4.8 Review

Immune regulation and emerging roles of noncoding RNAs in Mycobacterium tuberculosis infection

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

The exploitation of host autophagy and ubiquitin machinery by Mycobacterium tuberculosis in shaping immune responses and host defense during infection

Mohd Shariq et al.

Summary: Intracellular pathogens exploit the cellular ubiquitination process to evade host immunity. Ubiquitin modification, as a way to regulate cellular functions, is used by pathogens to subvert host defenses. The hijacking of host ubiquitination system allows pathogens to escape immune responses and enhance their virulence by manipulating host autophagy.

AUTOPHAGY (2023)

Article Biochemistry & Molecular Biology

Mycobacterium tuberculosis ESAT6 modulates host innate immunity by downregulating miR-222-3p target PTEN

Chen Zonghai et al.

Summary: The study revealed the critical role of ESAT6 in regulating miR-222-3p and its target gene PTEN in host immune responses to bacterial infection, providing a potential target for the development of anti-tuberculosis drugs.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2022)

Article Biochemistry & Molecular Biology

Down-regulation of hsa_circ_0045474 induces macrophage autophagy in tuberculosis via miR-582-5p/TNKS2 axis

Min Wu et al.

Summary: This study demonstrated that the down-regulation of hsa_circ_0045474 induced macrophage autophagy in tuberculosis via the miR-582-5p/TNKS2 axis, providing a potential novel strategy to treat active pulmonary tuberculosis caused by the immune escape of Mycobacterium tuberculosis.

INNATE IMMUNITY (2022)

Article Cell Biology

Screening differential circular RNA expression profiles reveals the regulatory role of circMARS in anti-tuberculosis drug-induced liver injury

Biao Li et al.

Summary: circMARS plays an important role in anti-tuberculosis drug-induced liver injury (ADLI) and may serve as a potential biomarker for ADLI diagnosis in TB patients.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

Review Oncology

The emerging roles of circRNAs in cancer and oncology

Lasse S. Kristensen et al.

Summary: Circular RNAs (circRNAs) are a novel class of primarily non-coding RNAs with increasingly recognized roles in cancer development and progression through diverse mechanisms of action. In this review, the authors summarize the current understanding of circRNA biogenesis, regulation, physiological functions and pathophysiological roles in cancer. They also discuss the clinical potential of circRNAs as biomarkers, therapeutic agents and drug targets in oncology, as well as the research controversies, technical issues, and biological knowledge gaps that need to be addressed.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

Review Cell Biology

Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics

Takayuki Nojima et al.

Summary: Mammalian genomes express protein-coding and non-coding RNA genes. Recent studies have revealed differences in transcription initiation and termination between non-coding RNA genes and protein-coding genes, which are relevant to genomic stress and DNA damage.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

Article Multidisciplinary Sciences

Screening and identification of differentially expressed long non-coding RNAs in multidrug-resistant tuberculosis

Junwei Zhao et al.

Summary: Efforts to eradicate MDR-TB are hindered by drug resistance. This study identifies differentially expressed lncRNAs and mRNAs in MDR-TB patients and reveals potential biomarkers such as lncRNA n335659. GO and KEGG analyses provide insights into the biological functions and signaling pathways associated with MDR-TB.
Article Immunology

LncRNA CCAT1 is overexpressed in tuberculosis patients and predicts their survival

Taosheng Ye et al.

Summary: CCAT1 is overexpressed in tuberculosis patients and is associated with IL-10. During treatment, CCAT1 levels decrease, and high CCAT1 levels are closely correlated with high mortality rates.

IMMUNITY INFLAMMATION AND DISEASE (2022)

Article Multidisciplinary Sciences

Negative pressure promotes macrophage M1 polarization after Mycobacterium tuberculosis infection via the lncRNA XIST/microRNA-125b-5p/A20/NF-κB axis

Xiao-Bo Luo et al.

Summary: Negative pressure treatment can promote macrophage polarization towards the proinflammatory M1 phenotype by regulating the XIST/miR-125b-5p/A20/NF-kappa B axis.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2022)

Article Immunology

LINC00870 regulates Th1/Th2 via the JAK/STAT pathway in peripheral blood mononuclear cells infected with Mycobacterium tuberculosis

Wang Jianfang et al.

Summary: In this study, the expression and effect of LINC00870 in Mycobacterium tuberculosis (MTB) infection were investigated. The results showed that LINC00870 was significantly increased in MTB-infected peripheral blood mononuclear cells (PBMCs) and its overexpression inhibited Th1-secreted cytokines while promoted Th2-secreted cytokines. Furthermore, LINC00870 promoted the activation of JAK/STAT signaling in MTB-infected PBMCs. Higher levels of LINC00870 were also found in sputum and plasma samples from TB and LTBI patients. After three months of therapy, the levels of LINC00870 decreased in both TB and LTBI patients. Therefore, LINC00870 may be a novel biomarker for diagnosing and treating tuberculosis.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

Article Immunology

Overexpression of VPS11 antagonizes the promoting effect of miR-542-3p on Mycobacterium tuberculosis survival in macrophages by regulating autophagy

Dan Luo et al.

Summary: The study revealed that decreased VPS11 expression and increased miR-542-3p expression were observed in macrophages after Mycobacterium tuberculosis (TB) infection. miR-542-3p promoted M. tuberculosis survival in human macrophages, while VPS11 overexpression antagonized this promoting effect. Overexpression of VPS11 or depletion of miR-542-3p promoted autophagy, which was suppressed upon TB infection.

MICROBIAL PATHOGENESIS (2022)

Article Microbiology

Screening of Long Non-coding RNAs Biomarkers for the Diagnosis of Tuberculosis and Preliminary Construction of a Clinical Diagnosis Model

Juli Chen et al.

Summary: Two differentially expressed lncRNAs (TCONS_00001838 and n406498) were identified in TB patients, and combining these lncRNAs with 8 EHR parameters can create an accurate diagnostic model for tuberculosis.

FRONTIERS IN MICROBIOLOGY (2022)

Article Multidisciplinary Sciences

MiR-25 blunts autophagy and promotes the survival of Mycobacterium tuberculosis by regulating NPC1

Wenqi Dong et al.

Summary: Researchers have found that miR-25 promotes the survival of mycobacteria during tuberculosis infection by targeting the NPC1 protein and impairing lysosomal function to inhibit autophagy. Moreover, Rv1759c induces the expression of miR-25, exacerbating the infection of mycobacteria.

ISCIENCE (2022)

Article Cell Biology

High miRNA-378 expression has high diagnostic values for pulmonary tuberculosis and predicts adverse outcomes

Xiaolu Sun et al.

Summary: The study found that miR-378 is highly expressed in pulmonary tuberculosis patients, which assists in the diagnosis of TB and can predict adverse outcomes.

BMC MOLECULAR AND CELL BIOLOGY (2022)

Article Immunology

Lnc-EST12, which is negatively regulated by mycobacterial EST12, suppresses antimycobacterial innate immunity through its interaction with FUBP3

Qili Yao et al.

Summary: The study revealed that the M.tb protein EST12 activates pyroptosis in macrophages and plays a key role in M.tb-induced immunity, while mouse lncRNA lnc-EST12 negatively regulates anti-M.tb innate immunity through interaction with FUBP3.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

Review Biochemistry & Molecular Biology

TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling

Anna Ciesielska et al.

Summary: This article discusses the role of TLR4 in promoting inflammatory responses, including internalization and intracellular trafficking of exogenous endotoxin and bacteria. The authors emphasize the significant impact of internalization rate and endo-lysosomal compartment transport rate on inflammatory responses.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Review Oncology

lncRNA involvement in cancer stem cell function and epithelial-mesenchymal transitions

Evan M. McCabe et al.

Summary: The epithelial to mesenchymal transition (EMT) is a cellular process crucial in embryogenesis, where cancer stem cells (CSCs) play a role by differentiating and undergoing EMT. Long noncoding RNAs (lncRNAs) also have a role in CSCs and EMT, with the potential to serve as biomarkers and therapeutic targets in cancer progression.

SEMINARS IN CANCER BIOLOGY (2021)

Article Immunology

ESAT-6 impedes IL-18 mediated phagosome lysosome fusion via microRNA-30a upon Calcimycin treatment in mycobacteria infected macrophages

Assirbad Behura et al.

Summary: This study elucidates the contradictory roles of miR-30a-3p and miR-30a-5p in regulating IL-18 signaling by ESAT-6, affecting phagosome-lysosome fusion and intracellular killing of mycobacteria in dTHP-1 cells upon Calcimycin treatment.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Article Immunology

MicroRNA-142-3p inhibits autophagy and promotes intracellular survival of Mycobacterium tuberculosis by targeting ATG16L1 and ATG4c

Yuliang Qu et al.

Summary: miR-142-3p inhibits M. tuberculosis-induced activation of autophagy, promotes H37Ra survival in macrophages, and exerts its function by targeting ATG16L1 and ATG4c.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Article Immunology

MicroRNA-106a Inhibits Autophagy Process and Antimicrobial Responses by Targeting ULK1, ATG7, and ATG16L1 During Mycobacterial Infection

Kunmei Liu et al.

Summary: miR-106a acts as a negative regulator in autophagy and antimicrobial effects during M. tuberculosis infection by targeting ULK1, ATG7, and ATG16L1, impacting the survival of the mycobacteria.

FRONTIERS IN IMMUNOLOGY (2021)

Article Oncology

Non-coding RNA derived from extracellular vesicles in cancer immune escape: Biological functions and potential clinical applications

Mingyao Huang et al.

Summary: The tumor microenvironment is a complex matrix containing cancer cells and other cell types that form organ-like structures. Extracellular vesicles (EVs) play a crucial role in cancer progression by delivering biologically active molecules, particularly in cancer immune escape. Current research focuses on targeting EV-ncRNAs for potential therapeutic options.

CANCER LETTERS (2021)

Article Biochemistry & Molecular Biology

LncRNA MIAT regulates autophagy and apoptosis of macrophage infected by Mycobacterium tuberculosis through the miR-665/ULK1 signaling axis

Fang Jiang et al.

Summary: The study reveals that the expression of MIAT is upregulated and miR-665 level is downregulated in THP1 cells infected with Bacillus Calmette-Guerin. Disruption of MIAT enhances cell viability and restricts apoptosis, while also promoting macrophage autophagy.

MOLECULAR IMMUNOLOGY (2021)

Review Immunology

Autophagy in inflammation, infection, and immunometabolism

Vojo Deretic

Summary: Autophagy is a crucial cellular protection mechanism that impacts various diseases when disrupted, including infections, autoimmune diseases, and cancer. It plays a role in clearing harmful substances in and out of cells, protecting against inflammatory damage. The article focuses on the role of autophagy in inflammation, as well as its intersections with immunity, metabolism, and organelle functions.

IMMUNITY (2021)

Article Immunology

Circ_0001490/miR-579-3p/FSTL1 axis modulates the survival of mycobacteria and the viability, apoptosis and inflammatory response in Mycobacterium tuberculosis-infected macrophages

Qun Deng et al.

Summary: The study demonstrated that circ_0001490 suppressed M.tb survival and promoted the viability and inflammatory response of M.tb-infected THP-1 macrophages partly by regulating the miR-579-3p/FSTL1 axis.

TUBERCULOSIS (2021)

Article Immunology

MIR337-3p Enhances Mycobacterial Pathogenicity Involving TLR4/MYD88 and STAT3 Signals, Impairing VDR Antimicrobial Response and Fast-Acting Immunity

Shanshan Liang et al.

Summary: This study identified a mechanism where MIR337-3p inhibits VitD-dependent antimicrobial response pathways, promoting mycobacterial entry and replication in host cells and impairing fast-acting anti-TB immunity. High levels of MIR337-3p were associated with decreased ability of innate cell populations to respond to intracellular mycobacterial infection, leading to enhanced pathogenicity.

FRONTIERS IN IMMUNOLOGY (2021)

Article Immunology

A Dual Marker for Monitoring MDR-TB Treatment: Host-Derived miRNAs and M. tuberculosis-Derived RNA Sequences in Serum

Claudia Carranza et al.

Summary: Dual markers composed of host-derived miR-let7e-5p and M. tuberculosis-derived RNA could serve as indicators of treatment failure or relapse in MDR-TB patients. MiR-let7e-5p could be used as a long-term monitoring biomarker for MDR-TB treatment, and the combination of host-derived miRNA and M. tuberculosis RNA in serum EVs may be a promising approach for monitoring TB treatment.

FRONTIERS IN IMMUNOLOGY (2021)

Article Toxicology

Altered expressions of circulating microRNAs 122 and 192 during antitubercular drug induced liver injury indicating their role as potential biomarkers

S. Bakshi et al.

Summary: Drug induced liver toxicity is a serious problem with high mortality rates. Current first line antitubercular drugs often cause liver injury. Research suggests that microRNAs 122 and 192 show significantly decreased expression levels in antitubercular drug induced liver injury patients, indicating their potential as tools for predicting or treating liver injury in the future.

HUMAN & EXPERIMENTAL TOXICOLOGY (2021)

Article Immunology

Identification of differentially expressed lncRNAs as potential plasma biomarkers for active tuberculosis

Yalun Fang et al.

Summary: The study identified four differentially expressed lncRNAs in the plasma of TB patients that could serve as potential diagnostic biomarkers for TB, showing promise for improving TB diagnosis.

TUBERCULOSIS (2021)

Article Biochemical Research Methods

Exosomal ncRNAs profiling of mycobacterial infection identified miRNA-185-5p as a novel biomarker for tuberculosis

Aman Chandra Kaushik et al.

Summary: The study indicates that exosomal ncRNAs may serve as useful functional biomarkers in tuberculosis, with miR-185-5p identified as a potential biomarker for tuberculosis.

BRIEFINGS IN BIOINFORMATICS (2021)

Article Biochemistry & Molecular Biology

MiR-342 controls Mycobacterium tuberculosis susceptibility by modulating inflammation and cell death

Beibei Fu et al.

Summary: The research reveals that the miR-342-3p/SOCS6 axis plays a crucial role in regulating anti-Mtb immunity and the balance between cell apoptosis and necrosis during Mtb infection, providing new insights for developing host-directed therapies targeting these pathways.

EMBO REPORTS (2021)

Article Medical Laboratory Technology

Integrating serum microRNAs and electronic health records improved the diagnosis of tuberculosis

Shu-Hui Gao et al.

Summary: There were differential expression of miR-30c and miR-142-3p between TB patients and HCs. Integrating serum miR-142-3p and EHRs is a good strategy for improving TB diagnosis, significantly improving diagnostic performance.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

Article Oncology

MicroRNA-502-3p promotes Mycobacterium tuberculosis survival in macrophages by modulating the inflammatory response by targeting ROCK1

Fang Liu et al.

Summary: The study found that miR-502-3p expression was significantly increased in macrophages of tuberculosis patients, potentially impacting the survival of Mycobacterium tuberculosis by regulating inflammatory cytokine expression and the TLR4/NF-kappa B signaling pathway. Furthermore, the interaction between miR-502-3p and ROCK1 may provide a promising therapeutic target for tuberculosis.

MOLECULAR MEDICINE REPORTS (2021)

Article Immunology

Potential biomarker enhancing the activity of tuberculosis, hsa-miR-346

Shunsuke Uno et al.

Summary: hsa-miR-346 levels are significantly elevated in human macrophages infected with M. tuberculosis, showing a marked difference in serum levels between tuberculosis patients and healthy individuals, with a significant decrease after anti-tuberculosis treatment.

TUBERCULOSIS (2021)

Article Immunology

High sensitivity and specificity of a 5-analyte protein and microRNA biosignature for identification of active tuberculosis

Jessica L. Pedersen et al.

Summary: This study examined the biomarker capacity of a panel of plasma proteins alone and in conjunction with a previously identified miRNA signature to identify active TB disease. The combination of miRNA and proteins significantly improved the sensitivity and specificity as a biosignature over single biomarker candidates, showing potential for the development of a non-sputum test to aid the diagnosis of active TB disease.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2021)

Review Medicine, Research & Experimental

Strategies for advanced personalized tuberculosis diagnosis: Current technologies and clinical approaches

Xuerong Chen et al.

Summary: Diagnosing tuberculosis can be challenging due to advancements in molecular diagnostic methods and personalized medicine, leading to changes in the diagnostic framework. New technologies and strategies are providing more accurate and personalized approaches to tuberculosis diagnosis from bench to bed.

PRECISION CLINICAL MEDICINE (2021)

Review Oncology

Long noncoding RNAs in cancer metastasis

S. John Liu et al.

Summary: Long noncoding RNAs play crucial roles in promoting metastasis by participating in discrete pro-metastatic steps and influencing the metastatic tumor microenvironment. They have the potential for diagnostic and therapeutic applications, but also face controversies and ongoing technical challenges. Further research is needed to explore their mechanisms and potential as targets for novel therapies in cancer metastasis.

NATURE REVIEWS CANCER (2021)

Article Immunology

Circular RNA TRAPPC6B inhibits intracellular Mycobacterium tuberculosis growth while inducing autophagy in macrophages by targeting microRNA-874-3p

Hou-Long Luo et al.

Summary: Genetic and epigenetic mechanisms regulate antimicrobial immunity against Mycobacterium tuberculosis (Mtb) infection. The circular RNA TRAPPC6B (circTRAPPC6B) enhances autophagy and sequestration to restrict Mtb growth by targeting miR-874-3p and inhibiting its ability to suppress ATG16L1 in Mtb-infected macrophages. Both circTRAPPC6B and miR-874-3p mechanisms have the potential to be explored as therapeutics against Mtb infection.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia

Qinjie Weng et al.

CELL DEATH AND DIFFERENTIATION (2020)

Article Immunology

Down-Regulation of miR-378d Increased Rab10 Expression to Help Clearance of Mycobacterium tuberculosis in Macrophages

Yifan Zhu et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Article Cell & Tissue Engineering

The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis

Jianxiong Zeng et al.

CELL STEM CELL (2020)

Article Infectious Diseases

Integrated analyses reveal hsa_circ_0028883 as a diagnostic biomarker in active tuberculosis

Xiaolin Zhang et al.

INFECTION GENETICS AND EVOLUTION (2020)

Review Cell Biology

Tuberculosis-Associated MicroRNAs: From Pathogenesis to Disease Biomarkers

Alessandro Sinigaglia et al.

Article Biochemistry & Molecular Biology

Long non-coding PCED1B-AS1 regulates macrophage apoptosis and autophagy by sponging miR-155 in active tuberculosis

Mingying Li et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Biotechnology & Applied Microbiology

Serum Exosomal miRNAs Are Associated with Active Pulmonary Tuberculosis

Shamila D. Alipoor et al.

DISEASE MARKERS (2019)

Review Oncology

MicroRNA-125 in immunity and cancer

Jessica K. Wang et al.

CANCER LETTERS (2019)

Article Infectious Diseases

Clinical significance of lnc-AC145676.2.1-6 and lnc-TGS1-1 and their variants in western Chinese tuberculosis patients

Hao Bai et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2019)

Article Cell Biology

MiR-140 modulates the inflammatory responses of Mycobacterium tuberculosis-infected macrophages by targeting TRAF6

Xiaofei Li et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

Review Immunology

Long Noncoding RNAs in Host-Pathogen Interactions

Federica Agliano et al.

TRENDS IN IMMUNOLOGY (2019)

Review Genetics & Heredity

The biogenesis, biology and characterization of circular RNAs

Lasse S. Kristensen et al.

NATURE REVIEWS GENETICS (2019)

Article Biochemistry & Molecular Biology

microRNA-579 upregulation mediates death of human macrophages with mycobacterium tuberculosis infection

Jun Ma et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Cell Biology

Signature of circular RNAs in peripheral blood mononuclear cells from patients with active tuberculosis

Yurong Fu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

Review Cell Biology

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

Rumani Singh et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Allergy

MicroRNA

Thomas X. Lu et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Article Cell Biology

Dysregulated circRNAs in plasma from active tuberculosis patients

Zhengjun Yi et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

Review Medicine, General & Internal

Circular RNAs: Promising Biomarkers for Human Diseases

Zhongrong Zhang et al.

EBIOMEDICINE (2018)

Review Oncology

Non-coding RNA networks in cancer

Eleni Anastasiadou et al.

NATURE REVIEWS CANCER (2018)

Article Biochemistry & Molecular Biology

Aberrantly Expressed Long Non-Coding RNAs In CD8+ T Cells Response to Active Tuberculosis

Yurong Fu et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2017)

Article Genetics & Heredity

A map of human circular RNAs in clinically relevant tissues

Philipp G. Maass et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2017)

Article Biochemistry & Molecular Biology

Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection

Xiang Li et al.

MOLECULAR CELL (2017)

Article Medicine, Research & Experimental

Immune regulation of miR-30 on the Mycobacterium tuberculosis-induced TLR/MyD88 signaling pathway in THP-1 cells

Yuqing Wu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2017)

Article Multidisciplinary Sciences

Deregulated lncRNAs in B Cells from Patients with Active Tuberculosis

Yurong Fu et al.

PLOS ONE (2017)

Article Multidisciplinary Sciences

Screening and identification of lncRNAs as potential biomarkers for pulmonary tuberculosis

Zhong-liang Chen et al.

SCIENTIFIC REPORTS (2017)

Review Genetics & Heredity

Endogenous microRNA sponges: evidence and controversy

Daniel W. Thomson et al.

NATURE REVIEWS GENETICS (2016)

Article Biochemistry & Molecular Biology

Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2

William W. Du et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Biochemistry & Molecular Biology

Inhibition of IFN-β-Induced Nitric Oxide Dependent Antimycobacterial Activity by miR-155 and C/EBPβ

Yongwei Qin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Review Biochemistry & Molecular Biology

PIWI-Interacting RNA: Its Biogenesis and Functions

Yuka W. Iwasaki et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 84 (2015)

Article Biochemistry & Molecular Biology

MicroRNA-223 Is Upregulated in Active Tuberculosis Patients and Inhibits Apoptosis of Macrophages by Targeting FOXO3

Xiue Xi et al.

GENETIC TESTING AND MOLECULAR BIOMARKERS (2015)

Review Immunology

Immunoevasion and immunosuppression of the macrophage by Mycobacterium tuberculosis

Zakaria Hmama et al.

IMMUNOLOGICAL REVIEWS (2015)

Article Oncology

ROS-p53-cyclophilin-D signaling mediates salinomycin-induced glioma cell necrosis

Li-sen Qin et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2015)

Article Genetics & Heredity

The landscape of long noncoding RNAs in the human transcriptome

Matthew K. Iyer et al.

NATURE GENETICS (2015)

Article Biochemistry & Molecular Biology

Exon-intron circular RNAs regulate transcription in the nucleus

Zhaoyong Li et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

Article Multidisciplinary Sciences

Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection

Yang Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Biochemistry & Molecular Biology

Exon-intron circular RNAs regulate transcription in the nucleus

Zhaoyong Li et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

Review Biochemistry & Molecular Biology

Evolutionary conservation of long non-coding RNAs; sequence, structure, function

Per Johnsson et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2014)

Article Biochemistry & Molecular Biology

A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection

Katherine J. Siddle et al.

GENOME RESEARCH (2014)

Article Immunology

Dynamics of T-cell IFN-γ and miR-29a expression during active pulmonary tuberculosis

Anthony Afum-Adjei Awuah et al.

INTERNATIONAL IMMUNOLOGY (2014)

Article Cell Biology

Deregulated microRNAs in CD4+ T cells from individuals with latent tuberculosis versus active tuberculosis

Yurong Fu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2014)

Article Biochemistry & Molecular Biology

MicroRNA-149 Negatively Regulates TLR-Triggered Inflammatory Response in Macrophages by Targeting MyD88

Guangxian Xu et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2014)

Article Biochemistry & Molecular Biology

microRNA-124 negatively regulates TLR signaling in alveolar macrophages in response to mycobacterial infection

Chunyan Ma et al.

MOLECULAR IMMUNOLOGY (2014)

Review Microbiology

Bacteria-autophagy interplay: a battle for survival

Ju Huang et al.

NATURE REVIEWS MICROBIOLOGY (2014)

Review Cell Biology

Regulation of microRNA function in somatic stem cell proliferation and differentiation

Archana Shenoy et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Multidisciplinary Sciences

Circular RNA Is Expressed across the Eukaryotic Tree of Life

Peter L. Wang et al.

PLOS ONE (2014)

Article Multidisciplinary Sciences

Identification of Serum microRNA Biomarkers for Tuberculosis Using RNA-seq

Hongtai Zhang et al.

PLOS ONE (2014)

Review Immunology

Macrophage immunoregulatory pathways in tuberculosis

Murugesan V. S. Rajararna et al.

SEMINARS IN IMMUNOLOGY (2014)

Review Immunology

Toll-like receptor signaling pathways

Takumi Kawasaki et al.

FRONTIERS IN IMMUNOLOGY (2014)

Article Biochemistry & Molecular Biology

Ribosome Profiling Provides Evidence that Large Noncoding RNAs Do Not Encode Proteins

Mitchell Guttman et al.

Article Multidisciplinary Sciences

Natural RNA circles function as efficient microRNA sponges

Thomas B. Hansen et al.

NATURE (2013)

Article Multidisciplinary Sciences

A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes

Susan Carpenter et al.

SCIENCE (2013)

Article Genetics & Heredity

Cell-Type Specific Features of Circular RNA Expression

Julia Salzman et al.

PLOS GENETICS (2013)

Review Oncology

Noncoding RNAs in cancer and cancer stem cells

Tianzhi Huang et al.

CHINESE JOURNAL OF CANCER (2013)

Article Rheumatology

FSTL1 Promotes Arthritis in Mice by Enhancing Inflammatory Cytokine/Chemokine Expression

Yury Chaly et al.

ARTHRITIS AND RHEUMATISM (2012)

Review Pharmacology & Pharmacy

NF-κB as a Target for Modulating Inflammatory Responses

Chiara Gasparini et al.

CURRENT PHARMACEUTICAL DESIGN (2012)

Article Biochemistry & Molecular Biology

Inductive microRNA-21 impairs anti-mycobacterial responses by targeting IL-12 and Bcl-2

Zhongwen Wu et al.

FEBS LETTERS (2012)

Review Cell Biology

NF-κB, the first quarter-century: remarkable progress and outstanding questions

Matthew S. Hayden et al.

GENES & DEVELOPMENT (2012)

Article Biochemistry & Molecular Biology

The expression of damage-regulated autophagy modulator 2 (DRAM2) contributes to autophagy induction

Jung-Ho Yoon et al.

MOLECULAR BIOLOGY REPORTS (2012)

Review Biochemistry & Molecular Biology

Non-coding RNA and its potential role in Mycobacterium tuberculosis pathogenesis

Kristine B. Arnvig et al.

RNA BIOLOGY (2012)

Review Biochemistry & Molecular Biology

Akt, FoxO and regulation of apoptosis

Xinbo Zhang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)

Article Multidisciplinary Sciences

Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b

Murugesan V. S. Rajaram et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Microbiology

Manipulation of Host Cell Death Pathways during Microbial Infections

Mohamed Lamkanfi et al.

CELL HOST & MICROBE (2010)

Review Genetics & Heredity

Annotating non-coding regions of the genome

Roger P. Alexander et al.

NATURE REVIEWS GENETICS (2010)

Review Genetics & Heredity

The widespread regulation of microRNA biogenesis, function and decay

Jacek Krol et al.

NATURE REVIEWS GENETICS (2010)

Review Genetics & Heredity

Regulation Mechanisms and Signaling Pathways of Autophagy

Congcong He et al.

ANNUAL REVIEW OF GENETICS (2009)

Review Pathology

MicroRNAs in Cancer

Yong Sun Lee et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2009)

Article Biochemistry & Molecular Biology

Most mammalian mRNAs are conserved targets of microRNAs

Robin C. Friedman et al.

GENOME RESEARCH (2009)

Review Immunology

MicroRNA in the immune system, microRNA as an immune system

Li-Fan Lu et al.

IMMUNOLOGY (2009)

Article Immunology

Follistatin-Like Protein 1 Promotes Arthritis by Up-Regulating IFN-gamma

Suzanne D. Clutter et al.

JOURNAL OF IMMUNOLOGY (2009)

Review Genetics & Heredity

Long non-coding RNAs: insights into functions

Tim R. Mercer et al.

NATURE REVIEWS GENETICS (2009)

Article Multidisciplinary Sciences

A CREB-C/EBPβ cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair

Daniela Ruffell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

A Gene Network Regulating Lysosomal Biogenesis and Function

Marco Sardiello et al.

SCIENCE (2009)

Review Biochemistry & Molecular Biology

Shared principles in NF-κB signaling

Matthew S. Hayden et al.

Review Biochemistry & Molecular Biology

Autophagy in the pathogenesis of disease

Beth Levine et al.

Review Gastroenterology & Hepatology

Antituberculosis drug-induced hepatotoxicity: Concise up-to-date review

Alma Tostmann et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2008)

Article Cell Biology

An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure

Naonobu Fujita et al.

MOLECULAR BIOLOGY OF THE CELL (2008)

Review Cell Biology

The BCL-2 protein family: opposing activities that mediate cell death

Richard J. Youle et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Review Immunology

Micromanagement of the immune system by microRNAs

Harvey F. Lodish et al.

NATURE REVIEWS IMMUNOLOGY (2008)

Article Immunology

Follistatin-like protein-1 is a novel proinflammatory molecule

Takako Miyamae et al.

JOURNAL OF IMMUNOLOGY (2006)

Article Cell Biology

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

Chengyu Liang et al.

NATURE CELL BIOLOGY (2006)

Article Genetics & Heredity

microRNA target predictions in animals

Nikolaus Rajewsky

NATURE GENETICS (2006)

Review Cell Biology

Ubiquitin signalling in the NF-κB pathway

ZJJ Chen

NATURE CELL BIOLOGY (2005)