4.7 Article

Antimalarial and antitumour activities of the steroidal quinone-methide celastrol and its combinations with artemiside, artemisone and methylene blue

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Medicinal

The Role of the Iron Protoporphyrins Heme and Hematin in the Antimalarial Activity of Endoperoxide Drugs

Helenita C. Quadros et al.

Summary: Plasmodium has evolved the ability to regulate the levels and oxidative states of iron protoporphyrin IX. Antimalarial drugs may cause an imbalance in iron homeostasis by alkylating heme and forming hematin-drug adducts, which exhibit powerful cytocidal effects and can be potential antiplasmodial agents.

PHARMACEUTICALS (2022)

Article Chemistry, Medicinal

Biological Evaluation in Resistant Cancer Cells and Study of Mechanism of Action of Arylvinyl-1,2,4-Trioxanes

Jerome P. L. Ng et al.

Summary: The cytotoxic effects and anticancer mechanisms of 10 selected peroxides were investigated on different cancer cell lines. Peroxides 7 and 8 showed a better P-gp inhibitory effect and induced apoptosis through a ROS- and caspase-3-independent pathway.

PHARMACEUTICALS (2022)

Article Immunology

Streamlined and Robust Stage-Specific Profiling of Gametocytocidal Compounds Against Plasmodium falciparum

Janette Reader et al.

Summary: This study optimized a simple and cost-effective strategy for describing the stage-specific action of antimalarial compounds against different developmental stages of the malaria parasite.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Article Immunology

Clinical and In Vitro Resistance of Plasmodium falciparum to Artesunate- Amodiaquine in Cambodia

Melissa Mairet-Khedim et al.

Summary: The efficacy of artesunate-amodiaquine for uncomplicated falciparum malaria in Cambodia was found to be inadequate due to amodiaquine-resistant P. falciparum. The study identified that amodiaquine resistance was not associated with previously identified molecular markers.

CLINICAL INFECTIOUS DISEASES (2021)

Article Chemistry, Medicinal

Synthesis, computational docking and biological evaluation of celastrol derivatives as dual inhibitors of SERCA and P-glycoprotein in cancer therapy

Paolo Coghi et al.

Summary: Celastrol-dipeptide derivatives exhibit high anti-proliferative activity and selectivity towards liver cancer cells, inducing apoptosis and inhibiting P-gp-mediated drug efflux. Compound 3 shows greater efficiency in inhibiting drug efflux compared to the inhibitor verapamil.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Oncology

Artemisinin Mediates Its Tumor-Suppressive Activity in Hepatocellular Carcinoma Through Targeted Inhibition of FoxM1

Deeptashree Nandi et al.

Summary: FoxM1 overexpression is associated with tumor aggressiveness, while Artemisinin has been identified to curb its activity and potentially improve therapeutic response, especially in resistant liver cancer cells. The combination of Artemisinin with Thiostrepton showed enhanced efficacy in reducing growth and inducing cell death in liver cancer cells, providing a novel therapeutic option for resistant cancer patients.

FRONTIERS IN ONCOLOGY (2021)

Article Pharmacology & Pharmacy

The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage P. falciparum Parasites, DMPK Properties, and the Case for Artemiside

Liezl Gibhard et al.

Summary: Amino-artemisinins are being evaluated as possible replacements for current clinical artemisinins in artemisinin combination therapies, with metabolites showing higher efficacy and potential as superior alternatives to artemisinin.

PHARMACEUTICS (2021)

Article Microbiology

Toward New Transmission-Blocking Combination Therapies: Pharmacokinetics of 10-Amino-Artemisinins and 11-Aza-Artemisinin and Comparison with Dihydroartemisinin and Artemether

Daniel J. Watson et al.

Summary: The article reviews the pharmacokinetic properties of various amino-artemisinins in mice, highlighting their potential as components of triple combination therapies due to favorable efficacy and pharmacokinetics.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

Article Biotechnology & Applied Microbiology

Celastrol Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation

Mahmoud Youns et al.

Summary: Celastrol has been shown to inhibit pancreatic cancer cell growth, induce apoptosis, and inhibit PGE2 production. Its cytotoxic effect is mainly mediated through the modulation of specific genes and signaling pathways.

ONCOTARGETS AND THERAPY (2021)

Review Pharmacology & Pharmacy

Nanotechnology-Based Celastrol Formulations and Their Therapeutic Applications

Pushkaraj Rajendra Wagh et al.

Summary: Celastrol, a potent multi-functional compound, faces challenges in clinical translation due to low bioavailability and high organ toxicity. Nanotechnology-based formulations can enhance the efficacy of celastrol in vivo.

FRONTIERS IN PHARMACOLOGY (2021)

Review Materials Science, Biomaterials

Recent progress in nanotechnology-based drug carriers for celastrol delivery

Ling Guo et al.

Summary: Celastrol, an active ingredient from Tripterygium wilfordii, has demonstrated potential pharmacological activities in various diseases, but its clinical application is limited by low bioavailability and toxicity. Nanotechnology offers a solution to enhance the utilization of Celastrol.

BIOMATERIALS SCIENCE (2021)

Review Oncology

Artemisinin-type drugs for the treatment of hematological malignancies

R. Mancuso et al.

Summary: Qinghaosu, known as artemisinin, has been used in traditional Chinese medicine for over two millennia and is now a standard treatment for malaria worldwide. In addition to its anti-malarial properties, it also exhibits anticancer activities, particularly against hematologic malignancies. The chemical structure of artemisinin contains an endoperoxide bridge essential for its activity, and it works through mechanisms such as oxidative stress response, inhibition of proliferation, and induction of various types of cell death. Research on new pharmaceutically active compounds based on artemisinin could potentially enhance existing therapeutic alternatives for combating hematologic malignancies.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2021)

Review Chemistry, Medicinal

Biosynthesis, total synthesis, structural modifications, bioactivity, and mechanism of action of the quinone-methide triterpenoid celastrol

Yun Lu et al.

Summary: Celastrol, a quinone-methide triterpenoid, has shown potential in anticancer, anti-inflammatory, and antiobesity activities. Studies on its chemical structure and biosynthesis have advanced, but its clinical applications are limited due to toxic effects. Structural modifications have been explored to improve its pharmacological properties for future research.

MEDICINAL RESEARCH REVIEWS (2021)

Article Chemistry, Medicinal

Antimalarial N1,N3-Dialkyldioxonaphthoimidazoliums: Synthesis, Biological Activity, and Structure-activity Relationships

Stephen Ahenkorah et al.

ACS MEDICINAL CHEMISTRY LETTERS (2020)

Review Biochemistry & Molecular Biology

Artemisinin and its derivatives: a promising cancer therapy

Bushra Hafeez Kiani et al.

MOLECULAR BIOLOGY REPORTS (2020)

Review Parasitology

'Artemisinin Resistance': Something New or Old? Something of a Misnomer?

Thomas E. Wellems et al.

TRENDS IN PARASITOLOGY (2020)

Review Pharmacology & Pharmacy

Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing

Yolanda Augustin et al.

PHARMACOLOGY & THERAPEUTICS (2020)

Review Pharmacology & Pharmacy

Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application

Jinfeng Shi et al.

FRONTIERS IN PHARMACOLOGY (2020)

Review Pharmacology & Pharmacy

Anti-Cancer Effects of Pristimerin and the Mechanisms: A Critical Review

Jia-jun Li et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Pharmacology & Pharmacy

Combination Therapies of Artemisinin and its Derivatives as a Viable Approach for Future Cancer Treatment

Maushmi S. Kumar et al.

CURRENT PHARMACEUTICAL DESIGN (2019)

Article Chemistry, Medicinal

Ozonide Antimalarials Alkylate Heme in the Malaria Parasite Plasmodium falciparum

Carlo Giannangelo et al.

ACS INFECTIOUS DISEASES (2019)

Review Pharmacology & Pharmacy

A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F

Shao-Ru Chen et al.

FRONTIERS IN PHARMACOLOGY (2018)

Article Multidisciplinary Sciences

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

Jessica L. Bridgford et al.

NATURE COMMUNICATIONS (2018)

Article Infectious Diseases

Challenges to replace ACT as first-line drug

Aung Pyae Phyo et al.

MALARIA JOURNAL (2017)

Review Microbiology

The clinical impact of artemisinin resistance in Southeast Asia and the potential for future spread

Charles J. Woodrow et al.

FEMS MICROBIOLOGY REVIEWS (2017)

Article Pharmacology & Pharmacy

Cancer combination therapies with artemisinin-type drugs

Thomas Efferth

BIOCHEMICAL PHARMACOLOGY (2017)

Article Biochemistry & Molecular Biology

Inhibition of the Flavin-Dependent Monooxygenase Siderophore A (SidA) Blocks Siderophore Biosynthesis and Aspergillus fumigatus Growth

Julia S. Martin del Campo et al.

ACS CHEMICAL BIOLOGY (2016)

Article Chemistry, Medicinal

Redox Polypharmacology as an Emerging Strategy to Combat Malarial Parasites

Pavel Sidorov et al.

CHEMMEDCHEM (2016)

Article Nanoscience & Nanotechnology

In vitro anti-cancer effects of artemisone nano-vesicular formulations on melanoma cells

Anupma Dwivedi et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2015)

Article Multidisciplinary Sciences

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

Alassane Mbengue et al.

NATURE (2015)

Review Health Care Sciences & Services

Anticancer effect of antimalarial artemisinin compounds

A. K. Das

ANNALS OF MEDICAL AND HEALTH SCIENCES RESEARCH (2015)

Review Biochemistry & Molecular Biology

1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling

Lars-Oliver Klotz et al.

MOLECULES (2014)

Article Biochemistry & Molecular Biology

Evidence for NQO1 and NQO2 catalyzed reduction of ortho- and para-quinone methides

H. R. Kucera et al.

FREE RADICAL RESEARCH (2013)

Article Multidisciplinary Sciences

Anticancer Properties of Distinct Antimalarial Drug Classes

Rob Hooft van Huijsduijnen et al.

PLOS ONE (2013)

Article Chemistry, Medicinal

Discovery of Novel Alkylated (bis)Urea and (bis)Thiourea Polyamine Analogues with Potent Antimalarial Activities

Bianca K. Verlinden et al.

JOURNAL OF MEDICINAL CHEMISTRY (2011)

Article Multidisciplinary Sciences

Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue

Sophie H. Adjalley et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Infectious Diseases

Discovery, mechanisms of action and combination therapy of artemisinin

Liwang Cui et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2009)

Review Biotechnology & Applied Microbiology

New medicines to improve control and contribute to the eradication of malaria

Timothy N. C. Wells et al.

NATURE REVIEWS DRUG DISCOVERY (2009)

Review Microbiology

Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

Richard T. Eastman et al.

NATURE REVIEWS MICROBIOLOGY (2009)

Article Microbiology

Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum

Kathrin Buchholz et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)

Article Chemistry, Multidisciplinary

Artemisone - A highly active antimalarial drug of the artemisinin class

RK Haynes et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)

Article Chemistry, Multidisciplinary

Highly antimalaria-active artemisinin derivatives: Biological activity does not correlate with chemical reactivity

RK Haynes et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2004)

Article Microbiology

Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening

M Smilkstein et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)