Extracellular vesicles derived from Trichinella Spiralis larvae promote the polarization of macrophages to M2b type and inhibit the activation of fibroblasts

Article Parasitology

Extracellular vesicles derived from Trichinella spiralis prevent colitis by inhibiting M1 macrophage polarization

Xin Gao et al.

Summary: The study demonstrates that Trichinella spiralis EVs can influence the development of inflammation in DSS-induced colitis by inhibiting M1 macrophage polarization, showcasing their immunomodulatory ability.

ACTA TROPICA (2021)

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Review Cell Biology

The emerging role of microRNA in regulating the mTOR signaling pathway in immune and inflammatory responses

Nazanin Nazari et al.

Summary: mTOR, a critical regulator of cellular events and immune function, interacts with miRNAs to modulate immune responses. miRNAs target the mTOR signaling pathway to regulate immune reactions. Dysregulation of miRNAs and the mTOR pathway may contribute to immune-related diseases.

IMMUNOLOGY AND CELL BIOLOGY (2021)

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Article Veterinary Sciences

Modulatory Effects of Echinococcus multilocularis emu-let-7-5p on the Immunological Functions of RAW264.7 Macrophages

Xiaoliang Jin et al.

Summary: The study found that emu-let-7-5p can influence the immune functions of macrophages, potentially playing a role in the pathogen-host interaction during E. multilocularis infection.

FRONTIERS IN VETERINARY SCIENCE (2021)

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Article Immunology

Galectin-Receptor Interactions Regulates Cardiac Pathology Caused by Trichinella spiralis Infection

Jinghai Yan et al.

Summary: The study revealed that blocking galectin-receptor interactions during acute Trichinella spiralis infection resulted in cardiac dysfunction, exacerbated heart pathology, and increased cardiac fibrosis. This was associated with elevated heart eosinophil recruitment and upregulation of Gal-3, which plays a pivotal role in heart functional damage.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Nrf2 Participates in M2 Polarization by Trichinella spiralis to Alleviate TNBS-Induced Colitis in Mice

Xuemin Jin et al.

Summary: This study revealed that Nrf2 is essential for M2 polarization induced by T. spiralis ES to alleviate colitis in mice. Adoptive transfer of ES-treated M2 decreased IFN-gamma levels and increased IL-4 and IL-10 levels in vivo, while ES-treated Nrf2 KO macrophages showed impaired ability to treat colitis with deficient elevation of IL-4 and IL-10 levels.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Cell Biology

Parasite worm antigens instruct macrophages to release immunoregulatory extracellular vesicles

Amin Zakeri et al.

Summary: Recent studies indicate that soluble products from parasitic worms can stimulate macrophages to release anti-inflammatory extracellular vesicles (EVs), which can suppress inflammation without inducing M1 or M2 polarization. Additionally, EVs can enhance reactive oxygen species production in macrophages, leading to a deregulated redox balance. Proteomic analysis identified cytochrome p450 as a potential source of ROS in EVs, and pharmacological inhibition of CYP450 activity could suppress ROS production in macrophages.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Cell Biology

Trichinella spiralis Paramyosin Induces Colonic Regulatory T Cells to Mitigate Inflammatory Bowel Disease

Chunyue Hao et al.

Summary: The study demonstrates that the Trichinella-derived protein rTsPmy can ameliorate disease progression and reduce inflammatory responses in experimental colitis, by specifically promoting the expansion and differentiation of regulatory T cells in the inflamed colon. These findings provide insights into the immunological mechanisms involved in the therapeutic effect of helminth-derived proteins in inflammatory bowel diseases.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Cell Biology

Characterization of a Novel Glutamine Synthetase From Trichinella spiralis and Its Participation in Larval Acid Resistance, Molting, and Development

Tong Xu Zhuo et al.

Summary: TsGS, a novel glutamine synthetase identified from T. spiralis IIL, plays an important biological role in the parasite's life cycle. Investigation of its biological characteristics and functions in larval acid resistance, molting, and development reveals that TsGS is crucial in these processes.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Microbiology

Exosomal microRNA let-7-5p from Taenia pisiformis Cysticercus Prompted Macrophage to M2 Polarization through Inhibiting the Expression of C/EBP δ

Liqun Wang et al.

Summary: The study reveals that miR-let-7-5p released by Taenia pisiformis cysticercus plays a critical role in activating M2 macrophages, inducing M2 macrophage polarization by targeting C/EBP delta.

MICROORGANISMS (2021)

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Article Chemistry, Applied

Chitosan coated nanostructured lipid carriers for enhanced in vivo efficacy of albendazole against Trichinella spiralis

Rania K. Eid et al.

CARBOHYDRATE POLYMERS (2020)

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Article Medicine, Research & Experimental

MicroRNA exporter HuR clears the internalized pathogens by promoting pro-inflammatory response in infected macrophages

Avijit Goswami et al.

EMBO MOLECULAR MEDICINE (2020)

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Article Cell Biology

miR-142-5p and miR-130a-3p regulate pulmonary macrophage polarization and asthma airway remodeling

Jianting Shi et al.

IMMUNOLOGY AND CELL BIOLOGY (2020)

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Article Immunology

Immunomodulatory Properties ofLeishmaniaExtracellular Vesicles During Host-Parasite Interaction: Differential Activation of TLRs and NF-kappa B Translocation by Dermotropic and Viscerotropic Species

Paula Monalisa Nogueira et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Review Parasitology

The protein and microRNA cargo of extracellular vesicles from parasitic helminths - current status and research priorities

Javier Sotillo et al.

INTERNATIONAL JOURNAL FOR PARASITOLOGY (2020)

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Article Parasitology

The cellular and molecular origins of extracellular vesicles released by the helminth pathogen, Fasciola hepatica

Adam P. S. Bennett et al.

INTERNATIONAL JOURNAL FOR PARASITOLOGY (2020)

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Article Immunology

Extracellular Vesicles Derived FromTrichinella spiralisMuscle Larvae Ameliorate TNBS-Induced Colitis in Mice

Yong Yang et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Infectious Diseases

Fasciola hepatica Extracellular Vesicles isolated from excretory-secretory products using a gravity flow method modulate dendritic cell phenotype and activity

Anna Murphy et al.

PLOS NEGLECTED TROPICAL DISEASES (2020)

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Article Immunology

Trichinella spiralisThioredoxin Peroxidase 2 Regulates Protective Th2 Immune Response in Mice by Directly Inducing Alternatively Activated Macrophages

Qi-Wang Jin et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Immunology

Excretory/Secretory Products FromTrichinella spiralisAdult Worms Attenuated DSS-Induced Colitis in Mice by Driving PD-1-Mediated M2 Macrophage Polarization

Zixia Wang et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Cell Biology

Ivermectin inhibits extracellular vesicle secretion from parasitic nematodes

Hannah J. Loghry et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

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Article Cell Biology

Sja-miR-71a in Schistosome egg-derived extracellular vesicles suppresses liver fibrosis caused by schistosomiasis via targeting semaphorin 4D

Lifu Wang et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

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Article Biochemistry & Molecular Biology

Secretion of an Argonaute protein by a parasitic nematode and the evolution of its siRNA guides

Franklin Wang-Ngai Chow et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Multidisciplinary Sciences

Infection by the parasitic helminth Trichinella spiralis activates a Tas2r-mediated signaling pathway in intestinal tuft cells

Xiao-Cui Luo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Editorial Material Multidisciplinary Sciences

Extracellular vesicles in parasite survival

Yifat Ofir-Birin et al.

SCIENCE (2019)

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Article Immunology

Trichinella spiralis muscle larvae release extracellular vesicles with immunomodulatory properties

Maja Kosanovic et al.

PARASITE IMMUNOLOGY (2019)

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Article Multidisciplinary Sciences

Adoptive transfer of Trichinella spiralis-activated macrophages can ameliorate both Th1-and Th2-activated inflammation in murine models

Shin Ae Kang et al.

SCIENTIFIC REPORTS (2019)

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Article Medicine, Research & Experimental

Cross-Species Suppression of Hepatoma Cell Growth and Migration by a Schistosoma japonicum MicroRNA

Yu Lin et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

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Article Biochemistry & Molecular Biology

Taenia solium and Taenia crassiceps: miRNomes of the larvae and effects of miR-10-5p and let-7-5p on murine peritoneal macrophages

Abraham Landa et al.

BIOSCIENCE REPORTS (2019)

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Review Cell Biology

Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease

Marcelo A. Mori et al.

CELL METABOLISM (2019)

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Article Infectious Diseases

Surface molecules of extracellular vesicles secreted by the helminth pathogen Fasciola hepatica direct their internalisation by host cells

Eduardo de la Torre-Escudero et al.

PLOS NEGLECTED TROPICAL DISEASES (2019)

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Review Immunology

Extracellular Vesicle-Mediated Communication Within Host-Parasite Interactions

Zhenyu Wu et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Editorial Material Cell Biology

Extracellular vesicles and immune modulation

Melanie J. McConnell

IMMUNOLOGY AND CELL BIOLOGY (2018)

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Review Cell Biology

Immunobiology of parasitic worm extracellular vesicles

Ramon M. Eichenberger et al.

IMMUNOLOGY AND CELL BIOLOGY (2018)

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Review Cell Biology

Macrophage plasticity, polarization, and function in health and disease

Abbas Shapouri-Moghaddam et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

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Review Immunology

Immunomodulation by Helminths: Intracellular Pathways and Extracellular Vesicles

Amin Zakeri et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Cell Biology

Proteomic analysis reveals different composition of extracellular vesicles released by two Trypanosoma cruzi strains associated with their distinct interaction with host cells

Kleber Silva Ribeiro et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Biotechnology & Applied Microbiology

Meat sources of infection for outbreaks of human trichinellosis

Ali Rostami et al.

FOOD MICROBIOLOGY (2017)

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Review Microbiology

Current Research of Trichinellosis in China

Xue Bai et al.

FRONTIERS IN MICROBIOLOGY (2017)

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Article Biochemistry & Molecular Biology

Extracellular Vesicles from Trypanosoma brucei Mediate Virulence Factor Transfer and Cause Host Anemia

Anthony J. Szempruch et al.

CELL (2016)

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Review Biochemistry & Molecular Biology

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

Mercedes Tkach et al.

CELL (2016)

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Review Immunology

Macrophages in Tissue Repair, Regeneration, and Fibrosis

Thomas A. Wynn et al.

IMMUNITY (2016)

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Review Multidisciplinary Sciences

Macrophage biology in development, homeostasis and disease

Thomas A. Wynn et al.

NATURE (2013)

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Article Plant Sciences

High throughput sequencing reveals novel and abiotic stress-regulated microRNAs in the inflorescences of rice

Blanca E. Barrera-Figueroa et al.

BMC PLANT BIOLOGY (2012)

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Article Genetics & Heredity

The draft genome of the parasitic nematode Trichinella spiralis

Makedonka Mitreva et al.

NATURE GENETICS (2011)

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Extracellular vesicles derived from Trichinella Spiralis larvae promote the polarization of macrophages to M2b type and inhibit the activation of fibroblasts

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