4.7 Review

Recent nanotechnology advancements to treat multidrug-resistance pancreatic cancer: Pre-clinical and clinical overview

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Medicine, Research & Experimental

Nanocarriers for pancreatic cancer imaging, treatments, and immunotherapies

Luman Liu et al.

Summary: Pancreatic tumors are difficult to treat due to their highly fibrotic and immunosuppressive nature. Nanotechnology offers promising solutions by providing improved drug delivery and immunotherapy-based approaches. This review highlights the potential of nanoscale strategies for treating pancreatic tumors and discusses future research directions.

THERANOSTICS (2022)

Article Engineering, Biomedical

Smart hypoxia-responsive transformable and charge-reversible nanoparticles for the deep penetration and tumor microenvironment modulation of pancreatic cancer

Hongyi Chen et al.

Summary: The compact extracellular matrix (ECM) of pancreatic ductal adenocarcinoma (PDAC) hinders drug delivery and breaking the barrier can lead to uncontrollable growth and metastasis. Researchers have developed a smart nanoparticle that can reduce in size in the tumor microenvironment, promote drug penetration, and inhibit overactivated STAT3, changing the tumor microenvironment into an immune-activated state. This provides an inspiring opportunity in PDAC treatment.

BIOMATERIALS (2022)

Article Chemistry, Multidisciplinary

Nanoparticle combination for precise stroma modulation and improved delivery for pancreatic cancer

Mubin Tarannum et al.

Summary: Mesoporous silica nanoparticles (MSNs) can be used as drug carriers to reduce the stroma in pancreatic cancer by inhibiting the sonic hedgehog (SHh) pathway, leading to improved therapeutic outcomes.

JOURNAL OF CONTROLLED RELEASE (2022)

Article Chemistry, Multidisciplinary

Remediating Desmoplasia with EGFR-Targeted Photoactivable Multi-Inhibitor Liposomes Doubles Overall Survival in Pancreatic Cancer

Girgis Obaid et al.

Summary: Desmoplasia, a characteristic of pancreatic ductal adenocarcinoma (PDAC), poses barriers to treatment and affects patient outcomes. This study demonstrates a novel targeted liposomal therapy that combines photodynamic and chemotherapeutic effects while also remediating desmoplasia. The results show significant inhibition of tumor growth and improved survival, highlighting the potential of this therapy in extending the lives of PDAC patients.

ADVANCED SCIENCE (2022)

Article Oncology

Natural product-based nanoformulations for cancer therapy: Opportunities and challenges

Dharambir Kashyap et al.

Summary: The application of natural product-based nanoformulations in the treatment of various human diseases, such as cancer, is a growing field. Nanotechnology in cancer therapeutics has overcome the limitations of conventional drug delivery systems, with promising results in targeting tumor cells and reducing side effects. The integration of phytotherapy and nanotechnology in clinical settings may lead to better pharmacological responses and improved clinical outcomes for patients.

SEMINARS IN CANCER BIOLOGY (2021)

Article Engineering, Biomedical

Polyanhydride nanoparticles stabilize pancreatic cancer antigenMUC4β

Luman Liu et al.

Summary: The study utilized amphiphilic polyanhydride copolymers to synthesize nanoparticles for delivering MUC4 beta protein, which showed stable release and generated specific antibody responses in mice. These results suggest that polyanhydride nanoparticles are promising vaccine carriers for PC immunotherapy.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2021)

Article Medicine, Research & Experimental

Intraperitoneal siRNA Nanoparticles for Augmentation of Gemcitabine Efficacy in the Treatment of Pancreatic Cancer

Siyuan Tang et al.

Summary: The study demonstrates that a combination of CXCR4 inhibition and PLK1 knockdown enhances the therapeutic effect of gemcitabine in an orthotopic model of metastatic pancreatic cancer. Nanoparticles containing cholesterol showed synergism in vitro, with the triple combination of PAMD-CHOL/siPLK1 and GEM exhibiting superior anticancer activity in vivo compared to single or dual combinations.

MOLECULAR PHARMACEUTICS (2021)

Review Chemistry, Multidisciplinary

Tailor-Made Nanomaterials for Diagnosis and Therapy of Pancreatic Ductal Adenocarcinoma

Xi Hu et al.

Summary: Nanomaterials have potential applications in the diagnosis and treatment of PDAC, but a deeper understanding of nano-bio interactions in the microenvironment of PDAC is needed. Detecting potential biomarkers and understanding nano-bio interactions in the tumor microenvironment is crucial for designing effective nanomedicine tailored to PDAC.

ADVANCED SCIENCE (2021)

Article Pharmacology & Pharmacy

Exosomes as new therapeutic vectors for pancreatic cancer treatment

Constanca Oliveira et al.

Summary: Pancreatic cancer is a deadly cancer with low survival rates and often goes undetected until late stages. Despite extensive research, the 5-year survival rate has not significantly improved. However, new therapeutic approaches using exosomes show promise in delivering anti-cancer drugs effectively and with less toxicity.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2021)

Review Pharmacology & Pharmacy

Advanced nanomedicine and cancer: Challenges and opportunities in clinical translation

Juan Gonzalez-Valdivieso et al.

Summary: Nanomedicine offers a promising approach towards personalized medicine for cancer patients, with novel tools being developed for treatment, imaging, and theranostic purposes. Despite successful preclinical studies, promising nanosystems face obstacles before being adopted as safe options for cancer patients in clinical practice.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Pharmacology & Pharmacy

M1 Macrophage-Derived Exosomes Loaded with Gemcitabine and Deferasirox against Chemoresistant Pancreatic Cancer

Yongmei Zhao et al.

Summary: This study developed a specific drug delivery system based on M1 macrophage-derived exosomes for pancreatic cancer with chemoresistance. The nanoformulation combining GEM and DFX in M1Exo significantly enhanced therapeutic efficacy against GEM-resistant cancer cells.

PHARMACEUTICS (2021)

Review Pharmacology & Pharmacy

Overcoming the Tumor Microenvironmental Barriers of Pancreatic Ductal Adenocarcinomas for Achieving Better Treatment Outcomes

Rami Alzhrani et al.

Summary: PDAC is a highly aggressive disease with a complex tumor microenvironment, leading to challenges in traditional treatment methods. New strategies, such as immune checkpoint inhibitors and nanomedicines, are being explored to improve the outcome of PDAC therapies.

ADVANCED THERAPEUTICS (2021)

Article Instruments & Instrumentation

Challenges in nanomedicine clinical translation

Josbert M. Metselaar et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2020)

Review Oncology

The tumour microenvironment in pancreatic cancer - clinical challenges and opportunities

Won Jin Ho et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Review Biochemistry & Molecular Biology

Protein arginine methylation promotes therapeutic resistance in human pancreatic cancer

Victoria Katie Xie et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2020)

Review Oncology

Molecular mediators of peritoneal metastasis in pancreatic cancer

Leela Rani Avula et al.

CANCER AND METASTASIS REVIEWS (2020)

Review Oncology

Immunotherapy for pancreatic cancer: A 2020 update

Dimitrios Schizas et al.

CANCER TREATMENT REVIEWS (2020)

Review Oncology

Stroma-Targeting Therapy in Pancreatic Cancer: One Coin With Two Sides?

Bolun Jiang et al.

FRONTIERS IN ONCOLOGY (2020)

Review Medicine, General & Internal

Early Diagnosis of Pancreatic Cancer: The Key for Survival

Gina Gheorghe et al.

DIAGNOSTICS (2020)

Review Pharmacology & Pharmacy

Exosomes as therapeutic solutions for pancreatic cancer

Batoul Farran et al.

DRUG DISCOVERY TODAY (2020)

Review Medicine, Research & Experimental

Noncoding RNAs in drug-resistant pancreatic cancer: A review

Zhengjun Lin et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Article Pharmacology & Pharmacy

A Polymeric Nanogel-Based Treatment Regimen for Enhanced Efficacy and Sequential Administration of Synergistic Drug Combination in Pancreatic Cancer

Kruti S. Soni et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2019)

Article Oncology

Pancreatic Adenocarcinoma, Version 1.2019

Margaret A. Tempero et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2019)

Review Chemistry, Multidisciplinary

Survey of Clinical Translation of Cancer Nanomedicines-Lessons Learned from Successes and Failures

Hongliang He et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

Review Biochemistry & Molecular Biology

Chemoresistance in Pancreatic Cancer

Siyuan Zeng et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Oncology

Cancer statistics, 2019

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2019)

Review Oncology

Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors

Prashanth Rawla et al.

WORLD JOURNAL OF ONCOLOGY (2019)

Review Pharmacology & Pharmacy

Recent advances in metal nanoparticles in cancer therapy

Ankush Sharma et al.

JOURNAL OF DRUG TARGETING (2018)

Review Oncology

Status and future directions in the management of pancreatic cancer: potential impact of nanotechnology

Catherine M. Sielaff et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2018)

Review Biochemistry & Molecular Biology

Nanoparticle-Mediated Combination Therapy: Two-in-One Approach for Cancer

Sangiliyandi Gurunathan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Biochemistry & Molecular Biology

Applications of Noble Metal-Based Nanoparticles in Medicine

Bartosz Klebowski et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Editorial Material Pharmacology & Pharmacy

Cancer nanomedicines: oversold or underappreciated?

Roy van der Meel et al.

EXPERT OPINION ON DRUG DELIVERY (2017)

Review Genetics & Heredity

MicroRNA in pancreatic cancer

Keiichi Yonemori et al.

JOURNAL OF HUMAN GENETICS (2017)

Review Immunology

Immunotherapy of cancers comes of age

Hila Yousefi et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2017)

Review Biochemistry & Molecular Biology

Cancer stem cells revisited

Eduard Batlle et al.

NATURE MEDICINE (2017)

Article Gastroenterology & Hepatology

Microenvironment in determining chemo-resistance in pancreatic cancer: Neighborhood matters

Patricia Dauer et al.

PANCREATOLOGY (2017)

Review Oncology

Nanotechnology-based combination therapy for overcoming multidrug-resistant cancer

Meng Zhang et al.

CANCER BIOLOGY & MEDICINE (2017)

Review Pharmacology & Pharmacy

Nanotechnologies in Pancreatic Cancer Therapy

Ayesha Manzur et al.

PHARMACEUTICS (2017)

Review Pharmacology & Pharmacy

Using Properties of Tumor Microenvironments for Controlling Local, On-Demand Delivery from Biopolymer-Based Nanocarriers

Abdullah K. Alshememry et al.

CURRENT PHARMACEUTICAL DESIGN (2017)

Review Biochemistry & Molecular Biology

Pancreatic Cancer Therapy Review: From Classic Therapeutic Agents to Modern Nanotechnologies

Ana Rebelo et al.

CURRENT DRUG METABOLISM (2017)

Review Oncology

Advances in the Genetics and Biology of Pancreatic Cancer

Andrew J. Aguirre et al.

CANCER JOURNAL (2017)

Article Biochemical Research Methods

Effect of Terminal-Group Functionality on the Ability of Dendrimers to Bind Proteins

Fumiko Chiba et al.

BIOCONJUGATE CHEMISTRY (2017)

Article Oncology

Pancreatic Cancer Genomes: Implications for Clinical Management and Therapeutic Development

Stephan B. Dreyer et al.

CLINICAL CANCER RESEARCH (2017)

Review Biochemistry & Molecular Biology

EMT: 2016

M. Angela Nieto et al.

Review Pathology

Surgical and molecular pathology of pancreatic neoplasms

Wenzel M. Hackeng et al.

DIAGNOSTIC PATHOLOGY (2016)

Review Pharmacology & Pharmacy

Nanoparticle delivery of anticancer drugs overcomes multidrug resistance in breast cancer

Yueling Yuan et al.

DRUG DELIVERY (2016)

Article Multidisciplinary Sciences

Genomic analyses identify molecular subtypes of pancreatic cancer

Peter Bailey et al.

NATURE (2016)

Article Multidisciplinary Sciences

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

Amira Elgogary et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Engineering, Biomedical

Nanoparticle formulation of ormeloxifene for pancreatic cancer

Sheema Khan et al.

BIOMATERIALS (2015)

Review Pharmacology & Pharmacy

Gemcitabine resistance in pancreatic ductal adenocarcinoma

Yoav Binenbaum et al.

DRUG RESISTANCE UPDATES (2015)

Review Oncology

Pathological and Molecular Evaluation of Pancreatic Neoplasms

Arvind Rishi et al.

SEMINARS IN ONCOLOGY (2015)

Article Nanoscience & Nanotechnology

Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer

Armando Lucero-Acuna et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2014)

Review Medicine, General & Internal

Pancreatic Adenocarcinoma

David P. Ryan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Oncology

NF-κB, an Active Player in Human Cancers

Yifeng Xia et al.

CANCER IMMUNOLOGY RESEARCH (2014)

Review Pharmacology & Pharmacy

Nanodrug delivery in reversing multidrug resistance in cancer cells

Sonali Kapse-Mistry et al.

FRONTIERS IN PHARMACOLOGY (2014)

Review Physiology

Aphid polyphenisms: trans-generational developmental regulation through viviparity

Kota Ogawa et al.

FRONTIERS IN PHYSIOLOGY (2014)

Article Oncology

A Phase II Trial of nab-Paclitaxel as Second-line Therapy in Patients With Advanced Pancreatic Cancer

Peter J. Hosein et al.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2013)

Review Gastroenterology & Hepatology

Roles for KRAS in Pancreatic Tumor Development and Progression

Marina Pasca di Magliano et al.

GASTROENTEROLOGY (2013)

Article Medicine, General & Internal

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

Daniel D. Von Hoff et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Gastroenterology & Hepatology

Differences in Transcript Levels of ABC Transporters Between Pancreatic Adenocarcinoma and Nonneoplastic Tissues

Beatrice Mohelnikova-Duchonova et al.

PANCREAS (2013)

Article Multidisciplinary Sciences

Targeting CXCL12 from FAP-expressing carcinomaassociated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

Christine Feig et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Physiology

pH sensing and regulation in cancer

Mehdi Damaghi et al.

FRONTIERS IN PHYSIOLOGY (2013)

Review Pharmacology & Pharmacy

Molecular Pathology of Pancreatic Cancer: From Bench-to-Bedside Translation

Vincenzo Corbo et al.

CURRENT DRUG TARGETS (2012)

Review Pharmacology & Pharmacy

Nanotechnology-based combinational drug delivery: an emerging approach for cancer therapy

Priyambada Parhi et al.

DRUG DISCOVERY TODAY (2012)

Article Biochemistry & Molecular Biology

Cancer stem cells

Zuoren Yu et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)

Review Nanoscience & Nanotechnology

The Upcoming Field of Theranostic Nanomedicine: An Overview

Priyanka Prabhu et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2012)

Article Chemistry, Multidisciplinary

Challenges to effective cancer nanotheranostics

Marites P. Melancon et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Review Chemistry, Multidisciplinary

Polymeric micelles drug delivery system in oncology

Jian Gong et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Review Gastroenterology & Hepatology

The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

Mert Erkan et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2012)

Review Oncology

Treating metastatic cancer with nanotechnology

Avi Schroeder et al.

NATURE REVIEWS CANCER (2012)

Review Pharmacology & Pharmacy

Utilisation of Nanoparticle Technology in Cancer Chemoresistance

Duncan Ayers et al.

JOURNAL OF DRUG DELIVERY (2012)

Review Oncology

Nanomedicine in cancer therapy: Innovative trends and prospects

Elvin Blanco et al.

CANCER SCIENCE (2011)

Article Gastroenterology & Hepatology

Pancreatic Cancer Cells Resistant to Chemoradiotherapy Rich in Stem-Cell-Like Tumor Cells

Zhiyong Du et al.

DIGESTIVE DISEASES AND SCIENCES (2011)

Review Biochemistry & Molecular Biology

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

A. Singh et al.

ONCOGENE (2010)

Review Biochemistry & Molecular Biology

NF-κB and epithelial to mesenchymal transition of cancer

Chengyin Min et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2008)

Review Medicine, General & Internal

Biology and management of pancreatic cancer

P. Ghaneh et al.

POSTGRADUATE MEDICAL JOURNAL (2008)

Article Oncology

Development and characterization of gemcitabine-resistant pancreatic tumor cells

Ami N. Shah et al.

ANNALS OF SURGICAL ONCOLOGY (2007)

Review Gastroenterology & Hepatology

Biology and management of pancreatic cancer

Paula Ghaneh et al.

Article Oncology

New target therapies in advanced pancreatic cancer

S. Cascinu et al.

ANNALS OF ONCOLOGY (2006)

Article Gastroenterology & Hepatology

Differential diagnosis of pancreatic tumors using ultrasound contrast imaging

A Sofuni et al.

JOURNAL OF GASTROENTEROLOGY (2005)

Article Surgery

The genetics of pancreatic cancer

SM Cowgill et al.

AMERICAN JOURNAL OF SURGERY (2003)

Review Oncology

Pancreatic cancer biology and genetics

N Bardeesy et al.

NATURE REVIEWS CANCER (2002)