期刊
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
卷 49, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ctcp.2022.101666
关键词
Black seed; Complementary medicine; Nigella sativa; Osteoarthritis; Traditional Persian medicine
资金
- Institute of Medicinal Plants (Karaj, Iran)
- Academic Center for Education, Culture and Research
- Baqiyatallah University of Medical Sciences (Tehran, Iran)
This study evaluated the efficacy and safety of Nigella sativa oil in the treatment of knee osteoarthritis. The results showed that NS oil can safely reduce symptoms and analgesic dose, and improve patient satisfaction.
Background and purpose: The oil of Nigella sativa (NS) seeds has analgesic and anti-inflammatory effects. Therefore, the efficacy and safety of NS oil in the treatment of knee osteoarthritis were evaluated.Materials and methods: One hundred and sixteen patients aged 50-70 years were randomly assigned to take 2.5 mL NS oil (N = 58) or placebo (N = 58) orally every 8 h for 1 month. WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) was the primary outcome measure and Visual Analog Scale (VAS) for pain, number of 500 mg acetaminophen tablets taken per day during the trial, patients' satisfaction with the in-terventions, complete blood count and the blood levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, creatinine and blood urea nitrogen were the secondary outcome measures.Results: Fifty two and 54 patients respectively in the NS oil and placebo groups completed the study. The VAS scores were decreased by 33.96 +/- 17.04% (NS oil group) and 9.21 +/- 0.32% (placebo group) (p < 0.001), and WOMAC total scores were decreased by 27.72 +/- 18.61% (NS oil group) and 1.34 +/- 2.31% (placebo group) (p < 0.001) compared to baseline. The NS oil reduced the dose of acetaminophen significantly compared with the placebo (p = 0.001). The patients were significantly more satisfied with the NS oil than the placebo (p < 0.001). The NS oil had no significant effect on the other variables. There was no side effect.Conclusion: Oral NS oil safely reduces the osteoarthritis symptoms and analgesic dose in the knee osteoarthritis patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据