☆ 4.7 Review

Scutellaria baicalensis georgi is a promising candidate for the treatment of autoimmune diseases

FRONTIERS IN PHARMACOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Pathology

Role of the Inflammasome in Liver Disease

Marcelle de Carvalho Ribeiro et al.

Summary: The involvement of inflammasomes in chronic liver diseases is widely recognized. NLRP3 is the most studied type in the pathogenesis of ALD, NAFLD, and fibrosis. Inflammasomes are cellular complexes that activate the production of cytokines and cell death upon sensing danger signals. This study discusses the different types of inflammasomes involved in liver diseases and potential therapeutic strategies.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2022)

添加到收藏夹

Article Cell Biology

CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma

Jingyue Yao et al.

Summary: The study revealed that CDK9 inhibitors blocked PINK1-PRKN-mediated mitophagy in HCC, promoting mitochondrial dysfunction and cell death. A novel CDK9 inhibitor, oroxylin A (OA), showed strong therapeutic potential against HCC, overcoming drug resistance without extreme repression of general transcription associated with existing CDK9 inhibitors.

AUTOPHAGY (2022)

添加到收藏夹

Review Allergy

Emerging strategies for treating autoimmune disorders with genetically modified Treg cells

Dominic A. Boardman et al.

Summary: This article reviews the application of gene editing technologies in Treg cell therapy, focusing on preclinical strategies to enhance the efficacy, function, and survival of Treg cells. It explores methods for generating immunoregulatory cells ex vivo, discusses emerging strategies such as using chimeric antigen receptors for antigen specificity, and outlines concepts for repurposing conventional T cells to target and destroy autoreactive and alloreactive lymphocytes. The article also discusses the key obstacles currently limiting the clinical adoption of Treg cell therapy and proposes potential future research directions.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

添加到收藏夹

Review Plant Sciences

Therapeutic effect of baicalin on inflammatory bowel disease: A review

Xian Wang et al.

Summary: This review compiled the efficacy of baicalin in treating inflammatory bowel disease, showing that its mechanisms mainly include anti-inflammation, antioxidant, immune regulation, maintenance of intestinal barrier, and maintenance of intestinal flora balance.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

Autoimmune susceptibility gene PTPN2 is required for clearance of adherent-invasive Escherichia coli by integrating bacterial uptake and lysosomal defence

Marianne Rebecca Spalinger et al.

Summary: Loss of PTPN2 significantly impairs the ability of macrophages to clear invading bacteria through increased uptake, reduced autophagy, and compromised lysosomal acidification. The findings suggest that lack of PTPN2 in macrophages leads to increased susceptibility to bacterial infection.

GUT (2022)

添加到收藏夹

Review Rheumatology

Regulation of activated T cell survival in rheumatic autoimmune diseases

Florencia Rosetti et al.

Summary: In this article, the authors discuss the mechanisms that normally limit the function and survival of activated T cells, as well as how defects in these mechanisms contribute to chronic inflammatory responses and organ damage in rheumatic autoimmune diseases. They highlight the importance of regulating the expansion and duration of activated T cell clones to minimize immunopathology and prevent autoimmunity. However, in patients with rheumatic autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis, activated lymphocytes are able to survive and perform effector functions for prolonged periods, defying the normal mechanisms that limit their capabilities.

NATURE REVIEWS RHEUMATOLOGY (2022)

添加到收藏夹

Review Rheumatology

Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach

Yoshiya Tanaka et al.

Summary: This Review discusses the therapeutic use of Janus kinase inhibitors in autoimmune rheumatic diseases, highlighting their disease-specific mechanisms of action. JAK inhibitors suppress intracellular signaling mediated by multiple cytokines, offering potential treatment options for a range of immune and inflammatory disorders.

NATURE REVIEWS RHEUMATOLOGY (2022)

添加到收藏夹

Review Chemistry, Medicinal

Wogonin and its analogs for the prevention and treatment of cancer: A systematic review

Kishore Banik et al.

Summary: This article evaluates the therapeutic potential and mechanisms of action of WOG against different cancers. Studies have shown that WOG has immense therapeutic potential against various cancers by regulating cell signaling pathways, and its combination with chemotherapeutic drugs improves treatment efficacy. Further human trials are needed to validate these findings and establish the clinical efficacy of WOG for cancer prevention and treatment.

PHYTOTHERAPY RESEARCH (2022)

添加到收藏夹

Article Multidisciplinary Sciences

TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models

Jiao Wu et al.

Summary: In this study, the authors use a mouse model of rheumatoid arthritis (RA) and single-cell RNA sequencing to show that inducing ferroptosis and suppressing TNF signaling can reduce the number of fibroblasts in the synovium and improve experimental arthritis. They further identify two groups of fibroblasts with distinct susceptibility to ferroptosis and show that TNF signaling protects fibroblasts from ferroptosis through promoting cystine uptake and glutathione biosynthesis. Finally, the combination of low-dose ferroptosis inducer and TNF antagonist attenuates arthritis progression in the mouse model.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease

Xue-qi Liu et al.

Summary: Wogonin has been shown to alleviate glomerulopathy and podocyte injury in diabetic kidney disease (DKD) by regulating the Bcl-2-mediated crosstalk between autophagy and apoptosis. The study also demonstrated the inhibitory effects of wogonin on cellular damage and apoptosis induced by high glucose, as well as its promotion of autophagy in podocytes.

ACTA PHARMACOLOGICA SINICA (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Inhibitory activities of flavonoids from Scutellaria baicalensis Georgi on amyloid aggregation related to type 2 diabetes and the possible structural requirements for polyphenol in inhibiting the nucleation phase of hIAPP aggregation

Ying Wang et al.

Summary: The active compounds in Scutellaria baicalensis can effectively inhibit hIAPP aggregation, with baicalein and baicalin, which have ortho-hydroxyl groups on the Aring, being more effective. Flavonoids with ortho-hydroxyl groups on the B-ring also exhibit high anti-nucleation activity. These results provide a valuable structural template for the development of polyphenol-based inhibitors of amyloid peptides.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

添加到收藏夹

Review Endocrinology & Metabolism

The interplay between diabetes mellitus and menopause: clinical implications

Irene Lambrinoudaki et al.

Summary: The menopausal transition may increase the risk of diabetes mellitus, while existing diabetes mellitus can cause early menopause. This Review discusses the interaction between diabetes mellitus and menopause, including therapeutic management strategies for both conditions.

NATURE REVIEWS ENDOCRINOLOGY (2022)

添加到收藏夹

Article Chemistry, Applied

Reducing the intestinal side effects of acarbose by baicalein through the regulation of gut microbiota: An in vitro study

Yuesheng Dong et al.

Summary: The combination of baicalein and acarbose can reduce the risk of prediabetes developing into type 2 diabetes mellitus, possibly by decreasing gas production through reducing residual starch ratio and decreasing acarbose dosage, which in turn reduces relative abundance of gut bacteria.

FOOD CHEMISTRY (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

LW-213 induces cell apoptosis in human cutaneous T-cell lymphomas by activating PERK-eIF2α-ATF4-CHOP axis

Xiao-xuan Yu et al.

Summary: The study shows that LW-213 effectively inhibits the growth of CTCL cells and induces apoptosis. The mechanisms involve ROS formation, calcium release, and activation of different signaling pathways.

ACTA PHARMACOLOGICA SINICA (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Uncovering the mechanism of Ge-Gen-Qin-Lian decoction for treating ulcerative colitis based on network pharmacology and molecular docking verification

Lin Xu et al.

Summary: This study investigated the pharmacological mechanisms of Ge-Gen-Qin-Lian Decoction (GGQLD) against ulcerative colitis (UC) using network pharmacology. The research identified potential therapeutic targets and active ingredients of GGQLD, revealing its anti-inflammatory, antioxidative, and immunomodulatory effects. The results suggest that GGQLD may regulate cytokine balance and inflammation-related pathways to treat UC effectively.

BIOSCIENCE REPORTS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Regulation of cell signaling pathways by Wogonin in different cancers: Mechanistic review

Ghazala Butt et al.

Summary: Natural products have been historically invaluable as a source of therapeutic agents, and recent advancements in research have shed light on the diversity of proteins targeted by these products. Wogonin, an O-methylated flavone, has shown pharmacological targeting abilities in different cancers and potential in preventing carcinogenesis and metastasis. Further research is needed to understand the pleiotropic role of wogonin and its regulation of non-coding RNAs for a comprehensive understanding of its chemopreventive properties.

CELLULAR AND MOLECULAR BIOLOGY (2021)

添加到收藏夹

Article Integrative & Complementary Medicine

The Effectiveness of Scutellaria baicalensis on Migraine: Implications from Clinical Use and Experimental Proof

Chung-Chih Liao et al.

Summary: Scutellaria baicalensis, a traditional Chinese medicine, has shown beneficial effects in relieving migraine-related behaviors in an experimental nitroglycerin-induced migraine model, suggesting its potential as a treatment for migraine.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Pyroptosis by caspase-11 inflammasome-Gasdermin D pathway in autoimmune diseases

Jiasi Wu et al.

Summary: Inflammasomes are complex molecular structures that play a critical role in various diseases. The non-canonical inflammasome involving caspase-11 is particularly important in autoimmune diseases. Inhibiting caspase-11 may hold promise as a therapeutic strategy for autoimmune diseases.

PHARMACOLOGICAL RESEARCH (2021)

添加到收藏夹

Article Immunology

AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis

Chunmei Ma et al.

Summary: The study reveals that AIM2 plays a negative regulatory role in EAE by enhancing microglia activation and infiltration of peripheral immune cells, leading to neuroinflammation and demyelination. Additionally, AIM2 controls neuroinflammation induced by cGAS and DNA-PK through negative regulation of DNA-PK-AKT3 in microglia.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

添加到收藏夹

Article Plant Sciences

Exploration of the potential mechanism of Banxia Xiexin Decoction for the effects on TNBS-induced ulcerative colitis rats with the assistance of network pharmacology analysis

Weiwei Wang et al.

Summary: The study compared the pharmacological effects of extracts of BXD prepared by ancient and modern methods on TNBS-induced UC in rats. Both BXD-AED and BXD-MED were found to alleviate the severity of UC, with BXD-AED performing better at similar doses. Network pharmacology analysis identified key active components related to anti-UC/inflammation, with higher contents in BXD-AED than BXD-MED, indicating that BXD is an effective drug candidate for modern UC treatment.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1

Na Kong et al.

Summary: Baicalin, an active component in Scutellaria baicalensis Georgi, shows anticancer activity in bladder cancer cells by inducing ferroptosis, suggesting a potential novel therapeutic approach for bladder cancer treatment.

ACTA PHARMACEUTICA SINICA B (2021)

添加到收藏夹

Article Immunology

Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases

Guang-Ming Ren et al.

Summary: The inhibitor THL effectively blocks the activation of NLRP3 inflammasome through various pathways and mutant variants. Mechanistic studies revealed that THL inhibits NLRP3 deubiquitination and activation through suppressing the BRISC complex. Holomycin, a natural derivative of THL, showed even higher inhibitory activity against NLRP3 inflammasome. Future clinical development of THL derivatives may offer new therapies for NLRP3-related diseases.

SCIENCE IMMUNOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Baicalin regulates mRNA expression of VEGF-c, Ang-1/Tie2, TGF-β and Smad2/3 to inhibit wound healing in streptozotocin-induced diabetic foot ulcer rats

Xuefei Mao et al.

Summary: The present study investigated the wound healing activity of baicalin in STZ-induced diabetic foot ulcer (DFU) rats, showing that baicalin treatment promoted epithelization, improved angiogenesis, and reduced inflammatory cell infiltration in diabetic wounds. Baicalin upregulated protein and mRNA expressions related to wound healing and antidiabetic effects, indicating its potential as a therapeutic candidate for DFU and chronic wounds treatment.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)

添加到收藏夹

Editorial Material Multidisciplinary Sciences

Autoimmune disease

Richard Hodson

NATURE (2021)

添加到收藏夹

Review Cell Biology

Baicalein, Baicalin, and Wogonin: Protective Effects against Ischemia-Induced Neurodegeneration in the Brain and Retina

Li Pan et al.

Summary: This review focuses on the therapeutic potentials of three major active flavonoids extracted from Scutellaria baicalensis Georgi against ischemia-induced neurotoxicity and damage. These compounds have been shown to have promising pharmacological capabilities in preventing cell and tissue damage, and their bioactivity and bioavailability are also discussed. It is hoped that the therapeutic potential of these flavonoids can be utilized as natural treatments for ischemia-induced injuries of the central nervous system (CNS).

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Main active components of Jiawei Gegen Qinlian decoction protects against ulcerative colitis under different dietary environments in a gut microbiota-dependent manner

Qinmei Li et al.

Summary: The study found that PBM has the potential to exert anti-UC activity through gut microbiota dependence, possibly by increasing Akkermansia and Romboutsia while decreasing Escherichia-Shigella to regulate gut microbiota. Additionally, PBM was also able to increase the production of propionate and total short-chain fatty acids (SCFAs) in colitis rats, regulate medium and long chain fatty acids (M-LCFAs), maintain bile acids (BAs) homeostasis, and regulate amino acids (AAs) metabolism.

PHARMACOLOGICAL RESEARCH (2021)

添加到收藏夹

Article Chemistry, Medicinal

Wogonin Alleviates Kidney Tubular Epithelial Injury in Diabetic Nephropathy by Inhibiting PI3K/ Akt/NF-κB Signaling Pathways

Lei Lei et al.

Summary: The study showed that wogonin mitigated tubulointerstitial fibrosis and renal tubular cell injury by regulating PI3K/Akt/NF-kappa B signaling pathway-mediated autophagy and inflammation. It may serve as a potential therapeutic drug for treating tubular epithelial injury in diabetic nephropathy by targeting PI3K.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Wogonin ameliorate complete Freund's adjuvant induced rheumatoid arthritis via targeting NF-κB/MAPK signaling pathway

Yuntai Huang et al.

BIOFACTORS (2020)

添加到收藏夹

Article Immunology

Pharmacological inhibition of soluble epoxide hydrolase attenuates chronic experimental autoimmune encephalomyelitis by modulating inflammatory and anti-inflammatory pathways in an inflammasome-dependent and -independent manner

Merve Biliktu et al.

INFLAMMOPHARMACOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Contrast-enhanced ultrasound with sub-micron sized contrast agents detects insulitis in mouse models of type1 diabetes

David G. Ramirez et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Oroxylin A suppresses ACTN1 expression to inactivate cancer-associated fibroblasts and restrain breast cancer metastasis

Yue Cao et al.

PHARMACOLOGICAL RESEARCH (2020)

添加到收藏夹

Review Immunology

Pyroptotic and non-pyroptotic effector functions of caspase-11

Arwa Abu Khweek et al.

IMMUNOLOGICAL REVIEWS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Baicalin suppresses renal fibrosis through microRNA-124/TLR4/NF-κB axis in streptozotocin-induced diabetic nephropathy mice and high glucose-treated human proximal tubule epithelial cells

Shefeng Zhang et al.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2020)

添加到收藏夹

Article Oncology

Baicalin alleviates collagen-induced arthritis and suppresses TLR2/MYD88/NF-κB p65 signaling in rats and HFLS-RAs

Lin Bai et al.

MOLECULAR MEDICINE REPORTS (2020)

添加到收藏夹

Article Chemistry, Medicinal

Wogonin Ameliorates Renal Inflammation and Fibrosis by Inhibiting NF-κB and TGF-β1/Smad3 Signaling Pathways in Diabetic Nephropathy

Zhi-chao Zheng et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2020)

添加到收藏夹

Article Cell Biology

Baicalin reversal of DNA hypermethylation-associated Klotho suppression ameliorates renal injury in type 1 diabetic mouse model

Xiao-Tan Zhang et al.

CELL CYCLE (2020)

添加到收藏夹

Review Medicine, General & Internal

Cytokine Storm

David C. Fajgenbaum et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Potential therapeutic and pharmacological effects of Wogonin: an updated review

Do Luong Huynh et al.

MOLECULAR BIOLOGY REPORTS (2020)

添加到收藏夹

Article Cell Biology

Baicalin attenuates collagen-induced arthritis via inhibition of JAK2-STAT3 signaling and regulation of Th17 cells in mice

Fengchun Sun et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

The role of flavonoids in autoimmune diseases: Therapeutic updates

Kannan R. R. Rengasamy et al.

PHARMACOLOGY & THERAPEUTICS (2019)

添加到收藏夹

Article Cell Biology

Baicalin ameliorates lupus autoimmunity by inhibiting differentiation of Tfh cells and inducing expansion of Tfr cells

Ji Yang et al.

CELL DEATH & DISEASE (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Changes in the levels of 12/15-lipoxygenase, apoptosis-related proteins and inflammatory factors in the cortex of diabetic rats and the neuroprotection of baicalein

Yuke Li et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Reference Genome Sequence of Scutellaria baicalensis Provides Insights into the Evolution of Wogonin Biosynthesis

Qing Zhao et al.

MOLECULAR PLANT (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Can Wogonin be Used in Controlling Diabetic Cardiomyopathy?

Shahzad Khan et al.

CURRENT PHARMACEUTICAL DESIGN (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

Tiantian Zhao et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2019)

添加到收藏夹

Article Endocrinology & Metabolism

Baicalin alleviates hyperglycemia-induced endothelial impairment via Nrf2

Gen Chen et al.

JOURNAL OF ENDOCRINOLOGY (2019)

添加到收藏夹

Article Pharmacology & Pharmacy

The Comparative Study of the Therapeutic Effects and Mechanism of Baicalin, Baicalein, and Their Combination on Ulcerative Colitis Rat

Shuai Liang et al.

FRONTIERS IN PHARMACOLOGY (2019)

添加到收藏夹

Article Rheumatology

Baicalein ameliorates pristane-induced lupus nephritis via activating Nrf2/HO-1 in myeloid-derived suppressor cells

Dan Li et al.

ARTHRITIS RESEARCH & THERAPY (2019)

添加到收藏夹

Article Pharmacology & Pharmacy

Baicalin modulates the Treg/Teff balance to alleviate uveitis by activating the aryl hydrocarbon receptor

Wenjie Zhu et al.

BIOCHEMICAL PHARMACOLOGY (2018)

添加到收藏夹

Article Immunology

Epigenetics as biomarkers in autoimmune diseases

Haijing Wu et al.

CLINICAL IMMUNOLOGY (2018)

添加到收藏夹

Article Oncology

Therapeutic effect of the natural compounds baicalein and baicalin on autoimmune diseases

Jian Xu et al.

MOLECULAR MEDICINE REPORTS (2018)

添加到收藏夹

Article Cell Biology

Baicalin administration attenuates hyperglycemia-induced malformation of cardiovascular system

Guang Wang et al.

CELL DEATH & DISEASE (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Baicalin prevents tumor necrosis factor-α-induced apoptosis and dysfunction of pancreatic β-cell line Min6 via upregulation of miR-205

Wenjun You et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

添加到收藏夹

Article Medicine, Research & Experimental

TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation

Cun-Jin Zhang et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Baicalin Ameliorates Collagen-Induced Arthritis Through the Suppression of Janus Kinase 1 (JAK1)/Signal Transducer and Activator of Transcription 3 (STAT3) Signaling in Mice

Chunxiao Wang et al.

MEDICAL SCIENCE MONITOR (2018)

添加到收藏夹

Review Plant Sciences

A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis

Zi-Long Wang et al.

PHARMACEUTICAL BIOLOGY (2018)

添加到收藏夹

Review Chemistry, Medicinal

Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders

Biswanath Dinda et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

添加到收藏夹

Review Immunology

Towards personalized medicine for patients with autoimmune diseases: Opportunities and challenges

Soheil Tavakolpour

IMMUNOLOGY LETTERS (2017)

添加到收藏夹

Article Medicine, Research & Experimental

Wogonoside alleviates inflammation induced by traumatic spinal cord injury by suppressing NF-κB and NLRP3 inflammasome activation

Yonglin Zhu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2017)

添加到收藏夹

Article Neurosciences

The flavonoid Baicalein attenuates cuprizone-induced demyelination via suppression of neuroinflammation

Miho Hashimoto et al.

BRAIN RESEARCH BULLETIN (2017)

添加到收藏夹

Review Pharmacology & Pharmacy

Recent Updates in Imperative Natural Compounds for Healthy Brain and Nerve Function: A Systematic Review of Implications for Multiple Sclerosis

Nima Sanadgol et al.

CURRENT DRUG TARGETS (2017)

添加到收藏夹

Review Immunology

Neutrophil extracellular traps (NETs) in autoimmune diseases: A comprehensive review

Keum Hwa Lee et al.

AUTOIMMUNITY REVIEWS (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Scutellarin Alleviates Behavioral Deficits in a Mouse Model of Multiple Sclerosis, Possibly Through Protecting Neural Stem Cells

Wei-Wei Wang et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2016)

添加到收藏夹

Article Immunology

Baicalin ameliorates experimental inflammatory bowel disease through polarization of macrophages to an M2 phenotype

Wei Zhu et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2016)

添加到收藏夹

Article Cell Biology

Wogonin attenuates diabetic cardiomyopathy through its anti-inflammatory and anti-oxidative properties

Shahzad Khan et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2016)

添加到收藏夹

Article Oncology

Treatment of experimental autoimmune uveoretinitis with different natural compounds

Man Li et al.

MOLECULAR MEDICINE REPORTS (2016)

添加到收藏夹

Article Oncology

Protective effects of Huangqin Decoction against ulcerative colitis and associated cancer in mice

Gang Chen et al.

ONCOTARGET (2016)

添加到收藏夹

Review Pharmacology & Pharmacy

San-Huang-Xie-Xin-Tang Constituents Exert Drug-Drug Interaction of Mutual Reinforcement at Both Pharmacodynamics and Pharmacokinetic Level: A Review

Jiasi Wu et al.

FRONTIERS IN PHARMACOLOGY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

A specialized flavone biosynthetic pathway has evolved in the medicinal plant, Scutellaria baicalensis

Qing Zhao et al.

SCIENCE ADVANCES (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Wogonin suppresses osteopontin expression in adipocytes by activating PPARα

Ye-min Zhang et al.

ACTA PHARMACOLOGICA SINICA (2015)

添加到收藏夹

Article Chemistry, Medicinal

PF2405, standardized fraction of Scutellaria baicalensis, ameliorates colitis in vitro and in vivo

Wen-Yi Jiang et al.

ARCHIVES OF PHARMACAL RESEARCH (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Wogonin Induced Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Human Malignant Neuroblastoma Cells Via IRE1α-Dependent Pathway

Wenliang Ge et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Therapeutic effect of baicalin on experimental autoimmune encephalomyelitis is mediated by SOCS3 regulatory pathway

Yuan Zhang et al.

SCIENTIFIC REPORTS (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Wogonin Protects Rat Dorsal Root Ganglion Neurons Against Tunicamycin-Induced ER Stress Through the PERK-eIF2α-ATF4 Signaling Pathway

Fangyi Chen et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2015)

添加到收藏夹

Review Endocrinology & Metabolism

Gender differences in autoimmune disease

S. T. Ngo et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2014)

添加到收藏夹

Review Ophthalmology

Potential Therapeutic Effects of Baicalein, Baicalin, and Wogonin in Ocular Disorders

Jing-Ru Xiao et al.

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2014)

添加到收藏夹

Article Gastroenterology & Hepatology

Herb-induced autoimmune-like hepatitis in C57BL/6J mice

Jir-You Wang et al.

LIVER INTERNATIONAL (2014)

添加到收藏夹

Article Plant Sciences

Baicalein protects against hypertension associated with diabetes: Effect on vascular reactivity and stiffness

Hany M. El-Bassossy et al.

PHYTOMEDICINE (2014)

添加到收藏夹

Article Pharmacology & Pharmacy

Inhibitory Effect of Baicalin on Collagen-Induced Arthritis in Rats through the Nuclear Factor-κB Pathway

Hong-Zhi Wang et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Baicalein Selectively Induces Apoptosis in Activated Lymphocytes and Ameliorates Concanavalin A-Induced Hepatitis in Mice

Yan Zhang et al.

PLOS ONE (2013)

添加到收藏夹

Article Cell Biology

Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPARβ/δ: a potential therapeutic role for CNS autoimmune disease

J. Xu et al.

CELL DEATH & DISEASE (2013)

添加到收藏夹

Review Oncology

New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin

Min Li-Weber

CANCER TREATMENT REVIEWS (2009)

添加到收藏夹

Article Oncology

Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma

M Bonham et al.

CLINICAL CANCER RESEARCH (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.