Identification of hub genes associated with acute kidney injury induced by renal ischemia-reperfusion injury in mice

Article Urology & Nephrology

Activation of STAT3 signaling pathway in the kidney of COVID-19 patients

Fadi Salem et al.

Summary: This study suggests that serine phosphorylation of STAT3, instead of tyrosine phosphorylation, is commonly activated in the kidney of patients with COVID-19.

JOURNAL OF NEPHROLOGY (2022)

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Article Critical Care Medicine

Cell cycle arrest biomarkers for predicting renal recovery from acute kidney injury: a prospective validation study

Hui-Miao Jia et al.

Summary: Urinary cell cycle arrest biomarkers can predict recovery in patients who develop AKI after ICU admission. The predictive accuracy can be improved when combined with clinical factors and scoring systems.

ANNALS OF INTENSIVE CARE (2022)

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Article Medical Laboratory Technology

Clinical value of serum miR-320-3p expression in predicting the prognosis of sepsis-induced acute kidney injury

Jian Ji et al.

Summary: The expression of miR-320-3p in children with sepsis-induced AKI was significantly increased. The combination of NGAL, KIM-1, and APACHE II scores had good value for prognosis prediction in children. MiR-320-3p, NGAL, KIM-1 levels, and APACHE II scores combined showed the highest accuracy in predicting death in children with sepsis and AKI.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2022)

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Article Pediatrics

Evaluation of acute kidney injury by urinary tissue inhibitor metalloproteinases-2 and insulin-like growth factor-binding protein 7 after pediatric cardiac surgery

Yue Tao et al.

Summary: In this study, the utility of [TIMP-2]*[IGFBP7] as an earlier biomarker for predicting AKI in Chinese infants and small children was validated. Results showed that urinary [TIMP-2]*[IGFBP7] could predict late severe AKI as early as 2 hours following complex cardiac surgery in pediatric patients.

PEDIATRIC NEPHROLOGY (2022)

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Article Pharmacology & Pharmacy

Maslinic Acid Attenuates Ischemia/Reperfusion-Induced Acute Kidney Injury by Suppressing Inflammation and Apoptosis Through Inhibiting NF-?B and MAPK Signaling Pathway

Wenjuan Sun et al.

Summary: The study demonstrates the renoprotective effect of maslinic acid (MA) on acute kidney injury (AKI) induced by renal ischemia-reperfusion injury (IRI) through inhibiting inflammation and apoptosis-related signaling pathways. MA shows promising potential as a therapeutic agent for kidney diseases.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Pharmacology & Pharmacy

JAK/STAT Signaling: Molecular Targets, Therapeutic Opportunities, and Limitations of Targeted Inhibitions in Solid Malignancies

Bilal Rah et al.

Summary: The JAK/STAT signaling pathway plays an important role in regulating cellular processes such as immune regulation, cell proliferation, survival, apoptosis, and hematopoiesis. Dysregulation of this pathway is associated with various immunological disorders, hematological diseases, and solid malignancies. Understanding the intricate mechanisms of JAK/STAT signaling in solid malignancies is crucial for drug development and improving cancer therapies.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Subclinical AKI and Clinical Outcomes in Elderly Patients Undergoing Cardiac Surgery: Diagnostic Utility of NGAL versus Standard Creatinine Increase Criteria

Matteo Marcello et al.

Summary: This study aimed to investigate the utility of NGAL in diagnosing SAKI within 48 hours after cardiac surgery and its ability to predict adverse clinical outcomes compared to current AKI criteria. The results showed that SAKI was significantly associated with 30-day and 6-month mortality, adverse renal outcomes, and the need for RRT. CrIAKI was significantly associated with 30-day mortality and adverse renal outcomes, but not with 6-month mortality or the need for RRT.

CARDIORENAL MEDICINE (2022)

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Article Physiology

Blockade of STAT3 signaling alleviates the progression of acute kidney injury to chronic kidney disease through antiapoptosis

Jae Yoon Park et al.

Summary: This study investigates the role of STAT3 isoforms in the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). The researchers found that STAT3 activation is associated with AKI progression and STAT3 alpha may play a significant role. Inhibition of STAT3 can attenuate tubular damage, inflammation, and fibrosis in AKI models. The study suggests that STAT3 inhibitors may be a novel strategy for the management of AKI.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2022)

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Article Physiology

Identification of Hub Genes Associated with the Development of Acute Kidney Injury by Weighted Gene Co-Expression Network Analysis

Xiao Lin et al.

Summary: This study identified key genes and pathways related to the progression of AKI using WGCNA method and experimental validation, laying a foundation for understanding the pathogenesis and development of therapeutic agents for AKI.

KIDNEY & BLOOD PRESSURE RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Integration of the Drug-Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts

Sharon L. Freshour et al.

Summary: The Drug-Gene Interaction Database (DGIdb) is a web resource that provides information on drug-gene interactions and druggable genes. DGIdb 4.0 is the latest major version release, featuring integration with crowdsourced efforts, addition of new sources, and updates to the data.

NUCLEIC ACIDS RESEARCH (2021)

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Article Biotechnology & Applied Microbiology

Identification of Potential Gene and MicroRNA Biomarkers of Acute Kidney Injury

Si-Yang Wang et al.

Summary: This study identified potential key genes, miRNAs, and pathways in AKI through bioinformatics analysis. The findings enrich the current understanding of AKI and offer new insights for AKI research and treatment.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Urology & Nephrology

Conceptual advances and evolving terminology in acute kidney disease

John A. Kellum et al.

Summary: The concepts of kidney damage and dysfunction, including subclinical damage and loss of renal functional reserve, are relevant to the detection of acute kidney injury (AKI). New insights and biomarkers challenge the traditional definition of AKI, leading to the emergence of the concept of acute kidney disease with a need for new definitions of acute syndromes of kidney impairment and injury.

NATURE REVIEWS NEPHROLOGY (2021)

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Article Urology & Nephrology

Novel predictive biomarkers for acute injury superimposed on chronic kidney disease

Wuhua Jiang et al.

Summary: This study evaluated whether biomarkers robustly expressed in acute kidney injury could predict acute injury based on CKD. The results showed that IGFBP7 protein can be used as a sensitive biomarker to predict and differentiate AonC severity, while RHBDL2 and SDC-1 showed promising performance in predicting severe AonC, providing new biomarkers for predicting AonC.

NEFROLOGIA (2021)

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Article Cell Biology

c-MYC-induced long noncoding RNA MEG3 aggravates kidney ischemia-reperfusion injury through activating mitophagy by upregulation of RTKN to trigger the Wnt/β-catenin pathway

Dajun Liu et al.

Summary: The study revealed the crucial role of MEG3 in renal ischemia-reperfusion injury by promoting mitophagy and inducing apoptosis. Furthermore, MEG3 was found to bind with miR-145-5p, leading to upregulation of RTKN and activation of the Wnt/beta -catenin pathway. This positive feedback loop contributes to renal IRI and suggests potential therapeutic targets for treating renal injury.

CELL DEATH & DISEASE (2021)

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Article Multidisciplinary Sciences

Identification of hub genes and transcription factor-miRNA-mRNA pathways in mice and human renal ischemia-reperfusion injury

Peng Ke et al.

Summary: In this study, 15 hub genes and multiple TF-miRNA-mRNA pathways were identified in renal IRI, aiding in the understanding of molecular and regulatory mechanisms. Junb-miR-223-Ranbp3l, Cebpb-miR-223-Ranbp3l, Cebpb-miR-21Ranbp3l, and Cebpb-miR-181b-Bsnd were highlighted as the most important pathways, with Spp1, Fos, Timp1, Tnc, Fosl2, and Junb as key hub genes. Potential negative feedback loops in renal IRI were identified, including Fosl2-miR-155, Fosl2-miR-146a, Cebpb-miR-155, and Mafk-miR-25.

PEERJ (2021)

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Article Cell Biology

Glutamine Administration Attenuates Kidney Inflammation in Obese Mice Complicated with Polymicrobial Sepsis

Li-Han Su et al.

Summary: Obesity aggravates inflammation, while post-sepsis GLN administration in obese mice alleviates inflammation and attenuates AKI, reversing a series of inflammatory responses induced by sepsis.

MEDIATORS OF INFLAMMATION (2021)

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Article Multidisciplinary Sciences

HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury

David D. Aufhauser et al.

Summary: Histone/protein deacetylases (HDAC) 1 and 2 have differential effects on CoREST complex stability within renal tubules, influencing outcomes of renal ischemia reperfusion injury (IRI) and implicating endothelin as a potential downstream mediator.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

Identification of fibroblast activation-related genes in two acute kidney injury models

Weiming Deng et al.

Summary: In this study, key genes and pathways related to fibroblast activation in two mouse models of AKI were identified through analysis of gene expression profiles. These genes are mainly involved in functions such as transport, oxidation-reduction process, metabolic process, metal ion binding, hydrolase activity, and oxidoreductase activity.

PEERJ (2021)

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Article Genetics & Heredity

Bioinformatic analysis identifies potential biomarkers and therapeutic targets of septic-shock-associated acute kidney injury

Yun Tang et al.

Summary: The study found that septic shock and acute kidney injury are closely related, and genes VMP1, SLPI, PTX3, TIMP1, OLFM4, LCN2, and S100A9 are significantly associated with novel biomarkers involved in the occurrence and development of SSAKI.

HEREDITAS (2021)

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Article Endocrinology & Metabolism

The FOS/AP-1 Regulates Metabolic Changes and Cholesterol Synthesis in Human Periovulatory Granulosa Cells

Yohan Choi et al.

Summary: This study found that hCG regulates the expression of FOS and its partners by activating protein kinase A and p42/44MAPK signaling pathways. High-throughput RNA sequencing revealed that inhibition of FOS affects the expression of multiple genes involved in the periovulatory process.

ENDOCRINOLOGY (2021)

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Article Biochemistry & Molecular Biology

The Role of TRPC6 in Renal Ischemia/Reperfusion and Cellular Hypoxia/Reoxygenation Injuries

Xin Hou et al.

Summary: This study found that TRPC6 knockout can significantly improve renal damage induced by I/R, enhance autophagy levels, alleviate MMP depolarization and apoptotic changes caused by I/R, and down-regulate PI3K/AKT and ERK signaling, providing a new avenue for future AKI therapies.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Multidisciplinary Sciences

clusterProfiler 4.0: A universal enrichment tool for interpreting omics data

Tianzhi Wu et al.

Summary: The updated version of clusterProfiler 4.0 is a powerful tool for functional enrichment analysis in a wide range of organisms, offering tidy interfaces for data operation and visualization, as well as new features like gene set enrichment analysis and comparison of results from multiple gene lists.

INNOVATION (2021)

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Article Biochemistry & Molecular Biology

KEGG: integrating viruses and cellular organisms

Minoru Kanehisa et al.

Summary: KEGG is a curated resource integrating eighteen databases categorized into systems, genomic, chemical and health information, providing mapping tools for understanding cellular and organism-level functions from genome sequences and other molecular datasets. The network variation maps in the KEGG database show how different pathogens and environmental factors influence cellular signaling pathways.

NUCLEIC ACIDS RESEARCH (2021)

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Article Cardiac & Cardiovascular Systems

Association between preoperative aspirin and acute kidney injury following coronary artery bypass grafting

Sleiman Sebastian Aboul-Hassan et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2020)

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Article Critical Care Medicine

The Role of Biomarkers in Acute Kidney Injury

Nattachai Srisawat et al.

CRITICAL CARE CLINICS (2020)

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Review Medicine, Research & Experimental

ERK/MAPK signalling pathway and tumorigenesis

Yan-Jun Guo et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

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Article Genetics & Heredity

Identification and Validation of Potential Biomarkers and Their Functions in Acute Kidney Injury

Jianwen Chen et al.

FRONTIERS IN GENETICS (2020)

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Review Cell Biology

Structural and Biophysical Insights into the Function of the Intrinsically Disordered Myc Oncoprotein

Marie-Eve Beaulieu et al.

CELLS (2020)

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Article Immunology

Protective effect of taraxasterol on ischemia/reperfusion-induced acute kidney injury via inhibition of oxidative stress, inflammation, and apoptosis

Chuanlei Li et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Urology & Nephrology

Proximal Tubular Transcription Factors in Acute Kidney Injury: Recent Advances

Sian E. Piret et al.

NEPHRON (2020)

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Review Oncology

Research progress on the PI3K/AKT signaling pathway in gynecological cancer (Review)

Xiang Shi et al.

MOLECULAR MEDICINE REPORTS (2019)

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Review Neurosciences

Lipid Metabolism in Neurons: A Brief Story of a Novel c-Fos-Dependent Mechanism for the Regulation of Their Synthesis

Lucia Rodriguez-Berdini et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

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Review Urology & Nephrology

Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment

Sadudee Peerapornratana et al.

KIDNEY INTERNATIONAL (2019)

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Article Oncology

miRNA-mRNA regulatory network analysis of mesenchymal stem cell treatment in cisplatin-induced acute kidney injury identifies roles for miR-210/Serpine1 and miR-378/Fos in regulating inflammation

Chunmei Zhang et al.

MOLECULAR MEDICINE REPORTS (2019)

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Article Cell Biology

miR-191 secreted by platelet-derived microvesicles induced apoptosis of renal tubular epithelial cells and participated in renal ischemia-reperfusion injury via inhibiting CBS

Xiao-qiang Wu et al.

CELL CYCLE (2019)

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Article Biochemistry & Molecular Biology

STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

Damian Szklarczyk et al.

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The Gene Ontology Resource: 20 years and still GOing strong

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Article Gastroenterology & Hepatology

Urinary Neutrophil Gelatinase Associated Lipocalins (NGALs) predict acute kidney injury post liver transplant

Francis P. Robertson et al.

HPB (2019)

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Article Oncology

The utility of neutrophil gelatinase-associated Lipocalin (NGAL) as a marker of acute kidney injury (AKI) in critically ill patients

Shabnum Khawaja et al.

BIOMARKER RESEARCH (2019)

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Article Biology

CXCL8(3-72) K11R/G31P protects against sepsis-induced acute kidney injury via NF-B and JAK2/STAT3 pathway

Yunfeng Zhou et al.

BIOLOGICAL RESEARCH (2019)

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Review Urology & Nephrology

Mechanisms and therapeutic targets of ischemic acute kidney injury

Sang Jun Han et al.

KIDNEY RESEARCH AND CLINICAL PRACTICE (2019)

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TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions

Heonjong Han et al.

NUCLEIC ACIDS RESEARCH (2018)

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Review Cell Biology

Comparison of acute kidney injury of different etiology reveals in-common mechanisms of tissue damage

Michael Hultstrom et al.

PHYSIOLOGICAL GENOMICS (2018)

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Review Oncology

The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

Patrick A. Carroll et al.

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Article Medicine, Research & Experimental

Transcriptional trajectories of human kidney injury progression

Pietro E. Cippa et al.

JCI INSIGHT (2018)

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Article Immunology

Endothelial STAT3 Modulates Protective Mechanisms in a Mouse Ischemia-Reperfusion Model of Acute Kidney Injury

Shataakshi Dube et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2017)

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Review Biochemistry & Molecular Biology

Cell Cycle Arrest as a Therapeutic Target of Acute Kidney Injury

Wei-gang Wang et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2017)

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Article Cell Biology

MiR-155 is Involved in Renal Ischemia-Reperfusion Injury via Direct Targeting of FoxO3a and Regulating Renal Tubular Cell Pyroptosis

Haoyu Wu et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2016)

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Article Multidisciplinary Sciences

miR-144 and targets, c-fos and cyclooxygenase-2 (COX2), modulate synthesis of PGE2 in the amnion during pregnancy and labor

Huanan Li et al.

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Article Critical Care Medicine

Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study

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limma powers differential expression analyses for RNA-sequencing and microarray studies

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starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data

Jun-Hao Li et al.

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Article Mathematical & Computational Biology

HeatmapGenerator: high performance RNAseq and microarray visualization software suite to examine differential gene expression levels using an R and C++ hybrid computational pipeline

Bohdan B. Khomtchouk et al.

SOURCE CODE FOR BIOLOGY AND MEDICINE (2014)

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Article Hematology

Potential Role of Neutrophil Gelatinase-Associated Lipocalin in Identifying Critically Ill Patients With Acute Kidney Injury Stage 2-3 Who Subsequently Require Renal Replacement Therapy

Khajohn Tiranathanagul et al.

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Review Critical Care Medicine

Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1)

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clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

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OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

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Transcriptome Analysis of Renal Ischemia/Reperfusion Injury and Its Modulation by Ischemic Pre-Conditioning or Hemin Treatment

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Cytoscape: A software environment for integrated models of biomolecular interaction networks

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GENOME RESEARCH (2003)

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Identification of hub genes associated with acute kidney injury induced by renal ischemia-reperfusion injury in mice

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