4.7 Article

Poldip2 knockdown protects against lipopolysaccharide-induced acute lung injury via Nox4/Nrf2/NF-κB signaling pathway

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Poldip2/Nox4 Mediates Lipopolysaccharide-Induced Oxidative Stress and Inflammation in Human Lung Epithelial Cells

Yueguo Wang et al.

Summary: The study demonstrates that Poldip2 mediates LPS-induced oxidative stress and inflammation through interaction with Nox4, regulated by the PI3K-AKT signaling pathway. Targeting Poldip2 could be a beneficial therapeutic strategy for acute lung injury.

MEDIATORS OF INFLAMMATION (2022)

Article Dermatology

An Avant-Garde Model of Injury-Induced Regenerative Vaginal Wound Healing

Jennifer M. McCracken et al.

Summary: A novel murine model of full-thickness vaginal wound healing was designed and validated to study the impact of estrogen signaling-driven healing kinetics, inflammation, and neovascularization. Accelerated vaginal mucosal repair potentially regulated by estrogen signaling through ER alpha was observed, providing a cellular and molecular foundation for understanding healing responses to injury in the vagina.

ADVANCES IN WOUND CARE (2021)

Article Biochemistry & Molecular Biology

Functional crosstalk between myeloid Foxo1-β-catenin axis and Hedgehog/Gli1 signaling in oxidative stress response

Changyong Li et al.

Summary: The study demonstrates that myeloid-specific Foxo1 knockout mice are resistant to oxidative stress-induced liver injury by enhancing beta-catenin-mediated Gli1/Snail signaling, reducing inflammation, and inhibiting necroptosis. The colocalization of Foxo1 and beta-catenin in macrophages leads to the activation of Gli1/Snail signaling and suppression of RIPK3 and NEK7/NLRP3 expression under inflammatory conditions. Disruption of this axis exacerbates liver damage, leading to increased necroptosis and inflammatory response.

CELL DEATH AND DIFFERENTIATION (2021)

Article Oncology

Structured triglyceride attenuates lung injury and inflammation in lipopolysaccharide-induced acute lung injury by enhancing GPR120 expression

Haiyun Sun et al.

Summary: The study showed that structured triglyceride (STG) alleviated lung injury and inflammation in lipopolysaccharide (LPS)-induced acute lung injury (ALI) by enhancing G-protein coupled receptor 120 (GPR120) expression and inhibiting the TAK1/NF-κB pathway activity. The findings suggest the therapeutic potential of STG in the treatment of ALI.

MOLECULAR MEDICINE REPORTS (2021)

Article Biochemistry & Molecular Biology

Nitraria tangutorum Bobr.-derived polysaccharides protect against LPS-induced lung injury

Jing Meng et al.

Summary: The polysaccharides derived from Nitraria tangutorum Bobr. show anti-inflammatory and protective effects in lipopolysaccharide-induced acute lung injury in mice. The main monosaccharide components of these polysaccharides include mannose, rhamnose, glucuronic acid, etc.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Chemistry, Medicinal

Discovery of Novel Pterostilbene-Based Derivatives as Potent and Orally Active NLRP3 Inflammasome Inhibitors with Inflammatory Activity for Colitis

Liu Zeng Chen et al.

Summary: This study established a screening model targeting inflammasome activation and identified pterostilbene as an active scaffold. 50 pterostilbene derivatives were designed and synthesized, with compound 47 showing the best efficacy in inhibiting cell pyroptosis by targeting NLRP3. Further studies revealed compound 47's ability to affect NLRP3 inflammasome assembly and its significant alleviation of DSS-induced colitis in mice.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Galectin-1 ameliorates lipopolysaccharide-induced acute lung injury via AMPK-Nrf2 pathway in mice

Xiao-Ting Huang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

Article Biochemistry & Molecular Biology

Embelin impact on paraquat-induced lung injury through suppressing oxidative stress, inflammatory cascade, and MAPK/NF-κB signaling pathway

Nagaraja SreeHarsha

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2020)

Article Cell Biology

The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury

Zhao Gao et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

Article Cell Biology

CXCL16/CXCR6 is involved in LPS-induced acute lung injury via P38 signalling

Guo-wei Tu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

Review Cell Biology

Shaping the Nrf2-ARE-related pathways in Alzheimer's and Parkinson's diseases

Ligia Fao et al.

AGEING RESEARCH REVIEWS (2019)

Article Medicine, Research & Experimental

Dihydroartemisinin attenuates lipopolysaccharide-induced acute lung injury in mice by suppressing NF-κB signaling in an Nrf2-dependent manner

Xiao-Ting Huang et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019)

Article Immunology

Poldip2 mediates blood-brain barrier disruption in a model of sepsis-associated encephalopathy

Daniel S. Kikuchi et al.

JOURNAL OF NEUROINFLAMMATION (2019)

Review Cell Biology

Role of Nrf2 and Its Activators in Respiratory Diseases

Qinmei Liu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Article Biochemistry & Molecular Biology

FABP4 inhibitors suppress inflammation and oxidative stress in murine and cell models of acute lung injury

Yuanqi Gong et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Pharmacology & Pharmacy

Oridonin inhibits vascular inflammation by blocking NF-kappa B and MAPK activation

Weichen Huang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2018)

Article Biochemistry & Molecular Biology

Nrf2 protects against acute lung injury and inflammation by modulating TLR4 and Akt signaling

Jia Yan et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

Article Biotechnology & Applied Microbiology

AAV6-Mediated IL-10 Expression in the Lung Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice

Fumio Kurosaki et al.

HUMAN GENE THERAPY (2018)

Review Medicine, General & Internal

Acute Respiratory Distress Syndrome Advances in Diagnosis and Treatment

Eddy Fan et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

Review Biochemistry & Molecular Biology

Oxidative stress: a concept in redox biology and medicine

Helmut Sies

REDOX BIOLOGY (2015)

Article Biochemistry & Molecular Biology

An Inhibitor of NADPH Oxidase-4 Attenuates Established Pulmonary Fibrosis in a Rodent Disease Model

Elizabeth R. Jarman et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2014)

Review Immunology

Crosstalk in NF-κB signaling pathways

Andrea Oeckinghaus et al.

NATURE IMMUNOLOGY (2011)

Article Cardiac & Cardiovascular Systems

Poldip2, a Novel Regulator of Nox4 and Cytoskeletal Integrity in Vascular Smooth Muscle Cells

Alicia N. Lyle et al.

CIRCULATION RESEARCH (2009)

Article Medicine, Research & Experimental

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis

RK Thimmulappa et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)