Th17-cells in depression: Implication in multiple sclerosis

Depression is one of the most common neuropsychological symptoms of multiple sclerosis. However, in addition to mood disorder, depression can also influence on multiple sclerosis course. The mechanism of this dependence is not fully understood. The recent studies suggest the possible common immune mechanisms in the pathogenesis of depression and multiple sclerosis. In particular, it was shown that along with biogenic amines disturbance, neuroinflammation also play an important role in the pathogenesis of depression. Significant attention is drawn to Th17-cells subsets, which are considered as critical players in the pathogenesis of inflammatory diseases of the central nervous system, including multiple sclerosis. This brief report reviews the literature data on the role of neuroinflammation in the reciprocal influence of multiple sclerosis and depression with focus on Th17-cells, which may underlie pathogenetic mechanisms of both this diseases.

Automated summary

Depression is a common neuropsychological symptom in multiple sclerosis, and it may have a common immune mechanism with the disease. Neuroinflammation, along with disturbances in biogenic amines, is believed to play a significant role in the pathogenesis of depression. Th17 cells are highlighted as critical players in inflammatory diseases of the central nervous system, including multiple sclerosis.