期刊
ADVANCED SCIENCE
卷 9, 期 31, 页码 -出版社
WILEY
DOI: 10.1002/advs.202204535
关键词
antimicrobial ability; black phosphorus; chloroplasts; osteogenesis; self-defensive
资金
- National Natural Science Foundation of China [51973133, 51925304, 52073191]
- Sichuan Science and Technology Program [2020YJ0024]
This study develops a self-defensive bone scaffold inspired by chloroplasts for the treatment of infected bone defects. The scaffold has stable photothermal properties and antibacterial capabilities, effectively inhibiting bacterial infections and promoting the repair of bone defect areas.
Bone implant-associated infections induced by bacteria frequently result in repair failure and threaten the health of patients. Although black phosphorus (BP) material with superior photothermal conversion ability is booming in the treatment of bone disease, the development of BP-based bone scaffolds with excellent photothermal stability and antibacterial properties simultaneously remains a challenge. In nature, chloroplasts cannot only convert light into chemical energy, but also hold a protective and defensive envelope membrane. Inspired by this, a self-defensive bone scaffold with stable photothermal property is developed for infected bone defect therapy. Similar to thylakoid and stroma lamella in chloroplasts, BP is integrated with chitosan and polycaprolactone fiber networks. The mussel-inspired polydopamine multifunctional envelope membrane wrapped above not only strengthens the photothermal stability of BP-based scaffolds, but also realizes the in situ anchoring of silver nanoparticles. Bacteria-triggered infection of femur defects in vivo can be commendably inhibited at the early stage via these chloroplast-inspired implants, which then effectively promotes endogenous repair of the defect area under mild hyperthermia induced by near-infrared irradiation. This chloroplast-inspired strategy shows outstanding performance for infected bone defect therapy and provides a reference for the functionality of other biomedical materials.
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