Engineering Self-Powered Electrochemical Sensors Using Analyzed Liquid Sample as the Sole Energy Source

Many healthcare and environmental monitoring devices use electrochemical techniques to detect and quantify analytes. With sensors progressively becoming smaller-particularly in point-of-care (POC) devices and wearable platforms-it creates the opportunity to operate them using less energy than their predecessors. In fact, they may require so little power that can be extracted from the analyzed fluids themselves, for example, blood or sweat in case of physiological sensors and sources like river water in the case of environmental monitoring. Self-powered electrochemical sensors (SPES) can generate a response by utilizing the available chemical species in the analyzed liquid sample. Though SPESs generate relatively low power, capable devices can be engineered by combining suitable reactions, miniaturized cell designs, and effective sensing approaches for deciphering analyte information. This review details various such sensing and engineering approaches adopted in different categories of SPES systems that solely use the power available in liquid sample for their operation. Specifically, the categories discussed in this review cover enzyme-based systems, battery-based systems, and ion-selective electrode-based systems. The review details the benefits and drawbacks with these approaches, as well as prospects of and challenges to accomplishing them.

Automated summary

This review provides a detailed overview of different sensing and engineering approaches used in self-powered electrochemical sensors (SPES) systems that solely operate using the available energy in liquid samples. The categories discussed include enzyme-based, battery-based, and ion-selective electrode-based systems. The review evaluates the benefits and drawbacks of these approaches and explores the prospects and challenges in accomplishing them.