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COVID-19 pandemic: A multidisciplinary perspective on the pathogenesis of a novel coronavirus from infection, immunity and pathological responses

期刊

FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.978619

关键词

COVID-19; SARS-CoV-2; pathogenic mechanism; virus infected; immune pathogenesis

资金

  1. Scientific research project of Tianjin Education Commission
  2. Tianjin Municipal Education Commission Scientific Research Project
  3. Science and Technology Program of Tianjin, China
  4. National Key Research and Development Program of China
  5. Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine
  6. Scientific and technological innovation project of China Academy of Chinese Medical Sciences
  7. [2021KJ134]
  8. [2019ZD11]
  9. [21ZYJDJC00070]
  10. [2019YFC1708803]
  11. [ZYYCXTD-C-202203]
  12. [C12021A04701]

向作者/读者索取更多资源

This paper reviews the research progress on the pathogenesis of the novel coronavirus (SARS-CoV-2), focusing on its pathogenic characteristics, loci of action, pathogenic mechanisms leading to immune response malfunction, as well as summarizing the pathological damage and manifestations it causes.
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus2 (SARS-CoV-2), has spread to more than 200 countries and regions, having a huge impact on human health, hygiene, and economic activities. The epidemiological and clinical phenotypes of COVID-19 have increased since the onset of the epidemic era, and studies into its pathogenic mechanisms have played an essential role in clinical treatment, drug development, and prognosis prevention. This paper reviews the research progress on the pathogenesis of the novel coronavirus (SARS-CoV-2), focusing on the pathogenic characteristics, loci of action, and pathogenic mechanisms leading to immune response malfunction of SARS-CoV-2, as well as summarizing the pathological damage and pathological manifestations it causes. This will update researchers on the latest SARS-CoV-2 research and provide directions for future therapeutic drug development.

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