期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.974332
关键词
Trichinella spiralis; extracellular vesicles; microRNA; macrophages; fibroblasts
类别
资金
- National Natural Science Foundation of China [81902081, 81871682, 81860365]
- Natural Science Foundation of Guangdong Province [2020A1515011573, 2019A1515012068, 2021A1515010976]
- Guangzhou key laboratory for clinical rapid diagnosis and early warning of infectious diseases [202102100003]
This study found that Trichinella-derived extracellular vesicles and their miR-1-3p and let-7-5p can regulate the immune response and fibroblasts of the host, promoting the polarization of macrophages while inhibiting fibroblast activation.
Trichinella spiralis (T. spiralis) is a globally distributed food-borne parasite that can coexist with the host for a long time after infection. Trichinella-derived secretions can regulate the immune response and fibroblasts of the host, but the specific mechanisms involved are still unclear. The purpose of this study was to investigate the role of T. spiralis larvae-derived extracellular vesicles (EVs) and their key miRNAs in the process of T. spiralis-host interaction. In this study, we found that the EVs of T. spiralis larvae, as well as miR-1-3p and let-7-5p, expressed in T. spiralis larvae-derived EVs, can promote the polarization of bone marrow macrophages to M2b type while inhibiting the activation of fibroblasts. These findings will contribute to further understanding of the molecular mechanisms underlying T. spiralis-host interactions.
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