4.7 Article

Potential benefits of metformin and pioglitazone combination therapy via gut microbiota and metabolites in high-fat diet-fed mice

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Nutrition & Dietetics

Assessing the validity of plasma phospholipid fatty acids as biomarkers of dairy fat intake using data from a randomized controlled intervention trial

Hilary J. Bethancourt et al.

Summary: This study found that liver fat content may affect the relative concentrations of phospholipid C15:0 and C17:0, raising questions about their validity as biomarkers of dairy fat intake. The study also found that the combination of trans-C16:1n-7 and iso-C17:0 may provide the most robust estimate of dairy fat consumption.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2022)

Article Endocrinology & Metabolism

IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045

Hong Sun et al.

Summary: This study provides global, regional, and country-level estimates of diabetes prevalence and health expenditures for 2021 and projections for 2045. The global prevalence of diabetes is increasing and is expected to have the greatest relative increase in middle-income countries. Diabetes-related health expenditures are also projected to rise.

DIABETES RESEARCH AND CLINICAL PRACTICE (2022)

Article Biochemistry & Molecular Biology

Modulation of Insulin Resistance, Dyslipidemia and Serum Metabolome in iNOS Knockout Mice following Treatment with Nitrite, Metformin, Pioglitazone, and a Combination of Ampicillin and Neomycin

Hobby Aggarwal et al.

Summary: Oxidative and nitrosative stress play a key role in the incidence of metabolic disorders. This study found that nitrite, L-arginine, antidiabetic drugs, and antibiotics have beneficial effects on metabolic perturbations observed in iNOS (-/-) mice. Additionally, the study highlights the crucial role of gut microbiota in these metabolic disturbances.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Pharmacology & Pharmacy

San-Huang-Yi-Shen Capsule Ameliorates Diabetic Nephropathy in Rats Through Modulating the Gut Microbiota and Overall Metabolism

Xiuhai Su et al.

Summary: This study revealed the therapeutic effects and mechanisms of San-Huang-Yi-Shen capsule (SHYS) on diabetic nephropathy (DN). The results showed that SHYS treatment alleviated the symptoms and injuries caused by DN through improving the gut microbiota and related metabolic pathways.

FRONTIERS IN PHARMACOLOGY (2022)

Review Food Science & Technology

High animal protein diet and gut microbiota in human health

Jie Cai et al.

Summary: The role of intestinal flora in health and disease is a hot research topic. High-protein diets (HPDs) may increase the risk of certain diseases, particularly with long-term consumption. Short-term HPDs have minimal impact on healthy individuals under 65 but may be more challenging for those over 65 to meet protein needs.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

Article Agriculture, Dairy & Animal Science

Bacillus subtilis inhibits intestinal inflammation and oxidative stress by regulating gut flora and related metabolites in laying hens

X. Y. Zou et al.

Summary: This study investigated the effects of dietary Bacillus subtilis on intestinal histomorphology, innate immunity, microbiota composition, transcriptomics, and related metabolomics. The results showed that Bacillus subtilis can inhibit gut inflammation and improve antioxidative status and barrier integrity in laying hens by regulating gut microbial composition.

ANIMAL (2022)

Article Food Science & Technology

Tectorigenin ameliorated high-fat diet-induced nonalcoholic fatty liver disease through anti-inflammation and modulating gut microbiota in mice

Ruiqian Duan et al.

Summary: The study found that Tectorigenin (Tg) can alleviate NAFLD by mediating the liver-gut axis, mainly manifested in improving lipid metabolism abnormalities, restoring intestinal barrier, inhibiting pro-inflammatory cytokines release, and affecting intestinal microbiota.

FOOD AND CHEMICAL TOXICOLOGY (2022)

Article Food Science & Technology

Tyrosol Ameliorates the Symptoms of Obesity, Promotes Adipose Thermogenesis, and Modulates the Composition of Gut Microbiota in HFD Fed Mice

Xiaoping Li et al.

Summary: Tyrosol consumption attenuates obesity and related symptoms in HFD-fed mice probably via the modulation of PPAR alpha-thermogenesis and gut microbiota.

MOLECULAR NUTRITION & FOOD RESEARCH (2022)

Article Microbiology

Maternal Dietary Betaine Prevents High-Fat Diet-Induced Metabolic Disorders and Gut Microbiota Alterations in Mouse Dams and Offspring From Young to Adult

Jieying Liu et al.

Summary: Maternal betaine supplementation improves glucose and lipid metabolism disorders in both dams and offspring and regulates gut microbiota. The persistent alterations in gut microbiota may play a critical role in uncovering the intergenerational metabolic benefits of maternal betaine.

FRONTIERS IN MICROBIOLOGY (2022)

Article Medicine, Research & Experimental

Adipocyte-derived PGE2 is required for intermittent fasting-induced Treg proliferation and improvement of insulin sensitivity

Chunqing Wang et al.

Summary: The intermittent fasting (IF) diet has been found to have significant benefits for diabetes prevention, but the specific mechanisms underlying its effects are not well understood. This study shows that COX-2 expression is suppressed in the white adipose tissue (WAT) of obese humans and is upregulated in the WAT of obese mice when subjected to IF. Depletion of COX-2 in adipocytes leads to a decrease in the fractions of Tregs and a decrease in the frequency of macrophages in WAT, along with an increase in the abundance of gamma delta T cells. Adipocyte-derived PGE2 promotes Treg proliferation and is essential for the immune and metabolic benefits of IF.

JCI INSIGHT (2022)

Article Nutrition & Dietetics

Beneficial Actions of Essential Fatty Acids in Streptozotocin-Induced Type 1 Diabetes Mellitus

Junhui Shen et al.

Summary: This study investigates the effects of ALA and LA on the metabolism, gut microbiota, and inflammatory and retinal indices in T1DM animals. The results show that ALA and LA have significant benefits in reversing the changes seen in T1DM, suggesting their importance in diabetes mellitus.

FRONTIERS IN NUTRITION (2022)

Article Microbiology

Identification of Crucial Amino Acid Residues for Antimicrobial Activity of Angiogenin 4 and Its Modulation of Gut Microbiota in Mice

Mst. Farzana Sultana et al.

Summary: Angiogenin 4 (Ang4) is an endogenous antimicrobial protein expressed in the intestine. This study identified the specific amino acid residues responsible for its antibacterial activity against Salmonella typhimurium and demonstrated its ability to modulate the gut microbiota in mice.

FRONTIERS IN MICROBIOLOGY (2022)

Article Endocrinology & Metabolism

9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes-2021

Summary: The ADA Standards of Medical Care in Diabetes provide clinical practice recommendations to evaluate care quality and set treatment goals. The multidisciplinary expert committee is responsible for annual updates. Readers can share their feedback on the standards on the website.

DIABETES CARE (2021)

Article Gastroenterology & Hepatology

Gut microbiota-derived metabolites as central regulators in metabolic disorders

Allison Agus et al.

Summary: Metabolic disorders are closely linked to alterations in the composition and function of the gut microbiota. Specific classes of microbiota-derived metabolites play crucial roles in the pathogenesis of metabolic disorders.
Article Endocrinology & Metabolism

Identification of gut microbiota and microbial metabolites regulated by an antimicrobial peptide lipocalin 2 in high fat diet-induced obesity

Xiaoxue Qiu et al.

Summary: In this study, it was found that short-term high fat diet feeding stimulates intestinal Lcn2 expression, but as the feeding period prolongs, fecal Lcn2 levels decrease. Lcn2 deficiency accelerates the development of HFD-induced intestinal inflammation and microbiota dysbiosis, as well as leads to a remodeling of microbiota-derived metabolome.

INTERNATIONAL JOURNAL OF OBESITY (2021)

Article Integrative & Complementary Medicine

Si-Wu-Tang ameliorates fibrotic liver injury via modulating intestinal microbiota and bile acid homeostasis

Xiaoyong Xue et al.

Summary: Si-Wu-Tang (SWT) showed significant therapeutic effects against carbon tetrachloride-induced liver fibrosis, improving collagen accumulation in the liver, intestinal barrier injury, and hepatic and intestinal inflammatory responses. By restructuring gut microbiota, influencing bile acid homeostasis, and activating the FXR pathways, SWT effectively protected against fibrotic liver injury induced by CCl4.

CHINESE MEDICINE (2021)

Article Pharmacology & Pharmacy

Metformin Exerts Anti-inflammatory and Mucus Barrier Protective Effects by Enriching Akkermansia muciniphila in Mice With Ulcerative Colitis

Haoran Ke et al.

Summary: This study demonstrated that metformin alleviated DSS-induced UC in mice and protected against cell damage by affecting the gut microbiota, with Lactobacillus and Akkermansia species increasing in abundance while Erysipelatoclostridium decreased. Antibiotic treatment partially abolished metformin's anti-inflammatory and mucus-protecting effects. The probiotic A. muciniphila showed potential benefits for UC.

FRONTIERS IN PHARMACOLOGY (2021)

Article Endocrinology & Metabolism

Metformin Affects Gut Microbiome Composition and Function and Circulating Short-Chain Fatty Acids: A Randomized Trial

Noel T. Mueller et al.

Summary: The study found that metformin treatment significantly altered gut microbiota composition at both 6 months and 12 months, while behavioral weight loss did not have the same effect. Additionally, both metformin and behavioral weight loss changed circulating SCFAs at 6 months, with an increase in acetate correlating with lower fasting insulin levels. Further research is needed to explore whether the gut microbiome mediates or modifies the health effects of metformin.

DIABETES CARE (2021)

Article Biochemistry & Molecular Biology

Gut microbiota-dependent catabolites of tryptophan play a predominant role in the protective effects of turmeric polysaccharides against DSS-induced ulcerative colitis

Chengcheng Yang et al.

Summary: The study demonstrated that turmeric polysaccharides (TPS) can significantly improve the pathological phenotype and colon inflammation in colitis mice by modulating gut microbiota, improving microbial metabolites, and enhancing gut barrier function.

FOOD & FUNCTION (2021)

Article Geriatrics & Gerontology

Metformin Reduces Aging-Related Leaky Gut and Improves Cognitive Function by Beneficially Modulating Gut Microbiome/Goblet Cell/Mucin Axis

Shokouh Ahmadi et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2020)

Review Medicine, General & Internal

Role of gut microbiota in type 2 diabetes pathophysiology

Manoj Gurung et al.

EBIOMEDICINE (2020)

Review Microbiology

Lifestyle, metabolism and environmental adaptation in Lactococcus lactis

Michiel Kleerebezem et al.

FEMS MICROBIOLOGY REVIEWS (2020)

Review Gastroenterology & Hepatology

The role of short-chain fatty acids in microbiota-gut-brain communication

Boushra Dalile et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Review Endocrinology & Metabolism

Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

Yan Zheng et al.

NATURE REVIEWS ENDOCRINOLOGY (2018)

Editorial Material Endocrinology & Metabolism

Diabetes and branched-chain amino acids: What is the link?

Zachary Bloomgarden

JOURNAL OF DIABETES (2018)

Article Biochemistry & Molecular Biology

Suppression of adipocyte differentiation and lipid accumulation by stearidonic acid (SDA) in 3T3-L1 cells

Yueru Li et al.

LIPIDS IN HEALTH AND DISEASE (2017)

Article Medicine, Research & Experimental

Protective effect of Sophoraflavanone G on streptozotocin (STZ)-induced inflammation in diabetic rats

Hanqing Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

Review Endocrinology & Metabolism

Metformin and the gastrointestinal tract

Laura J. McCreight et al.

DIABETOLOGIA (2016)

Review Biochemistry & Molecular Biology

PPARγ signaling and metabolism: the good, the bad and the future

Maryam Ahmadian et al.

NATURE MEDICINE (2013)

Article Biochemical Research Methods

Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing

Nicholas A. Bokulich et al.

NATURE METHODS (2013)

Article Multidisciplinary Sciences

A metagenome-wide association study of gut microbiota in type 2 diabetes

Junjie Qin et al.

NATURE (2012)

Article Biotechnology & Applied Microbiology

Metagenomic biomarker discovery and explanation

Nicola Segata et al.

GENOME BIOLOGY (2011)

Article Pharmacology & Pharmacy

Piogfitazone/metformin

Emma D. Deeks et al.