期刊
ADVANCED MATERIALS
卷 28, 期 7, 页码 1375-1380出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201504993
关键词
Bt toxin; Bt-resistant pests; perylenediimide chromophores; drug resistance; protein nanocarriers
类别
资金
- 973 program [2013CB127603]
- National Science Foundation of China [21174012, 51221002, 21574009]
- Beijing Natural Science Foundation [2142026]
- Fundamental Research Funds for the Central Universities [YS201402, 2015NX001, 2015QC094]
Large-scale cultivation of Bacillus thuringiensis Berliner (Bt) crops has led to the rapid development of drug resistance. Herein, a fluorescent star poly(amino acid) is synthesized with L-isoleucine functionalization for the efficient delivery of either positively or negatively charged exogenous proteins into live cells. Poly(amino acid)s (P1)/Cry1Ab complexes greatly increase the cytotoxicity of the Bt toxin, Cry1Ab, and efficiently kill Bt-resistant pests.
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