Relationship between Nutrition, Lifestyle, and Neurodegenerative Disease: Lessons from ADH1B, CYP1A2 and MTHFR

In the present review, the main features involved in the susceptibility and progression of neurodegenerative disorders (NDDs) have been discussed, with the purpose of highlighting their potential application for promoting the management and treatment of patients with NDDs. In particular, the impact of genetic and epigenetic factors, nutrients, and lifestyle will be presented, with particular emphasis on Alzheimer's disease (AD) and Parkinson's disease (PD). Metabolism, dietary habits, physical exercise and microbiota are part of a complex network that is crucial for brain function and preservation. This complex equilibrium can be disrupted by genetic, epigenetic, and environmental factors causing perturbations in central nervous system homeostasis, contributing thereby to neuroinflammation and neurodegeneration. Diet and physical activity can directly act on epigenetic modifications, which, in turn, alter the expression of specific genes involved in NDDs onset and progression. On this subject, the introduction of nutrigenomics shed light on the main molecular players involved in the modulation of health and disease status. In particular, the review presents data concerning the impact of ADH1B, CYP1A2, and MTHFR on the susceptibility and progression of NDDs (especially AD and PD) and how they may be exploited for developing precision medicine strategies for the disease treatment and management.

Automated summary

This review discusses the main features of susceptibility and progression in neurodegenerative disorders (NDDs), focusing on Alzheimer's disease (AD) and Parkinson's disease (PD). Metabolism, dietary habits, physical exercise, and microbiota are essential for brain function and preservation. Genetic, epigenetic, and environmental factors can disrupt this balance, leading to neuroinflammation and neurodegeneration. Diet and exercise can directly impact epigenetic modifications and alter the expression of specific genes involved in NDDs. Nutrigenomics provides insights into precision medicine strategies for the treatment and management of these diseases.