期刊
NANOMATERIALS
卷 12, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/nano12193412
关键词
metalloporphyrin; caffeic-acid biosensor; multi-walled carbon nanotubes; chitosan
类别
资金
- Natural Science Foundation of China [81671779, 81273993]
- Tianjin Education Commission [202110071014, 202110071008]
This study modified the amino side chains of chitosan and chelated it with protoporphyrin IX to prepare a sensitive-selective electrochemical biosensor. The modified electrode showed good electrocatalytic activity towards caffeic acid, with a wide linear range, high sensitivity, and low detection limit. It also demonstrated excellent reproducibility, stability, and selectivity.
Caffeic acid is an antioxidant that has been widely been related to the health benefits of people in recent years. In this paper, the amino side chains of chitosan (CS) were modified with protoporphyrin IX by amide cross-linking, and then Zn ions were chelated. The properties of metalloporphyrin-preparing functionalized multi-walled carbon nanotubes (MWCNTs) and Zn ions chelated by protoporphyrin IX composites were used as sensitive-selective electrochemical biosensors for the determination of caffeic acid. The morphology and structure of nanocomposite Zn-PPIX-CS-MWCNTs were observed by X-ray spectroscopy mapping (EDX mapping), transmission electron microscopy (TEM), and Fourier-transform infrared spectroscopy (FTIR). The electrochemical behaviors of Zn-PPIX-CS-MWCNT-modified glassy carbon (GC) electrodes were evaluated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The results show that the modified electrode had good electrocatalytic activity towards caffeic acid with a wide linear range of 0.0008-1.6 mM, an excellent sensitivity of 886.90 mu AmM(-1)cm(-1), and a detection limit of 0.022 mu M. In addition, the caffeic acid sensor had excellent reproducibility, stability, and selectivity to various interfering substances. Therefore, the modified electrode prepared by this experiment can also be applied to electrochemical sensors of other substances.
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