The hexosamine biosynthesis pathway-related gene signature correlates with immune infiltration and predicts prognosis of patients with osteosarcoma

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Review Oncology

Origin and Therapies of Osteosarcoma

Brice Moukengue et al.

Summary: Osteosarcoma is a common malignant bone tumor in children and young adults, with treatment outcomes dependent on disease aggressiveness and treatment response. Despite advancements in therapy, challenges exist in improving survival rates, attributed to limited knowledge on disease origin and therapeutic options.

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The cancer metabolic reprogramming and immune response

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The hexosamine biosynthetic pathway and cancer: Current knowledge and future therapeutic strategies

Christine Lam et al.

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Role and Function of O-GlcNAcylation in Cancer

Jii Bum Lee et al.

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Summary: While low-risk localized prostate cancer has a good prognosis with effective treatments, metastatic prostate cancer remains incurable and treatment resistance is a major issue. Resistance is primarily driven by tumor heterogeneity, altered genetic signatures, and metabolic reprogramming enabling tumors to adapt to drugs. Understanding prostate cancer metabolism may offer insights into therapy-induced adaptive responses and more durable therapeutic outcomes.

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Hijacking the Hexosamine Biosynthetic Pathway to Promote EMT-Mediated neoplastic Phenotypes

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UAP1 is overexpressed in prostate cancer and is protective against inhibitors of N-linked glycosylation

H. M. Itkonen et al.

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O-GlcNAcylation Regulates Cancer Metabolism and Survival Stress Signaling via Regulation of the HIF-1 Pathway

Christina M. Ferrer et al.

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O-Linked β-N-Acetylglucosaminylation (O-GlcNAcylation) in Primary and Metastatic Colorectal Cancer Clones and Effect of N-Acetyl-β-D-glucosaminidase Silencing on Cell Phenotype and Transcriptome

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Autocrine motility factor/phosphoglucose isomerase regulates ER stress and cell death through control of ER calcium release

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Tumor-Infiltrating Macrophages Are Associated with Metastasis Suppression in High-Grade Osteosarcoma: A Rationale for Treatment with Macrophage Activating Agents

Emilie P. Buddingh et al.

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Otto Warburg's contributions to current concepts of cancer metabolism

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Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1

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Hexosamine biosynthesis and protein O-glycosylation: The first line of defense against stress, ischemia, and trauma

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The hexosamine biosynthesis pathway-related gene signature correlates with immune infiltration and predicts prognosis of patients with osteosarcoma

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