3 trial

Rene Westhovens et al.

Summary: The study showed that Filgotinib significantly improved symptoms and physical function in active RA patients treated in combination with MTX, while FIL200 monotherapy did not show a significant advantage in ACR20 response rate compared to MTX.

ANNALS OF THE RHEUMATIC DISEASES (2021)

Article Medicine, General & Internal

A Prospective Controlled Trial to Evaluate Safety and Efficacy of in vitro Expanded Recipient Regulatory T Cell Therapy and Tocilizumab Together With Donor Bone Marrow Infusion in HLA-Mismatched Living Donor Kidney Transplant Recipients (Trex001)

Rainer Oberbauer et al.

Summary: This study aims to investigate whether treatment with recipient Tregs and donor BM can lead to transient chimerism in kidney transplant recipients, potentially offering a new therapeutic option for immunomodulation in organ transplantation.

FRONTIERS IN MEDICINE (2021)

Article Immunology

Functional Characteristics and Phenotypic Plasticity of CD57+PD1- CD4 T Cells and Their Relationship with Transplant Immunosuppression

Brian Shaw et al.

Summary: The study reveals that CD57(+)PD1(-) CD4 T cells are associated with age and CMV infection both before and after transplantation. These cells are unable to replicate on their own but proliferate in the presence of unsorted PBMCs in a contact-independent manner. Stimulation causes these cells to upregulate activation markers and potentially change their CD57/PD1 expression, with PD1 upregulation accentuated by rapamycin but prevented by tacrolimus.

JOURNAL OF IMMUNOLOGY (2021)

Article Urology & Nephrology

Long-Term Immunosuppression Management Opportunities and Uncertainties

David Wojciechowski et al.

Summary: The long-term management of maintenance immunosuppression in kidney transplant recipients is complex, with various drug regimens having their own advantages and disadvantages. Balancing between treatment efficacy and adverse effects is crucial in decision-making for these patients.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

Article Transplantation

Belatacept Conversion in Kidney After Liver Transplantation

Octav Cristea et al.

Summary: This study demonstrates that belatacept-based therapy can potentially facilitate CNI-free maintenance immunosuppression in liver transplant recipients requiring subsequent kidney transplantation, suggesting belatacept conversion as a viable method of CNI avoidance.

TRANSPLANTATION DIRECT (2021)

Review Medicine, General & Internal

Long-Term Survival after Kidney Transplantation

Sundaram Hariharan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Rheumatology

A Decade of JAK Inhibitors: What Have We Learned and What May Be the Future?

Christine Liu et al.

Summary: The discovery of cytokines led to the development of targeted biologic therapies, with subsequent research identifying JAKs as therapeutic targets. Ten years since the approval of the first JAK inhibitors, there are now 9 approved for various diseases, with demonstrated efficacy and safety in clinical studies. Future developments include more selective inhibitors and drugs targeting kinase families beyond JAKs.

ARTHRITIS & RHEUMATOLOGY (2021)

Review Cell Biology

Targeting immunometabolism as an anti-inflammatory strategy

Eva M. Palsson-McDermott et al.

CELL RESEARCH (2020)

Review Immunology

Memory T Cells in Transplantation: Old Challenges Define New Directions

Michael Nicosia et al.

TRANSPLANTATION (2020)

Article Surgery

CD11b is a novel alternate receptor for CD154 during alloimmunity

Danya Liu et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2020)

Review Medicine, Research & Experimental

Genetic Engineering of T Cells for Immune Tolerance

David W. Scott

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)

Article Immunology

Translating JAKs to Jakinibs

Massimo Gadina et al.

JOURNAL OF IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

PIRs mediate innate myeloid cell memory to nonself MHC molecules

Hehua Dai et al.

SCIENCE (2020)

Review Immunology

Nanoparticle Platforms for Antigen-Specific Immune Tolerance

Edward B. Thorp et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Medicine, General & Internal

Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease

Robert Zeiser et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Surgery

Kidney transplantation using alemtuzumab, belatacept, and sirolimus: Five-year follow-up

Robin Schmitz et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2020)

Review Immunology

Costimulation Blockade in Vascularized Composite Allotransplantation

Dimitrios Giannis et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Immunology

Regulatory T cells in solid organ transplantation

Muhammad Atif et al.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2020)

Review Transplantation

The past, present, and future of costimulation blockade in organ transplantation

Paul M. Schroder et al.

CURRENT OPINION IN ORGAN TRANSPLANTATION (2019)

Review Biotechnology & Applied Microbiology

Next-generation regulatory T cell therapy

Leonardo M. R. Ferreira et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Review Transplantation

Innate immunity in ischemia-reperfusion injury and graft rejection

Kojiro Nakamura et al.

CURRENT OPINION IN ORGAN TRANSPLANTATION (2019)

Article Surgery

Aquaporin 4 blockade improves survival of murine heart allografts subjected to prolonged cold ischemia

Katayoun Ayasoufi et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2018)

Article Biochemistry & Molecular Biology

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism

Eleonora Trotta et al.

NATURE MEDICINE (2018)

Article Medicine, Research & Experimental

CD122 signaling in CD8+ memory T cells drives costimulation-independent rejection

David Mathews et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Medicine, Research & Experimental

Allograft dendritic cell p40 homodimers activate donor-reactive memory CD8+ T cells

Hidetoshi Tsuda et al.

JCI INSIGHT (2018)

Article Immunology

Co-inhibitory profile and cytotoxicity of CD57+PD-1- T cells in end-stage renal disease patients

R. Kraaijeveld et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2018)

Article Medicine, General & Internal

Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis

Peter C. Taylor et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Biochemistry & Molecular Biology

Metabolic Instruction of Immunity

Michael D. Buck et al.

Article Medicine, Research & Experimental

CTLA4-Ig in combination with FTY720 promotes allograft survival in sensitized recipients

Stella H. Khiew et al.

JCI INSIGHT (2017)

Article Surgery

CD57+ CD4 T Cells Underlie Belatacept-Resistant Allograft Rejection

J. Espinosa et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2016)

Article Multidisciplinary Sciences

Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice

Esilida Sula Karreci et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Multidisciplinary Sciences

Trained immunity: A program of innate immune memory in health and disease

Mihai G. Netea et al.

SCIENCE (2016)

Review Urology & Nephrology

How Kidney Cell Death Induces Renal Necroinflammation

Shrikant R. Mulay et al.

SEMINARS IN NEPHROLOGY (2016)

Article Surgery

Belatacept for renal rescue in lung transplant patients

Irina Timofte et al.

TRANSPLANT INTERNATIONAL (2016)

Article Surgery

Evaluation of the Effect of Tofacitinib Exposure on Outcomes in Kidney Transplant Patients

F. Vincenti et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2015)

Review Rheumatology

Proteasome inhibitors as experimental therapeutics of autoimmune diseases

Sue Ellen Verbrugge et al.

ARTHRITIS RESEARCH & THERAPY (2015)

Article Cell Biology

Preventing Allograft Rejection by Targeting Immune Metabolism

Chen-Fang Lee et al.

CELL REPORTS (2015)

Article Surgery

Endogenous Memory CD8 T Cells Directly Mediate Cardiac Allograft Rejection

C. A. Su et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2014)

Article Engineering, Biomedical

Immunotherapy with injectable hydrogels to treat obstructive nephropathy

Danielle E. Soranno et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2014)

Article Cardiac & Cardiovascular Systems

T-regulatory cell treatment prevents chronic rejection of heart allografts in a murine mixed chimerism model

Nina Pilat et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2014)

Review Urology & Nephrology

Targeting co-stimulatory pathways: transplantation and autoimmunity

Mandy L. Ford et al.

NATURE REVIEWS NEPHROLOGY (2014)

Article Surgery

Critical Role of Proinflammatory Cytokine IL-6 in Allograft Rejection and Tolerance

X. Zhao et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2012)

Article Surgery

Deleterious Effect of CTLA4-Ig on a Treg-Dependent Transplant Model

L. V. Riella et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2012)

Article Cardiac & Cardiovascular Systems

Aquaporin-4 in the heart: expression, regulation and functional role in ischemia

Arkady Rutkovskiy et al.

BASIC RESEARCH IN CARDIOLOGY (2012)

Review Immunology

Heterogeneity within T cell memory: implications for transplant tolerance

Scott M. Krummey et al.

FRONTIERS IN IMMUNOLOGY (2012)

Review Immunology

The impact of infection and tissue damage in solid-organ transplantation

Anita S. Chong et al.

NATURE REVIEWS IMMUNOLOGY (2012)

Review Surgery

Delayed Graft Function in the Kidney Transplant

A. Siedlecki et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2011)

Review Biotechnology & Applied Microbiology

Integrins as therapeutic targets: lessons and opportunities

Dermot Cox et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

Article Immunology

TLR Signals Promote IL-6/IL-17-Dependent Transplant Rejection

Luqiu Chen et al.

JOURNAL OF IMMUNOLOGY (2009)

Article Urology & Nephrology

IL-6 and TNF-α Synergistically Inhibit Allograft Acceptance

Hua Shen et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)

Article Transplantation

C5 Blockade with Conventional Immunosuppression Induces Long-Term Graft Survival in Presensitized Recipients

R. P. Rother et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2008)

Article Medicine, Research & Experimental

Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice

Julia Yuen-Shan Tsang et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

Article Immunology

Mechanisms underlying blockade of allograft acceptance by TLR ligands

Paige M. Porrett et al.

JOURNAL OF IMMUNOLOGY (2008)

Article Multidisciplinary Sciences

Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

Yasushi Onishi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Prevention of acute and chronic allograft rejection with CD4(+)CD25(+)Foxp3(+) regulatory T lymphocytes

Olivier Joffre et al.

NATURE MEDICINE (2008)

Article Immunology

FTY720 preferentially depletes naive T cells from peripheral and lymphoid organs

Matthias Hofmann et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2006)

Article Surgery

TLR engagement prevents transplantation tolerance

L. Chen et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2006)

Article Medicine, Research & Experimental

Distinct contribution of IL-6, TNF-α, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice

H Hata et al.

JOURNAL OF CLINICAL INVESTIGATION (2004)

Article Multidisciplinary Sciences

Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor

PS Changelian et al.

SCIENCE (2003)

Review Urology & Nephrology

Memory T cells: A hurdle to immunologic tolerance

FG Lakkis et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2003)

Article Medicine, Research & Experimental

Heterologous immunity provides a potent barrier to transplantation tolerance

AB Adams et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

Article Cardiac & Cardiovascular Systems

A clinically relevant CTLA4-Ig-based regimen induces chimerism and tolerance to heart grafts

S Li et al.

ANNALS OF THORACIC SURGERY (2001)

Article Immunology

An antagonist IL-15/Fc protein prevents costimulation blockade-resistant rejection

S Ferrari-Lacraz et al.

JOURNAL OF IMMUNOLOGY (2001)

Letter Immunology

Anti-CD154 monoclonal antibody and thromboembolism

L Buhler et al.

TRANSPLANTATION (2001)

Article Multidisciplinary Sciences

Control of homeostasis of CD8+ memory T cells by opposing cytokines

CC Ku et al.

SCIENCE (2000)

Article Pharmacology & Pharmacy

CTLA4-Ig: a novel immunosuppressive agent

N Najafian et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2000)